Plasma CHI3L1 associates with brain volume loss and glial activation in multiple sclerosis
Ahola V, Saraste M, Nylund M, Matilainen M, Luoma A, Vuorimaa A, Lehto J, Laaksonen S, Brockmann E, Kuhle J, Leppert D, Soukka T, Lamminmäki U, Airas L. Plasma CHI3L1 associates with brain volume loss and glial activation in multiple sclerosis. Journal Of Neurology Neurosurgery & Psychiatry 2025, jnnp-2025-336063. PMID: 40379482, DOI: 10.1136/jnnp-2025-336063.Peer-Reviewed Original ResearchDistribution volume ratioBrain volume lossHealthy controlsPositron emission tomographyPlasma CHI3L1Smoldering inflammationMultiple sclerosisGlial activationInnate immune cell activationAssociated with Expanded Disability Status ScaleImmune cell activationChitinase-3-like protein 1Expanded Disability Status ScaleAssociated with smaller brain volumesDisability Status ScaleCHI3L1 concentrationsIndependent of relapsesVolume lossStudy cohortCell activationImaging outcomesTSPO-PETCHI3L1Emission tomographyStatus Scale
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