2023
Cellular activation pathways and interaction networks in vascularized composite allotransplantation
Knoedler L, Knoedler S, Panayi A, Lee C, Sadigh S, Huelsboemer L, Stoegner V, Schroeter A, Kern B, Mookerjee V, Lian C, Tullius S, Murphy G, Pomahac B, Kauke-Navarro M. Cellular activation pathways and interaction networks in vascularized composite allotransplantation. Frontiers In Immunology 2023, 14: 1179355. PMID: 37266446, PMCID: PMC10230044, DOI: 10.3389/fimmu.2023.1179355.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationComposite allotransplantationRecipient-derived lymphocytesTreatment of patientsCellular activation pathwaysMultidrug immunosuppressionVCA graftsVCA patientsVCA rejectionGraft rejectionDevastating injuriesClinical managementNovel therapiesReconstructive surgeryLimb lossRejection responseFacial disfigurementAllotransplantationPatientsGraftActivation pathwayTissue cellsDifferent cell typesTissue typesCell typesModalities to Deliver Cell Therapy for Treatment of Chronic Limb Threatening Ischemia
Setia O, Lee S, Dardik A. Modalities to Deliver Cell Therapy for Treatment of Chronic Limb Threatening Ischemia. Advances In Wound Care 2023, 13: 253-279. PMID: 37002893, PMCID: PMC11305013, DOI: 10.1089/wound.2022.0114.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsChronic limb threatening ischemiaPeripheral arterial diseaseSevere peripheral arterial diseaseLimb threatening ischemiaClinical trialsCell therapyStem cell therapyIschemic limbsFeasible therapeutic alternativePromising treatment optionPre-clinical studiesCell deliveryPAD patientsArterial diseaseClinical benefitTreatment optionsSurgical methodsTherapeutic alternativeBest modalityHigh riskLimb lossSevere formTherapeutic benefitPatientsTherapy
2021
Development and Implementation of the Military Treatment Facility Engagement Committee (MTFEC) to Support Pragmatic Clinical Trials in the Military Health System
Scarton DV, Roddy WT, Taylor JA, Geda M, Brandt CA, Peduzzi P, Kerns RD, Pasquina PF. Development and Implementation of the Military Treatment Facility Engagement Committee (MTFEC) to Support Pragmatic Clinical Trials in the Military Health System. Military Medicine 2021, 186: 70-75. PMID: 33499543, PMCID: PMC7980475, DOI: 10.1093/milmed/usaa368.Peer-Reviewed Original ResearchConceptsPain Management CollaboratoryPragmatic clinical trialsMilitary treatment facilitiesHealth care systemPain managementClinical trialsDOD health care systemVA health care systemCare systemChronic pain managementService membersTraumatic brain injuryMilitary Health SystemMilitary service membersChronic painNonpharmacological approachesBrain injuryLimb lossClinical practiceHealth systemCoordinating CenterTrialsVA programsNational InstituteDepartment of Defense
2020
The Role of Lower Extremity Amputation in Chronic Limb-Threatening Ischemia
Kim TI, Mena C, Sumpio BE. The Role of Lower Extremity Amputation in Chronic Limb-Threatening Ischemia. International Journal Of Angiology 2020, 29: 149-155. PMID: 32904807, PMCID: PMC7458760, DOI: 10.1055/s-0040-1710075.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaImproved limb salvage ratesChronic limb threatening ischemiaRole of amputationLimb salvage rateLimb threatening ischemiaLimb-threatening ischemiaPeripheral artery diseaseLower extremity amputationMajor amputationPrimary amputationArtery diseaseLimb salvageSalvage rateExtremity amputationImproved careLimb lossSevere formMultidisciplinary teamAmputationRevascularizationIschemiaPatientsHigh rateSalvageAll hands on deck: Hand replantation versus transplantation
Heineman J, Bueno E, Kiwanuka H, Carty M, Sampson C, Pribaz J, Pomahac B, Talbot S. All hands on deck: Hand replantation versus transplantation. SAGE Open Medicine 2020, 8: 2050312120926351. PMID: 32537157, PMCID: PMC7268554, DOI: 10.1177/2050312120926351.Peer-Reviewed Original ResearchHand replantationAdverse events/side effectsSystematic reviewPatient satisfaction/qualityPost-operative considerationsDeterminants of outcomePre-operative considerationsMeta-Analyses (PRISMA) guidelinesSatisfaction/qualityPreferred Reporting ItemsBest possible outcomeUpper limb lossAcute amputationsSurgical repairHand transplantationSurgical techniqueOperative techniquePatient commitmentComplete amputationDaily livingForearm levelLimb lossPatient expectationsSide effectsBetter outcomes
2019
Management of Asymptomatic Popliteal Artery Aneurysms
Kim TI, Sumpio BE. Management of Asymptomatic Popliteal Artery Aneurysms. International Journal Of Angiology 2019, 28: 005-010. PMID: 30880884, PMCID: PMC6417913, DOI: 10.1055/s-0038-1676792.Peer-Reviewed Original ResearchAsymptomatic popliteal artery aneurysmsPopliteal artery aneurysmsArtery aneurysmEndovascular repairCommon peripheral artery aneurysmsPeripheral artery aneurysmsChoice of repairEndovascular meansTreatment choiceLimb lossBetter outcomesProper diagnosisAneurysmsKey articlesHigh rateRepairMorbidityDiagnosis
2017
Racial disparities after infrainguinal bypass surgery in hemodialysis patients
Arhuidese I, Wang S, Locham S, Faateh M, Nejim B, Malas M. Racial disparities after infrainguinal bypass surgery in hemodialysis patients. Journal Of Vascular Surgery 2017, 66: 1163-1174. PMID: 28647200, DOI: 10.1016/j.jvs.2017.04.044.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmputation, SurgicalBlack or African AmericanBlood Vessel Prosthesis ImplantationChi-Square DistributionDatabases, FactualFemaleHealthcare DisparitiesHispanic or LatinoHumansKaplan-Meier EstimateKidney DiseasesLimb SalvageLogistic ModelsMaleMedicareMiddle AgedMultivariate AnalysisOdds RatioPeripheral Arterial DiseasePostoperative ComplicationsProcess Assessment, Health CarePropensity ScoreProportional Hazards ModelsRenal DialysisRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeUnited StatesVascular PatencyWhite PeopleConceptsInfrainguinal bypass surgeryGraft failureHD patientsPeripheral arterial diseaseLimb salvageBypass surgeryEvaluate long-term graft patencyArtery diseaseWhite patientsGraft patencyBlack patientsSurgical treatment of peripheral arterial diseaseLong-term graft failurePrimary assisted patencyAcute graft failureCox regression analysisLong-term mortalityLong-term graft patencyAll-Cause MortalityLimb lossTreatment of peripheral arterial diseasePopliteal-tibial bypassAssisted patencyPrimary patencySecondary patencyDistal embolization during lower extremity endovascular interventions
Chaar C, Shebl F, Sumpio B, Dardik A, Indes J, Sarac T. Distal embolization during lower extremity endovascular interventions. Journal Of Vascular Surgery 2017, 66: 143-150. PMID: 28366300, DOI: 10.1016/j.jvs.2017.01.032.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmputation, SurgicalAngioplasty, BalloonAtherectomyChi-Square DistributionCritical IllnessDatabases, FactualDisease-Free SurvivalEmbolismFemaleFemoral ArteryHumansIncidenceIntermittent ClaudicationIschemiaLimb SalvageLower ExtremityMaleMiddle AgedMultivariate AnalysisNew EnglandOdds RatioPeripheral Arterial DiseaseProportional Hazards ModelsRegistriesRetrospective StudiesRisk AssessmentRisk FactorsStentsTime FactorsTreatment OutcomeVascular PatencyConceptsLower Extremity Endovascular InterventionsSuperficial femoral arteryCritical limb ischemiaDistal embolizationLoss of patencyEndovascular interventionBalloon angioplastyLimb ischemiaAdditional endovascular interventionArterial endovascular interventionUse of atherectomyVascular Study GroupLength of occlusionNew England databaseNumber of arteriesMajor amputationMost patientsPatient characteristicsFemoral arteryRisk factorsStudy groupMultivariable regressionLimb lossLower riskAngioplasty
2016
Is the Prosthetic Homologue Necessary for Embodiment?
Dornfeld C, Swanston M, Cassella J, Beasley C, Green J, Moshayev Y, Wininger M. Is the Prosthetic Homologue Necessary for Embodiment? Frontiers In Neurorobotics 2016, 10: 21. PMID: 28066228, PMCID: PMC5168425, DOI: 10.3389/fnbot.2016.00021.Peer-Reviewed Original ResearchA Mobile Extracorporeal Extremity Salvage System for Replantation and Transplantation
Kueckelhaus M, Fischer S, Sisk G, Kiwanuka H, Bueno E, Dermietzel A, Alhefzi M, Aycart M, Diehm Y, Pomahac B. A Mobile Extracorporeal Extremity Salvage System for Replantation and Transplantation. Annals Of Plastic Surgery 2016, 76: 355-360. PMID: 26808757, DOI: 10.1097/sap.0000000000000681.Peer-Reviewed Original ResearchConceptsMuscle damageLimb lossPerfusion deviceDeceased organ donorsIschemic muscle damageBilateral hind limbsPreferred treatmentBilateral limbsMuscle biopsyOrgan donorsTraumatic amputationHealthy limbPerfusion solutionReplantationArterial systemTransplantationHypoxic cellsPerfusate compositionHind limbPorcine limbsLimbSignificant differencesYorkshire pigsSalvage systemSimilar changes
2015
Reconstruction for All: The Case for Pediatric Hand Transplantation
Colen D, Bank J, McAndrew C, Levin L. Reconstruction for All: The Case for Pediatric Hand Transplantation. Vascularized Composite Allotransplantation 2015, 2: 47-52. DOI: 10.1080/23723505.2015.1133268.Peer-Reviewed Original ResearchVascularized Composite AllotransplantationReconstructive hand transplantationHand transplantationPediatric hand transplantationProper patient selectionFirst successful hand transplantPediatric recipientsHand therapyPatient selectionUpper extremityViable restorative optionHand transplantReconstructive surgeryLimb lossComposite allotransplantationReconstructive ladderAnatomic configurationRestorative optionsTransplant medicineAutologous tissueTransplantationFunctional defectsMedical communityAlloplastic materialsSocial support
2014
New advances in limb salvage.
Chin JA, Sumpio BE. New advances in limb salvage. Surgical Technology Online 2014, 25: 212-6. PMID: 25433346.Peer-Reviewed Original ResearchCritical limb ischemiaLimb salvageDistal vein patchType of therapyDrug-eluting stentsQuality of lifeEndovascular therapyLimb ischemiaPatient mortalityVein patchPoor outcomeEndovascular interventionTreatment optionsMorbid diseaseVascular surgerySurgical techniqueLimb lossHealthcare costsEpidemiologic problemNew advancesTherapySalvageInterventionFurther researchFacial and Hand Allotransplantation
Pomahac B, Gobble R, Schneeberger S. Facial and Hand Allotransplantation. Cold Spring Harbor Perspectives In Medicine 2014, 4: a015651. PMID: 24478387, PMCID: PMC3935393, DOI: 10.1101/cshperspect.a015651.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationFacial transplantationLong-term immunosuppressionMinimization of immunosuppressionGood functional outcomeTreatment of patientsMultidisciplinary team approachNovel therapeutic optionsSevere facial disfigurementAllograft survivalHand allotransplantationSkin rejectionTherapeutic optionsFunctional outcomeLimb lossComposite allotransplantationSide effectsTeam approachTransplantationSurgical planningFacial disfigurementImmunosuppressionAllotransplantationComplex proceduresPatients
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