2025
Changes in the FXR-cistrome and alterations in bile acid physiology in Wilson disease
Wooton-Kee C, Yalamanchili H, Mohamed I, Hassan M, Setchell K, Rivas M, Coskun A, Putluri V, Putluri N, Jalal P, Schilsky M, Moore D. Changes in the FXR-cistrome and alterations in bile acid physiology in Wilson disease. Hepatology Communications 2025, 9: e0707. PMID: 40408300, PMCID: PMC12106221, DOI: 10.1097/hc9.0000000000000707.Peer-Reviewed Original ResearchConceptsWild-type miceFarnesoid X receptorWilson's diseaseNon-parenchymal cellsDistal intergenic regionsLiver bile acid concentrationWD patientsHealthy controlsMetabolic target genesFarnesoid X Receptor RegulationBile salt export pumpIntergenic regionFXR activationAutosomal recessive disorderBile acid homeostasisBile acid physiologyFarnesoid X receptor activationPromoter regionHomeostasis pathwaysBile acid metabolismDecreasing FXR activityTarget genesBile acid profilesMarker genesStress pathways
2023
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions
Kaffe E, Roulis M, Zhao J, Qu R, Sefik E, Mirza H, Zhou J, Zheng Y, Charkoftaki G, Vasiliou V, Vatner D, Mehal W, AlcHepNet, Kluger Y, Flavell R. Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions. Cell 2023, 186: 3793-3809.e26. PMID: 37562401, PMCID: PMC10544749, DOI: 10.1016/j.cell.2023.07.017.Peer-Reviewed Original ResearchConceptsMetabolic functionsSpecies-specific interactionsKey metabolic functionsCell-autonomous mechanismsNon-alcoholic fatty liver diseaseMajor metabolic hubNon-parenchymal cellsMetabolic hubHuman hepatocytesMicroenvironmental regulationHuman diseasesHuman-specific aspectsHuman pathologiesHomeostatic processesSpecies mismatchCholesterol uptakeFatty liver diseaseParacrine mannerHuman immuneBile acid conjugationSinusoidal endothelial cellsHepatic metabolic functionMouse liverEndothelial cellsCells
2020
Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease
Shim Y, Jeong W. Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease. Experimental & Molecular Medicine 2020, 52: 772-780. PMID: 32457490, PMCID: PMC7272465, DOI: 10.1038/s12276-020-0438-5.Peer-Reviewed Original ResearchConceptsDamage-associated molecular patternsAlcoholic liver diseaseNon-parenchymal cellsSterile inflammationLiver diseaseGeneration of damage-associated molecular patternsCellular pattern recognition receptorsMultiple pro-inflammatory cytokinesSpectrum of alcoholic liver diseaseToll-like receptorsPro-inflammatory cytokinesHepatic stellate cellsAlcoholic liver injuryPattern recognition receptorsDouble-stranded RNACross-talkInter-organ cross-talkAlcohol-mediatedBone marrowImmune cellsInduce de novo lipogenesisMitochondrial double-stranded RNALiver injuryKupffer cellsPortal circulation
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply