2024
Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation
Kim J, Zimmermann M, Mathison A, Lomberk G, Urrutia R, Hong J. Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation. Annals Of Surgery Open 2024, 5: e444-e444. PMID: 38911661, PMCID: PMC11191965, DOI: 10.1097/as9.0000000000000444.Peer-Reviewed Original ResearchOrthotopic liver transplantationIschemia-reperfusion injuryCold ischemiaLiver transplantationPrimary orthotopic liver transplantationGraft ischemia-reperfusion injuryClinical orthotopic liver transplantationEffects of ischemia-reperfusion injuryLiver graft ischemia-reperfusion injuryHuman orthotopic liver transplantationTherapeutic targetLiver allograft biopsiesHuman liver transplantationInflammatory response genesIAF groupAllograft injuryDecreased metabolic activityAllograft dysfunctionAllograft functionAllograft biopsiesGene expressionSurrogate markerFatty acid-metabolizing activitiesMetabolic activityHistological evaluation
2022
A Composite End Point of Graft Status and eGFR at 1 Year to Improve the Scientific Registry of Transplant Recipients’ Five-Tier Rating System
Wang K, Deng Y, Stewart D, Formica R. A Composite End Point of Graft Status and eGFR at 1 Year to Improve the Scientific Registry of Transplant Recipients’ Five-Tier Rating System. Journal Of The American Society Of Nephrology 2022, 33: 1613-1624. PMID: 35537779, PMCID: PMC9342646, DOI: 10.1681/asn.2022010078.Peer-Reviewed Original ResearchConceptsComposite end pointTraditional end pointsTransplant programsEnd pointAllograft functionGraft survivalScientific RegistryFive-tier systemLong-term graft outcomeDonor graft survivalKidney transplant programAllograft failureAllograft survivalGraft outcomeTransplant recipientsGraft statusGraft failureEGFR differenceSRTR dataSurvival rateEGFRSurvivalRegistryMeaningful differencesConcept study
2020
Postcontrast Acute Kidney Injury after Peripheral Vascular Interventions in Kidney Transplant Recipients
Lee SR, Dardik A, Ochoa Chaar CI. Postcontrast Acute Kidney Injury after Peripheral Vascular Interventions in Kidney Transplant Recipients. Annals Of Vascular Surgery 2020, 68: 8-14. PMID: 32428641, DOI: 10.1016/j.avsg.2020.04.057.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsPeripheral vascular interventionsPostcontrast acute kidney injuryPC-AKIAcute kidney injuryKidney transplantKidney injuryTransplant recipientsRisk factorsVascular interventionsNew dialysis requirementPoor allograft functionPropensity-matched patientsPeripheral artery diseaseVascular Quality InitiativeGroup of patientsKaplan-Meier analysisMultivariable logistic regressionLong-term survivalAllograft functionBaseline warfarinHospital mortalityDialysis requirementPerioperative outcomesFeared complicationDefining chronic rejection in vascularized composite allotransplantation—The American Society of Reconstructive Transplantation and International Society of Vascularized Composite Allotransplantation chronic rejection working group: 2018 American Society of Reconstructive Transplantation meeting report and white paper Research goals in defining chronic rejection in vascularized composite allotransplantation
Kaufman C, Kanitakis J, Weissenbacher A, Brandacher G, Mehra M, Amer H, Zelger B, Zelger B, Pomahac B, McDiarmid S, Cendales L, Morelon E. Defining chronic rejection in vascularized composite allotransplantation—The American Society of Reconstructive Transplantation and International Society of Vascularized Composite Allotransplantation chronic rejection working group: 2018 American Society of Reconstructive Transplantation meeting report and white paper Research goals in defining chronic rejection in vascularized composite allotransplantation. SAGE Open Medicine 2020, 8: 2050312120940421. PMID: 32704373, PMCID: PMC7361482, DOI: 10.1177/2050312120940421.Peer-Reviewed Original ResearchChronic rejectionComposite allograftsFunctional declineReconstructive transplantationComposite allotransplantationHistologic evidenceDe novo donor-specific antibodiesAmerican SocietyNovo donor-specific antibodiesNormal allograft functionDonor-specific antibodiesInternational SocietyVascularized Composite AllotransplantationAcute rejectionAllograft functionAllograft recipientsImmunosuppressive therapyTreatment regimensRisk factorsUterine transplantationUpper extremityMeeting reportAllograftsTransplantationClinical cases
2018
Successful treatment of primary donor‐derived human herpesvirus‐8 infection and hepatic Kaposi Sarcoma in an adult liver transplant recipient
Fu W, Merola J, Malinis M, Lacy J, Barbieri A, Liapakis AH, Mulligan DC, Yoo PS. Successful treatment of primary donor‐derived human herpesvirus‐8 infection and hepatic Kaposi Sarcoma in an adult liver transplant recipient. Transplant Infectious Disease 2018, 20: e12966. PMID: 30014622, DOI: 10.1111/tid.12966.Peer-Reviewed Case Reports and Technical NotesConceptsHuman herpesvirus 8 infectionHepatic Kaposi sarcomaKaposi's sarcomaTransplant recipientsAdult liver transplant recipientsRegression of KSSplit liver transplantAcute cellular rejectionLiver transplant recipientsSuccessful therapeutic strategiesAllograft functionCellular rejectionLiver transplantSeropositive donorsSuccessful treatmentLiposomal doxorubicinTherapeutic strategiesRecipientsSarcomaInfectionTreatmentImmunosuppressionPatientsMalignancyTransplantInflammasome Priming Mediated via Toll-Like Receptors 2 and 4, Induces Th1-Like Regulatory T Cells in De Novo Autoimmune Hepatitis
Arterbery AS, Yao J, Ling A, Avitzur Y, Martinez M, Lobritto S, Deng Y, Geliang G, Mehta S, Wang G, Knight J, Ekong UD. Inflammasome Priming Mediated via Toll-Like Receptors 2 and 4, Induces Th1-Like Regulatory T Cells in De Novo Autoimmune Hepatitis. Frontiers In Immunology 2018, 9: 1612. PMID: 30072988, PMCID: PMC6060440, DOI: 10.3389/fimmu.2018.01612.Peer-Reviewed Original ResearchToll-like receptor 2Monocytes/macrophagesAutoimmune hepatitisReceptor 2De novo autoimmune hepatitisRegulatory T cell phenotypeTumor necrosis factor αLate allograft dysfunctionLiver transplant subjectsNormal allograft functionNovo autoimmune hepatitisRegulatory T cellsLiver of patientsAdaptive immune mechanismsIFN-γ productionPro-inflammatory cytokinesT-cell phenotypeNecrosis factor αInflammatory signaling pathwaysAllograft dysfunctionAllograft functionDysfunctional TregsSpecific innateTransplant subjectsLiver transplantation
2017
Tissue conservation for transplantation
Krezdorn N, Tasigiorgos S, Wo L, Turk M, Lopdrup R, Kiwanuka H, Win T, Bueno E, Pomahac B. Tissue conservation for transplantation. Innovative Surgical Sciences 2017, 2: 171-187. PMID: 31579751, PMCID: PMC6754021, DOI: 10.1515/iss-2017-0010.Peer-Reviewed Original ResearchOrgan preservationLong-term allograft functionPreservation of organsStatic cold storageAllograft functionSubsequent reperfusionIschemic preconditioningPathophysiological changesMechanical perfusionTransplantationTissue conservationCurrent literature pointsTherapeutic additivesGold standardPreservation protocolsOrgansCurrent bodyTissueReperfusionIschemiaInjuryPerfusionAssociations Between Deceased-Donor Urine MCP-1 and Kidney Transplant Outcomes
Mansour SG, Puthumana J, Reese PP, Hall IE, Doshi MD, Weng FL, Schröppel B, Thiessen-Philbrook H, Bimali M, Parikh CR. Associations Between Deceased-Donor Urine MCP-1 and Kidney Transplant Outcomes. Kidney International Reports 2017, 2: 749-758. PMID: 28730184, PMCID: PMC5512592, DOI: 10.1016/j.ekir.2017.03.007.Peer-Reviewed Original ResearchDelayed graft functionAcute kidney injuryMonocyte chemoattractant protein-1MCP-1 concentrationsUMCP-1Graft failureDonor Acute Kidney InjuryRecipient delayed graft functionUrine MCP-1Deceased kidney donorsKidney transplant outcomesChemoattractant protein-1Organ procurement organizationsMinimal clinical utilityAllograft functionAllograft outcomesGraft functionKidney injuryTransplant outcomesKidney procurementStudy cohortKidney donorsIndependent associationMacrophage recruitmentClinical utility
2016
Liver Transplantation: An Overview
Kim J, Hong J. Liver Transplantation: An Overview. 2016, 599-619. DOI: 10.1007/978-3-319-30103-7_36.Peer-Reviewed Original ResearchOrthotopic liver transplantationLiver transplantationGraft failurePrimary nonfunctionRecurrence of primary liver diseaseAbsence of systemic metastasisOrthotopic liver transplant recipientsPatient’s MELD scorePractice of liver transplantationDeceased donor liver graftsIrreversible liver failureBile duct cancerPrimary liver diseaseLiver transplant waiting listPatient survival outcomesDonor liver graftsWaiting listHepatic allograft functionTransplant waiting listImmunosuppressive regimensSystemic metastasesAllograft functionChronic rejectionLife-saving treatmentSurvival outcomesAssociations of Perfusate Biomarkers and Pump Parameters With Delayed Graft Function and Deceased Donor Kidney Allograft Function
Parikh C, Hall I, Bhangoo R, Ficek J, Abt P, Thiessen-Philbrook H, Lin H, Bimali M, Murray P, Rao V, Schröppel B, Doshi M, Weng F, Reese P. Associations of Perfusate Biomarkers and Pump Parameters With Delayed Graft Function and Deceased Donor Kidney Allograft Function. American Journal Of Transplantation 2016, 16: 1526-1539. PMID: 26695524, PMCID: PMC4844819, DOI: 10.1111/ajt.13655.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsBiomarkersCadaverDelayed Graft FunctionFemaleFollow-Up StudiesHumansHypothermia, InducedKidney Failure, ChronicKidney Function TestsKidney TransplantationMaleMiddle AgedOrgan PreservationPerfusionPrognosisProspective StudiesTime FactorsTissue and Organ ProcurementTissue DonorsConceptsDelayed graft functionHypothermic machine perfusionTransplanted kidneysAllograft functionGraft functionPerfusate biomarkersDeceased donor kidney transplantationKidney allograft functionL-FABP concentrationDonor kidney transplantationHigher NGALKidney transplantationKidney qualityMachine perfusionOrgan qualityBiomarker levelsMost recipientsBiomarker concentrationsPerfusion biomarkersKidneyAdditional studiesBiomarkersEGFRRecipientsMedian resistance
2015
Associations between Deceased-Donor Urine Injury Biomarkers and Kidney Transplant Outcomes
Reese PP, Hall IE, Weng FL, Schröppel B, Doshi MD, Hasz RD, Thiessen-Philbrook H, Ficek J, Rao V, Murray P, Lin H, Parikh CR. Associations between Deceased-Donor Urine Injury Biomarkers and Kidney Transplant Outcomes. Journal Of The American Society Of Nephrology 2015, 27: 1534-1543. PMID: 26374609, PMCID: PMC4849827, DOI: 10.1681/asn.2015040345.Peer-Reviewed Original ResearchConceptsDelayed graft functionRecipient delayed graft functionKidney injury molecule-1Graft functionInjury biomarkersDonor AKIDeceased donor organ qualityLiver-type fatty acidEarly allograft functionL-FABP concentrationRecipient renal functionUrinary NGAL concentrationsKidney transplant recipientsInjury molecule-1Kidney transplant outcomesAllograft functionUrinary NGALKidney injuryTransplant outcomesTransplant recipientsNGAL concentrationsRenal functionNeutrophil gelatinaseDeceased donorsIL-18
2013
Chitinase-Like Protein Brp-39/YKL-40 Modulates the Renal Response to Ischemic Injury and Predicts Delayed Allograft Function
Schmidt IM, Hall IE, Kale S, Lee S, He CH, Lee Y, Chupp GL, Moeckel GW, Lee CG, Elias JA, Parikh CR, Cantley LG. Chitinase-Like Protein Brp-39/YKL-40 Modulates the Renal Response to Ischemic Injury and Predicts Delayed Allograft Function. Journal Of The American Society Of Nephrology 2013, 24: 309-319. PMID: 23291472, PMCID: PMC3559482, DOI: 10.1681/asn.2012060579.Peer-Reviewed Original ResearchMeSH KeywordsAdipokinesAnimalsApoptosisBiomarkersCells, CulturedChitinase-3-Like Protein 1Delayed Graft FunctionDisease Models, AnimalEpithelial CellsGlycoproteinsHumansKidneyKidney TransplantationLectinsMacrophagesMaleMiceMice, Inbred C57BLPhosphatidylinositol 3-KinasesPredictive Value of TestsProto-Oncogene Proteins c-aktReperfusion InjurySignal TransductionTransplantation, HomologousConceptsBRP-39/YKLGraft functionKidney injuryYKL-40Reparative responseDeceased donor kidney transplantationKidney ischemia/reperfusionHours of transplantImmediate graft functionDelayed graft functionTubular cell deathIschemia/reperfusionDegree of injuryAllograft functionCell apoptotic deathKidney hypoperfusionKidney transplantationSystemic hypotensionRenal failureIschemic injuryRenal ischemiaRenal responseUrinary levelsBRP-39Activation of Akt
2012
Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection
Sayah DM, Koff JL, Leard LE, Hays SR, Golden JA, Singer JP. Rhinovirus and other respiratory viruses exert different effects on lung allograft function that are not mediated through acute rejection. Clinical Transplantation 2012, 27: e64-e71. PMID: 23278569, PMCID: PMC3558613, DOI: 10.1111/ctr.12054.Peer-Reviewed Original ResearchConceptsLung transplant recipientsAcute rejectionAllograft functionCARV infectionBiopsy-proven acute rejectionIncidence of ARLung allograft functionTransbronchial biopsy resultsReference groupChronic allograft rejectionRespiratory virus infectionsAllograft dysfunctionLung allograftsTransplant recipientsAllograft rejectionExpiratory volumePrimary outcomeRespiratory virusesAdverse outcomesClinical recordsRV infectionBaseline incidenceBiopsy resultsMonths postinfectionVirus infection
2010
Reconstruction of late‐onset transplant ureteral stricture disease
Helfand BT, Newman JP, Mongiu AK, Modi P, Meeks JJ, Gonzalez CM. Reconstruction of late‐onset transplant ureteral stricture disease. BJU International 2010, 107: 982-987. PMID: 20825404, DOI: 10.1111/j.1464-410x.2010.09559.x.Peer-Reviewed Original ResearchConceptsTransplant ureteral stricturesUreteral strictureGraft failureImmunosuppressive drug regimenKidney-pancreas transplantationStable allograft functionBaseline clinical characteristicsSerum creatinine levelsUrinary tract infectionLarge patient cohortUreteral stricture diseaseTime of reconstructionAllograft functionPostoperative complicationsRenal transplantationClinical characteristicsCreatinine levelsDrug regimenTract infectionsBalloon dilationMedian ageRepeat dilationStricture recurrenceSurgical managementOpen reconstruction
2004
Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers used for the treatment of hypertension appear to be safe in the early posttransplant period
Formica RN, Friedman AL, Lorber MI, Bia MJ. Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers used for the treatment of hypertension appear to be safe in the early posttransplant period. Transplantation Proceedings 2004, 36: 2675-2678. PMID: 15621121, DOI: 10.1016/j.transproceed.2004.10.013.Peer-Reviewed Original ResearchConceptsAngiotensin II receptor blockersEarly posttransplant periodII receptor blockersCalcium channel blockersTreatment of hypertensionPosttransplant periodReceptor blockersEnzyme inhibitorsAcute renal dysfunctionAdministration of ACEAdult renal transplantsAppropriate clinical criteriaRenal transplant patientsGlomerular filtration rateType of transplantUse of ACESerum potassium concentrationAllograft functionPancreas transplantsRenal dysfunctionRenal transplantTransplant patientsSerum creatininePosttransplant erythrocytosisSerum potassium
2001
LONG-TERM ISLET ALLOGRAFT FUNCTION IN THE ABSENCE OF CHRONIC IMMUNOSUPPRESSION: A CASE REPORT OF A NONHUMAN PRIMATE PREVIOUSLY MADE TOLERANT TO A RENAL ALLOGRAFT FROM THE SAME DONOR1
Kawai T, Sogawa H, Koulmanda M, Smith R, O’Neil J, Wee S, Boskovic S, Sykes M, Colvin R, Sachs D, Auchincloss H, Cosimi A, Ko D. LONG-TERM ISLET ALLOGRAFT FUNCTION IN THE ABSENCE OF CHRONIC IMMUNOSUPPRESSION: A CASE REPORT OF A NONHUMAN PRIMATE PREVIOUSLY MADE TOLERANT TO A RENAL ALLOGRAFT FROM THE SAME DONOR1. Transplantation 2001, 72: 351-354. PMID: 11477369, DOI: 10.1097/00007890-200107270-00036.Peer-Reviewed Original ResearchMeSH KeywordsABO Blood-Group SystemAnimalsAntilymphocyte SerumBlood GlucoseBone Marrow TransplantationCell SeparationC-PeptideCyclosporineDiabetes Mellitus, ExperimentalGraft SurvivalHistocompatibility TestingImmunosuppression TherapyInsulinIslets of LangerhansMacaca fascicularisMajor Histocompatibility ComplexMaleSplenectomyTransplantation, HomologousWhole-Body IrradiationConceptsDonor bone marrow transplantationEvidence of rejectionLong-term toleranceLong-term islet allograft functionHistological evidenceIslet transplantationHistologic evidence of rejectionWeeks of cyclosporineSolid organ allograftsTotal body irradiationBone marrow transplantationStreptozocin-induced diabetesIslet allograft functionNonmyeloablative conditioningThymic irradiationChronic immunosuppressionRecurrent diabetesAllograft functionBody irradiationMarrow transplantationNative nephrectomyKidney allograftsOrgan allograftsRenal allograftsKidney rejection
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