2024
Develop and validate a computable phenotype for the identification of Alzheimer's disease patients using electronic health record data
He X, Wei R, Huang Y, Chen Z, Lyu T, Bost S, Tong J, Li L, Zhou Y, Li Z, Guo J, Tang H, Wang F, DeKosky S, Xu H, Chen Y, Zhang R, Xu J, Guo Y, Wu Y, Bian J. Develop and validate a computable phenotype for the identification of Alzheimer's disease patients using electronic health record data. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2024, 16: e12613. PMID: 38966622, PMCID: PMC11220631, DOI: 10.1002/dad2.12613.Peer-Reviewed Original ResearchElectronic health record dataElectronic health recordsComputable phenotypeHealth record dataManual chart reviewHealth recordsAlzheimer's diseaseDiagnosis codesRecord dataChart reviewUTHealthAlzheimer's disease patientsUniversity of MinnesotaAD diagnosisAD identificationDisease patientsPatientsAlzheimerAD patientsDemographicsDiagnosisDiseaseCodeDataUniversity
2021
Effects of genetic risk for alcohol dependence and onset of regular drinking on the progression to alcohol dependence: A polygenic risk score approach
Yeung EW, Spychala KM, Miller AP, Otto JM, Deak JD, Kim H, Gilder DA, Ehlers CL, Wilhelmsen KC, Gizer IR. Effects of genetic risk for alcohol dependence and onset of regular drinking on the progression to alcohol dependence: A polygenic risk score approach. Drug And Alcohol Dependence 2021, 230: 109117. PMID: 34844060, PMCID: PMC8714681, DOI: 10.1016/j.drugalcdep.2021.109117.Peer-Reviewed Original ResearchConceptsRate of progressionRegular drinkingAlcohol dependenceCox proportional hazards regression analysisProportional hazards regression analysisEarly onsetGenetic riskHazards regression analysisHazard of progressionMixed-effects logistic regressionEuropean-ancestry adultsHigh clinical relevanceAD risk variantsEffects logistic regressionAD independentPolygenic risk score approachClinical courseRapid progressionAD preventionFaster progressionPolygenic risk scoresRisk scoreClinical relevanceLate onsetAD diagnosis
2019
Reduction of AHI1 in the serum of Taiwanese with probable Alzheimer’s disease
Sheu JJ, Yang LY, Sanotra MR, Wang ST, Lu HT, Kam RSY, Hsu IU, Kao SH, Lee CK, Shieh JC, Lin YF. Reduction of AHI1 in the serum of Taiwanese with probable Alzheimer’s disease. Clinical Biochemistry 2019, 76: 24-30. PMID: 31786207, DOI: 10.1016/j.clinbiochem.2019.11.011.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAD seraAD patientsEarly diagnosisAD model mouse brainsC-terminal APP fragmentsMini-Mental State Examination scoreSerum samplesHealthy control subjectsState Examination scoreBlood-based biomarkersModel mouse brainProbable Alzheimer's diseaseAge-dependent mannerGood diagnostic performanceHC seraControl subjectsAPP fragmentsAD biomarkersMouse brainYounger ageAD diagnosisNeuronal cellsWestern blottingDisease
2017
PET Imaging for Early Detection of Alzheimer’s Disease From Pathologic to Physiologic Biomarkers
Bao W, Jia H, Finnema S, Cai Z, Carson RE, Huang YH. PET Imaging for Early Detection of Alzheimer’s Disease From Pathologic to Physiologic Biomarkers. PET Clinics 2017, 12: 329-350. PMID: 28576171, DOI: 10.1016/j.cpet.2017.03.001.Peer-Reviewed Original Research
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