2023
Inflammation, stress and depression: An exploration of ketamine’s therapeutic profile
Johnston J, Greenwald M, Henter I, Kraus C, Mkrtchian A, Clark N, Park L, Gold P, Zarate C, Kadriu B. Inflammation, stress and depression: An exploration of ketamine’s therapeutic profile. Drug Discovery Today 2023, 28: 103518. PMID: 36758932, PMCID: PMC10050119, DOI: 10.1016/j.drudis.2023.103518.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUnique therapeutic mechanismTherapeutic profileCentral nervous system inflammationHypothalamic pituitary adrenal axisNervous system inflammationRapid-acting antidepressantsTreatment-resistant depressionAnti-inflammatory actionPeripheral inflammatory biomarkersSystem inflammationInflammatory biomarkersProinflammatory stateCytokine suppressionAdrenal axisKynurenine pathwayTherapeutic effectTherapeutic mechanismAnimal modelsInflammationDepressionAntidepressantsKetamineFurther investigationBiomarkers
2021
Toxicological analysis and efficacy of 2-phenylchromone on mycobacteria viability and inflammatory response induced by Mycobacterium bovis
Moreira F, Radai J, de Souza V, Berno C, de Araújo F, Andrade-Silva M, Oliveira R, Arena A, de Oliveira Henriques M, Kassuya C, Croda J. Toxicological analysis and efficacy of 2-phenylchromone on mycobacteria viability and inflammatory response induced by Mycobacterium bovis. Phytomedicine Plus 2021, 1: 100117. DOI: 10.1016/j.phyplu.2021.100117.Peer-Reviewed Original ResearchInflammatory responseOral treatmentSplenic phagocytosisTumor necrosis factor levelsAnti-inflammatory actionNecrosis factor levelsAcute oral toxicity testAnti-inflammatory propertiesMycobacterium bovisMycobacterium tuberculosis strainsDifferential leukocyte countsOral toxicity testPleurisy inductionCytokine productionPleurisy modelLeukocyte countMinimum inhibitory concentrationMycobacteria infectionMycobacteria viabilityPleural exudatesLeukocyte migrationTuberculosis strainsVivo modelToxicity signsFactor levels
2020
Exploring the molecular approach of COX and LOX in Alzheimer’s and Parkinson’s disorder
Kumar A, Behl T, Jamwal S, Kaur I, Sood A, Kumar P. Exploring the molecular approach of COX and LOX in Alzheimer’s and Parkinson’s disorder. Molecular Biology Reports 2020, 47: 9895-9912. PMID: 33263931, DOI: 10.1007/s11033-020-06033-x.Peer-Reviewed Original ResearchConceptsParkinson's diseaseDocosahexaenoic acidAlzheimer's diseaseArachidonic acidLipid mediatorsAnti-inflammatory actionAppropriate therapeutic optionPro-inflammatory eicosanoidsProduction of eicosanoidsResolution of inflammationRole of AACOX-2 enzymeLOX pathwayNeuroinflammatory responseNeuroinflammatory eventsTherapeutic optionsAD patientsCytokine secretionEpidemiological studiesLeukocyte traffickingNF-κBEicosanoid productionBrain disordersNeurological disordersCyclooxygenase
2018
THU0056 14–3–3 is a molecular switch regulating macrophage polarisation in inflammatory arthritis
Fu W, Hettinghouse A, Liu C. THU0056 14–3–3 is a molecular switch regulating macrophage polarisation in inflammatory arthritis. Annals Of The Rheumatic Diseases 2018, 77: 252-253. DOI: 10.1136/annrheumdis-2018-eular.4729.Peer-Reviewed Original ResearchAnti-inflammatory actionTNF receptor 2Mean fluorescence intensityAnti-inflammation actionClinical arthritis scoreInflammatory arthritisCIA miceAnti-inflammatory effectsAnti-inflammatory activityMacrophage polarizationProtective effectArthritis scoreCritical downstream mediatorM2 polarizationΔ miceM1-M2 polarizationPresence of progranulinAnti-inflammatory pathwaySeverity of CIADownstream mediatorSignificant decreasePercentage of CD206Hallmarks of macrophagesPGRN effectsWT mice
2016
Limonene reduces hyperalgesia induced by gp120 and cytokines by modulation of IL-1 β and protein expression in spinal cord of mice
Piccinelli A, Morato P, dos Santos Barbosa M, Croda J, Sampson J, Kong X, Konkiewitz E, Ziff E, Amaya-Farfan J, Kassuya C. Limonene reduces hyperalgesia induced by gp120 and cytokines by modulation of IL-1 β and protein expression in spinal cord of mice. Life Sciences 2016, 174: 28-34. PMID: 27888114, DOI: 10.1016/j.lfs.2016.11.017.Peer-Reviewed Original ResearchConceptsIL-1βSpinal cordMechanical hyperalgesiaIntrathecal injectionIL-10Electronic von Frey apparatusAbility of gp120SOD expressionAnti-inflammatory actionIL-1β injectionMale Swiss miceIL-1 βIL-1β applicationGp120 administrationGp120 injectionAntihyperalgesic effectIntrathecal administrationMechanical sensitivityPrior administrationCytokine productionSwiss miceBlood samplesSterile salineHyperalgesiaPeripheral increaseHuman dental pulp stem cells transplantation combined with treadmill training in rats after traumatic spinal cord injury
Nicola F, Rodrigues L, Crestani T, Quintiliano K, Sanches E, Willborn S, Aristimunha D, Boisserand L, Pranke P, Netto C. Human dental pulp stem cells transplantation combined with treadmill training in rats after traumatic spinal cord injury. Brazilian Journal Of Medical And Biological Research 2016, 49: e5319. PMID: 27509306, PMCID: PMC4988478, DOI: 10.1590/1414-431x20165319.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCombined Modality TherapyDental PulpEnzyme-Linked Immunosorbent AssayExercise TherapyFlow CytometryHumansLocomotionMalePhysical Conditioning, AnimalRandom AllocationRats, WistarRecovery of FunctionSpinal Cord InjuriesStem Cell TransplantationTime FactorsTooth ExfoliationTreatment OutcomeTumor Necrosis Factor-alphaConceptsStem cell transplantationSpinal cord injuryTNF-a levelsCell transplantationCord injuryDental pulp stem cell transplantationEffects of stem cellsHuman exfoliated deciduous teethExfoliated deciduous teethExperimental spinal cord injuryGlial scarSpinal cord lesionsSpinal cord injury groupTraumatic spinal cord injuryAnti-inflammatory actionSHED transplantationMotor functionNYU impactorImprovement of motor functionCord lesionsDeciduous teethBBB scaleWistar ratsCystic cavityEffective treatment
2014
The Pro-Resolving Lipid Mediator Maresin 1 (MaR1) Attenuates Inflammatory Signaling Pathways in Vascular Smooth Muscle and Endothelial Cells
Chatterjee A, Sharma A, Chen M, Toy R, Mottola G, Conte MS. The Pro-Resolving Lipid Mediator Maresin 1 (MaR1) Attenuates Inflammatory Signaling Pathways in Vascular Smooth Muscle and Endothelial Cells. PLOS ONE 2014, 9: e113480. PMID: 25409514, PMCID: PMC4237455, DOI: 10.1371/journal.pone.0113480.Peer-Reviewed Original ResearchMeSH KeywordsCell AdhesionCells, CulturedCyclic AMPDocosahexaenoic AcidsDown-RegulationE-SelectinEndothelial CellsHumansMuscle, Smooth, VascularNADPH OxidasesNF-kappa BOxidative StressPhosphorylationReactive Oxygen SpeciesSignal TransductionTranscription Factor RelATumor Necrosis Factor-alphaU937 CellsUp-RegulationConceptsInflammatory signaling pathwaysBroad anti-inflammatory actionsMonocyte adhesionCyclic AMPTumor necrosis factor alphaAdhesion molecules E-selectinPro-resolving responseNF-κB p65 subunitPro-inflammatory mediatorsAnti-inflammatory actionPro-inflammatory signalsVascular smooth muscleNecrosis factor alphaAttenuation of TNFHuman saphenous vein ECsHuman vascular endothelialBioactive lipid mediatorsNF-κB activationSmooth muscle cellsTNF-α effectSignaling pathwaysBronchial epithelial cellsIntracellular cyclic AMPTime-dependent increaseVascular inflammation
2013
Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke
Regenhardt RW, Desland F, Mecca AP, Pioquinto DJ, Afzal A, Mocco J, Sumners C. Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke. Neuropharmacology 2013, 71: 154-163. PMID: 23583926, PMCID: PMC3664115, DOI: 10.1016/j.neuropharm.2013.03.025.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IAnimalsAnti-Inflammatory Agents, Non-SteroidalBrain IschemiaCells, CulturedCerebral CortexDisease Models, AnimalGene Expression RegulationMaleMiceMice, Inbred StrainsMice, KnockoutMicrogliaNerve Tissue ProteinsNeuroprotective AgentsNitric OxideNitric Oxide Synthase Type IIPeptide FragmentsProto-Oncogene MasProto-Oncogene ProteinsRatsRats, Sprague-DawleyReceptors, G-Protein-CoupledSpecific Pathogen-Free OrganismsStrokeConceptsInducible nitric oxide synthaseAnti-inflammatory effectsIschemic strokeEndothelin-1Cerebral cortexMiddle cerebral artery occlusionCerebral infarct sizeDifferentiation molecule 11bIntracerebral inflammatory responseCerebral artery occlusionAnti-inflammatory actionLipopolysaccharide-induced increasePro-inflammatory cytokinesCerebral blood flowINOS protein expressionNitric oxide synthaseNitric oxide productionNitric oxide generationExpression of mRNAAng-(1-7) treatmentSignificant cerebroprotectionCerebral vasoconstrictionArtery occlusionCerebroprotective actionReceptor Mas
2012
Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Resuehr D, Glore DR, Taylor HS, Bruner-Tran KL, Osteen KG. Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Fertility And Sterility 2012, 98: 948-956.e1. PMID: 22789143, PMCID: PMC3462249, DOI: 10.1016/j.fertnstert.2012.06.009.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsEndometrial tissueStromal cellsCannabinoid receptor type 1 expressionProgesterone-dominated secretory phaseMRNA expressionAnti-inflammatory actionMessenger RNATetrachlorodibenzo-p-dioxin (TCDD) exposureHuman endometrial tissueProgesterone receptor antagonistType 1 expressionSteroid-induced expressionProgesterone-dependent regulationEndometrial biopsyReceptor antagonistCannabinoid signalingHuman endometriumMedical CenterMAIN OUTCOMESecretory phaseControl donorsEndometriosisDifferentiation-related expressionExposure disrupts
2003
Thymulin reverses inflammatory hyperalgesia and modulates the increased concentration of proinflammatory cytokines induced by i.c.v. endotoxin injection
Safieh-Garabedian B, Ochoa-Chaar CI, Poole S, Massaad CA, Atweh SF, Jabbur SJ, Saadé NE. Thymulin reverses inflammatory hyperalgesia and modulates the increased concentration of proinflammatory cytokines induced by i.c.v. endotoxin injection. Neuroscience 2003, 121: 865-873. PMID: 14580936, DOI: 10.1016/s0306-4522(03)00500-1.Peer-Reviewed Original ResearchConceptsCytokine levelsEndotoxin injectionDifferent pain testsInjections of thymulinThymic hormone thymulinPain-related behaviorsAnti-inflammatory actionLevels of cytokinesEffect of pretreatmentInjection of endotoxinDose-dependent mannerIntracerebral inflammationPeak hyperalgesiaInflammatory hyperalgesiaPain testsNeuroprotective roleNociceptive thresholdProinflammatory cytokinesConscious ratsRat modelHyperalgesiaThymulinDifferent dosesSignificant decreaseEndotoxin
2000
Endogenous Adenosine and Secondary Injury after Chest Trauma
Davis K, Fabian T, Ragsdale D, Trenthem L, Proctor A. Endogenous Adenosine and Secondary Injury after Chest Trauma. Journal Of Trauma And Acute Care Surgery 2000, 49: 892-898. PMID: 11086782, DOI: 10.1097/00005373-200011000-00017.Peer-Reviewed Original ResearchConceptsBlunt chest traumaBlunt chest injuryChest traumaAdenosine-regulating agentSecondary injuryBAL proteinChest injuriesEndogenous adenosineLung myeloperoxidase levelsTime of resuscitationAnti-inflammatory actionProgressive inflammatory responseAction of adenosineAlveolar-capillary membraneWet-dry ratioBAL WBCPulmonary contusionContralateral lungMyeloperoxidase levelsSystemic hemodynamicsUninjured lungsLung edemaRight chestMongrel pigsPathophysiologic changesGeldanamycin, an inhibitor of heat shock protein 90 (Hsp90) mediated signal transduction has anti‐inflammatory effects and interacts with glucocorticoid receptor in vivo
Bucci M, Roviezzo F, Cicala C, Sessa W, Cirino G. Geldanamycin, an inhibitor of heat shock protein 90 (Hsp90) mediated signal transduction has anti‐inflammatory effects and interacts with glucocorticoid receptor in vivo. British Journal Of Pharmacology 2000, 131: 13-16. PMID: 10960063, PMCID: PMC1572305, DOI: 10.1038/sj.bjp.0703549.Peer-Reviewed Original ResearchConceptsAnti-inflammatory effectsAnti-inflammatory actionEdema formationRU 486Heat shock protein 90Shock protein 90Endothelial nitric oxide synthaseEndothelium-dependent relaxationAnti-inflammatory dosePotential anti-inflammatory drugsVascular endothelial growth factorNitric oxide synthaseAnti-inflammatory drugsEndothelial growth factorDose-dependent mannerProtein 90Specific inhibitorIntact blood vesselsIntraplantar administrationPaw edemaMiddle arteryOxide synthaseRat aortaTherapeutic rationaleGlucocorticoid receptor
1999
Selective Anti-Inflammatory Action of Interleukin-11 in Murine Lyme Disease: Arthritis Decreases while Carditis Persists
Anguita J, Barthold S, Samanta S, Ryan J, Fikrig E. Selective Anti-Inflammatory Action of Interleukin-11 in Murine Lyme Disease: Arthritis Decreases while Carditis Persists. The Journal Of Infectious Diseases 1999, 179: 734-737. PMID: 9952389, DOI: 10.1086/314613.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAnti-Inflammatory AgentsArthritis, InfectiousFemaleHumansInflammationInterferon-gammaInterleukin-11Interleukin-12Interleukin-4Lyme DiseaseMiceMice, Inbred C3HMyocarditisNitric Oxide SynthaseNitric Oxide Synthase Type IIRecombinant ProteinsRNA, MessengerTranscription, GeneticConceptsMurine Lyme diseaseIL-11Potent anti-inflammatory propertiesInducible nitric oxide synthaseLyme diseaseMurine Lyme carditisAnti-inflammatory actionRole of interleukinAnti-inflammatory propertiesNitric oxide synthaseInnate immune responseB. burgdorferi-infected miceBurgdorferi-infected miceLyme carditisCardiac inflammationLyme arthritisIL-12Less arthritisIL-4Oxide synthaseBlocking antibodiesImmune responseControl animalsInterleukin-11Borrelia burgdorferi
1997
Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome
Donnelly S, Haslett C, Reid P, Grant I, Wallace W, Metz C, Bruce L, Bucala R. Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nature Medicine 1997, 3: 320-323. PMID: 9055860, DOI: 10.1038/nm0397-320.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeMigration inhibitory factorRespiratory distress syndromeDistress syndromeSignificant pro-inflammatory effectsInhibitory factorMacrophage migration inhibitory factorPro-inflammatory cytokine secretionPulmonary inflammatory responseAnti-inflammatory actionAnti-inflammatory effectsPro-inflammatory effectsIL-8 secretionConcentration-related fashionNovel therapeutic approachesInflammatory diseasesCytokine secretionInflammatory responseTherapeutic approachesAlveolar airspaceAlveolar cellsPatientsGlucocorticoidsSyndromeSecretion
1986
Effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis.
Sandle G, Hayslett J, Binder H. Effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis. Gut 1986, 27: 309. PMID: 3699552, PMCID: PMC1433405, DOI: 10.1136/gut.27.3.309.Peer-Reviewed Original ResearchConceptsActive ulcerative colitisInactive ulcerative colitisUlcerative colitisControl subjectsPharmacological dosesIntravenous administrationNet sodiumAcute ulcerative colitisAnti-inflammatory actionEffects of glucocorticoidsNet sodium absorptionColonic sodiumRectal pdAcute increaseAcute effectsColitisHydrocortisone hemisuccinateNormal subjectsPatientsGlucocorticoid hormonesSodium absorptionNet electrolyteGlucocorticoidsSimilar increaseSimilar changes
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply