Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes
Promet L, Meda S, Alliey-Rodriguez N, Clementz B, Gershon E, Hill S, Ivleva E, Keedy S, Keshavan M, McDowell J, Parker D, Tamminga C, Pearlson G. Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes. Schizophrenia Bulletin 2025, sbaf022. PMID: 40448350, DOI: 10.1093/schbul/sbaf022.Peer-Reviewed Original ResearchBrain age gapBipolar-Schizophrenia NetworkDSM diagnosesBrain agingPRS-SZComorbid disordersNon-psychotic first-degree relativesHealthy controlsAssociated with symptom severityPsychotic bipolar disorderSubtypes of psychosisStructural T1-weighted imagesBrain structural differencesPsychotropic medication useSchizoaffective disorderPsychosis probandsPsychotic disordersBipolar disorderPolygenic risk scoresSymptom severityFirst-degree relativesPsychosisAge gapDSMIntermediate phenotypes
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