2025
Causes of Death Among US Medical Residents
Yaghmour N, Bynum W, Hafferty F, Könings K, Richter T, Brigham T, Nasca T. Causes of Death Among US Medical Residents. JAMA Network Open 2025, 8: e259238. PMID: 40366660, PMCID: PMC12079293, DOI: 10.1001/jamanetworkopen.2025.9238.Peer-Reviewed Original ResearchConceptsResident deathsIncidence rate ratiosRate of deathCross-sectional studyGender-matched peersHighest death rateDeath rateTraining programCalculate incidence rate ratiosNational Death IndexTrainee well-beingFactors of distressPoisson regression modelsFellowship training programsAccidental poisoningACGME-accredited residenciesDeath IndexMain OutcomesMedical residentsRate ratiosCause of deathUS residentsGeneral populationSecondary outcomesNeoplastic diseaseLong-term mortality from imaging-diagnosed pulmonary embolism in women and men
Sosner E, Mathai B, Bordon A, Ye K, Moadel R, Haramati L, Lazarus M. Long-term mortality from imaging-diagnosed pulmonary embolism in women and men. Clinical Imaging 2025, 122: 110469. PMID: 40273669, DOI: 10.1016/j.clinimag.2025.110469.Peer-Reviewed Original ResearchConceptsElectronic health recordsOne-year mortalityIncreased one-year mortalityCox proportional hazards modelsCharlson Comorbidity IndexProportional hazards modelLong-term mortalityUrban academic medical centerNational Death IndexMortality of womenHazards modelAcademic medical centerStudy of adultsHigher hazard ratioHealth recordsDeath IndexHealth statusInclusion of ageImpact of PEHazard ratioRetrospective study of adultsMedical CenterRisk factorsComorbidity indexPulmonary embolismSocial Determinants of Health, Cardiovascular Health, and Mortality in Sexual Minority Individuals in the United States
Satti D, Chan J, Mszar R, Mehta A, Kwapong Y, Chan R, Agboola O, Spatz E, Spitz J, Nasir K, Javed Z, Bonomo J, Sharma G. Social Determinants of Health, Cardiovascular Health, and Mortality in Sexual Minority Individuals in the United States. Journal Of The American College Of Cardiology 2025, 85: 515-525. PMID: 39909683, DOI: 10.1016/j.jacc.2024.11.026.Peer-Reviewed Original ResearchConceptsSocial determinants of healthDeterminants of healthCVH scoreCardiovascular healthSocial determinantsSocial determinants of health domainsNational Health Interview SurveySM individualsGreater social deprivationDeath certificate informationHealth Interview SurveyHigher risk of cardiovascular mortalityNational Death IndexCardiovascular mortalityHigher scoresAssociated with higher risk of cardiovascular mortalityRisk of cardiovascular mortalityCardiovascular mortality riskSexual minoritiesHigher cardiovascular mortality riskAssociated with higher riskHealth disparitiesUnited StatesDeath IndexInterview Survey
2024
Temporal Trends and Racial Disparities in Long-Term Survival After Stroke
Robinson D, Ding L, Howard G, Stanton R, Khoury J, Sucharew H, Haverbusch M, Nobel L, Khatri P, Adeoye O, Broderick J, Ferioli S, Mackey J, Woo D, Rios La Rosa F, Flaherty M, Slavin S, Star M, Martini S, Demel S, Walsh K, Coleman E, Jasne A, Mistry E, Kleindorfer D, Kissela B. Temporal Trends and Racial Disparities in Long-Term Survival After Stroke. Neurology 2024, 103: e209653. PMID: 39008784, PMCID: PMC11249510, DOI: 10.1212/wnl.0000000000209653.Peer-Reviewed Original ResearchConceptsPremorbid functional statusFunctional statusRacial disparitiesAcute ischemic strokeBlack individualsPopulation-based stroke studyBlack raceEffect of black raceNational Death IndexAssociated with 5-year mortalityBaseline functional statusAcute ischemic stroke casesRisk of deathPhysician adjudicationIntracerebral hemorrhageDeath IndexIntracerebral hemorrhage casesUS populationICD codesGeneral populationCalendar yearLogistic regressionModified Rankin ScaleStroke StudyMedical recordsHeart Rate Variability, Deceleration Capacity of Heart Rate, and Death: A Veteran Twins Study
Huang M, Shah A, Lampert R, Bliwise D, Johnson D, Clifford G, Sloan R, Goldberg J, Ko Y, Da Poian G, Perez‐Alday E, Almuwaqqat Z, Shah A, Garcia M, Young A, Moazzami K, Bremner J, Vaccarino V. Heart Rate Variability, Deceleration Capacity of Heart Rate, and Death: A Veteran Twins Study. Journal Of The American Heart Association 2024, 13: e032740. PMID: 38533972, PMCID: PMC11179789, DOI: 10.1161/jaha.123.032740.Peer-Reviewed Original ResearchConceptsLow-frequency heart rate variabilityHazard of deathAssociated with reduced mortality riskMortality riskMultivariable Cox frailty modelsHeart rate variabilityAssociated with decreased hazard of deathNational Death IndexDeceleration capacityAssociated with lower hazardWithin-pair analysesTwin studiesCox frailty modelsHazard ratio of deathRatio of deathDeceleration capacity of heart rateAssociated with decreased hazardDeath IndexHeart rateAll-cause deathHazard ratioFrequency domain heart rate variabilityStrong associations
2023
Accordance to a MIND–Style Diet is Associated with Decreased Risk of Dementia Mortality in the REasons for Geographic and Racial Disparities in Stroke (REGARDS) Cohort
Judd S, Howard G, Tangney C, Pearson K, Shikany J, Cushman M, Wilson N, Howard V, Sawyer R, Oladele C, Manly J. Accordance to a MIND–Style Diet is Associated with Decreased Risk of Dementia Mortality in the REasons for Geographic and Racial Disparities in Stroke (REGARDS) Cohort. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.072481.Peer-Reviewed Original ResearchMIND diet scoreDiet scoreMIND dietDementia mortalityHigher MIND diet scoresDementia-related mortalityHistory of strokeNational Death IndexProportional hazards regressionBi-racial cohortMediterranean-DASH InterventionRate of dementiaBaseline cognitive impairmentNeurodegenerative Delay (MIND) dietDeath HRDementia deathCohort studyPrimary outcomeREGARDS cohortStroke cohortDietary interventionDeath IndexDecreased riskHazards regressionMedical conditionsCauses of Death of Transgender and Gender Diverse Veterans
Henderson E, Boyer T, Wolfe H, Blosnich J. Causes of Death of Transgender and Gender Diverse Veterans. American Journal Of Preventive Medicine 2023, 66: 664-671. PMID: 37979623, PMCID: PMC10957325, DOI: 10.1016/j.amepre.2023.11.014.Peer-Reviewed Original ResearchCause of deathVeterans Health Administration electronic health record dataDiverse veteransNational Death Index dataChronic ischemic heart diseaseChronic obstructive pulmonary diseaseDeath Index dataObstructive pulmonary diseaseIschemic heart diseaseNational Death IndexElectronic health record dataVeterans Health AdministrationCause-specific mortalityBehavioral health disordersHealth record dataDeath certificate recordsTargeted prevention effortsPsychoactive substance useDiabetes mellitusPulmonary diseaseCardiac dysrhythmiasDeath IndexConduction disordersHeart diseaseDeath certificatesAssociation of 7-Day Follow-Up With 6-Month Suicide Mortality Following Hospitalization for Suicidal Thoughts or Behaviors Among Older Adults
Schmutte T, Olfson M, Xie M, Marcus S. Association of 7-Day Follow-Up With 6-Month Suicide Mortality Following Hospitalization for Suicidal Thoughts or Behaviors Among Older Adults. American Journal Of Geriatric Psychiatry 2023, 32: 128-134. PMID: 37690981, PMCID: PMC10841311, DOI: 10.1016/j.jagp.2023.08.011.Peer-Reviewed Original ResearchAdjusted risk ratioMental health careSuicide riskPrior mental health careSuicidal thoughtsOutpatient mental health careSuicide-specific interventionsRetrospective cohort analysisNational Death IndexHealth careHigh-risk groupShort-term suicide riskMedicare Advantage enrolleesHigh suicide riskPostdischarge periodDeath IndexTimely followRisk ratioCohort analysisHigh riskMedicare dataTreatment weightsSuicidal ideationSuicidal behaviorInverse probabilityCombination Treatment with Sipuleucel-T and Abiraterone Acetate or Enzalutamide for Metastatic Castration-Resistant Prostate Cancer: STAMP and STRIDE Trials
Antonarakis E, Subudhi S, Pieczonka C, Karsh L, Quinn D, Hafron J, Wilfehrt H, Harmon M, Sheikh N, Shore N, Petrylak D. Combination Treatment with Sipuleucel-T and Abiraterone Acetate or Enzalutamide for Metastatic Castration-Resistant Prostate Cancer: STAMP and STRIDE Trials. Clinical Cancer Research 2023, 29: 2426-2434. PMID: 37058234, PMCID: PMC10320463, DOI: 10.1158/1078-0432.ccr-22-3832.Peer-Reviewed Original ResearchConceptsMetastatic castration-resistant prostate cancerAndrogen receptor-targeted agentsMedian overall survivalCastration-resistant prostate cancerOverall survivalNational Death IndexConcurrent administrationProstate cancerAntigen-presenting cell activationCurrent prescribing informationNew safety signalsKaplan-Meier methodologyLong-term outcomesConfidence intervalsReceptor-targeted agentsProstatic acid phosphataseAbiraterone acetateFirst infusionDeath IndexPrescribing informationHumoral responseSubsequent infusionSequential administrationSafety signalsImmune responseEvaluation of a Model to Target High-risk Psychiatric Inpatients for an Intensive Postdischarge Suicide Prevention Intervention
Kessler R, Bauer M, Bishop T, Bossarte R, Castro V, Demler O, Gildea S, Goulet J, King A, Kennedy C, Landes S, Liu H, Luedtke A, Mair P, Marx B, Nock M, Petukhova M, Pigeon W, Sampson N, Smoller J, Miller A, Haas G, Benware J, Bradley J, Owen R, House S, Urosevic S, Weinstock L. Evaluation of a Model to Target High-risk Psychiatric Inpatients for an Intensive Postdischarge Suicide Prevention Intervention. JAMA Psychiatry 2023, 80: 230-240. PMID: 36652267, PMCID: PMC9857842, DOI: 10.1001/jamapsychiatry.2022.4634.Peer-Reviewed Original ResearchConceptsClinical notesElectronic health recordsPsychiatric hospitalizationVHA electronic health recordsCount of medicationsPsychiatric hospital dischargeHigh-risk patientsHealth recordsShort-term psychiatric hospitalizationNational Death IndexSuicide prevention interventionsPostdischarge suicideUnique hospitalizationsHospital dischargeDeath IndexPrevention interventionsHigh riskMAIN OUTCOMEHospitalizationDrug AdministrationUS FoodRecord databasePsychiatric inpatientsSocial determinantsCase managementAssociations Between Natural Language Processing–Enriched Social Determinants of Health and Suicide Death Among US Veterans
Mitra A, Pradhan R, Melamed R, Chen K, Hoaglin D, Tucker K, Reisman J, Yang Z, Liu W, Tsai J, Yu H. Associations Between Natural Language Processing–Enriched Social Determinants of Health and Suicide Death Among US Veterans. JAMA Network Open 2023, 6: e233079. PMID: 36920391, PMCID: PMC10018322, DOI: 10.1001/jamanetworkopen.2023.3079.Peer-Reviewed Original ResearchConceptsAdjusted odds ratioRisk of suicideSocial determinantsUS Veterans Health AdministrationSuicide deathsCohort entry dateStudy end dateNational Death IndexVeterans Health AdministrationCase-control studyConditional logistic regressionElectronic health record notesUnstructured clinical notesCohort entryDeath IndexMean ageUS veteransOdds ratioSDOHsVeteran deathsMAIN OUTCOMEHealth StudySDOHLarge effect sizesHealth Administration
2021
Discrimination and Calibration of the Veterans Aging Cohort Study Index 2.0 for Predicting Mortality Among People With Human Immunodeficiency Virus in North America
McGinnis KA, Justice AC, Moore RD, Silverberg MJ, Althoff KN, Karris M, Lima VD, Crane HM, Horberg MA, Klein MB, Gange SJ, Gebo KA, Mayor A, Tate JP, Benson C, Bosch R, Kirk G, Marconi V, Colasanti J, Mayer K, Grasso C, Hogg R, Lima V, Montaner J, Sereda P, Salters K, Buchacz K, Li J, Gebo K, Moore R, Moore R, Jacobson J, Horberg M, Silverberg M, Thorne J, Brown T, Tien P, D’Souza G, Smith G, Loutfy M, Gupta M, Klein M, Rabkin C, Kroch A, Burchell A, Betts A, Lindsay J, Nijhawan A, Mayor A, Gill M, Martin J, Li J, Brooks J, Saag M, Mugavero M, Willig J, Bamford L, Karris M, Eron J, Napravnik S, Kitahata M, Crane H, Sterling T, Haas D, Rebeiro P, Turner M, McGinnis K, Justice A, Moore R, Althoff K, Gange S, Kitahata M, Lee J, Saag M, Horberg M, Klein M, McKaig R, Freeman A, Moore R, Althoff K, Freeman A, Kitahata M, Van Rompaey S, Crane H, Morton L, McReynolds J, Lober W, Gange S, Lee J, Hogan B, You B, Humes E, Gerace L, Stewart C, Coburn S. Discrimination and Calibration of the Veterans Aging Cohort Study Index 2.0 for Predicting Mortality Among People With Human Immunodeficiency Virus in North America. Clinical Infectious Diseases 2021, 75: 297-304. PMID: 34609485, PMCID: PMC9410720, DOI: 10.1093/cid/ciab883.Peer-Reviewed Original ResearchConceptsNorth American AIDS Cohort CollaborationVACS Index 2.0National Death IndexHIV-1 RNAHuman immunodeficiency virusCopies/mLRisk of mortalityRace/ethnicityCohort CollaborationNA-ACCORDCause mortalityCD4 countMedian ageDeath IndexImmunodeficiency virusPredicting MortalityMortality ascertainmentMortality rateMortalitySpecific biomarkersPWHDiverse cohortObserved mortalityCohortHIVSuicide risk in first year after dementia diagnosis in older adults
Schmutte T, Olfson M, Maust DT, Xie M, Marcus SC. Suicide risk in first year after dementia diagnosis in older adults. Alzheimer's & Dementia 2021, 18: 262-271. PMID: 34036738, PMCID: PMC8613307, DOI: 10.1002/alz.12390.Peer-Reviewed Original ResearchConceptsStandardized mortality ratioADRD diagnosisOverall standardized mortality ratioSuicide riskGeneral geriatric populationChronic pain conditionsNational Death IndexSuicide risk screeningRecent mental healthRisk of suicideFirst yearPain conditionsDeath IndexGeriatric populationNational cohortMortality ratioRisk screeningHigh riskMedicare feeDementia diagnosisService beneficiariesAlzheimer's diseaseRural residenceMental healthOlder adultsAnalysis of unused prescription opioids and benzodiazepines remaining after death among Medicare decedents
Baum L, Bruzelius E, Kiang M, Humphreys K, Basu S, Baum A. Analysis of unused prescription opioids and benzodiazepines remaining after death among Medicare decedents. Drug And Alcohol Dependence 2021, 219: 108502. PMID: 33421803, PMCID: PMC7914112, DOI: 10.1016/j.drugalcdep.2020.108502.Peer-Reviewed Original ResearchConceptsMedicare beneficiariesNational sample of Medicare beneficiariesHistory of mental illnessSample of Medicare beneficiariesNational Death IndexNon-Hispanic whitesEnd-of-lifePrescription opioidsPart D claimsLower-income beneficiariesDrug use disordersMedicare decedentsAsian decedentsDeath IndexMental illnessMisuse of prescription opioidsUnused prescription opioidsD claimsBenzodiazepine prescriptionsChronic painMedication disposalNational sampleTime of deathNorth American nativesDecedents
2020
Association of Perceived Stress Levels With Long-term Mortality in Patients With Peripheral Artery Disease
Malik AO, Peri-Okonny P, Gosch K, Thomas M, Mena C, Hiatt WR, Jones PG, Provance JB, Labrosciano C, Jelani QU, Spertus JA, Smolderen KG. Association of Perceived Stress Levels With Long-term Mortality in Patients With Peripheral Artery Disease. JAMA Network Open 2020, 3: e208741. PMID: 32573710, PMCID: PMC7312389, DOI: 10.1001/jamanetworkopen.2020.8741.Peer-Reviewed Original ResearchConceptsModifiable risk factorsSelf-perceived stressChronic stressCause mortalityCohort studyRisk factorsCox proportional hazards regression modelLong-term mortality riskProportional hazards regression modelsSymptoms of PADLong-term mortalityPeripheral arterial diseasePeripheral artery diseasePrimary study outcomeEvidence-based management strategiesNational Death IndexHazards regression modelsRisk of mortalityAssessment of mortalityOnly patientsArtery diseaseFinal cohortArterial diseaseDeath IndexMulticenter studyNovel microsimulation model of tobacco use behaviours and outcomes: calibration and validation in a US population
Reddy KP, Bulteel AJB, Levy DE, Torola P, Hyle EP, Hou T, Osher B, Yu L, Shebl FM, Paltiel AD, Freedberg KA, Weinstein MC, Rigotti NA, Walensky RP. Novel microsimulation model of tobacco use behaviours and outcomes: calibration and validation in a US population. BMJ Open 2020, 10: e032579. PMID: 32404384, PMCID: PMC7228509, DOI: 10.1136/bmjopen-2019-032579.Peer-Reviewed Original ResearchConceptsNational Health Interview SurveyCessation ratesQuit attemptsTobacco useMortality riskSmoking relapseSurveillance Modeling Network (CISNET) modelsNational Death IndexHealth Interview SurveyCigarette smoking behaviorNicotine product useExternal validationCumulative mortality curvesTobacco control policiesTobacco use behaviorsCurrent smokersDeath IndexSmoking prevalenceSustained abstinenceUS womenRelapseSmoking behaviorWomen/menUS populationNatural history
2019
Scoring of Coronary Artery Disease Characteristics on Coronary CT Angiograms by Using Machine Learning
Johnson KM, Johnson HE, Zhao Y, Dowe DA, Staib LH. Scoring of Coronary Artery Disease Characteristics on Coronary CT Angiograms by Using Machine Learning. Radiology 2019, 292: 182061. PMID: 31237495, DOI: 10.1148/radiol.2019182061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsFemaleHumansImage Interpretation, Computer-AssistedMachine LearningMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsRisk FactorsSeverity of Illness IndexYoung AdultConceptsCoronary CT angiographyCoronary Artery Disease ReportingNonfatal myocardial infarctionHeart disease deathCT angiographyCause mortalityDisease deathsMyocardial infarctionCoronary heart disease deathDisease reportingCoronary artery diseaseNational Death IndexData System scoreCardiovascular eventsCoronary deathAdverse eventsArtery diseaseCoronary diseaseDeath IndexCoronary segmentsPrognostic informationVessel scorePatientsSystem scoreSubsequent death
2018
Mortality Following Pediatric Congenital Heart Surgery: An Analysis of the Causes of Death Derived From the National Death Index
McCracken C, Spector LG, Menk JS, Knight JH, Vinocur JM, Thomas AS, Oster ME, St Louis JD, Moller JH, Kochilas L. Mortality Following Pediatric Congenital Heart Surgery: An Analysis of the Causes of Death Derived From the National Death Index. Journal Of The American Heart Association 2018, 7: e010624. PMID: 30571499, PMCID: PMC6404427, DOI: 10.1161/jaha.118.010624.Peer-Reviewed Original ResearchConceptsCongenital heart surgeryNational Death IndexCongenital heart defectsStandardized mortality ratioCause of deathHeart surgeryDeath IndexCardiovascular disordersHeart failureSeverity of CHDCause-specific standardized mortality ratiosPediatric Cardiac Care ConsortiumRetrospective cohort studyAdjusted odds ratioLong-term outcomesRisk of deathLong-term riskConclusions SurvivorsMedian followNoncardiac conditionsCohort studyResidual morbidityEarly outcomesLate causesCardiac arrestRacial Disparities in Patient Characteristics and Survival After Acute Myocardial Infarction
Graham GN, Jones PG, Chan PS, Arnold SV, Krumholz HM, Spertus JA. Racial Disparities in Patient Characteristics and Survival After Acute Myocardial Infarction. JAMA Network Open 2018, 1: e184240. PMID: 30646346, PMCID: PMC6324589, DOI: 10.1001/jamanetworkopen.2018.4240.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionWhite patientsBlack patientsMortality rate differencesMortality ratePatient characteristicsMyocardial infarctionPropensity scoreAcute Myocardial Infarction Patients' Health Status (TRIUMPH) registrySelf-identified black patientsObserved survival differencesNational Death IndexTime of admissionLower propensity scoreProspective registryClinical characteristicsCohort studyDeath IndexHighest quintileBlack raceC-statisticSurvival differencesWorse outcomesMAIN OUTCOMEPatientsEffectiveness of Lung-RADS in Reducing False-Positive Results in a Diverse, Underserved, Urban Lung Cancer Screening Cohort
Kaminetzky M, Milch H, Shmukler A, Kessler A, Peng R, Mardakhaev E, Bellin E, Levsky J, Haramati L. Effectiveness of Lung-RADS in Reducing False-Positive Results in a Diverse, Underserved, Urban Lung Cancer Screening Cohort. Journal Of The American College Of Radiology 2018, 16: 419-426. PMID: 30146484, DOI: 10.1016/j.jacr.2018.07.011.Peer-Reviewed Original ResearchConceptsLung cancer screening cohortNational Lung Screening TrialPercent of patientsNational Death IndexLung cancer screeningLung-RADSLung cancer ratesCancer ratesScreening cohortDeath IndexCancer screeningLung cancerScreening TrialCT resultsLung CT Screening ReportingFirst annual examinationLung cancer prevalenceLung-RADS 1Lung-RADS 2Lung-RADS 3Institutional review board approvalLung-RADS categoriesClinical screening programReview board approvalUnderserved urban population
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