2024
Advances in Ischemia Reperfusion Injury Prevention in Free Flaps and Vascularized Composite Allotransplantation
Hadzimustafic N, D’Elia A, Duru C, Haykal S. Advances in Ischemia Reperfusion Injury Prevention in Free Flaps and Vascularized Composite Allotransplantation. Cardiology And Cardiovascular Medicine 2024, 4 DOI: 10.5772/intechopen.112993.Peer-Reviewed Original ResearchIschemia-reperfusion injuryVascularized Composite AllotransplantationFree flapsStatic cold storagePharmacological strategiesAdvanced reconstructive optionsAttenuation of ischemia-reperfusion injuryIrreversible ischemic damagePost-operative monitoringStem cell strategiesPre-clinical studiesPlastic and Reconstructive SurgeryPost-ischemic periodPost-ischemicReperfusion injuryReconstructive optionsIschemia-reperfusionPre-ischemicReconstructive surgeryIschemic periodPre-ischemic periodIschemic damageClinical toolFlapMachine perfusion
2022
L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL
Finotti M, Barahona M, Maina R, Lysyy T, Agarwal R, Schmitt P, Caturegli G, Di Renzo C, Anselmo A, Mulligan D, Geibel J, D'Amico F. L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL. Transplantation Reports 2022, 7: 100096. DOI: 10.1016/j.tpr.2022.100096.Peer-Reviewed Original ResearchIschemic injuryIntestinal segmentsIschemic damageIntraluminal perfusionNitric oxide-arginine pathwayMale Sprague-Dawley ratsN-nitroarginine methyl esterSprague-Dawley ratsEx vivo perfusion modelVivo perfusion modelNon-ischemic conditionsSmall intestinal segmentsFITC-inulinExtraluminal sideL-NAMEReperfusion injuryProtective effectL-arginineSmall intestinePerfusion modelInjuryIntestinal regionsFluid secretionReduced susceptibilityPerfusion
2020
Human Small Intestine Transplantation: Segmental Susceptibility to Ischemia Using Different Preservation Solutions and Conditions
Lysyy T, Finotti M, Maina RM, Morotti R, Munoz-Abraham AS, Bertacco A, Ibarra C, Barahona M, Agarwal R, D'Amico F, Rodriguez-Davalos MI, Mulligan D, Geibel J. Human Small Intestine Transplantation: Segmental Susceptibility to Ischemia Using Different Preservation Solutions and Conditions. Transplantation Proceedings 2020, 52: 2934-2940. PMID: 32768284, DOI: 10.1016/j.transproceed.2020.06.031.Peer-Reviewed Original ResearchConceptsContinuous perfusion preservationIntestinal graftIschemic damagePerfusion preservationAppropriate graft selectionCold static storageSmall intestinal graftsSmall intestine graftDifferent preservation solutionsBlinded histological evaluationCross clampIntestine graftsPostoperative complicationsDifferent time pointsIschemic injuryDeceased donorsPatient survivalGraft selectionRinger's lactateHistological evaluationBack tableVascular perfusionLuminal flushAbdominal organsSmall intestine
2018
Prevention of Ischemic Injury in Colon and Small Intestine in an Ex Vivo Perfusion Animal Model
Finotti M, Lysyy T, Barahona M, Maina R, Caturegli G, D'Amico F, Mulligan D, Geibel J. Prevention of Ischemic Injury in Colon and Small Intestine in an Ex Vivo Perfusion Animal Model. Transplantation 2018, 102: s709. DOI: 10.1097/01.tp.0000543675.85457.d2.Peer-Reviewed Original ResearchIschemia-reperfusion injuryIschemic injuryIschemic damageL-arginineSmall intestineL-NAMEDistal colonPerfusion machineMale Sprague-Dawley ratsIntestinal ischemic damageIntestinal ischemic injuryAnti-ischemic effectsSprague-Dawley ratsIntestinal graftInflammatory injuryInflammatory pathwaysIntestinal viabilityProtective effectAbdominal cavityColon segmentsIschemic conditionsIntestinal wallIntraluminal secretionsAnimal modelsIntestine segments
2017
The Spinal Cord Collateral Network: Implications for Endovascular Aortic Repair
Geisbüsch S, Di Luozzo G, Griepp E, Griepp R. The Spinal Cord Collateral Network: Implications for Endovascular Aortic Repair. 2017, 105-112. DOI: 10.1007/978-3-319-15192-2_7.Peer-Reviewed Original ResearchTemporary aneurysm sac perfusionCollateral networkEndovascular aortic repairAortic repairDevastating complicationHypogastric arteryThoracoabdominal aortaIschemic damageEndovascular techniquesEndovascular coilingParaspinous musclesSpinal cordCollateral vasculatureArteryCordSubstantial numberVasculatureEndovascularComplicationsParaplegiaAortaPerfusion
2013
Endothelin-1 induced middle cerebral artery occlusion model for ischemic stroke with laser Doppler flowmetry guidance in rat.
Ansari S, Azari H, Caldwell KJ, Regenhardt RW, Hedna VS, Waters MF, Hoh BL, Mecca AP. Endothelin-1 induced middle cerebral artery occlusion model for ischemic stroke with laser Doppler flowmetry guidance in rat. Journal Of Visualized Experiments 2013 PMID: 23438950, PMCID: PMC3601209, DOI: 10.3791/50014.Peer-Reviewed Original ResearchConceptsEndothelin-1Laser Doppler flowmetryCerebral ischemiaIschemic strokeHuman strokeMiddle cerebral artery occlusion modelMiddle cerebral artery areaET-1 modelArtery occlusion modelET-1 infusionFocal cerebral ischemiaCause of deathDuration of occlusionNumber one causeArtery constrictionPartial reperfusionReperfusion ratesIschemic damageMCAO modelStereotaxic injectionArtery areaStroke volumeDoppler flowmetryExtracranial vesselsOcclusion model
2011
Staged Approach Prevents Spinal Cord Injury in Hybrid Surgical-Endovascular Thoracoabdominal Aortic Aneurysm Repair: An Experimental Model
Bischoff MS, Scheumann J, Brenner RM, Ladage D, Bodian CA, Kleinman G, Ellozy SH, Di Luozzo G, Etz CD, Griepp RB. Staged Approach Prevents Spinal Cord Injury in Hybrid Surgical-Endovascular Thoracoabdominal Aortic Aneurysm Repair: An Experimental Model. The Annals Of Thoracic Surgery 2011, 92: 138-146. PMID: 21718839, DOI: 10.1016/j.athoracsur.2011.03.098.Peer-Reviewed Original ResearchMeSH KeywordsAngiographyAngioplastyAnimalsAortic Aneurysm, ThoracicCombined Modality TherapyDisease Models, AnimalFemaleFollow-Up StudiesIntraoperative ComplicationsMonitoring, IntraoperativeRandom AllocationRisk AssessmentSpinal CordSpinal Cord InjuriesStentsSurvival RateSwineTreatment OutcomeVascular Surgical ProceduresConceptsGroup 1Group 2Thoracoabdominal aortic aneurysm repairJuvenile Yorkshire pigsSevere ischemic damageHind limb functionAortic aneurysm repairStent graft occlusionLumbar spinal cordModified Tarlov scoreSpinal cord injuryEndovascular coverageTarlov scoreGraft occlusionAneurysm repairArtery ligationIntercostal arteriesIschemic damageCord injuryLimb functionSudden occlusionSpinal cordLower thoracicHistopathologic analysisPorcine model
2010
Experimental Two-Stage Simulated Repair of Extensive Thoracoabdominal Aneurysms Reduces Paraplegia Risk
Zoli S, Etz CD, Roder F, Brenner RM, Bodian CA, Kleinman G, Di Luozzo G, Griepp RB. Experimental Two-Stage Simulated Repair of Extensive Thoracoabdominal Aneurysms Reduces Paraplegia Risk. The Annals Of Thoracic Surgery 2010, 90: 722-729. PMID: 20732484, DOI: 10.1016/j.athoracsur.2010.04.047.Peer-Reviewed Original ResearchConceptsSpinal cord perfusion pressureHind limb functionGroup 2Artery sacrificeLimb functionExtensive segmental artery sacrificeExtensive thoracoabdominal aneurysmsJuvenile Yorkshire pigsSevere ischemic damageMotor-evoked potentialsLumbar spinal cordSpinal cord functionModified Tarlov scoreSpinal cord injuryParaplegia riskTarlov scoreThoracoabdominal aneurysmsAneurysm repairCord functionDistal stumpIschemic damagePerfusion pressureCord injurySpinal cordLower thoracic
2009
Matrix Metalloproteinases in Cerebral Hypoxia-Ischemia
Gu Z, Cui J, Lipton S. Matrix Metalloproteinases in Cerebral Hypoxia-Ischemia. Contemporary Clinical Neuroscience 2009, 225-238. DOI: 10.1007/978-1-60327-579-8_11.Peer-Reviewed Original ResearchNeuronal nitric oxide synthaseAcute cerebral ischemiaCerebral ischemiaMMP-9Neuronal apoptosisCerebral ischemia/reperfusionTransient focal cerebral ischemiaAcute stroke patientsCerebral hypoxia-ischemiaHypoxic-ischemic insultFocal cerebral ischemiaFuture clinical trialsIschemia/reperfusionNitric oxide synthaseMMP-9 activityMMP-2/9 inhibitorNeuronal cell deathShort-term therapyActivation of MMPsS-nitrosylationSignificant therapeutic potentialHypoxia-ischemiaNeuronal injuryIschemic damageStroke patients
2004
Chapter 41 Ischemic White Matter Damage
Stys P, Waxman S. Chapter 41 Ischemic White Matter Damage. 2004, 985-1007. DOI: 10.1016/b978-012439510-7/50094-2.Peer-Reviewed Original ResearchIschemic white matter injuryIschemic white matter damageIschemic CNS injuryMore chronic statesWhite matter injuryWhite matter damageMammalian white matterClinical disabilityAcute strokePeriventricular leukomalaciaAxonal disordersCerebral palsyIschemic damageVascular dementiaMultiple sclerosisCNS injuryMatter damageSocioeconomic burdenMyelinated fibersSuccessful therapyChronic stateWhite matterIrreversible compromiseDeleterious eventsWestern populations
1991
Fetal akinesia deformation sequence (Pena-Shokeir phenotype) associated with acquired intrauterine brain damage.
Lavi E, Montone K, Rorke L, Kliman H. Fetal akinesia deformation sequence (Pena-Shokeir phenotype) associated with acquired intrauterine brain damage. Neurology 1991, 41: 1467-8. PMID: 1891100, DOI: 10.1212/wnl.41.9.1467.Peer-Reviewed Original ResearchConceptsIntrauterine brain damageFocal cerebral infarctionTetralogy of FallotFetal akinesia deformation sequenceCocaine-using mothersPena-Shokeir phenotypeDiffuse brainstemCerebral infarctionNeuropathologic findingsPulmonary hypoplasiaIschemic damagePathologic findingsNeuronal degenerationBrain damageFacial anomaliesFallotInfarctionBrainstemTetralogyInfantsHypoplasiaCamptodactylyArthrogryposisFindingsDegeneration
1989
Ischemic Damage in Hippocampal CA1 is Dependent on Glutamate Release and Intact Innervation from CA3
Benveniste H, Jørgensen M, Sandberg M, Christensen T, Hagberg H, Diemer N. Ischemic Damage in Hippocampal CA1 is Dependent on Glutamate Release and Intact Innervation from CA3. Cerebrovascular And Brain Metabolism Reviews 1989, 9: 629-639. PMID: 2570785, DOI: 10.1038/jcbfm.1989.90.Peer-Reviewed Original ResearchConceptsCA1 regionPyramidal cellsGlutamate releaseIntact innervationHippocampal tissueCA1 tissueInjection siteIschemia-induced releaseIschemia-induced damageTransient global ischemiaCA1 pyramidal cellsRelease of glutamateGlutamatergic afferentsIschemic damageHippocampal CA1CA1 pyramidsGlobal ischemiaCA3 regionPathogenetic significanceIschemiaNeurotoxic potentialCA3CA1GlutamateInnervation
1988
Magnesium Inhibits Ischemia Induced Calcium Accumulation in Hilar Neurones: Possible Effect of Nmda-Receptor
Benveniste H, Diemer N. Magnesium Inhibits Ischemia Induced Calcium Accumulation in Hilar Neurones: Possible Effect of Nmda-Receptor. Advances In Behavioral Biology 1988, 35: 377-377. DOI: 10.1007/978-1-4684-5562-5_40.Peer-Reviewed Original ResearchHilar neuronsCA 1 pyramidal cellsN-methyl-D-aspartate receptorsCalcium accumulationIschemic brain damageExcessive calcium accumulationIschemic changesIschemic damageBrain damageNMDA receptorsPyramidal cellsSelective vulnerabilityHilar neuronesCalcium influxIrreversible morphological changesCalcium conductanceIschemiaMorphological damageExcessive accumulationNeuronsPivotal roleMorphological changesHoursPossible effectsDamage
1983
Accelerated cellular recovery after an ischemic renal injury.
Gaudio K, Ardito T, Reilly H, Kashgarian M, Siegel N. Accelerated cellular recovery after an ischemic renal injury. American Journal Of Pathology 1983, 112: 338-46. PMID: 6604459, PMCID: PMC1916386.Peer-Reviewed Original ResearchConceptsProximal tubular pressureCellular morphologic featuresRenal ischemiaATP-MgCl2Back leakTubular integrityMorphologic featuresCellular damageIschemic cellular damageProgressive ischemic injurySevere ischemic damageIschemic renal injurySaline-treated ratsGroups of ratsEarly regenerative changesRenal injuryIschemic damageIschemic injuryIschemic alterationsNormal salineRegenerative changesSaline ratsEnhances recoverySalutary effectsHistomorphometric analysis
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