2024
Encoding and context-dependent control of reward consumption within the central nucleus of the amygdala
Fraser K, Kim T, Castro M, Drieu C, Padovan-Hernandez Y, Chen B, Pat F, Ottenheimer D, Janak P. Encoding and context-dependent control of reward consumption within the central nucleus of the amygdala. IScience 2024, 27: 109652. PMID: 38650988, PMCID: PMC11033178, DOI: 10.1016/j.isci.2024.109652.Peer-Reviewed Original ResearchCentral amygdalaCentral nucleus of the amygdalaEnhanced alcohol intakeOptogenetic stimulationAlcohol use disorderAmygdala neural activityCentral amygdala neuronsReward consumptionDrinking sucroseReward choicesUse disorderAberrant choiceAmygdala neuronsAmygdala stimulationCentral nucleusNeural activityAmygdalaReward approachRewardMale ratsActivity changesAlcohol intakeAlcoholIdentity optionsRats
2015
Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy
Gruenbaum SE, Wang H, Zaveri HP, Tang AB, Lee TS, Eid T, Dhaher R. Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy. Epilepsy & Behavior 2015, 51: 96-103. PMID: 26262937, PMCID: PMC4663049, DOI: 10.1016/j.yebeh.2015.07.015.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnalysis of VarianceAnhedoniaAnimalsBrainCentral Amygdaloid NucleusComorbidityDepressive DisorderDisease Models, AnimalElectroencephalographyEnzyme InhibitorsEpilepsy, Temporal LobeGlutamate-Ammonia LigaseHippocampusMaleMethionine SulfoximineNeuronsRatsRats, Sprague-DawleySeizuresConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyRecurrent seizuresLobe epilepsyCentral nucleusMale Sprague-Dawley ratsPrevalence of depressionSprague-Dawley ratsGlutamine synthetase inhibitor methionine sulfoximineMeasures of anhedoniaRight CeA.Seizure activityAnhedonic behaviorDentate gyrusMedial amygdalaSucrose preferenceRat modelCommon causeAstrocytic enzymeBasolateral amygdalaLateral amygdalaOsmotic pumpPatientsEpilepsyAmygdala
2014
Nf1 Regulates Alcohol Dependence-Associated Excessive Drinking and Gamma-Aminobutyric Acid Release in the Central Amygdala in Mice and Is Associated with Alcohol Dependence in Humans
Repunte-Canonigo V, Herman MA, Kawamura T, Kranzler HR, Sherva R, Gelernter J, Farrer LA, Roberto M, Sanna PP. Nf1 Regulates Alcohol Dependence-Associated Excessive Drinking and Gamma-Aminobutyric Acid Release in the Central Amygdala in Mice and Is Associated with Alcohol Dependence in Humans. Biological Psychiatry 2014, 77: 870-879. PMID: 25483400, PMCID: PMC4428692, DOI: 10.1016/j.biopsych.2014.07.031.Peer-Reviewed Original ResearchConceptsChronic intermittent ethanol vapor exposureGABA releaseWild-type miceGamma-aminobutyric acidAlcohol dependenceCentral amygdalaGamma-aminobutyric acid releaseIntermittent ethanol vapor exposureExcessive drinkingMouse central amygdalaEthanol vapor exposureHeterozygous null miceAlcohol dependence riskInduction of dependenceAlcohol drinkingAlcohol-related behaviorsDependent drinkingBinge drinkingTranslational investigationsNull miceCentral nucleusType 1 geneMiceAmygdalaAcid release
1996
Role of the Amygdala in the Coordination of Behavioral, Neuroendocrine, and Prefrontal Cortical Monoamine Responses to Psychological Stress in the Rat
Goldstein L, Rasmusson A, Bunney B, Roth R. Role of the Amygdala in the Coordination of Behavioral, Neuroendocrine, and Prefrontal Cortical Monoamine Responses to Psychological Stress in the Rat. Journal Of Neuroscience 1996, 16: 4787-4798. PMID: 8764665, PMCID: PMC6579011, DOI: 10.1523/jneurosci.16-15-04787.1996.Peer-Reviewed Original ResearchConceptsAmygdala lesionsMonoaminergic systemsMetabolic activationAdrenocortical activationStress-induced freezing behaviorStress-induced exacerbationStress-induced freezingPosttraumatic stress disorderAnteromedial prefrontal cortexNorepinephrine metabolismMonoamine responseAfferent controlNeuroendocrine componentBilateral NMDAPFC dopamineSchizophrenic symptomsCentral nucleusMild stressPrefrontal cortexStress disorderPsychological stressLesionsDopamineStress activationUltrasonic vocalizations
1994
Increased mRNA for corticotrophin releasing hormone in the amygdala of Fawn‐hooded rats: A potential animal model of anxiety
Altemus M, Smith M, Diep V, Aulakh C, Murphy D. Increased mRNA for corticotrophin releasing hormone in the amygdala of Fawn‐hooded rats: A potential animal model of anxiety. Anxiety 1994, 1: 251-257. PMID: 9160583, DOI: 10.1002/anxi.3070010602.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnimalsAnxiety DisordersArousalCorticosteroneCorticotropin-Releasing HormoneDisease Models, AnimalHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemRatsRats, Inbred StrainsRats, WistarReceptors, GlucocorticoidReceptors, MineralocorticoidRNA, MessengerSpecies SpecificityTyrosine 3-MonooxygenaseConceptsFawn-Hooded ratsAdrenal axis activityBasal corticosterone levelsParaventricular nucleusCRH mRNAAdrenal weightAxis activityWistar ratsReceptor mRNACorticosterone levelsArginine vasopressinRat strainsCentral nucleusAdult-onset hypertensionFawn-hooded strainFawn-hooded rat strainMineralocorticoid receptor mRNAUrinary catecholamine levelsHypothalamic paraventricular nucleusGlucocorticoid receptor mRNAWistar rat strainPotential animal modelTyrosine hydroxylase mRNAMore freezing behaviorAVP mRNA expression
1984
Enkephalin convertase localization by [3H]guanidinoethylmercaptosuccinic acid autoradiography: selective association with enkephalin-containing neurons.
Lynch DR, Strittmatter SM, Snyder SH. Enkephalin convertase localization by [3H]guanidinoethylmercaptosuccinic acid autoradiography: selective association with enkephalin-containing neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 6543-6547. PMID: 6436816, PMCID: PMC391961, DOI: 10.1073/pnas.81.20.6543.Peer-Reviewed Original ResearchConceptsEnkephalin convertaseSpinal trigeminal tractDorsal parabrachial nucleusTrigeminal tractSolitary tractAcid autoradiographySubstantia gelatinosaParabrachial nucleusDentate gyrusLocus coeruleusPreoptic hypothalamusInterpeduncular nucleusLateral septumBed nucleusRat brainStria terminalisMedian eminenceMagnocellular nucleusCentral nucleusImmunocytochemical localizationHypothalamusEnkephalin biosynthesisEnkephalinTractGuanidinoethylmercaptosuccinic acid
1981
Neurogenetic gradients in the superior and inferior colliculi of the rhesus monkey
Cooper M, Rakic P. Neurogenetic gradients in the superior and inferior colliculi of the rhesus monkey. The Journal Of Comparative Neurology 1981, 202: 309-334. PMID: 7298901, DOI: 10.1002/cne.902020303.Peer-Reviewed Original ResearchConceptsSuperior colliculusInferior colliculusCentral nucleusInferior colliculiRhesus monkeysVentrodorsal gradientLateral-medial gradientAnterior-posterior gradientTectal neuronsNeurogenetic gradientsPeak proliferationSubventricular zoneSelective cell deathRostrocaudal gradientCNS cellsFinal mitosisNeuronsDistinctive spatiotemporal patternsNeurogenesisEmbryonic dayColliculiColliculusGestation periodCell deathLateral cell movement
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