2024
C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via selective activation of monocyte subsets
Kiefer J, Zeller J, Schneider L, Thomé J, McFadyen J, Hoerbrand I, Lang F, Deiss E, Bogner B, Schaefer A, Chevalier N, Horner V, Kreuzaler S, Kneser U, Kauke-Navarro M, Braig D, Woollard K, Pomahac B, Peter K, Eisenhardt S. C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via selective activation of monocyte subsets. Journal Of Advanced Research 2024, 72: 401-420. PMID: 38992424, PMCID: PMC12147648, DOI: 10.1016/j.jare.2024.07.007.Peer-Reviewed Original ResearchAcute allograft rejectionC-reactive proteinVascularized Composite AllotransplantationAllograft rejectionAcute rejectionAllograft survivalGraft rejectionAttenuate acute allograft rejectionPreventing acute allograft rejectionImmune responseLong-term allograft survivalFacial Vascularized Composite AllotransplantationClinical allograft rejectionReduced allograft survivalChronic allograft rejectionIntravital imagingNon-classical monocytesMarkers of inflammationAcute-phase reactantsImmune-inflammatory reactionPro-inflammatory propertiesMononuclear phagocyte systemAcute-phase responseGraft infiltrationInnate immune response
2022
Donor–Recipient Non-HLA Variants, Mismatches and Renal Allograft Outcomes: Evolving Paradigms
Jethwani P, Rao A, Bow L, Menon MC. Donor–Recipient Non-HLA Variants, Mismatches and Renal Allograft Outcomes: Evolving Paradigms. Frontiers In Immunology 2022, 13: 822353. PMID: 35432337, PMCID: PMC9012490, DOI: 10.3389/fimmu.2022.822353.Peer-Reviewed Original ResearchConceptsAllograft outcomesImportant recent dataRenal allograft outcomeAcute allograft rejectionKidney allograft outcomesDonor-recipient mismatchRecipient's immune systemNatural history studiesNon-HLA lociMajority of casesOrgan allocation processPolymorphic HLA genesAcute rejectionAllograft longevityAllograft lossMaintenance immunosuppressionTransplant outcomesAllograft rejectionImmune mechanismsPatient deathRecipient pairsDonor organsHLA variantsImmune systemOvert evidence
2018
Eosinophilia and Kidney Disease: More than Just an Incidental Finding?
Gauckler P, Shin J, Mayer G, Kronbichler A. Eosinophilia and Kidney Disease: More than Just an Incidental Finding? Journal Of Clinical Medicine 2018, 7: 529. PMID: 30544782, PMCID: PMC6306805, DOI: 10.3390/jcm7120529.Peer-Reviewed Original ResearchPeripheral blood eosinophiliaRenal replacement therapyAcute interstitial nephritisAcute kidney injuryChronic kidney diseaseKidney diseaseHypereosinophilic syndromePersistent peripheral blood eosinophiliaManagement of EGPAAcute allograft rejectionAssociated with peripheral blood eosinophiliaIgG4-related diseasePrimary eosinophilic disorderManagement of patientsContext of kidney diseaseBlocks interleukin-5IgG4-RDFunctions of eosinophilsUnderdiagnosed entityAllograft rejectionEosinophilic granulomatosisReplacement therapyTherapeutic optionsBlood eosinophiliaKidney injury
2016
Blocking MHC class II on human endothelium mitigates acute rejection
Abrahimi P, Qin L, Chang WG, Bothwell AL, Tellides G, Saltzman WM, Pober JS. Blocking MHC class II on human endothelium mitigates acute rejection. JCI Insight 2016, 1: e85293. PMID: 26900601, PMCID: PMC4756651, DOI: 10.1172/jci.insight.85293.Peer-Reviewed Original ResearchClass II MHC moleculesCytotoxic T lymphocytesII MHC moleculesClass I MHC moleculesMHC moleculesI MHC moleculesEndothelial cellsAcute rejectionT cellsEffector memory T cellsT cell-mediated destructionAcute allograft rejectionCell-mediated destructionGraft endothelial cellsMemory T cellsAlloreactive cytotoxic T lymphocytesExperimental rodent modelsMajor histocompatibility complex moleculesSecondary lymphoid organsMHC class IIClass I major histocompatibility complex moleculesAllogeneic human lymphocytesHistocompatibility complex moleculesPrevents CD4Artery graft
2001
Up-regulation of macrophage migration inhibitory factor in acute renal allograft rejection in the rat
Brown F, Nikolic-Paterson D, Metz C, Bucala R, Atkins R, Lan H. Up-regulation of macrophage migration inhibitory factor in acute renal allograft rejection in the rat. Clinical & Experimental Immunology 2001, 118: 329-336. PMID: 10540199, PMCID: PMC1905421, DOI: 10.1046/j.1365-2249.1999.01048.x.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMIF mRNA expressionAcute renal allograft rejectionAcute allograft rejectionRenal allograft rejectionAllograft rejectionMigration inhibitory factorDay 5MIF expressionRenal allograftsMRNA expressionDay 1Inhibitory factorLocal MIF productionMIF protein expressionNormal renal functionT-cell infiltratesCell-mediated diseaseSevere tubular damageCellular immune responsesImmune cell-mediated diseasesSevere tubulitisSevere rejectionCreatinine clearanceMIF production
2000
Cytoprotection of Human Umbilical Vein Endothelial Cells Against Apoptosis and CTL-Mediated Lysis Provided by Caspase-Resistant Bcl-2 Without Alterations in Growth or Activation Responses
Zheng L, Dengler T, Kluger M, Madge L, Schechner J, Maher S, Pober J, Bothwell A. Cytoprotection of Human Umbilical Vein Endothelial Cells Against Apoptosis and CTL-Mediated Lysis Provided by Caspase-Resistant Bcl-2 Without Alterations in Growth or Activation Responses. The Journal Of Immunology 2000, 164: 4665-4671. PMID: 10779771, DOI: 10.4049/jimmunol.164.9.4665.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisCaspasesCell DivisionCell Line, TransformedCells, CulturedCulture Media, ConditionedCytotoxicity, ImmunologicEndothelial Growth FactorsEndothelium, VascularGenetic VectorsGreen Fluorescent ProteinsHumansLuminescent ProteinsProto-Oncogene Proteins c-bcl-2RetroviridaeT-Lymphocytes, CytotoxicTransduction, GeneticTransfectionUmbilical VeinsConceptsGraft endothelial cellsAllograft rejectionBcl-2Endothelial cellsAcute allograft rejectionClass I MHC moleculesNF-kappaB activationHuman umbilical vein endothelial cellsI MHC moleculesUmbilical vein endothelial cellsHost CTLVein endothelial cellsEndothelial injuryAnti-apoptotic gene Bcl-2MHC moleculesGene Bcl-2Induction of apoptosisBcl-2-transduced cellsClass IActivation responseApoptotic effectsCTLHUVECTNFGrowth factor withdrawal
1998
Fas LIGAND, TUMOR NECROSIS FACTOR-α EXPRESSION, AND APOPTOSIS DURING ALLOGRAFT REJECTION AND TOLERANCE
Josien R, Müschen M, Gilbert E, Douillard P, Heslan J, Soulillou J, Cuturi M. Fas LIGAND, TUMOR NECROSIS FACTOR-α EXPRESSION, AND APOPTOSIS DURING ALLOGRAFT REJECTION AND TOLERANCE. Transplantation 1998, 66: 887-893. PMID: 9798699, DOI: 10.1097/00007890-199810150-00013.Peer-Reviewed Original ResearchConceptsAllograft rejectionTNF-alphaDonor-specific blood transfusionApoptotic cellsNecrosis factor α expressionRole of CD95LAcute allograft rejectionDonor-specific transfusionGraft-infiltrating cellsHeterotopic cardiac allograftsCytotoxic T cellsTarget cell lysisTNF-alpha expressionTumor necrosis factorExpression of CD95LCD95/CD95LExpression of FasAcute rejectionCardiac allograftsBlood transfusionIntragraft expressionNecrosis factorT cellsCD95 antigenAllografts
1997
Influence of steroid withdrawal on proteinuria in renal allograft recipients
Ghandour FZ, Knauss TC, Mulligan DC, Schulak JA, Hricik DE. Influence of steroid withdrawal on proteinuria in renal allograft recipients. Clinical Transplantation 1997, 11: 395-398. PMID: 9361929, DOI: 10.1111/j.1399-0012.1997.tb00840.x.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnalysis of VarianceAnti-Inflammatory AgentsAzathioprineChi-Square DistributionChronic DiseaseCreatinineCyclosporineFemaleFollow-Up StudiesGlucocorticoidsGraft RejectionHumansImmunosuppressive AgentsKidney TransplantationLinear ModelsLogistic ModelsMaleMiddle AgedMultivariate AnalysisPrednisoneProteinuriaRecurrenceTransplantation, HomologousConceptsSteroid withdrawalUrinary protein excretionAllograft rejectionProtein excretionPrimary renal transplant recipientsAcute allograft rejectionRenal allograft recipientsRenal transplant recipientsChronic allograft rejectionSpot urine specimensAcute rejectionAllograft recipientsSteroid therapyTransplant recipientsClinical variablesUrine creatinineUrine specimensPatientsProteinuriaWithdrawalExcretionRecipientsRejectionCreatinineTransplantation
1987
568 Detection of Acute Allograft Rejection by Indium-111 Labeled Platelet Scintigraphy in Renal Transplant Patients
Bia M, Desir G, Ezekowitz M, Lange R, Smith E, Kashgarian M, Schiff M. 568 Detection of Acute Allograft Rejection by Indium-111 Labeled Platelet Scintigraphy in Renal Transplant Patients. Journal Of Urology 1987, 137: 245a. DOI: 10.1016/s0022-5347(17)75718-7.Peer-Reviewed Original ResearchDetection of acute allograft rejection by indium-111 labeled platelet scintigraphy in renal transplant patients.
Desir G, Bia MJ, Lange RC, Smith EO, Kashgarian M, Flye W, Schiff M, Ezekowitz MD. Detection of acute allograft rejection by indium-111 labeled platelet scintigraphy in renal transplant patients. Transplantation Proceedings 1987, 19: 1677-80. PMID: 3547876.Peer-Reviewed Original Research
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