In Vivo Expansion of Regulatory T Cells by Low-Dose Interleukin-2 Treatment Increases Allograft Survival in Corneal Transplantation
Tahvildari M, Omoto M, Chen Y, Emami-Naeini P, Inomata T, Dohlman T, Kaye A, Chauhan S, Dana R. In Vivo Expansion of Regulatory T Cells by Low-Dose Interleukin-2 Treatment Increases Allograft Survival in Corneal Transplantation. Transplantation 2016, 100: 525-532. PMID: 26881788, PMCID: PMC4764457, DOI: 10.1097/tp.0000000000001044.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAllograftsAnimalsCell ProliferationCells, CulturedChemotaxis, LeukocyteCorneaCorneal TransplantationDrug Administration ScheduleForkhead Transcription FactorsGraft SurvivalInterferon-gammaInterleukin-2Interleukin-2 Receptor alpha SubunitLymphocyte ActivationMaleMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLT-Lymphocytes, RegulatoryTime FactorsConceptsCorneal allograft survivalLong-term allograft survivalRegulatory T cellsAllograft survivalIL-2T cellsCorneal transplantationImmunosuppressive functionImproving long-term allograft survivalLow-dose IL-2 administrationExpansion of regulatory T cellsLow doses of IL-2Graft-infiltrating immune cellsIL-2-treated groupLow-dose IL-2Survival of corneal allograftsDoses of IL-2In vitro proliferation assayAllogeneic corneal transplantationInfiltration of CD45Suppress alloimmune responsesFrequency of effector T cellsFrequency of TregsIL-2 administrationKaplan-Meier survival analysis
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