Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers
Wang J, Huang Q, Chen X, You Z, He K, Mao X, Huang Y, Franzmeier N, Schöll M, Guo T, Zhao J, Guan Y, Ni R, Li B, Xie F. Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers. Alzheimer's & Dementia 2025, 21: e70333. PMID: 40432308, PMCID: PMC12117192, DOI: 10.1002/alz.70333.Peer-Reviewed Original ResearchConceptsAssociated with longitudinal cognitive declineLongitudinal cognitive declineSynaptic lossCognitive declineSynapse lossPositron emission tomographyTau depositionTau positron emission tomographyTau burdenHealthy controlsAlzheimer's diseaseSynaptic densityMedial temporal lobePlasma glial fibrillary acidic proteinIncreased tau burdenPhosphorylated tau181Longitudinal changesCognitively impaired individualsAcidic proteinTau pathologyTemporal lobeAmyloid positron emission tomographyGlial fibrillary acidic proteinPlasma phosphorylated tau181CI group
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