Local Delivery of Regulatory T Cells Promotes Corneal Allograft Survival
Shao C, Chen Y, Nakao T, Amouzegar A, Yin J, Tahvildari M, Lužnik Z, Chauhan S, Dana R. Local Delivery of Regulatory T Cells Promotes Corneal Allograft Survival. Transplantation 2019, 103: 182-190. PMID: 30247445, PMCID: PMC6309927, DOI: 10.1097/tp.0000000000002442.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAllograftsAnimalsAntigen-Presenting CellsChemotaxis, LeukocyteCorneaCorneal TransplantationCytokinesGraft SurvivalGreen Fluorescent ProteinsKineticsLymph NodesLymphocyte ActivationMaleMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicT-Lymphocytes, RegulatoryTh1 CellsConceptsDraining Lymph NodesTreg cellsAntigen-presenting cellsAllograft survivalIL-10Mature antigen-presenting cellsLong-term allograft survivalCorneal allograft recipientsCorneal allograft survivalTGF-bExpression of IFN-gCell-based immunotherapyLevels of IL-10Conventional T cellsPromote transplant survivalGFP transgenic miceCell-based modalitiesExpression of IFNGHost immune responseSuppress host immune responsesEnzyme-linked immunosorbent assayIpsilateral corneaTh1 frequencyReverse transcription polymerase chain reactionCorneal transplantation
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