2023
Sensory‐Evoked 40Hz Gamma Oscillation: A Feasible and Promising Treatment Option for Alzheimer’s Disease
Hajos M, Boasso A, Cimenser A, Shpokayte M, Hempel E, Da X, Seshagiri C, Megerian J, Vaughan B, Malchano Z. Sensory‐Evoked 40Hz Gamma Oscillation: A Feasible and Promising Treatment Option for Alzheimer’s Disease. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.072957.Peer-Reviewed Original ResearchClinical trialsAlzheimer's diseaseActive armPotential novel therapeutic interventionsSensory stimulationOccipital cortical thicknessAmyloid plaque loadAbnormal neuronal activityPivotal clinical trialsStimulation systemPromising treatment optionDifferent therapeutic approachesNovel therapeutic interventionsMinimal side effectsQuantitative MRI analysisNeuronal network oscillationsDaily therapyPlaque loadADCS-ADLBrain atrophyClinical presentationTreatment armsClinical benefitClinical efficacyAD pathologyModalities to Deliver Cell Therapy for Treatment of Chronic Limb Threatening Ischemia
Setia O, Lee S, Dardik A. Modalities to Deliver Cell Therapy for Treatment of Chronic Limb Threatening Ischemia. Advances In Wound Care 2023, 13: 253-279. PMID: 37002893, PMCID: PMC11305013, DOI: 10.1089/wound.2022.0114.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsChronic limb threatening ischemiaPeripheral arterial diseaseSevere peripheral arterial diseaseLimb threatening ischemiaClinical trialsCell therapyStem cell therapyIschemic limbsFeasible therapeutic alternativePromising treatment optionPre-clinical studiesCell deliveryPAD patientsArterial diseaseClinical benefitTreatment optionsSurgical methodsTherapeutic alternativeBest modalityHigh riskLimb lossSevere formTherapeutic benefitPatientsTherapy
2022
Oxidative Stress in Traumatic Brain Injury
Fesharaki-Zadeh A. Oxidative Stress in Traumatic Brain Injury. International Journal Of Molecular Sciences 2022, 23: 13000. PMID: 36361792, PMCID: PMC9657447, DOI: 10.3390/ijms232113000.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryAntioxidant therapyBrain injuryClinical settingPost-traumatic brain injuryOxidative stressReactive oxygen speciesUnderlying pathophysiological mechanismsSecondary injury cascadePromising treatment optionLipid peroxidation productsFree radical generating enzymesReal clinical settingNeurometabolic cascadeFree radical scavengerInjury cascadeChronic inflammationPathophysiological mechanismsSynaptic dysfunctionPost injuryTreatment optionsTBI treatmentSide effectsTBI symptomsInjuryDecision-making about gene therapy in transfusion dependent thalassemia
Quarmyne M, Ross D, Sinha C, Bakshi N, Boudreaux J, Krishnamurti L. Decision-making about gene therapy in transfusion dependent thalassemia. BMC Pediatrics 2022, 22: 536. PMID: 36085025, PMCID: PMC9461218, DOI: 10.1186/s12887-022-03598-3.Peer-Reviewed Original ResearchConceptsTransfusion-dependent thalassemiaPatient/family knowledgeDependent thalassemiaTransfusion independenceTreatment optionsStudy participantsGene therapyFamily knowledgeElimination of transfusionsFrequency of transfusionMorbidity/mortalityStem cell transplantationLong-term outcomesPreferred treatment modalityPromising treatment optionBackgroundHematopoietic stem cell transplantationPatients/familiesMethodsParents of childrenCurative intentTransfusion reductionHost diseaseDonor HSCTParents of childrenCell transplantationMean age
2020
Systematic Review: Treatment for Addictive Disorder in Transplant Patients
Luchsinger W, Zimbrean P. Systematic Review: Treatment for Addictive Disorder in Transplant Patients. American Journal On Addictions 2020, 29: 445-462. PMID: 32410396, DOI: 10.1111/ajad.13054.Peer-Reviewed Original ResearchConceptsTransplant patientsAlcohol use disorderUse disordersOrgan transplantationAddictive disordersSystematic reviewLiver transplant patientsOpioid use disorderNumber of patientsPromising treatment optionSubstance use disordersOpioid disordersFirst systematic reviewTransplant candidatesHeart transplantTreatment optionsCase reportOutcome measuresMedical statusHigh riskPatientsDatabases PubMedTreatment interventionsControl groupLiterature search
2019
Sympathetic Nerve Block in Lymphedema Treatment: A Systematic Review
Forte AJ, Boczar D, Huayllani MT, Lu X, McLaughlin SA. Sympathetic Nerve Block in Lymphedema Treatment: A Systematic Review. Cureus 2019, 11: e5700. PMID: 31720168, PMCID: PMC6823032, DOI: 10.7759/cureus.5700.Peer-Reviewed Original ResearchSympathetic nerve blockNerve blockLymphedema treatmentSystematic reviewEligibility criteriaLymphedema patientsLarge randomized clinical trialsSympathetic nerve systemPatient-reported outcomesRandomized clinical trialsNerve block techniquePromising treatment optionComprehensive systematic reviewTreatment of lymphedemaLymphedema improvementConservative therapyPatient characteristicsTreatment optionsClinical trialsLocal anestheticsAnesthesiology proceduresPubMed databaseLimb circumferenceNerve systemLymphatic circulation
2013
Drug-eluting balloon angioplasty for in-stent restenosis: a systematic review and meta-analysis of randomised controlled trials
Indermuehle A, Bahl R, Lansky AJ, Froehlich GM, Knapp G, Timmis A, Meier P. Drug-eluting balloon angioplasty for in-stent restenosis: a systematic review and meta-analysis of randomised controlled trials. Heart 2013, 99: 327. PMID: 23335497, DOI: 10.1136/heartjnl-2012-302945.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsDrug-eluting balloonsDrug-eluting balloon angioplastyBalloon angioplastyStent restenosisStent thrombosisMyocardial infarctionRelative riskSegment restenosisTreatment optionsSystematic reviewIncidence of MIRisk of STAdverse cardiac eventsPooled relative riskPlain balloon angioplastyOptimal treatment optionsPromising treatment optionDrug-eluting stentsRandom-effects modelLesion revascularisationCardiac eventsCoronary angioplastyMain endpointClinical trials
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