Atmospheric nanoparticles affect vascular function using a 3D human vascularized organotypic chip
Li Y, Wu Y, Liu Y, Deng Q, Mak M, Yang X. Atmospheric nanoparticles affect vascular function using a 3D human vascularized organotypic chip. Nanoscale 2019, 11: 15537-15549. PMID: 31393488, DOI: 10.1039/c9nr03622a.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCell Culture TechniquesHuman Umbilical Vein Endothelial CellsHumansIntercellular Adhesion Molecule-1Lab-On-A-Chip DevicesMaleMiceMice, Inbred BALB CMicroscopy, ConfocalMicrovesselsModels, CardiovascularNanoparticlesNF-kappa BNitric OxideProtein CoronaTissue EngineeringVascular Endothelial Growth Factor AZonula Occludens-1 ProteinConceptsVascular endothelial growth factorEndothelin-1Vessel permeabilityVascular functionImbalance of nitric oxideHuman vascular functionLoss of tight junctionsEndothelial cell contractionAbnormal expressionIntercellular cell adhesion molecule 1Cell adhesion molecule 1Human vesselsNitric oxideEndothelial growth factorAdhesion molecule 1Expression of intercellular cell adhesion molecule 1Expression of nuclear factor-kBNuclear factor-KBPathological responseVascular toxicityICAM-1In vitro resultsTight junctionsZO-1Vascular inflammation
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