2025
Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes
Promet L, Meda S, Alliey-Rodriguez N, Clementz B, Gershon E, Hill S, Ivleva E, Keedy S, Keshavan M, McDowell J, Parker D, Tamminga C, Pearlson G. Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes. Schizophrenia Bulletin 2025, sbaf022. PMID: 40448350, DOI: 10.1093/schbul/sbaf022.Peer-Reviewed Original ResearchBrain age gapBipolar-Schizophrenia NetworkDSM diagnosesBrain agingPRS-SZComorbid disordersNon-psychotic first-degree relativesHealthy controlsAssociated with symptom severityPsychotic bipolar disorderSubtypes of psychosisStructural T1-weighted imagesBrain structural differencesPsychotropic medication useSchizoaffective disorderPsychosis probandsPsychotic disordersBipolar disorderPolygenic risk scoresSymptom severityFirst-degree relativesPsychosisAge gapDSMIntermediate phenotypes
2015
Task-based functional connectivity as an indicator of genetic liability to schizophrenia
Poppe AB, Carter CS, Minzenberg MJ, MacDonald AW. Task-based functional connectivity as an indicator of genetic liability to schizophrenia. Schizophrenia Research 2015, 162: 118-123. PMID: 25592803, DOI: 10.1016/j.schres.2014.11.022.Peer-Reviewed Original ResearchConceptsFirst-degree relativesMiddle frontal gyrusFunctional connectivityGroup independent component analysisGenetic liabilityPatients' first-degree relativesRight middle frontal gyrusTask-based functional connectivityImpaired functional connectivityNon-psychotic first-degree relativesPosterior parietal lobeUnexpressed genetic liabilityControl relativesConnectivity abnormalitiesTask-related networksSchizophrenia patientsParietal lobePatientsBrain regionsCognitive deficitsContext processing taskFronto-parietal networkSchizophreniaFrontal gyrusPosterior parietal
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