2025
Methylone promotes neurite outgrowth and has long-lasting effects on fear extinction learning
Warner-Schmidt J, Stogniew M, Mandell B, Kelmendi B. Methylone promotes neurite outgrowth and has long-lasting effects on fear extinction learning. Neuropsychopharmacology 2025, 1-10. PMID: 40849539, DOI: 10.1038/s41386-025-02206-z.Peer-Reviewed Original ResearchPost-traumatic stress disorderFear extinction learningStructural neuroplasticityExtinction learningBehavioral effectsTreatment of post-traumatic stress disorderEffects of methyloneInhibitors of monoamine transportersStress disorderRecall memoryBrain areasNeuroplastic effectsMonoamine transportersNeuroplasticityDebilitating disorderMethyloneTrkB receptorsNeurite outgrowthCultured cortical neuronsFunctional enrichment analysisDisordersMemoryRNA-seqFearClinical trials
2024
Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA
Warner-Schmidt J, Stogniew M, Mandell B, Rowland R, Schmidt E, Kelmendi B. Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA. Frontiers In Neuroscience 2024, 18: 1353131. PMID: 38389788, PMCID: PMC10882719, DOI: 10.3389/fnins.2024.1353131.Peer-Reviewed Original ResearchPost-traumatic stress disorderTreatment of post-traumatic stress disorderFrontal cortexBrain areasMDMA-Assisted PsychotherapyEffects of methyloneMonoamine uptake inhibitorsNeuroplasticity-related genesMyelin-related genesAntidepressant-likeAnxiolytic effectsBrain substratesStress disorderPsychiatric disordersNeuropsychiatric disordersUptake inhibitorsBrain effectsAvailable pharmacotherapiesMDMAMDDEmotional learningMethyloneAmygdalaGene expression changesDisorders
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