2025
39 Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration
Datta D, Perone I, Wijegunawardana D, Liang F, Morozov Y, Arellano J, Duque A, Xie Z, van Dyck C, Joyce M, Arnsten A. 39 Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration. Journal Of Clinical And Translational Science 2025, 9: 13-13. PMCID: PMC12038495, DOI: 10.1017/cts.2024.726.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexEntorhinal cortexStatistically significant age-related increaseTau pathologySignificant age-related increaseAlzheimer's diseaseAge-related increaseBrain circuitsRhesus macaquesAged rhesus macaquesAging BrainAged macaquesCortical pathologyCortexAge spanDendritic spinesEarly-stage neurodegenerationBrainTau speciesSubcellular localizationInhibitory synapsesPhosphorylated proteinsDysmorphic mitochondriaPostsynaptic compartmentsThe WAVE complex in developmental and adulthood brain disorders
Kim H, Berdasco C, Nairn A, Kim Y. The WAVE complex in developmental and adulthood brain disorders. Experimental & Molecular Medicine 2025, 57: 13-29. PMID: 39774290, PMCID: PMC11799376, DOI: 10.1038/s12276-024-01386-w.Peer-Reviewed Original ResearchConceptsWiskott-Aldrich syndrome protein family verprolin-homologous proteinActin polymerizationCellular processesArp2/3 complex-mediated actin polymerizationRegulatory proteinsOrganization of actin filamentsMaintenance of neuronal plasticityBrain disordersActin regulatory proteinsAutism spectrum disorderPathophysiology of Alzheimer's diseaseDe novo mutationsIntellectual disabilityActin filamentsExtracellular cuesSpectrum disorderMaladaptive feedingDevelopmental disordersAging BrainHeteropentameric complexNeuronal plasticityIntracellular signalingIntracellular eventsBehavioral adaptationsDisorders
2024
Nanoscale imaging of pT217‐tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early‐stage neurodegeneration
Datta D. Nanoscale imaging of pT217‐tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early‐stage neurodegeneration. Alzheimer's & Dementia 2024, 20: e089418. PMCID: PMC11709465, DOI: 10.1002/alz.089418.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexEntorhinal cortexStatistically significant age-related increaseAged macaquesTau pathologySignificant age-related increaseAlzheimer's diseaseAge-related increaseCognitive deficitsBrain circuitsBrain expressionAging BrainBrain pathologyCortical pathologyCortexEfficacy of novel treatmentsDLPFCAge spanDendritic spinesEarly-stage neurodegenerationInhibitory synapsesLayer IIBrainRhesus macaquesMitochondrial network reorganization and transient expansion during oligodendrocyte generation
Bame X, Hill R. Mitochondrial network reorganization and transient expansion during oligodendrocyte generation. Nature Communications 2024, 15: 6979. PMID: 39143079, PMCID: PMC11324877, DOI: 10.1038/s41467-024-51016-2.Peer-Reviewed Original ResearchConceptsDecreased mitochondrial sizeLoss of mitochondriaMitochondrial motilityMitochondrial dynamicsCellular checkpointsMitochondrial distributionMitochondrial sizeMitochondrial contentOligodendrocyte precursor cellsSubcellular partitioningDistal processesMotilityOligodendrocyte generationOligodendrocyte processesLocal microenvironmentPrecursor cellsExtensive expansionMitochondriaOligodendrocyte lineageTransient expansionLineagesOligodendrocytesAging BrainMyelinating oligodendrocytesMorphometricsMulti-modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain
Bueichekú E, Diez I, Gagliardi G, Kim C, Mimmack K, Sepulcre J, Vannini P. Multi-modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain. Communications Medicine 2024, 4: 65. PMID: 38580832, PMCID: PMC10997795, DOI: 10.1038/s43856-024-00497-9.Peer-Reviewed Original ResearchMemory declineMedial anterior prefrontal cortexAging BrainWhole-brain voxel-wiseAnterior prefrontal cortexRegion-of-interest analysisResting-state functional MRIObjective memory declineOccipito-parietal regionsMulti-modal neuroimagingNetwork connectivity patternsAlzheimer's diseaseFunctional connectivity networksPrefrontal cortexMnemonic anosognosiaTau burdenBiomarkers of AD pathologyMode networkParieto-occipital areasFunctional network connectivity disruptionFunctional MRIBrain phenotypesVoxel-wiseBehavioral conditionsBehavioral biomarkers
2023
Multi‐modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain
Bueichekú E, Diez I, Gagliardi G, Kim C, Mimmack K, Sepulcre J, Vannini P. Multi‐modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.080294.Peer-Reviewed Original ResearchMnemonic anosognosiaOccipito-parietal regionsMemory declineBrain phenotypesSelf-referential brain networkObjective memory testsObjective memory declineResting-state fMRIPosterior cerebral cortexMulti-modal neuroimagingNetwork connectivity patternsAlzheimer's diseaseFunctional connectivity networksGraph theory metricsTau burdenNeurocognitive profileBiomarkers of AD pathologyMemory testMemory impairmentBetween-group comparisonsFunctional network connectivity disruptionBrain networksAging BrainAnosognosiaBehavioral conditionsEvidence Accumulation Rate Moderates the Relationship between Enriched Environment Exposure and Age-Related Response Speed Declines
Brosnan M, Pearce D, O’Neill M, Loughnane G, Fleming B, Zhou S, Chong T, Nobre A, Connell R, Bellgrove M. Evidence Accumulation Rate Moderates the Relationship between Enriched Environment Exposure and Age-Related Response Speed Declines. Journal Of Neuroscience 2023, 43: 6401-6414. PMID: 37507230, PMCID: PMC10500991, DOI: 10.1523/jneurosci.2260-21.2023.Peer-Reviewed Original ResearchConceptsCognitive functionBrain healthOlder adultsNeural metricsTrajectories of cognitive agingMarkers of brain healthLevel of cognitive functioningEnriched environmentEvidence accumulation ratesPreservation of cognitive functionGlobal cognitive functionInfluence of EENeurocognitive vulnerabilityCognitive agingCognitive reserveMotor processesSensory evidenceBrain activityNeurocognitive healthEvidence accumulationResponse speedBrain agingAging BrainSocial stimulationSpeed declineAging brain shows joint declines in brain within-network connectivity and between-network connectivity: a large-sample study (N > 6,000)
Du Y, Guo Y, Calhoun V. Aging brain shows joint declines in brain within-network connectivity and between-network connectivity: a large-sample study (N > 6,000). Frontiers In Aging Neuroscience 2023, 15: 1159054. PMID: 37273655, PMCID: PMC10233064, DOI: 10.3389/fnagi.2023.1159054.Peer-Reviewed Original ResearchFunctional network connectivityWithin-network connectivityCognitive control networkFunctional networksIncreased within-network connectivityDecreased within-network connectivityWhole-brain functional networksControl networkReduced functional network connectivityBetween-network connectivityWhole-brain levelNon-pathological agingSub-cortical networksIndependent component analysisBrain functional networksMode networkAging-related changesSensorimotor networkNeuroimaging dataConnectivity declineVisual networkWhole-brainBrain agingAging BrainEffects of age
2021
College education as a modulator of the aging brain
Sepulcre J. College education as a modulator of the aging brain. Nature Aging 2021, 1: 980-981. PMID: 37118340, DOI: 10.1038/s43587-021-00131-6.Peer-Reviewed Original Research
2019
Astrocyte senescence: Evidence and significance
Cohen J, Torres C. Astrocyte senescence: Evidence and significance. Aging Cell 2019, 18: e12937. PMID: 30815970, PMCID: PMC6516680, DOI: 10.1111/acel.12937.Peer-Reviewed Original ResearchConceptsCentral nervous systemNeurodegenerative diseasesNeurodegenerative disordersAge-associated neurodegenerative diseasesCellular senescenceProgression of neurodegenerative diseasesAge-related neurodegenerative diseasesCentral nervous system dysfunctionLoss of astrocyte functionMechanisms of agingPhysiological roleNeuroinflammatory functionsIn vitro characterizationAging BrainCognitive decline
2017
Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain
Sepulcre J, Sabuncu M, Li Q, Fakhri G, Sperling R, Johnson K. Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain. Alzheimer's & Dementia 2017, 13: 1261-1269. PMID: 28366797, PMCID: PMC5623176, DOI: 10.1016/j.jalz.2017.02.011.Peer-Reviewed Original ResearchConceptsAging BrainFunctional connectivityAlzheimer's disease-related pathologyCognitively normal individualsPositron emission tomography scanHyperconnected regionsFunctional network changesMisfolded tauDisease-related pathologyBrain areasEmission tomography scanAmyloid-bFunctional reorganizationB proteinHuman brainNeuronal circuitsTauBrainNeuronal functionNegative associationAmyloidCortical patternsNetwork changesElderly subjectsPositive association
2016
Implications of Cellular Senescence on Aging and Disease in the Brain
Crowe E, Tuzer S, Cohen J, Yetkin E, D’Agostino L, Sell C, Torres C. Implications of Cellular Senescence on Aging and Disease in the Brain. Healthy Ageing And Longevity 2016, 263-286. DOI: 10.1007/978-3-319-26239-0_14.Peer-Reviewed Original ResearchSenescence in vitroDisease in vivoAccumulation of senescent astrocytesHIV-associated dementiaIrreversible mitotic arrestSignificant neuronal lossResistance to apoptosisLow regenerative capacityPro-inflammatory signalingCNS cell typesResponse to insultsSenescence-like phenotypeProgenitor cellsAging BrainStress in vitroLoss of astrocyte functionMouse modelNeuroinflammatory functionsSynaptic plasticityInflammatory stressNeural stemNeurodegenerative diseasesGrowth factorRegenerative capacityReactive astrogliosis
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