2024
iGATE analysis improves the interpretability of single-cell immune landscape of influenza infection
Hill B, Zak A, Raja S, Bugada L, Rizvi S, Roslan S, Nguyen H, Chen J, Jiang H, Ono A, Goldstein D, Wen F. iGATE analysis improves the interpretability of single-cell immune landscape of influenza infection. JCI Insight 2024, 9: e172140. PMID: 38814732, PMCID: PMC11383363, DOI: 10.1172/jci.insight.172140.Peer-Reviewed Original ResearchInfluenza infectionImmune cell typesCourse of influenza infectionDefective T cell responsesSurvival of C57BL/6 miceCell typesDecreased IL-10 expressionEffect of host genetic backgroundT cell responsesGenetic backgroundTime-of-flight (CyTOFIL-10 expressionInflammatory cell typesCells in silicoHost genetic backgroundC57BL/6 miceAged miceMouse lungHost genotypeInfection susceptibilityHost factorsEffects of ageMiceHealth burdenInfection
2021
Effects of historical co‐infection on host shift abilities of exploitative and competitive viruses
Singhal S, Turner P. Effects of historical co‐infection on host shift abilities of exploitative and competitive viruses. Evolution 2021, 75: 1878-1888. PMID: 33969482, PMCID: PMC12058955, DOI: 10.1111/evo.14263.Peer-Reviewed Original ResearchConceptsNovel hostRNA viral pathogensHost population densityViral growthPhage genotypesCo-infecting virusesHost specificityIntracellular competitionHost exploitationHost genotypeEcological historyOriginal hostInfected bacteriaRNA bacteriophagesRapid evolutionEmergence potentialHostGrowth curvesPopulation densityEquivalent growthViral pathogensClonesInfectivity differencesGenotypesCompetitive viruses
2017
Simplified and representative bacterial community of maize roots
Niu B, Paulson J, Zheng X, Kolter R. Simplified and representative bacterial community of maize roots. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e2450-e2459. PMID: 28275097, PMCID: PMC5373366, DOI: 10.1073/pnas.1616148114.Peer-Reviewed Original ResearchConceptsCommunity assemblyBacterial communitiesDynamics of community assemblyComposition of plant microbiomesBacterial interspecies interactionsSynthetic bacterial communityPlant-associated microbesCulture-dependent methodsRoot microbiome assemblyHost-mediated selectionFusarium verticillioides</i>Maize rootsRoot microbiotaMicrobiome assemblyPlant microbiomeRoot microbiomePlant hostsHost genotypeKeystone speciesDominant phylaAbiotic factorsInterspecies interactionsModel ecosystemsMicrobiomeMaize seedlings
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