2024
Isolated unilateral alar ligamentous injury: illustrative cases
Reeves B, Valcarce-Aspegren M, Robert S, Elsamadicy A, Tucker A, Storm P, DiLuna M, Kundishora A. Isolated unilateral alar ligamentous injury: illustrative cases. Journal Of Neurosurgery Case Lessons 2024, 7: case23664. PMID: 38560931, PMCID: PMC10988229, DOI: 10.3171/case23664.Peer-Reviewed Original ResearchMagnetic resonance imagingCervical collarAdequate first-line treatmentAlar ligament injuryUpper cervical traumaMagnetic resonance imaging evidenceHard cervical collarRigid cervical collarFirst-line treatmentResolution of symptomsRigid external immobilizationNeck painNeck tendernessCervical traumaHalo fixationPediatric patientsDefinitive diagnosisNonsurgical managementCervical radiographsModerate courseFollow-upLigament strainExternal immobilizationOdontoid processPatients
2023
Illness Perception and the Impact of a Definitive Diagnosis on Women With Ischemia and No Obstructive Coronary Artery Disease: A Qualitative Study.
Tseng L, Göç N, Schwann A, Cherlin E, Kunnirickal S, Odanovic N, Curry L, Shah S, Spatz E. Illness Perception and the Impact of a Definitive Diagnosis on Women With Ischemia and No Obstructive Coronary Artery Disease: A Qualitative Study. Circulation Cardiovascular Quality And Outcomes 2023, 16: 521-529. PMID: 37476997, DOI: 10.1161/circoutcomes.122.009834.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary function testingCoronary artery diseaseInvasive coronary angiographyArtery diseaseCoronary angiographyFunction testingDefinitive diagnosisYale-New Haven HospitalNon-Hispanic blacksMore patient-centered careNew Haven HospitalPatient-centered careStructured telephone interviewQuality of lifeHealth care experiencesNon-Hispanic whitesGroup of womenCoronary functionIllness perceptionsMean ageINOCAUncertain causeMultidisciplinary teamPatient careFrequency and clinicoeconomic impact of delays to definitive diagnosis of obstructive hypertrophic cardiomyopathy in the United States
Naidu S, Sutton M, Gao W, Fine J, Xie J, Desai N, Owens A. Frequency and clinicoeconomic impact of delays to definitive diagnosis of obstructive hypertrophic cardiomyopathy in the United States. Journal Of Medical Economics 2023, 26: 682-690. PMID: 37170479, DOI: 10.1080/13696998.2023.2208966.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathyDefinitive diagnosisHypertrophic cardiomyopathyHCM diagnosisMedicare Supplemental databasesIBM MarketScan CommercialEmergency room visitsAdministrative claims dataMisclassification of patientsEligible patientsMarketScan CommercialMost patientsRoom visitsAlternative diagnosesPotential misdiagnosesCardiovascular conditionsInappropriate treatmentDatabase studyClaims dataHealthcare costsDiagnostic journeyPatientsEconomic burdenCurrent studyDiagnostic historyClinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors—A prospective study and guidelines for clinical testing
Galbraith K, Vasudevaraja V, Serrano J, Shen G, Tran I, Abdallat N, Wen M, Patel S, Movahed-Ezazi M, Faustin A, Spino-Keeton M, Roberts L, Maloku E, Drexler S, Liechty B, Pisapia D, Krasnozhen-Ratush O, Rosenblum M, Shroff S, Boué D, Davidson C, Mao Q, Suchi M, North P, Hopp A, Segura A, Jarzembowski J, Parsons L, Johnson M, Mobley B, Samore W, McGuone D, Gopal P, Canoll P, Horbinski C, Fullmer J, Farooqi M, Gokden M, Wadhwani N, Richardson T, Umphlett M, Tsankova N, DeWitt J, Sen C, Placantonakis D, Pacione D, Wisoff J, Hidalgo E, Harter D, William C, Cordova C, Kurz S, Barbaro M, Orringer D, Karajannis M, Sulman E, Gardner S, Zagzag D, Tsirigos A, Allen J, Golfinos J, Snuderl M. Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors—A prospective study and guidelines for clinical testing. Neuro-Oncology Advances 2023, 5: vdad076. PMID: 37476329, PMCID: PMC10355794, DOI: 10.1093/noajnl/vdad076.Peer-Reviewed Original ResearchCNS tumorsProspective studyHistologic diagnosisCentral nervous system tumorsDiagnostic accuracyCentral nervous system cancerPrimary CNS tumorsNervous system tumorsNervous system cancersCancer-associated deathsClinical trial designDiagnostic errorsPrimary diagnostic methodDNA methylation profilingMolecular diagnostic testsPrognostic subclassificationPediatric patientsHistologic subtypeWhole genome DNA methylation profilingDefinitive diagnosisPrognostic informationSystem tumorsSystem cancersPatient managementClinical utility
2022
Interface change in early mycosis fungoides: A potential mimicker of benign dermatoses
Tsang M, McNiff J. Interface change in early mycosis fungoides: A potential mimicker of benign dermatoses. Journal Of Cutaneous Pathology 2022, 50: 266-274. PMID: 36444501, DOI: 10.1111/cup.14369.Peer-Reviewed Original ResearchConceptsConnective tissue diseaseEarly mycosis fungoidesMycosis fungoidesInterface dermatitisEarly biopsy specimensPapillary dermal fibrosisPatch-stage diseaseLymphocyte atypiaEarly biopsyRepeat biopsyHistopathologic featuresInflammatory dermatosesPotential mimickersTissue diseaseDefinitive diagnosisLichenoid patternBenign dermatosesBiopsy specimensClinicopathologic correlationDermal-epidermal junctionHistopathologic evolutionAncillary studiesBenign diagnosisDermal fibrosisHistopathologic cluesThe Multiple Sclerosis Prodrome: Evidence to Action
Tremlett H, Munger KL, Makhani N. The Multiple Sclerosis Prodrome: Evidence to Action. Frontiers In Neurology 2022, 12: 761408. PMID: 35173664, PMCID: PMC8841819, DOI: 10.3389/fneur.2021.761408.Peer-Reviewed Original ResearchMultiple sclerosisProdromal phaseEarly recognitionImproved disease courseProdromal multiple sclerosisImmune-mediated diseasesMultiple sclerosis prodromeEarly disease managementDisease courseProdromal featuresDefinitive diagnosisClassical diseaseGeneral populationMS prodromeDisease preventionProdromeMajor long-term implicationsDisease managementPrognosisDiseaseLong-term implicationsPreventionSclerosisEvidenceSymptoms
2021
A Case of Possible Chronic Traumatic Encephalopathy and Alzheimer’s Disease in an Ex-Football Player
Fesharaki-Zadeh A. A Case of Possible Chronic Traumatic Encephalopathy and Alzheimer’s Disease in an Ex-Football Player. The Neurologist 2021, 27: 249-252. PMID: 34879014, PMCID: PMC9439689, DOI: 10.1097/nrl.0000000000000391.Peer-Reviewed Original ResearchConceptsChronic traumatic encephalopathyTraumatic encephalopathyAlzheimer's diseasePrior traumatic brain injuryBehavioral variant frontotemporal dementiaRepetitive head traumaTraumatic brain injuryPrior psychiatric historyPrimary progressive aphasiaVariant frontotemporal dementiaPositron emission tomographyCTE casesClinical presentationHead traumaCase reportClinical historyDefinitive diagnosisClinical algorithmBrain injuryComorbid moodPsychiatric historyCerebrospinal fluidNeuroimaging biomarkersProgressive aphasiaFrontotemporal dementia6. Time elapsed from initial presentation to diagnostic laparoscopy: factors affecting diagnostic delay in adolescents with biopsy-confirmed endometriosis
Li H, Cho Y, Taylor H, Vash-Margita A. 6. Time elapsed from initial presentation to diagnostic laparoscopy: factors affecting diagnostic delay in adolescents with biopsy-confirmed endometriosis. Journal Of Pediatric And Adolescent Gynecology 2021, 34: 241-242. DOI: 10.1016/j.jpag.2021.02.010.Peer-Reviewed Original ResearchBiopsy-proven endometriosisShorter diagnostic delayAdnexal massesDiagnostic delayMedian delayDiagnostic laparoscopyInitial presentationInitial imagingOB/GYN providersTertiary hospital systemChronic pelvic painMultiple regression analysisRegression analysisInstitutional review boardPelvic painSubspecialty referralConclusions PatientsYounger patientsMajor surgeryBackground EndometriosisMedian timeRetrospective reviewED visitationOutpatient settingDefinitive diagnosis
2020
Collagenofibrotic glomerulopathy in a kidney transplant recipient: A first report
Jdiaa SS, Moeckel GW, Kfoury H, Medawar WA, Abu-Alfa A. Collagenofibrotic glomerulopathy in a kidney transplant recipient: A first report. American Journal Of Transplantation 2020, 21: 1948-1952. PMID: 33206467, DOI: 10.1111/ajt.16399.Peer-Reviewed Case Reports and Technical NotesConceptsKidney transplant recipientsCollagenofibrotic glomerulopathyTransplant recipientsRenal dysfunctionType 3 fibresProgressive diseaseKidney diseaseDefinitive diagnosisUnknown causeRare diseaseDiseaseFirst caseRecipientsFirst reportHematuriaProteinuriaGlomerulopathyPatientsDysfunctionGlomeruliDiagnosisProgressionThyroid tissue outside the thyroid gland: Differential diagnosis and associated diagnostic challenges
Barbieri A, Prasad ML, Gilani SM. Thyroid tissue outside the thyroid gland: Differential diagnosis and associated diagnostic challenges. Annals Of Diagnostic Pathology 2020, 48: 151584. PMID: 32871503, DOI: 10.1016/j.anndiagpath.2020.151584.Peer-Reviewed Original ResearchConceptsDifferential diagnostic considerationsThyroid tissueThyroid glandLymph nodesDiagnostic challengeDifferential diagnosisDiagnostic considerationsLateral neck lymph nodesNeck lymph nodesRoutine daily practiceThyroglossal duct cystLocation of lesionsMalignant differential diagnosisDuct cystDefinitive diagnosisLingual thyroidAnatomic locationClinical settingThyroid folliclesDaily practiceDiagnosisParasitic nodulesGlandTissueHistologicAssessment of the Predictive Value of Outpatient Smartphone Videos for Diagnosis of Epileptic Seizures
Tatum WO, Hirsch LJ, Gelfand MA, Acton EK, LaFrance WC, Duckrow RB, Chen DK, Blum AS, Hixson JD, Drazkowski JF, Benbadis SR, Cascino GD. Assessment of the Predictive Value of Outpatient Smartphone Videos for Diagnosis of Epileptic Seizures. JAMA Neurology 2020, 77: 593-600. PMID: 31961382, PMCID: PMC6990754, DOI: 10.1001/jamaneurol.2019.4785.Peer-Reviewed Original ResearchConceptsPhysical examination resultsPsychogenic nonepileptic attacksVideo electroencephalogram monitoringEpileptic seizuresVideo electroencephalogramEpilepsy centersPhysical examinationElectroencephalogram monitoringNonepileptic attacksCorrect diagnosisPhysiologic nonepileptic eventsEvaluation of epilepsyExamination resultsMisdiagnosis of epilepsyDiagnostic accuracy studiesPsychogenic attacksMotor signsNonepileptic eventsDefinitive diagnosisPatient historyMAIN OUTCOMEClinic outpatientsPredictive valueSeizuresDiagnosis105 Babesiosis
Vannier E, Krause P. 105 Babesiosis. 2020, 799-802. DOI: 10.1016/b978-0-323-55512-8.00105-8.Peer-Reviewed Original ResearchPolymerase chain reactionProphylactic antibiotic regimenLife-threatening complicationsMainstay of treatmentSolid organ transplantationBest preventive measureAntibiotic regimenFrequent symptomsHospital admissionDefinitive diagnosisSevere babesiosisBlood productsOrgan transplantationEtiologic agentBabesia microtiPreventive measuresZoonotic diseaseChain reactionB. duncaniBabesiosisDiseaseB. venatorumHemoprotozoan parasitesB. divergensAlternative option
2019
Exome Sequencing in Clinical Hepatology
Vilarinho S, Mistry PK. Exome Sequencing in Clinical Hepatology. Hepatology 2019, 70: 2185-2192. PMID: 31222768, PMCID: PMC6885087, DOI: 10.1002/hep.30826.BooksConceptsWhole-exome sequencingClinical diagnosisUtility of WESCare of patientsCongenital chloride diarrheaLiver clinicLiver diseaseClinical hepatologyDefinitive diagnosisNovel genetic disorderPediatric disordersClinical relevanceChloride diarrheaSalt-wasting diseaseExome sequencingDiagnosisGenetic disordersDiseaseDisordersPractice of medicineNumerous studiesDiarrheaPatientsHepatologyClinicNeuroimaging in Dementias
Mahalingam S, Chen MK. Neuroimaging in Dementias. Seminars In Neurology 2019, 39: 188-199. PMID: 30925612, DOI: 10.1055/s-0039-1678580.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPositron emission tomographyAlzheimer's diseaseDisease dementiaDifferential diagnosisTau positron emission tomographyAmyloid positron emission tomographyParkinson's disease dementiaRole of imagingDiagnosis of dementiaFrontotemporal lobar dementiaGlobal health issueReversible causesVascular dementiaLewy bodiesDefinitive diagnosisClinical trialsCommon dementiaDiagnostic certaintyProdromal stageTesting modalitiesDementiaEmission tomographyMolecular imaging modalitiesHealth issuesDiagnosisNecrotizing Soft Tissue Infection
Fernando SM, Tran A, Cheng W, Rochwerg B, Kyeremanteng K, Seely AJE, Inaba K, Perry JJ. Necrotizing Soft Tissue Infection. Annals Of Surgery 2019, 269: 58-65. PMID: 29672405, DOI: 10.1097/sla.0000000000002774.Peer-Reviewed Original ResearchConceptsSoft tissue infectionsTissue infectionsComputed tomographyPlain radiographyEarly surgical consultationPhysical examination signsLife-threatening diagnosisLaboratory Risk IndicatorNecrotizing Fasciitis (LRINEC) scorePhysical examination featuresPoor sensitivityEnglish-language studiesHierarchical summary receiverExamination signsFasciitis (LRINEC) scoreLRINEC scoreSurgical managementPhysical examinationSurgical consultationDefinitive diagnosisExamination featuresBACKGROUND DATANSTI
2018
Patient with a Large Goiter Presenting for Thyroid Surgery
Gooden C, Ralph W. Patient with a Large Goiter Presenting for Thyroid Surgery. 2018, 295-302. DOI: 10.1093/med/9780190850692.003.0034.Peer-Reviewed Original ResearchTreatment of GravesMiddle-aged individualsDifferent organ systemsEye involvementAutoimmune disordersThyroid surgeryDefinitive diagnosisPeak incidencePhysical examinationTreatment optionsAge groupsImaging studiesOrgan systemsDiseaseDiagnosisDisordersGravesHyperthyroidismPresentingSurgeryGoiterIncidenceThe Subjective Experience of Patients Undergoing Shunt Surgery for Idiopathic Normal Pressure Hydrocephalus
Subramanian HE, Mahajan A, Sommaruga S, Falcone GJ, Kahle KT, Matouk CC. The Subjective Experience of Patients Undergoing Shunt Surgery for Idiopathic Normal Pressure Hydrocephalus. World Neurosurgery 2018, 119: e46-e52. PMID: 29981467, DOI: 10.1016/j.wneu.2018.06.209.Peer-Reviewed Original ResearchConceptsIdiopathic normal pressure hydrocephalusShunt surgeryNormal pressure hydrocephalusPreoperative courseClinical responsePressure hydrocephalusPatient's clinical responseVentriculoperitoneal shunt surgeryCounseling of patientsSaturation of themesClinical courseComorbid conditionsConsecutive seriesPostoperative assessmentDefinitive diagnosisPatients' caregiversPatient outcomesChallenges patientsDiagnostic criteriaPatientsSurgeryTelephone interviewsHydrocephalusDiagnosisSubjective experience33 Acute Interstitial Nephritis
Brewster U, Luciano R. 33 Acute Interstitial Nephritis. 2018, 320-325. DOI: 10.1016/b978-0-323-47794-9.00033-0.Peer-Reviewed Original ResearchAcute interstitial nephritisInterstitial nephritisCellular interstitial infiltratesForm of AKITriad of feverSetting of infectionUrine of patientsOccasional plasma cellsRenal tubular cellsKidney injuryMedication exposureSterile pyuriaCulprit medicationKidney biopsyMild proteinuriaInterstitial infiltratesSystemic diseaseAutoimmune diseasesDefinitive diagnosisCommon causePlasma cellsImmune responseUrine sedimentTubular cellsRapid treatmentAn Atypical Presentation of Trauma-related Disorder in Geriatric Patients
Oyelakin A, Maksymenko A, Jegede O, Olupona T, Germain W, Jolayemi K. An Atypical Presentation of Trauma-related Disorder in Geriatric Patients. Journal Of Traumatic Stress Disorders & Treatment 2018, 2018 DOI: 10.4172/2324-8947.1000185.Peer-Reviewed Original ResearchPast psychiatric historyHistory of traumaYounger age groupsDSM-5 criteriaTraumatic eventsElderly patientsAtypical presentationGeriatric patientsClinical presentationComplicated presentationDefinitive diagnosisCase reportPsychiatric illnessMultiple traumatic eventsPsychiatric historyComorbid diagnosesPatientsCognitive impairmentAge groupsFunctional lossFurther evaluationConsiderable distressTraumaDisorganized behaviorDiagnosis
2017
Non-alcoholic fatty liver disease: An expanded review
Benedict M, Zhang X. Non-alcoholic fatty liver disease: An expanded review. World Journal Of Hepatology 2017, 9: 715-732. PMID: 28652891, PMCID: PMC5468341, DOI: 10.4254/wjh.v9.i16.715.Peer-Reviewed Original ResearchNon-alcoholic fatty liver diseaseNAFLD patientsInsulin resistanceRisk factorsDevelopment of NAFLDTreatment of NAFLDFatty liver diseaseMedications/supplementsNumerous risk factorsNAFLD epidemiologyLiver transplantationCardiovascular mortalityLiver biopsySimple steatosisLiver diseaseMetabolic derangementsAssociated hepatitisDefinitive diagnosisPathologic changesFree fatty acidsAdvanced imagingLiver accumulationNatural historyProgressive steatosisGold standard
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