2023
Role of ascorbic acid in cardiac allograft vasculopathy
Chang A, Martin K, Colvin M, Bellumkonda L. Role of ascorbic acid in cardiac allograft vasculopathy. Clinical Transplantation 2023, 37: e15153. PMID: 37792313, DOI: 10.1111/ctr.15153.Peer-Reviewed Original ResearchConceptsCardiac allograft vasculopathySmooth muscle cell apoptosisAllograft vasculopathyDisease processMuscle cell apoptosisSignificant long-term morbidityCell apoptosisProgressive fibroproliferative diseasePost-transplant carePost-transplant managementLong-term morbiditySmall clinical trialsChallenging disease processVascular smooth muscle cell apoptosisHeart transplantationCAV progressionEndothelial dysfunctionRapamycin inhibitorsClinical trialsIntimal thickeningPrevents developmentInterferon γRodent modelsIntimal hyperplasiaMTOR inhibitors
2021
TET2 Protects Against Vascular Smooth Muscle Cell Apoptosis and Intimal Thickening in Transplant Vasculopathy
Ostriker AC, Xie Y, Chakraborty R, Sizer AJ, Bai Y, Ding M, Song WL, Huttner A, Hwa J, Martin KA. TET2 Protects Against Vascular Smooth Muscle Cell Apoptosis and Intimal Thickening in Transplant Vasculopathy. Circulation 2021, 144: 455-470. PMID: 34111946, PMCID: PMC8643133, DOI: 10.1161/circulationaha.120.050553.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsAnimalsApoptosisBiomarkersDioxygenasesDisease Models, AnimalDisease SusceptibilityDNA-Binding ProteinsHeart TransplantationHumansImmunohistochemistryInterferon-gammaMiceMice, KnockoutMyocytes, Smooth MuscleSignal TransductionSTAT1 Transcription FactorTunica IntimaVascular DiseasesConceptsCoronary allograft vasculopathyGraft arteriopathyIntimal thickeningCAV progressionRole of TET2VSMC apoptosisTransplant samplesGraft modelHigh-dose ascorbic acidTET2 expressionVSMC phenotypeContext of transplantCoronary blood flowEffect of IFNγTET2 activityTET2 depletionSmooth muscle cell apoptosisVascular smooth muscle cell apoptosisMuscle cell apoptosisAllograft vasculopathyDevastating sequelaeMedial thinningAortic graftHeart transplantTransplant failure
2014
Vein graft adaptation and fistula maturation in the arterial environment
Lu DY, Chen EY, Wong DJ, Yamamoto K, Protack CD, Williams WT, Assi R, Hall MR, Sadaghianloo N, Dardik A. Vein graft adaptation and fistula maturation in the arterial environment. Journal Of Surgical Research 2014, 188: 162-173. PMID: 24582063, PMCID: PMC3972303, DOI: 10.1016/j.jss.2014.01.042.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaVein graftsVein graft adaptationVenous adaptationGraft adaptationArterial environmentCommon surgical procedureAVF maturationDifferent hemodynamic conditionsFistula maturationVenous dilationUnderlying molecular mechanismsIntimal thickeningSurgical proceduresWall thickeningHemodynamic conditions
2011
Surgical Treatment of Vascular Occlusive Disease
Feigel A, Dardik A. Surgical Treatment of Vascular Occlusive Disease. 2011, 663-672. DOI: 10.1007/978-1-4419-6999-6_54.ChaptersPeripheral arterial diseaseBlood flowElderly patientsIntimal thickeningLower extremitiesElderly populationImpact of PADSymptoms of PADTreatment of PADVascular occlusive diseaseProgressive intimal thickeningDistal blood flowSpectrum of diseaseArterial blood flowAtherosclerotic intimal thickeningDistal emboliOcclusive diseaseCoronary diseaseSurgical treatmentArterial diseaseCarotid diseaseEndovascular treatmentVisceral circulationAbdominal visceraLuminal diameter
2007
Alloimmune-Mediated Vascular Remodeling of Human Coronary Artery Grafts in Immunodeficient Mouse Recipients Is Independent of Preexisting Atherosclerosis
Wang Y, Ahmad U, Yi T, Zhao L, Lorber MI, Pober JS, Tellides G. Alloimmune-Mediated Vascular Remodeling of Human Coronary Artery Grafts in Immunodeficient Mouse Recipients Is Independent of Preexisting Atherosclerosis. Transplantation 2007, 83: 1501-1505. PMID: 17565324, DOI: 10.1097/01.tp.0000264560.51845.67.Peer-Reviewed Original ResearchConceptsImmunodeficient mouse recipientsHuman coronary artery graftsCoronary artery graftsVascular remodelingArtery graftCoronary atherosclerosisMouse recipientsAllogeneic human peripheral blood mononuclear cellsHuman peripheral blood mononuclear cellsPeripheral blood mononuclear cellsBlood mononuclear cellsArterial injuryGraft arteriosclerosisIntimal injuryLuminal lossImmunosuppressive drugsLumen lossMononuclear cellsIntimal thickeningClinical studiesIntimal expansionAtherosclerotic lesionsOrgan donorsChimeric modelAtherosclerosis
2005
Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells
Akasaka K, Akasaka N, Di Luozzo G, Sasajima T, Sumpio BE. Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells. Journal Of Vascular Surgery 2005, 41: 517-522. PMID: 15838488, DOI: 10.1016/j.jvs.2004.12.043.Peer-Reviewed Original ResearchConceptsEffect of homocysteineMigration of SMCsLevels of homocysteineProgressive intimal thickeningAortic smooth muscle cellsSmooth muscle cell migrationBovine aortic smooth muscle cellsPotential therapeutic implicationsSmooth muscle cellsP38 activationExposure of SMCMuscle cell migrationSMC chemotaxisRisk factorsSelective blockadeIntimal thickeningTherapeutic implicationsP38-dependent pathwaySMC proliferationBoyden chamberChemotactic potentialMuscle cellsHomocysteineFetal bovine serumP38 inhibitor
1995
Intimal thickenings of human aorta contain modified reassembled lipoproteins
Tîrziu D, Dobrian A, Tasca C, Simionescu M, Simionescu N. Intimal thickenings of human aorta contain modified reassembled lipoproteins. Atherosclerosis 1995, 112: 101-114. PMID: 7772061, DOI: 10.1016/0021-9150(94)05405-8.Peer-Reviewed Original Research
1991
Effects of soluble factors and extracellular matrix components on vascular cell behavior in vitro and in vivo: Models of de‐endothelialization and repair
Madri J, Marx M, Merwin J, Basson C, Prinz C, Bell L. Effects of soluble factors and extracellular matrix components on vascular cell behavior in vitro and in vivo: Models of de‐endothelialization and repair. Journal Of Cellular Biochemistry 1991, 45: 123-130. PMID: 1711525, DOI: 10.1002/jcb.240450202.Peer-Reviewed Original ResearchConceptsSoluble factorsEndothelial cellsVascular smooth muscle cellsCell populationsSite of injuryMicrovascular endothelial cellsSmooth muscle cellsVessel endothelial cellsEndothelial vascular cellsLarge vessel endothelial cellsVascular cell populationsCell typesIntimal thickeningDenudation injuryVascular cell typesArterial mediaSubsequent lumen formationDifferent cell populationsInjuryCell responsesMuscle cellsVascular cellsExtracellular matrixSoft tissueVascular cell behavior
1989
The Interactions of Vascular Cells with Solid Phase (Matrix) and Soluble Factors
Madri J, Kocher O, Merwin J, Bell L, Yannariello-Brown J. The Interactions of Vascular Cells with Solid Phase (Matrix) and Soluble Factors. Journal Of Cardiovascular Pharmacology 1989, 14: s70-s75. DOI: 10.1097/00005344-198900146-00015.Peer-Reviewed Original ResearchVascular bedSoluble factorsVascular cellsEndothelial cellsVascular smooth muscle cellsCell populationsSite of injuryMicrovascular endothelial cellsSmooth muscle cellsVessel endothelial cellsLarge vessel endothelial cellsVascular cell populationsVascular injuryIntimal thickeningInjury variesPlatelet factorInjuryMuscle cellsSoft tissueTube formationVessel wallHeterogeneous cell populationsCell typesCellsRepair processThe Interactions of Vascular Cells with Solid Phase (Matrix) and Soluble Factors
Madri J, Kocher O, Merwin J, Bell L, Yannariello-Brown J. The Interactions of Vascular Cells with Solid Phase (Matrix) and Soluble Factors. Journal Of Cardiovascular Pharmacology 1989, 14: s70-s75. PMID: 2478828, DOI: 10.1097/00005344-198906146-00015.Peer-Reviewed Original ResearchConceptsVascular bedSoluble factorsVascular cellsEndothelial cellsVascular smooth muscle cellsCell populationsSite of injuryMicrovascular endothelial cellsSmooth muscle cellsVessel endothelial cellsLarge vessel endothelial cellsVascular cell populationsVascular injuryIntimal thickeningInjury variesPlatelet factorInjuryMuscle cellsSoft tissueTube formationVessel wallHeterogeneous cell populationsCell typesCellsRepair process
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