2025
The climate and health impact of U.S. radiation therapy: estimating greenhouse gas emissions, DALYs, and potential of hypofractionation
Lichter K, Asaro A, Qureshi M, Truong M, Parekh A, Witztum A, Anand C, Silva G, Royce T, Zaorsky N, Grover S, Abdel-Wahab M, Thiel C, Eckelman M, Prionas N, Yom S, Mohamad O. The climate and health impact of U.S. radiation therapy: estimating greenhouse gas emissions, DALYs, and potential of hypofractionation. Radiotherapy And Oncology 2025, 111161. PMID: 40983187, DOI: 10.1016/j.radonc.2025.111161.Peer-Reviewed Original ResearchExternal beam radiation therapyEarly-stage breast cancerNational Cancer DatabaseDisability-adjusted life yearsRadiation therapyBreast cancerExternal beam radiation therapy treatmentAdoption of hypofractionationBeam radiation therapyPatient transportBreast cancer treatmentFractionation schedulesCancer DatabaseRadiation oncologyHypofractionationTreatment guidelinesRetrospective analysisCancer treatmentPatientsCancer typesLife cycle assessmentClinical practiceCancerLife yearsTherapyLong-Term Results of External Beam Radiation Therapy with or Without Concurrent Chemotherapy in Differentiated Thyroid Cancer
Choi J, Sherman E, Dee E, Treechairusame T, Zakeri K, Kang J, Yu Y, Chen L, Shamseddine A, McBride S, Riaz N, Ho A, Tuttle R, Fagin J, Sabra M, Cracchiolo J, Shaha A, Wong R, Ghossein R, Katabi N, Lee N. Long-Term Results of External Beam Radiation Therapy with or Without Concurrent Chemotherapy in Differentiated Thyroid Cancer. Thyroid 2025, 35: 633-641. PMID: 40504742, PMCID: PMC12241838, DOI: 10.1089/thy.2025.0052.Peer-Reviewed Original ResearchConceptsTyrosine kinase inhibitorsExternal beam radiation therapyBeam radiation therapyConcurrent chemotherapyRadiation therapyTracheoesophageal fistulaLocoregional controlPercutaneous endoscopic gastrostomyOverall survivalResults of external beam radiation therapyPatients treated with concurrent chemotherapyFollow-upTKI initiationTreated with concurrent chemotherapyTyrosine kinase inhibitor therapyRare group of patientsLong-term follow-upGross residual diseaseTreated with RTRadioactive iodine therapySingle-institution experienceDifferentiated thyroid cancerMedian Follow-UpKaplan-Meier methodDay of RTImpact of radiation therapy on the immunological tumor microenvironment
Guilbaud E, Naulin F, Meziani L, Deutsch E, Galluzzi L. Impact of radiation therapy on the immunological tumor microenvironment. Cell Chemical Biology 2025, 32: 678-693. PMID: 40280118, DOI: 10.1016/j.chembiol.2025.04.001.Peer-Reviewed Original ResearchConceptsImmunological tumor microenvironmentRadiation therapyTumor microenvironmentExternal beam radiation therapyImpact of radiation therapyBeam radiation therapyImpact tumor growthIrradiated cancer cellsEffects of RTModern cancer managementMalignant cellsPalliative settingImmune cellsTumor ecosystemTumor growthCancer managementTherapeutic windowClinical effectsCancer cellsNormal cellsCellular mechanismsHealthy tissueCytotoxic effectsTherapyDNA damage
2024
Long-Term Results of External Beam Radiation Therapy (RT) with or without Concurrent Chemotherapy in Loco-Regionally Advanced or Recurrent Differentiated Thyroid Cancer (DTC)
Choi J, Sherman E, Youssef I, Kang J, Zakeri K, Yu Y, Chen L, Shamseddine A, McBride S, Riaz N, Hung T, Wong W, Michel L, Dunn L, Ho A, Tuttle R, Morris L, Shaha A, Wong R, Lee N. Long-Term Results of External Beam Radiation Therapy (RT) with or without Concurrent Chemotherapy in Loco-Regionally Advanced or Recurrent Differentiated Thyroid Cancer (DTC). International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e743-e744. DOI: 10.1016/j.ijrobp.2024.07.1633.Peer-Reviewed Original ResearchResults of external beam radiation therapyLocoregional controlRadioactive iodine therapyOverall survivalMultivariate analysisIodine therapyAdvanced diseaseBackward stepwise Cox regressionExternal beam radiation therapyRecurrent differentiated thyroid cancerProton beam RTBeam radiation therapyIntensity-modulated RTSingle-institution experienceTreated with RTMedian Follow-UpKaplan-Meier methodDay of RTStepwise Cox regressionGroup of patientsLong-term resultsBeam RTLate toxicityNon-medullaryConcurrent chemotherapyPrognostic Effect of Mismatch Repair Status in Early-Stage Endometrial Cancer Treated With Adjuvant Radiation: A Multi-institutional Analysis
Hathout L, Sherwani Z, Alegun J, Ohri N, Fields E, Shah S, Beriwal S, Horne Z, Kidd E, Leung E, Song J, Taunk N, Chino J, Huang C, Russo A, Dyer M, Li J, Albuquerque K, Damast S. Prognostic Effect of Mismatch Repair Status in Early-Stage Endometrial Cancer Treated With Adjuvant Radiation: A Multi-institutional Analysis. International Journal Of Radiation Oncology • Biology • Physics 2024, 119: 1158-1165. PMID: 38253292, DOI: 10.1016/j.ijrobp.2024.01.203.Peer-Reviewed Original ResearchRecurrence-free survivalEndometrioid endometrial adenocarcinomaMismatch repair statusAdjuvant radiation therapyOverall survivalRadiation therapyVaginal brachytherapyMismatch repair deficiencyAssociated with worse recurrence-free survivalMulti-institutional retrospective cohort studyTreated with adjuvant radiation therapyAssociated with recurrence-free survivalMultivariate analysisExternal beam radiation therapyRecurrence-free survival ratesMismatch repair deficiency statusBeam radiation therapyGrades 1 to 2Kaplan-Meier methodOutcomes of patientsMulti-institutional analysisRetrospective cohort studyCox proportional hazards modelsProportional hazards modelAdjuvant radiation
2023
Prognostic Impact of Mismatch Repair Deficiency on Stage I-II Endometrioid Endometrial Cancer Treated with Adjuvant Radiation Therapy: A Multi-Institutional Analysis
Sherwani Z, Alegun J, Russo A, Damast S, Albuquerque K, Nwachukwu C, Dyer M, Fields E, Beriwal S, Horne Z, Vergalasova I, Ohri N, Taunk N, Chino J, Kidd E, Leung E, Song J, Hathout L. Prognostic Impact of Mismatch Repair Deficiency on Stage I-II Endometrioid Endometrial Cancer Treated with Adjuvant Radiation Therapy: A Multi-Institutional Analysis. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: s8. DOI: 10.1016/j.ijrobp.2023.06.217.Peer-Reviewed Original ResearchEndometrioid endometrial cancerEarly-stage endometrioid endometrial cancerExternal beam radiation therapyAdjuvant radiation therapyLymphovascular space invasionOverall survivalGrade 3Radiation therapyStage IMultivariate analysisWorse RFSWorse OSEndometrial cancerUnivariate analysisMulti-institutional retrospective cohort studyFIGO 2009 stage IRecurrence-free survival ratesCox proportional hazards modelPost-surgical stagingRetrospective cohort studyKaplan-Meier methodDeep myometrial invasionFIGO grade 1Proportional hazards modelBeam radiation therapy
2022
Racial Disparities in Patients with Stage IIIC Endometrial Cancer
Patrich T, Wang Y, Elshaikh M, Zhu S, Damast S, Li J, Fields E, Beriwal S, Keller A, Kidd E, Usoz M, Jolly S, Jaworski E, Leung E, Donovan E, Taunk N, Chino J, Russo A, Lea J, Lee L, Albuquerque K, Hathout L. Racial Disparities in Patients with Stage IIIC Endometrial Cancer. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: e273-e274. DOI: 10.1016/j.ijrobp.2022.07.1283.Peer-Reviewed Original ResearchPositive paraaortic lymph nodesNon-black patientsRecurrence-free survivalExternal beam radiation therapyStage IIIC endometrial carcinomaNon-endometrioid histologyGrade 3 tumorsLymphovascular space invasionOverall survivalBlack patientsVaginal cuff brachytherapyEndometrial carcinomaCervical involvementWorse OSHazard ratioPropensity scoreStage IIIC endometrial cancerMulti-institutional cohort studyRetrospective multi-institutional cohort studyCox proportional hazards modelRacial disparitiesParaaortic lymph nodesKaplan-Meier methodProportional hazards modelBeam radiation therapyOutcomes and Toxicities of Nonmedullary Thyroid Tumors Treated with Proton Beam Radiation Therapy
Youssef I, Yoon J, Mohamed N, Zakeri K, Press R, Yu Y, Kang J, Wong R, Tuttle R, Shaha A, Sherman E, Lee N. Outcomes and Toxicities of Nonmedullary Thyroid Tumors Treated with Proton Beam Radiation Therapy. International Journal Of Particle Therapy 2022, 9: 20-30. PMID: 36060412, PMCID: PMC9415751, DOI: 10.14338/ijpt-22-00005.1.Peer-Reviewed Original ResearchPercent of patientsLocal-regional recurrenceThyroid cancerRadiation therapyGross diseaseOverall survivalPercutaneous endoscopic gastrostomy tubeProton therapyProton beam radiation therapyAcute grade 3Central neck compartmentFavorable therapeutic ratioIntensity-modulated radiation therapyBeam radiation therapyProton beam therapyConcurrent chemotherapyPalliative radiationUnresectable diseaseAdjuvant radiationDefinitive radiationT4 diseaseMetastatic diseaseNeck compartmentRegional recurrenceUpper mediastinum
2021
Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma
Puthenpura V, DeNunzio NJ, Zeng X, Giantsoudi D, Aboian M, Ebb D, Kahle KT, Yock TI, Marks AM. Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma. International Journal Of Particle Therapy 2021, 8: 58-65. PMID: 35127977, PMCID: PMC8768897, DOI: 10.14338/ijpt-21-00013.1.Peer-Reviewed Original ResearchRadiation necrosisAarskog-Scott syndromeProton beam radiation therapyHigh-dose dexamethasoneGross total resectionHyperbaric oxygen therapyPosterior fossa tumorsBeam radiation therapyGroup 3 medulloblastomaCancer predisposition syndromeRare genetic syndromeConcurrent vincristineTruncal weaknessRadiographic improvementClinical stabilizationOxygen therapyTotal resectionPathologic correlatesGait instabilityFossa tumorsRadiation therapyPossible associationSyndromeDevelopment of medulloblastomaPotential associationOutcomes and prognostic factors of major salivary gland tumors treated with proton beam radiation therapy
Zakeri K, Wang H, Kang JJ, Lee A, Romesser P, Mohamed N, Gelblum D, Sherman E, Dunn L, Boyle J, Wong R, Chen L, Yu Y, Tsai CJ, McBride SM, Riaz N, Lee N. Outcomes and prognostic factors of major salivary gland tumors treated with proton beam radiation therapy. Head & Neck 2021, 43: 1056-1062. PMID: 33606323, PMCID: PMC9371938, DOI: 10.1002/hed.26563.Peer-Reviewed Original ResearchConceptsMajor salivary gland tumorsProton beam radiation therapyBeam radiation therapySalivary gland tumorsRadiation therapyLocoregional controlGland tumorsProgression-free survivalPhoton radiation therapyOverall survivalPrognostic factorsCommon siteCystic carcinomaLarge cohortDosimetric advantagesParotid glandTherapyPatientsTumorsTherapy CenterSurvivalTreatmentProton Therapy CenterCarcinomaCohort
2020
Trends in Use and Comparison of Stereotactic Body Radiation Therapy, Brachytherapy, and Dose-Escalated External Beam Radiation Therapy for the Management of Localized, Intermediate-Risk Prostate Cancer
Nguyen KA, Lee A, Patel SA, Chakravorty A, Yu JB, Kishan AU, Chang AJ. Trends in Use and Comparison of Stereotactic Body Radiation Therapy, Brachytherapy, and Dose-Escalated External Beam Radiation Therapy for the Management of Localized, Intermediate-Risk Prostate Cancer. JAMA Network Open 2020, 3: e2017144. PMID: 32970153, PMCID: PMC7516602, DOI: 10.1001/jamanetworkopen.2020.17144.Peer-Reviewed Original ResearchConceptsStereotactic body radiation therapyBody radiation therapyRadiation therapyProstate cancerIntermediate-risk prostate cancerExternal beam radiation therapyManagement of LocalizedExternal beam radiotherapyUse of brachytherapyBeam radiation therapyCohort studyBeam radiotherapyTherapyDisease managementCancerBrachytherapyPatientsRadiotherapyLacrimal sac adenocarcinoma managed with androgen deprivation
Abramson D, Fallon J, Biran N, Francis J, Jaben K, Oh W. Lacrimal sac adenocarcinoma managed with androgen deprivation. American Journal Of Ophthalmology Case Reports 2020, 19: 100607. PMID: 32760849, PMCID: PMC7393461, DOI: 10.1016/j.ajoc.2020.100607.Peer-Reviewed Original ResearchAndrogen deprivation therapyOrbital massAndrogen receptorMagnetic resonance imagingTreatment modalitiesStaging positron emission tomography/computed tomographyExternal beam radiation therapyPositron Emission Tomography/Computed TomographyAndrogen deprivation monotherapyBeam radiation therapyRight orbital massEmission Tomography/Computed TomographyPrimary surgical managementPrimary treatment modalityEffective treatment modalitySexual side effectsAndrogen deprivationDeprivation therapyMetastatic diseaseTomography/Computed TomographyOrbital exenterationRadiation therapyClinical responseInferior rectiPartial resectionOcular adnexal lymphoma presenting as incidental tarsal follicles
Ahluwalia A, Feng PW, Meskin SW. Ocular adnexal lymphoma presenting as incidental tarsal follicles. American Journal Of Ophthalmology Case Reports 2020, 19: 100731. PMID: 32426554, PMCID: PMC7225618, DOI: 10.1016/j.ajoc.2020.100731.Peer-Reviewed Original ResearchLymphoma PresentingThorough slit lamp examinationExternal beam radiation therapySlit-lamp examinationLymphoid tissue lymphomaRoutine annual examinationDiagnosis of mucosaBeam radiation therapyGiant folliclesAtypical presentationLamp examinationTissue lymphomaConjunctival lymphomaSystemic symptomsComplete resolutionConjunctival biopsyInferior fornixRadiation therapyRoutine examinationRoutine examsAnnual examinationsFolliclesPresentingLymphomaExamination
2019
Peer Influence on Physician Use of Shorter Course External Beam Radiation Therapy for Patients with Breast Cancer
Yu JB, Pollack CE, Herrin J, Soulos PR, Zhu W, Xu X, Gross CP. Peer Influence on Physician Use of Shorter Course External Beam Radiation Therapy for Patients with Breast Cancer. Practical Radiation Oncology 2019, 10: 75-83. PMID: 31785370, PMCID: PMC7061062, DOI: 10.1016/j.prro.2019.11.001.Peer-Reviewed Original ResearchConceptsAdjuvant external beam radiation therapyExternal beam radiation therapyPhysician peer groupsPalliative external beam radiation therapyBeam radiation therapyBreast cancerAdjuvant therapyBone metastasesPatient receiptRadiation therapyBreast-conserving surgeryMixed-effects logistic regressionPatient-sharing relationshipsPalliative therapyCancer careMedicare beneficiariesPatientsPhysician useTherapyLogistic regressionShort courseCancerPhysiciansGroup rateMetastasis
2017
Postoperative complications following intraoperative radiotherapy in abdominopelvic malignancy: A single institution analysis of 113 consecutive patients
Abdelfatah E, Page A, Sacks J, Pierorazio P, Bivalacqua T, Efron J, Terezakis S, Gearhart S, Fang S, Safar B, Pawlik TM, Armour E, Hacker‐Prietz A, Herman J, Ahuja N. Postoperative complications following intraoperative radiotherapy in abdominopelvic malignancy: A single institution analysis of 113 consecutive patients. Journal Of Surgical Oncology 2017, 115: 883-890. PMID: 28252805, PMCID: PMC5572190, DOI: 10.1002/jso.24597.Peer-Reviewed Original ResearchConceptsExternal beam radiation therapyPostoperative complication rateIntraoperative radiotherapyComplication rateInstitution experienceGrade IIAcceptable perioperative morbidityComplications grade IICurative-intent resectionPostoperative surgical complicationsClavien-Dindo scaleMost common diagnosesMargin-negative resectionSingle-institution analysisJohns Hopkins HospitalBeam radiation therapyAbdominopelvic malignanciesRadiotherapy variablesLocoregional controlPerioperative complicationsPerioperative deathsPerioperative morbidityPostoperative complicationsWound complicationsSurgical complications
2016
Does Travel Time to a Radiation Facility Impact Patient Decision‐Making Regarding Treatment for Prostate Cancer? A Study of the New Hampshire State Cancer Registry
Ghali F, Celaya M, Laviolette M, Ingimarsson J, Carlos H, Rees J, Hyams E. Does Travel Time to a Radiation Facility Impact Patient Decision‐Making Regarding Treatment for Prostate Cancer? A Study of the New Hampshire State Cancer Registry. The Journal Of Rural Health 2016, 34: s84-s90. PMID: 27862285, DOI: 10.1111/jrh.12224.Peer-Reviewed Original ResearchConceptsNew Hampshire State Cancer RegistrySeason of diagnosisState Cancer RegistryNearest radiation facilityCancer RegistryProstate cancerTreatment decisionsRisk categoriesExternal beam radiation therapyD'Amico risk categoryLocalized prostate cancerYears of treatmentMultivariable regression analysisBeam radiation therapyHigh-risk categoryWinter diagnosisMultivariable analysisRadiation therapyNew diagnosisSignificant interactionMarried statusRural residenceOlder agePatientsUrban residenceChanges in quality of life after radiation therapy for localized prostate cancer after dissemination of intensity modulated radiation therapy
Wang E, Wang S, Soulos P, Chen R, Kim S, Gross C, Yu J. Changes in quality of life after radiation therapy for localized prostate cancer after dissemination of intensity modulated radiation therapy. Journal Of Radiation Oncology 2016, 6: 295-300. DOI: 10.1007/s13566-016-0269-0.Peer-Reviewed Original ResearchExternal beam radiation therapyIntensity-modulated radiation therapyMental component scoreRadiation therapyProstate cancerEnd Results-Medicare Health Outcomes SurveyEra of IMRTComponent scoresImproved health-related qualityNonmetastatic prostate cancerPhysical component scoreHealth-related qualityHealth Outcomes SurveyStandard of careProstate cancer patientsExternal beam radiotherapyBeam radiation therapyQuality of lifeMethodsThe SurveillanceElderly patientsHRQOL measurementCancer patientsOutcome SurveyBeam radiotherapyLater eraInfluence of robotic-assisted laparoscopic hysterectomy on vaginal cuff healing and brachytherapy initiation in endometrial carcinoma patients
Stahl JM, Park HS, Silasi DA, Azodi M, Damast S. Influence of robotic-assisted laparoscopic hysterectomy on vaginal cuff healing and brachytherapy initiation in endometrial carcinoma patients. Practical Radiation Oncology 2016, 6: 226-232. PMID: 27364883, DOI: 10.1016/j.prro.2015.09.015.Peer-Reviewed Original ResearchConceptsRobotic-assisted laparoscopic hysterectomyVaginal cuff healingEndometrial carcinoma patientsIntravaginal brachytherapyAdjuvant intravaginal brachytherapyCuff healingLaparoscopic hysterectomyCarcinoma patientsEndometrial carcinomaTAH patientsHealing statusHealing timeEarly-stage endometrial carcinomaExternal beam radiation therapyVaginal cuff recurrenceTotal abdominal hysterectomyBeam radiation therapyAbdominal hysterectomySecondary outcomesConsecutive patientsLocal recurrencePrimary outcomeOncology evaluationMean intervalHysterectomyRacial/ethnic differences in the relative risk of receipt of specific treatment among men with prostate cancer
Moses K, Orom H, Brasel A, Gaddy J, Underwood W. Racial/ethnic differences in the relative risk of receipt of specific treatment among men with prostate cancer. Urologic Oncology Seminars And Original Investigations 2016, 34: 415.e7-415.e12. PMID: 27161898, PMCID: PMC4996674, DOI: 10.1016/j.urolonc.2016.04.002.Peer-Reviewed Original ResearchConceptsReceipt of radical prostatectomyRadiation therapyProstate cancerRelative risk ratiosCombination therapyDefinitive treatmentExternal beam radiation therapyBeam radiation therapyWhite menEnd Results ProgramHispanic menLogistic regression analysisPredictors of receiptRadical prostatectomyImprove physician educationSignificant public health issueEnd ResultsBrachytherapySpecific treatmentRisk ratioProstateAA menAfrican AmericansRelative riskCryotherapyNeoadjuvant radiotherapy for retroperitoneal sarcoma: A systematic review
Cheng H, Miura J, Lalehzari M, Rajeev R, Donahue A, Bedi M, Gamblin T, Turaga K, Johnston F. Neoadjuvant radiotherapy for retroperitoneal sarcoma: A systematic review. Journal Of Surgical Oncology 2016, 113: 628-634. PMID: 26990903, DOI: 10.1002/jso.24221.Peer-Reviewed Original ResearchConceptsExternal beam radiation therapyRetroperitoneal sarcomaMedian 5-year OSPatients treated with IMRTTreatment of retroperitoneal sarcomasMeta-analysis of observational studiesBeam radiation therapyMedian Follow-UpMulti-modality treatmentNCI CTCAENeoadjuvant radiotherapyRandomized Controlled TrialsLRR rateLocal recurrenceNeoadjuvant radiationRadiation therapyHistological subtypesMedian ageTumor differentiationRetrospective studyTreatment regimensFollow-upLocal controlGrade 1Observational study
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