2025
Cannabinoid 1 receptor availability in posttraumatic stress disorder: A positron emission tomography study
Korem N, Bassir Nia A, Hillmer A, D’Souza D, Nabulsi N, Ropchan J, Huang Y, Cosgrove K, Levy I, Pietrzak R, Harpaz-Rotem I. Cannabinoid 1 receptor availability in posttraumatic stress disorder: A positron emission tomography study. Translational Psychiatry 2025, 15: 310. DOI: 10.1038/s41398-025-03519-9.BooksPathophysiology of posttraumatic stress disorderEmotional numbing symptomsCB1R availabilityPosttraumatic stress disorderEndocannabinoid systemStress disorderPositron emission tomographyTrauma-exposed participantsEndocannabinoid system's rolePositron emission tomography studiesCannabinoid receptor 1Emission tomography studiesMulti-faceted disorderFear learningCB1RSymptom expressionHealthy controlsCannabinoidDisordersTomography studiesEmission tomographyPreclinical studiesSymptomsHigher levelsReceptor 1
2024
Psilocybin Facilitates Fear Extinction: Importance of Dose, Context, and Serotonin Receptors
Woodburn S, Levitt C, Koester A, Kwan A. Psilocybin Facilitates Fear Extinction: Importance of Dose, Context, and Serotonin Receptors. ACS Chemical Neuroscience 2024, 15: 3034-3043. PMID: 39087917, PMCID: PMC12166970, DOI: 10.1021/acschemneuro.4c00279.Peer-Reviewed Original ResearchPost-traumatic stress disorderFear extinctionFear renewalExtinction retentionSerotonin receptorsPsilocybin effectsEffects of psilocybinExtinction-based therapiesProlonged exposure therapyFear conditioning paradigmAnalysis of sex differencesEnhanced fear extinctionFear learning paradigmAdministration of psilocybinConditioning paradigmExposure therapyFear learningStress disorderClassic psychedelicsPsilocybinSex differencesExtinction experimentsReceptor antagonismDrug effectsSerotoninThe effects of parental presence on amygdala and mPFC activation during fear conditioning: An exploratory study
Abramson L, Callaghan B, Silvers J, Choy T, VanTieghem M, Vannucci A, Fields A, Tottenham N. The effects of parental presence on amygdala and mPFC activation during fear conditioning: An exploratory study. Developmental Science 2024, 27: e13505. PMID: 38549194, PMCID: PMC11436486, DOI: 10.1111/desc.13505.Peer-Reviewed Original ResearchMedial prefrontal cortexMedial prefrontal cortex activationFear conditioning taskFear learningUnconditioned stimulusMPFC activityAmygdala activationConditioning taskUnconditioned responseConditioned threat cueConditioned fear stimuliChildren's stress responsesMultiple comparison correctionThreat cuesFear conditioningPrefrontal cortexSafety cuesAversive stimuliFearful stimuliAversive noiseBehavioral effectsRodent findingsStress responseBOLD activityUS presentations
2023
Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach
Jia R, Ruderman L, Pietrzak R, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal J, Harpaz-Rotem I, Levy I. Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Translational Psychiatry 2023, 13: 101. PMID: 36977676, PMCID: PMC10050320, DOI: 10.1038/s41398-023-02388-4.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderValuation systemStress disorderCombat veteransMaintenance of PTSDSubjective valueBrain valuation systemNeural valuation systemVentromedial prefrontal cortexFunctional MRI studyFunction of symptomsMale combat veteransNeural valuationSeries of choicesFear learningPunishment processingPosttrauma symptomsPTSD symptomsNeural encodingNeural mechanismsUncertain optionsPrefrontal cortexSubjective valuationVentral striatumMonetary gains
2021
The Reward System and Post-Traumatic Stress Disorder: Does Trauma Affect the Way We Interact With Positive Stimuli?
Seidemann R, Duek O, Jia R, Levy I, Harpaz-Rotem I. The Reward System and Post-Traumatic Stress Disorder: Does Trauma Affect the Way We Interact With Positive Stimuli? Chronic Stress 2021, 5: 2470547021996006. PMID: 33718742, PMCID: PMC7917421, DOI: 10.1177/2470547021996006.Peer-Reviewed Original ResearchPost-traumatic stress disorderStress disorderReward systemSelf-reported dataFear learningPositive stimuliMajority of researchImportant constructDisordersPrevalent disorderCurrent reviewComplex relationshipTraumaAnhedoniaFearFunctioningStimuliEthologyResearchLearningRelationshipConstructsPossible hindranceSufficient insightClinical observations
2020
Hippocampal knockdown of α2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning
Mineur YS, Ernstsen C, Islam A, Maibom KL, Picciotto MR. Hippocampal knockdown of α2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning. Genes Brain & Behavior 2020, 19: e12677. PMID: 32447811, PMCID: PMC8018799, DOI: 10.1111/gbb.12677.Peer-Reviewed Original ResearchConceptsFear learningShort-term learningNumber of paradigmsCued fearLight/dark boxFear conditioningContextual memoryStress-related behaviorsStress-induced reactivityTerm learningBrain circuitsRobust effectM1 mAChRHippocampal acetylcholineM1 muscarinic ACh receptorsNovelty-suppressed feeding testLearningMemoryDark boxHippocampus of malesM1 muscarinic acetylcholine receptorHippocampal knockdownFearMuscarinic ACh receptorsGroups of mice
2012
P-786 - The neural correlates of aversive learning among PTSD patients
Harpaz-Rotem I, Levy I, Schiller D. P-786 - The neural correlates of aversive learning among PTSD patients. European Psychiatry 2012, 27: 1. DOI: 10.1016/s0924-9338(12)74953-2.Peer-Reviewed Original ResearchFear responsesPTSD patientsUnconditioned stimulusAcquisition of fearAversive unconditioned stimulusContext of PTSDExtinction learningFear acquisitionFear extinctionFear learningNeural correlatesReversal learningAversive learningReversal taskDistinct predictionsReinforcement contingenciesHealthy controlsPTSDFirst CSCombat situationsStimuliLearningGSR dataDiminished abilityContext of war
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