2024
Association of binge alcohol use with functional outcomes among individuals with COVID-19 infection
Tong S, Gottlieb M, Mannan I, Zheng Z, Sinha M, Santangelo M, Gatling K, Kean E, Watts P, Wang R, Montoy J, Idris A, MacDonald S, Huebinger R, Hill M, O’Laughlin K, Gentile N, Dorney J, Malicki C, Elmore J, Roldan K, Chan G, Lin Z, Weinstein R, Stephens K. Association of binge alcohol use with functional outcomes among individuals with COVID-19 infection. Alcohol And Alcoholism 2024, 60: agae086. PMID: 39745829, PMCID: PMC11694663, DOI: 10.1093/alcalc/agae086.Peer-Reviewed Original ResearchConceptsBinge alcohol usePhysical function outcomesFunctional outcomesAlcohol useBinge drinkingPatient-Reported Outcomes Measurement Information SystemCOVID-19 infectionSocial determinants of healthOutcomes Measurement Information SystemDeterminants of healthMeasurement Information SystemLong-term functional outcomeGeneralized Estimating Equation modelsExcessive alcohol intakeCohort study designFrequency of binge drinkingSelf-reported binge drinkingPain interferenceSocial determinantsPhysical functionPhysical healthTime of infectionPrescription medicationsAlcohol intakeAlcohol consumptionComparison of combined intravenous and intra-arterial thrombolysis with intravenous thrombolysis alone in stroke patients undergoing mechanical thrombectomy: a propensity-matched analysis
Elawady S, Kasem R, Mulpur B, Cunningham C, Matsukawa H, Sowlat M, Orscelik A, Nawabi N, Isidor J, Maier I, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Samaniego E, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Grandhi R, Crosa R, Matouk C, Park M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Altschul D, Spiotta A, Levitt M, Goyal N. Comparison of combined intravenous and intra-arterial thrombolysis with intravenous thrombolysis alone in stroke patients undergoing mechanical thrombectomy: a propensity-matched analysis. Journal Of NeuroInterventional Surgery 2024, 17: e261-e268. PMID: 39179373, DOI: 10.1136/jnis-2024-021975.Peer-Reviewed Original ResearchSymptomatic intracranial hemorrhageAIS-LVO patientsIntracranial hemorrhageIntra-arteriallyModified Rankin ScaleNeurological improvementMechanical thrombectomyIAT groupFunctional outcomesIntra-arterial groupModified Rankin scale 0Long-term functional outcomeRate of recanalizationPropensity-matched analysisIntra-arterial thrombolysisLarge vessel occlusionStroke patientsAcute ischemic strokeSecondary outcomesPrimary outcomePropensity score matchingNo significant differencePropensity matchingAIS-LVOMT+IVT groupPrenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Rivero R, Stitelman D. Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery. Current Stem Cell Reports 2024, 10: 51-57. DOI: 10.1007/s40778-024-00237-8.Peer-Reviewed Original ResearchCongenital diaphragmatic herniaDiaphragmatic herniaAnimal modelsIntra-amniotic injectionLong-term functional outcomeParticle-based deliveryFetal therapyPrenatal therapySpinal defectsTarget specific tissuesCo-morbiditiesCongenital diseaseFunctional outcomesTreatment deliveryStructural diseaseClinical translationMyelomeningoceleTherapyHerniaSpecific tissuesTissueDiseaseDeliveryPrenatallyParticle deliveryExamining cocaine use reductions and long-term outcomes in two clinical trials of continuing care for cocaine dependence
Votaw V, Tuchman F, Roos C, Hebden H, McKay J, Kiluk B, Witkiewitz K. Examining cocaine use reductions and long-term outcomes in two clinical trials of continuing care for cocaine dependence. Journal Of Substance Use And Addiction Treatment 2024, 163: 209394. PMID: 38735481, PMCID: PMC11180556, DOI: 10.1016/j.josat.2024.209394.Peer-Reviewed Original ResearchCocaine use disorderCocaine useAssociated with less cocaine useTelephone-based continuing careLevel of cocaine useFollow-upDrug use consequencesAssociated with lower levelsClinical trialsBaseline to 12-month follow-upCocaine dependenceTreatment entryProblem severityUse disorderTimeline FollowbackCocaineInitial treatment phaseAbstinenceLow-frequency useLong-term functional outcomeEffect sizeTreatment phaseLong-term outcomesRandomized clinical trialsNegative consequencesSecond‐line immunotherapy in new onset refractory status epilepticus
Hanin A, Muscal E, Hirsch L. Second‐line immunotherapy in new onset refractory status epilepticus. Epilepsia 2024, 65: 1203-1223. PMID: 38430119, DOI: 10.1111/epi.17933.Peer-Reviewed Original ResearchFebrile infection-related epilepsy syndromeSecond-line immunotherapyOnset refractory status epilepticusRefractory status epilepticusIntrathecal dexamethasoneStatus epilepticusCytokine levelsFunctional outcomesCerebrospinal fluid cytokine levelsInitiation of anakinraReduction of seizure frequencyLong-term functional outcomeResponse to treatmentSE onsetElevated serumFebrile infectionsImmune dysregulationLong-term disabilityTreatment initiationCase reportCytokine measurementsProspective studyAnakinraImmunotherapyTocilizumab
2023
Shorter Door-to-Needle Times Are Associated With Better Outcomes After Intravenous Thrombolytic Therapy and Endovascular Thrombectomy for Acute Ischemic Stroke
Man S, Solomon N, Mac Grory B, Alhanti B, Uchino K, Saver J, Smith E, Xian Y, Bhatt D, Schwamm L, Hussain M, Fonarow G. Shorter Door-to-Needle Times Are Associated With Better Outcomes After Intravenous Thrombolytic Therapy and Endovascular Thrombectomy for Acute Ischemic Stroke. Circulation 2023, 148: 20-34. PMID: 37199147, PMCID: PMC10356148, DOI: 10.1161/circulationaha.123.064053.Peer-Reviewed Original ResearchConceptsIntravenous thrombolytic therapyAcute ischemic strokeGood long-term functional outcomeLong-term functional outcomeShorter DTN timesEndovascular thrombectomyFunctional outcomeDTN timeIschemic strokeCause mortalityNeedle timeThrombolytic therapyCox proportional hazards modelModified Rankin Scale (mRS) 0Older US patientsRankin Scale 0Multivariate logistic regressionProportional hazards modelLongitudinal functional outcomesHome timeEligible patientsEVT candidatesEVT timesGuidelines-StrokeThrombolytic administration
2022
Geriatric vulnerability and the burden of disability after major surgery
Gill TM, Murphy TE, Gahbauer EA, Leo‐Summers L, Becher RD. Geriatric vulnerability and the burden of disability after major surgery. Journal Of The American Geriatrics Society 2022, 70: 1471-1480. PMID: 35199332, PMCID: PMC9106872, DOI: 10.1111/jgs.17693.Peer-Reviewed Original ResearchConceptsBurden of disabilityMajor surgeryGeriatric vulnerabilitiesHospital dischargeElective surgeryFunctional outcomeLong-term functional outcomeStrong epidemiologic evidenceCommunity-living personsPoor functional outcomeNon-elective surgeryProspective longitudinal studyAdditional vulnerability factorVulnerability factorsMultivariable analysisEpidemiologic evidenceSurgery increasesBlack raceDisability burdenFemale sexMore disabilityAge 85Hispanic ethnicitySurgeryOlder persons
2021
End-of-Life Care Decision-Making in Stroke
Gao L, Zhao C, Hwang D. End-of-Life Care Decision-Making in Stroke. Frontiers In Neurology 2021, 12: 702833. PMID: 34650502, PMCID: PMC8505717, DOI: 10.3389/fneur.2021.702833.Peer-Reviewed Original ResearchStroke patientsImmediate post-stroke periodIntensive care unit careLong-term functional outcomeCare decisionsCode status changePost-stroke periodIntensive care unitIntracerebral hemorrhage patientsLong-term disabilityLife care discussionsLife-sustaining therapyCause of deathLife care decisionsClinician's subjectivityIschemic strokeUnit careCare unitHemorrhage patientsPatient survivalFunctional outcomeProvider recommendationPatient preferencesCare discussionsTreatment goalsAdverse events in the treatment of motorcycle-related isolated limb injuries at a regional hospital in Uganda: a prospective clinical analysis
Okullo GO, Flores MJ, Peck CJ, Socci AR, Kisitu DK. Adverse events in the treatment of motorcycle-related isolated limb injuries at a regional hospital in Uganda: a prospective clinical analysis. International Orthopaedics 2021, 46: 71-77. PMID: 34296324, DOI: 10.1007/s00264-021-05060-y.Peer-Reviewed Original ResearchConceptsClinical adverse eventsLimb injuriesRegional hospitalAdverse eventsLong-term functional outcomeProspective clinical analysisWeight-bearing statusLonger hospital stayMajority of patientsPain/discomfortPost-operative recoveryProspective descriptive studyResultsOne hundred twentyCourse of treatmentHospital stayDefinitive treatmentFunctional recoveryWound infectionFunctional outcomeInjury careHundred twentyLife measuresPatientsSevere injuriesHospitalPredicting 90-Day Outcome After Thrombectomy: Baseline-Adjusted 24-Hour NIHSS Is More Powerful Than NIHSS Score Change
Mistry EA, Yeatts S, de Havenon A, Mehta T, Arora N, La Rosa F, Starosciak AK, Siegler JE, Mistry AM, Yaghi S, Khatri P. Predicting 90-Day Outcome After Thrombectomy: Baseline-Adjusted 24-Hour NIHSS Is More Powerful Than NIHSS Score Change. Stroke 2021, 52: 2547-2553. PMID: 34000830, PMCID: PMC11261999, DOI: 10.1161/strokeaha.120.032487.Peer-Reviewed Original ResearchConceptsNIHSS scoreLong-term functional outcomeNIHSS score changeComprehensive stroke centerHealth Stroke ScaleProspective observational studyEarly time pointsStroke centersStroke ScaleEndovascular therapyMRS outcomesMRS scoreRankin ScaleStroke patientsFunctional outcomeSurrogate markerClinical studiesNIHSSMultivariable modelingObservational studyOutcome measuresPatientsPercent changeScore changeLogistic regressionThe Use of Computer Navigation and Robotic Technology in Complex Total Knee Arthroplasty
Ross KA, Wiznia DH, Long WJ, Schwarzkopf R. The Use of Computer Navigation and Robotic Technology in Complex Total Knee Arthroplasty. JBJS Reviews 2021, 9: e20.00200. PMID: 33999911, DOI: 10.2106/jbjs.rvw.20.00200.Peer-Reviewed Original ResearchConceptsDeformity correctionRevision casesPotential long-term cost savingsComplex total knee arthroplastyLong-term functional outcomeCAS navigationTotal knee arthroplasty systemTotal knee arthroplastyRapid hospital dischargeKnee arthroplasty systemComputer-assisted surgical navigationHospital dischargeBlood lossRobotic systemOperative timePreoperative deformityFunctional outcomeTibial deformityFemoral bowingKnee arthroplastyRevision rateTherapy requirementsMechanical axisPrimary casesRobotic technology
2020
Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis
Katsanos A, Alexandrov A, Mandava P, Köhrmann M, Soinne L, Barreto A, Sharma V, Mikulik R, Muir K, Rothlisberger T, Grotta J, Levi C, Molina C, Saqqur M, Palaiodimou L, Psaltopoulou T, Vosko M, Moreira T, Fiebach J, Rubiera M, Sandset E, de Havenon A, Kent T, Alexandrov A, Schellinger P, Tsivgoulis G, Investigators F. Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis. European Journal Of Neurology 2020, 27: 2453-2462. PMID: 32697894, DOI: 10.1111/ene.14447.Peer-Reviewed Original ResearchConceptsPatients treated with intravenous thrombolysisAcute ischaemic strokeIndependent functional outcomePulse pressure variabilityIntravenous thrombolysisIntracranial bleedingAssociated with adverse short-termFunctional outcomesBlood pressureStroke patients treated with intravenous thrombolysisTissue plasminogen activator bolusSystemic tissue plasminogen activatorAssociated with unfavorable outcomesAssociated with worse neurological outcomeSymptomatic intracranial bleedingLong-term functional outcomeSafety end pointPulse pressureAcute ischaemic stroke patientsAdverse short-termLysis of thrombiPressure variabilityTissue plasminogen activatorCombined Lysis of ThrombusIntravenous thrombolysis administration
2019
Essential elements of an outpatient total joint replacement programme.
Li J, Rubin LE, Mariano ER. Essential elements of an outpatient total joint replacement programme. Current Opinion In Anaesthesiology 2019, 32: 643-648. PMID: 31356361, DOI: 10.1097/aco.0000000000000774.Peer-Reviewed Original ResearchMeSH KeywordsAmbulatory Surgical ProceduresArthroplasty, Replacement, HipArthroplasty, Replacement, KneeCritical PathwaysFeasibility StudiesHealth Plan ImplementationHumansLength of StayMedicaidMedicarePatient Education as TopicPatient ReadmissionPatient SatisfactionPatient SelectionPostoperative ComplicationsProgram EvaluationTreatment OutcomeUnited StatesConceptsTotal joint arthroplastyOutpatient total joint arthroplastyPatient satisfactionLong-term functional outcomePatient/family educationTotal knee arthroplasty patientsOpioid-sparing analgesiaShort-term complicationsTotal joint replacement programKnee arthroplasty patientsSubset of patientsStandardized clinical pathwayPositive surgical outcomesProper patient selectionJoint replacement programEvidence-based guidanceNew care paradigmPostdischarge planningAdverse eventsArthroplasty patientsPatient selectionSurgical outcomesFunctional outcomeOutpatient surgeryInpatient proceduresSerum Anti-NMDA (N-Methyl-D-Aspartate)-Receptor Antibodies and Long-Term Clinical Outcome After Stroke (PROSCIS-B)
Sperber P, Siegerink B, Huo S, Rohmann J, Piper S, Prüss H, Heuschmann P, Endres M, Liman T. Serum Anti-NMDA (N-Methyl-D-Aspartate)-Receptor Antibodies and Long-Term Clinical Outcome After Stroke (PROSCIS-B). Stroke 2019, 50: 3213-3219. PMID: 31526121, DOI: 10.1161/strokeaha.119.026100.Peer-Reviewed Original ResearchConceptsSecondary vascular eventsFunctional outcomeVascular eventsHigh titersNMDAR1-ABSeronegative patientsSeropositive patientsFirst strokeLong-term clinical outcomesLong-term functional outcomeCombined end pointRecurrent vascular eventsOutcomes of patientsPoor functional outcomeSub-group analysisOutcomes of interestAnti-NMDAAutoimmune encephalitisCardiovascular riskProspective cohortRankin ScaleHazard ratioClinical outcomesNeuroprotective effectsReceptor antibodies
2018
Total Disc Arthroplasty Versus Anterior Interbody Fusion in the Lumbar Spine Have Relatively a Few Differences in Readmission and Short-term Adverse Events
Shultz BN, Wilson AT, Ondeck NT, Bovonratwet P, McLynn RP, Cui JJ, Grauer JN. Total Disc Arthroplasty Versus Anterior Interbody Fusion in the Lumbar Spine Have Relatively a Few Differences in Readmission and Short-term Adverse Events. Spine 2018, 43: e52-e59. PMID: 28723873, DOI: 10.1097/brs.0000000000002337.Peer-Reviewed Original ResearchConceptsAnterior lumbar interbody fusionTotal disc arthroplastyAdverse eventsBlood transfusionOperative timeInterbody fusionRisk factorsSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseShort-term adverse eventsQuality Improvement Program databaseShort-term clinical outcomesLong-term functional outcomeLumbar total disc arthroplastySerious adverse eventsImprovement Program databaseAnterior interbody fusionIndividual adverse eventsStand-alone Anterior Lumbar Interbody FusionGeneral health outcomesPotential risk factorsLumbar interbody fusionMultivariate Poisson regressionPerioperative outcomesPostoperative length
2017
Long Term Functional Outcome and Mortality in Elderly Patients After Intracerebral Hemorrhage (P2.258)
Leasure A, Sreekrishnan A, Zhou S, Hwang D, Sansing L, Greer D, Sheth K. Long Term Functional Outcome and Mortality in Elderly Patients After Intracerebral Hemorrhage (P2.258). Neurology 2017, 88 DOI: 10.1212/wnl.88.16_supplement.p2.258.Peer-Reviewed Original ResearchLong-term functional outcomeTerm functional outcomesElderly patientsIntracerebral hemorrhageFunctional outcome
2016
Neurovascular unit remodelling in the subacute stage of stroke recovery
Lake EMR, Bazzigaluppi P, Mester J, Thomason LAM, Janik R, Brown M, McLaurin J, Carlen PL, Corbett D, Stanisz GJ, Stefanovic B. Neurovascular unit remodelling in the subacute stage of stroke recovery. NeuroImage 2016, 146: 869-882. PMID: 27664828, DOI: 10.1016/j.neuroimage.2016.09.016.Peer-Reviewed Original ResearchConceptsPeri-lesional cortexVascular reactivityNeuronal lossSubacute stageEndothelin-1LFP activityLong-term functional outcomeLocal field potential responsesPeripheral somatosensory stimulationActivation of microgliaET-1 injectionFocal ischemic strokeFocal cerebral ischaemiaPeri-infarct zoneSensori-motor cortexSpontaneous neuronal activityAdult Sprague-DawleyField potential responsesExtended temporal windowDynamic functional changesIschemic strokeAstrocytic activationCerebral ischaemiaNeurovascular unitIschemic insult
2012
Mortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury
Badri S, Chen J, Barber J, Temkin NR, Dikmen SS, Chesnut RM, Deem S, Yanez ND, Treggiari MM. Mortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury. Intensive Care Medicine 2012, 38: 1800-1809. PMID: 23011528, DOI: 10.1007/s00134-012-2655-4.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryAverage intracranial pressureIntracranial pressureFunctional statusTBI patientsBrain injuryNeuropsychological functioningAbbreviated Injury Scale headLong-term functional outcomeSevere traumatic brain injuryAdult TBI patientsInjury scale headGlasgow Coma ScoreSevere TBI patientsPrimary endpointComa ScoreComposite endpointIndependent predictorsFunctional outcomeOdds ratioMultivariable regressionNeuropsychological outcomesNeuropsychological testingPatientsNeuropsychological functionInfarct Volume Is a Pivotal Biomarker After Intra-Arterial Stroke Therapy
Yoo A, Chaudhry Z, Nogueira R, Lev M, Schaefer P, Schwamm L, Hirsch J, González R. Infarct Volume Is a Pivotal Biomarker After Intra-Arterial Stroke Therapy. Stroke 2012, 43: 1323-1330. PMID: 22426317, DOI: 10.1161/strokeaha.111.639401.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overBiomarkersBrain InfarctionCohort StudiesDatabases, FactualFemaleFibrinolytic AgentsHumansInfusions, IntravenousMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingPredictive Value of TestsProspective StudiesRetrospective StudiesStrokeThrombolytic TherapyTissue Plasminogen ActivatorTomography, X-Ray ComputedTreatment OutcomeConceptsFinal infarct volumeIntra-arterial therapyAcute ischemic strokeInfarct volumeFunctional outcomeBetter outcomesIschemic strokePoor outcomeAnterior circulation acute ischemic strokeScale scoreHealth Stroke Scale scoreMedian admission National InstitutesMedian final infarct volumesLong-term functional outcomeIntra-arterial stroke therapyAdmission National InstitutesProximal artery occlusionStroke Scale scoreOnly independent predictorRankin Scale scoreArtery occlusionProspective cohortRankin ScaleIndependent predictorsClinical outcomes
2011
Slipped capital femoral epiphysis
Purcell D, Varthi A, Lee M. Slipped capital femoral epiphysis. Current Orthopaedic Practice 2011, 22: 81-89. DOI: 10.1097/bco.0b013e3181f49e80.Peer-Reviewed Original ResearchCapital femoral epiphysisFemoral epiphysisLong-term functional outcomeCommon hip disorderProximal femoral osteotomyProximal femoral deformityFemoral neck osteoplastyTreatment of SCFESitu screw fixationCapsular decompressionPrimary pathologyAcute reductionFunctional outcomeResidual deformityFemoral neckExpeditious diagnosisFemoral deformityFemoral osteotomyHip disordersPatient's abilityLong-term consequencesScrew fixationAlternative treatmentGold standardEpiphysis
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