2025
“Children of War”: Examining the Associations between War Exposure, Maternal PTSD, and Continuous Traumatic Stress on Israeli Children’s PTSD
Rachamim L, Aloni R, Mualem-Taylor H, Glickman O, Goodman A, Laor N. “Children of War”: Examining the Associations between War Exposure, Maternal PTSD, and Continuous Traumatic Stress on Israeli Children’s PTSD. Research On Child And Adolescent Psychopathology 2025, 53: 1047-1059. PMID: 40272634, PMCID: PMC12206200, DOI: 10.1007/s10802-025-01321-1.Peer-Reviewed Original ResearchConceptsPost-traumatic stress symptomsContinuous traumatic stressChildren's post-traumatic stress symptomsSchool-aged childrenWar exposureTraumatic stressTrauma-focused treatmentImprove children's resilienceParent-report questionnaireExposure to warEarly intervention needsEnhance parenting skillsMaternal PTSDStress symptomsChildren aged 3Self-ReportPTSDParenting skillsHealthcare servicesIsraeli childrenSociodemographic informationChildren's resiliencePreschool childrenPreschoolIntervention needsLongitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men
Ellis R, Webber T, Noble N, Linnstaedt S, Hinrichs R, Wiltshire C, Reda M, Davie W, House S, Beaudoin F, An X, Neylan T, Clifford G, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Punches B, Pascual J, Seamon M, Datner E, Pearson C, Peak D, Domeier R, Rathlev N, O'Neil B, Sergot P, Sanchez L, Bruce S, Joormann J, Kessler R, Ressler K, Koenen K, McLean S, Stevens J, Jovanovic T, Seligowski A. Longitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men. Stress And Health 2025, 41: e3522. PMID: 40119846, PMCID: PMC11991665, DOI: 10.1002/smi.3522.Peer-Reviewed Original ResearchConceptsFear-potentiated startleSkin conductancePotentiated StartlePTSD severityFear conditioningTrauma exposureTrauma recallAutonomic functionLongitudinal associationsPTSDAURORA studyEmergency departmentHigh oestradiol levelsFearEffect of oestradiolOestradiol levelsAssociated with autonomic dysfunctionStartleTraumaED-SCNegative correlationAutonomic dysfunctionRecallWomenOestradiolTrauma-Informed Cognitive Behavioral Therapy for Insomnia in Women Veterans: An Intervention Development Study
Carlson G, Kelly M, Erickson A, Saldaña K, Gomez G, Carlson K, Lee D, Pigeon W, McCarthy E, DeViva J, McGowan S, Josephson K, Alessi C, Yano E, Martin J, Hamilton A. Trauma-Informed Cognitive Behavioral Therapy for Insomnia in Women Veterans: An Intervention Development Study. Cognitive And Behavioral Practice 2025 DOI: 10.1016/j.cbpra.2025.03.002.Peer-Reviewed Original ResearchCognitive behavioral therapyCBT-IBehavioral therapyTrauma-related thoughtsTrauma-related symptomsBaseline to 3-month follow-upImprove sleep outcomesIntervention development studyVeterans Affairs providersPTSD treatmentPTSDPsychoeducationWomen veteransSleep outcomesVeteransInsomniaIntervention materialsEngagement groupRandomized clinical trialsDevelopment studiesEvaluation of clinical improvementPsychotherapyClinical improvementInterventionOutcome of developmentMEMORY RELATED STRUCTURAL AND FUNCTIONAL NEURAL CHANGES FOLLOWING A SINGLE INFUSION OF KETAMINE IN PTSD
Harpaz-Rotem *, Duek O, Korem N, Krystal J. MEMORY RELATED STRUCTURAL AND FUNCTIONAL NEURAL CHANGES FOLLOWING A SINGLE INFUSION OF KETAMINE IN PTSD. The International Journal Of Neuropsychopharmacology 2025, 28: i38-i38. PMCID: PMC11814760, DOI: 10.1093/ijnp/pyae059.066.Peer-Reviewed Original ResearchPost-retrieval extinctionInfusion of ketamineIntravenous infusion of ketamineTrauma memoriesTraumatic memoriesFear responsesSs' responsesAssociated with decreased connectivityAmygdala-vmPFC connectivityTrauma-focused psychotherapyTreatment of PTSDNMDA receptor antagonistPre-post treatmentAmygdala activationLower amygdalaReconsolidation windowUncinate fasciculusAssessed before treatmentKetamine administrationMemory learningNaturalistic stimuliLabile stateAmygdalaPTSDExtinction processMental Health After Mass Shootings: Research Findings and Clinical Considerations
Lowe S, Márquez-Greene N, Ranney M. Mental Health After Mass Shootings: Research Findings and Clinical Considerations. Journal Of Health Service Psychology 2025, 51: 5-13. DOI: 10.1007/s42843-025-00125-7.Peer-Reviewed Original ResearchMental healthAdverse mental health outcomesMental health outcomesPsychological first aidMental health consequencesEvidence-based assessmentClinical case studyPoor mental healthLow symptomsMass shootingsHealth outcomesKey themesFirst aidClinical considerationsEmpirical literatureRisk factorsEthical challengesResearch findingsPTSDHealthPsychologyTherapistsMentalUnited StatesOutcomesCorrelates of Impaired Sleep Duration Among Adults With Trauma Alone and With Posttraumatic Stress Disorder
Havlik J, Rhee T, Rosenheck R. Correlates of Impaired Sleep Duration Among Adults With Trauma Alone and With Posttraumatic Stress Disorder. Psychological Trauma Theory Research Practice And Policy 2025 PMID: 39836166, DOI: 10.1037/tra0001846.Peer-Reviewed Original ResearchImpaired sleep durationStress disorderSleep durationEffect sizePosttraumatic stress disorderClinically meaningful effect sizesNational Epidemiologic SurveyMeaningful effect sizesPsychiatric multimorbidityPTSDTrauma/PTSDImprove treatment outcomesMedical comorbiditySleep disturbanceImpaired sleepBehavioral variablesTreatment outcomesAllostatic loadNationally Representative SampleAdjusted multivariable regressionEpidemiological surveyDisordersBody mass indexRepresentative sampleSleepChapter 20 Neuroglia in anxiety disorders
Bonomi R, Pietrzak R, Cosgrove K. Chapter 20 Neuroglia in anxiety disorders. Handbook Of Clinical Neurology 2025, 210: 335-346. PMID: 40148054, DOI: 10.1016/b978-0-443-19102-2.00008-9.Peer-Reviewed Original ResearchConceptsAnxiety disordersPathology of anxiety disordersDebilitating anxiety disorderPosttraumatic stress disorderPathophysiology of PTSDTarget of treatmentStress disorderNeurobiological perspectivePTSDAnxietyGlial cellsHypothesized mechanismsDisordersCell typesIllnessNeuronal signalingNovel treatmentPrecision treatmentPathophysiologyPharmacological developmentNeurobiology
2024
Childhood Trauma as a Mediator of Intergenerational PTSD Symptom Transmission in Rwanda: A Cross-Sectional Study
Huang A, Bonumwezi J, Wang K, Mew E, Habintwali D, Lowe S. Childhood Trauma as a Mediator of Intergenerational PTSD Symptom Transmission in Rwanda: A Cross-Sectional Study. Journal Of Loss And Trauma 2024, 30: 642-665. DOI: 10.1080/15325024.2024.2422610.Peer-Reviewed Original ResearchPTSD symptomsChildhood traumaParental sexSexual abuseChildhood trauma subtypesMaternal PTSD symptomsCumulative childhood traumaHarsh parenting practicesIntergenerational traumaTrauma subtypesChildhood maltreatmentPhysical neglectParenting practicesPhysical abuseIntergenerational transmissionPTSDAbuseIndirect effectsAdult childrenSymptomsGenocide survivorsChildhoodCross-sectional studyOnline surveyParents42. STRESS EXPOSURE DYNAMICALLY REGULATES EQTL ACTIVITY IN THE POST-MORTEM BRAIN AND IN HIPSC-DERIVED NEURONS
Seah C, Signer R, Young H, Hicks E, Rusielewicz T, Bader H, Xu C, Breen M, Paull D, Yehuda R, Girgenti M, Brennand K, Huckins L. 42. STRESS EXPOSURE DYNAMICALLY REGULATES EQTL ACTIVITY IN THE POST-MORTEM BRAIN AND IN HIPSC-DERIVED NEURONS. European Neuropsychopharmacology 2024, 87: 71-72. DOI: 10.1016/j.euroneuro.2024.08.156.Peer-Reviewed Original ResearchPost-mortem brainsTranscription Factor Binding SitesAbsence of cellular stressCombat-exposed veteransFactor binding sitesImpact gene expressionBinding sitesGR binding sitesPositive regulatory activityMotif enrichmentSequence readsCRISPRi screenOpen chromatinFunctional annotationBrain regionsTraumatic stressCRISPR screensEQTLTraumatic experiencesLeading locusPTSDPerturbed genesRegulatory architectureTranscriptomic activityTranscriptomic responseLongitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study
Hyatt C, Reddi P, Sharpe B, Michopoulos V, van Rooij S, House S, Beaudoin F, An X, Stevens J, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Pizzagalli D, Sheridan J, Smoller J, Harte S, Elliott J, McLean S, Kessler R, Ressler K, Koenen K, Maples-Keller J. Longitudinal associations between five factor model and impulsive personality traits and PTSD symptoms: Findings from the AURORA study. Journal Of Research In Personality 2024, 112: 104524. DOI: 10.1016/j.jrp.2024.104524.Peer-Reviewed Original ResearchImpulsive personality traitsPTSD symptomsPersonality traitsOne-year post-traumaSevere PTSD symptomsPost-traumaFactor modelNegative urgencyLow agreeablenessLow conscientiousnessTrauma exposurePersonality assessmentPTSD riskProspective linksSymptom TotalPTSDLongitudinal associationsAURORA studyIncremental predictorNeuroticismTime pointsSymptomsTraitsAgreeablenessConscientiousnessMicroglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedoniaThe Psychological Impact of Wrongful Convictions: Exploring Retrospective Trajectories of Distress in Exonerees
Thomas K, Hoyt W. The Psychological Impact of Wrongful Convictions: Exploring Retrospective Trajectories of Distress in Exonerees. Psychological Trauma Theory Research Practice And Policy 2024, 16: 872-880. PMID: 36689380, DOI: 10.1037/tra0001425.Peer-Reviewed Original ResearchConceptsTrajectories of distressPositive world assumptionsGeneralized Anxiety Disorder-7Levels of PTSDPosttraumatic Growth InventorySatisfaction with Life ScaleRates of PTSDPresence of meaningFour-factor solutionPatient Health Questionnaire-9Satisfaction with lifePsychological impactWrongful convictionsDSM-5PTSD ChecklistAnxiety symptomsDepressive symptomsIntense distressWorld beliefsChronic distressBody of researchPTSDLife ScalePsychological experienceDistressComorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome
Hicks E, Niarchou M, Goleva S, Kabir D, Johnson J, Johnston K, Ciarcia J, Pathak G, Smoller J, Davis L, Nievergelt C, Koenen K, Huckins L, Choi K, Group P. Comorbidity Profiles of Posttraumatic Stress Disorder Across the Medical Phenome. Biological Psychiatry Global Open Science 2024, 4: 100337. PMID: 39050781, PMCID: PMC11268109, DOI: 10.1016/j.bpsgos.2024.100337.Peer-Reviewed Original ResearchElectronic health recordsClinical knowledge gapsPhysical health problemsPhenome-wide associationPheWAS analysisBiobank participantsHealth recordsEpidemiological researchHealthcare systemTest associationsMedical phenomeAssociated with osteoporosisPulmonary heart diseasePhecodesHealth problemsLogistic regressionPosttraumatic stress disorderSex differencesPheWASComorbidity profilesHeart diseaseStress disorderInteraction termsAssociationPTSDIntensive longitudinal assessment following index trauma to predict development of PTSD using machine learning
Horwitz A, McCarthy K, House S, Beaudoin F, An X, Neylan T, Clifford G, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Swor R, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Peak D, Domeier R, Rathlev N, Sergot P, Sanchez L, Bruce S, Joormann J, Harte S, Koenen K, McLean S, Sen S. Intensive longitudinal assessment following index trauma to predict development of PTSD using machine learning. Journal Of Anxiety Disorders 2024, 104: 102876. PMID: 38723405, PMCID: PMC11215748, DOI: 10.1016/j.janxdis.2024.102876.Peer-Reviewed Original ResearchTraumatic exposureIntensive longitudinal assessmentDevelopment of PTSDTrauma-related symptomsExposure to traumaFollow-up careTrauma exposureIndex traumaEmergency carePTSDAssess symptomsLongitudinal assessmentAssessment protocolCareParticipantsSymptomsFollow-upInterventionMachine learning analysisTraumaRiskIndividualsWeeksLearning analysisNervousnessEfficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis
Yao Y, Guo D, Lu T, Liu F, Huang S, Diao M, Li S, Zhang X, Kosten T, Shi J, Bao Y, Lu L, Han Y. Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis. Psychiatry Research 2024, 335: 115886. PMID: 38574699, DOI: 10.1016/j.psychres.2024.115886.Peer-Reviewed Original ResearchConceptsMental disordersTreatment of mental disordersBorderline personality disorderObsessive-compulsive disorderTreat mood disordersSubstance-use disordersBody dysmorphic disorderPersonality disorderMood disordersDysmorphic disorderNegative moodEating DisordersLasting adverse effectsTobacco addictionPsychedelicsDisordersTreat symptomsPsilocybinSleep disordersAyahuascaTherapeutic effectMeta-analyzedLSDPTSDMDMAAssociations of Posttraumatic Stress Disorder Symptom Clusters and Pain Interference in Post-9/11 Veterans: Exploring Sleep Impairment and Physical Activity as Underlying Mechanisms
Emrich M, Gnall K, Garnsey C, George J, Park C, Mazure C, Hoff R. Associations of Posttraumatic Stress Disorder Symptom Clusters and Pain Interference in Post-9/11 Veterans: Exploring Sleep Impairment and Physical Activity as Underlying Mechanisms. International Journal Of Behavioral Medicine 2024, 32: 371-384. PMID: 38438749, DOI: 10.1007/s12529-024-10268-4.Peer-Reviewed Original ResearchPost-9/11 veteransPain interferencePhysical activityPTSD symptomsAssociated with pain interferenceModifiable health factorsSleep impairmentSymptom clustersPosttraumatic stress disorder symptom clustersWorsening pain interferencePTSD symptom clustersRe-experiencing symptomsBackgroundPosttraumatic stress disorderHealth factorsSecondary analysisTargeting sleepMethodsThe present studyVeteransHyperarousal symptomsRe-experiencingStress disorderStudy variablesPTSDPainAssociated with changesItem-wise validity study of the Impact of Event Scale - Revised (IES-R): self-reported reactions of hospital personnel exposed to a stressful workplace.
Petrilli-Mazon V, Carvalho-Alves M, Miguel E, Corchs F, Curi M, Wang Y. Item-wise validity study of the Impact of Event Scale - Revised (IES-R): self-reported reactions of hospital personnel exposed to a stressful workplace. Brazilian Journal Of Psychiatry 2024 PMID: 39602572, DOI: 10.47626/1516-4446-2024-3882.Peer-Reviewed Original ResearchIES-RItem response theoryTraumatic experiencesAssociated with traumatic experiencesItem analysisPresentation of PTSDTrauma-related distressMental disorder ratesSelf-reported reactionsPTSD measuresTrauma symptomsTraumatic exposureTraumatic symptomsTraumatic distressItem poolDistress severityDisorder ratesPTSDSleep disturbanceEffective scaleResponse theoryDistressItem parametersItemsHeterogeneous prevalence
2023
Progesterone Attenuates the Stress Response in Individuals with Alcohol Dependence and Post-Traumatic Stress Disorder – A Pilot Study
Ralevski E, Newcomb J, Pisani E, DeNegre D, Peltier M, Jane J, Yoon G, Petrakis I. Progesterone Attenuates the Stress Response in Individuals with Alcohol Dependence and Post-Traumatic Stress Disorder – A Pilot Study. Journal Of Dual Diagnosis 2023, 20: 39-51. PMID: 38147491, PMCID: PMC11214330, DOI: 10.1080/15504263.2023.2294989.Peer-Reviewed Original ResearchAlcohol use disorderStress-induced cravingCognitive performanceNegative affectNeutral scriptsStress disorderPost-traumatic stress disorderComorbid alcohol use disorderTraumatic Stress DisorderMeasures of cravingCurrent alcohol use disorderPositive emotionsTrauma scriptsPhysiological measuresCravingStress-induced symptomsTest sessionsPTSDAnxietyAffectUse disordersLaboratory sessionsCocaine dependenceAlcohol dependenceIndividualsPerceptions of psychedelic-assisted therapy among Black Americans
Carter S, Packard G, Coghlan C, George J, Brown A, Ching T, Julian J, Maples-Keller J. Perceptions of psychedelic-assisted therapy among Black Americans. Journal Of Mood And Anxiety Disorders 2023, 4: 100023. DOI: 10.1016/j.xjmad.2023.100023.Peer-Reviewed Original ResearchPsychedelic-assisted therapySymptom severityPTSD symptom severityDepressive symptom severityPsilocybin-assisted therapyBlack American participantsStudy investigated differencesBlack AmericansMental health carePositive viewWhite AmericansPTSD symptomsPsychological treatmentPsychedelic therapyPsychedelic researchTrauma historyPerceived stressPsychoeducationAmerican participantsWhite participantsDepressionBlack participantsPTSDParticipantsBaseline viewsEvaluating a novel 8-factor dimensional model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Stiltner B, Fischer I, Duek O, Polimanti R, Harpaz-Rotem I, Pietrzak R. Evaluating a novel 8-factor dimensional model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2023, 346: 303-307. PMID: 37979626, PMCID: PMC12109547, DOI: 10.1016/j.jad.2023.11.041.Peer-Reviewed Original ResearchConceptsIndex traumaPTSD symptomsNational HealthPosttraumatic stress disorder (PTSD) symptomsVeterans StudyMilitary veteransTrauma-exposed populationsClinician-administered interviewU.S. military veteransConfirmatory factor analysisDSM-5 modelStrong significant associationTrauma exposureIntrusive symptomsDisorder symptomsCombat exposureHigh riskU.S. veteransDSM-5Significant associationSymptomsInterpersonal violenceFactor analysisPTSDScarce research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply