2025
A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells
Chen X, Tang X, Xie Y, Cuffari B, Tang C, Cao F, Gao X, Meng Z, Noble P, Young M, Turk O, Shirali A, Gera J, Nishimura R, Zhou J, Hansen J. A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells. Science Signaling 2025, 18: eadk3320. PMID: 40132052, PMCID: PMC12076517, DOI: 10.1126/scisignal.adk3320.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusOrthotopic models of glioblastomaNecrotic tumor cellsPathophysiology of autoimmunityNonviral gene deliveryModels of glioblastomaTumor immunityOrthotopic modelT cellsLupus erythematosusTumor cellsGene deliveryAnimal survivalCyclic GMP-AMP synthaseImmune responseAutoantibodiesTherapeutic opportunitiesCancer treatmentPromote animal survivalDeliver RNAImmune signalingLiving miceAntibodiesCellsMuscle tissue
2023
The Plasma Cell Infiltrate Populating the Muscle Tissue of Patients with Inclusion Body Myositis Features Distinct B Cell Receptor Repertoire Properties
Jiang R, Roy B, Wu Q, Mohanty S, Nowak R, Shaw A, Kleinstein S, O’Connor K. The Plasma Cell Infiltrate Populating the Muscle Tissue of Patients with Inclusion Body Myositis Features Distinct B Cell Receptor Repertoire Properties. ImmunoHorizons 2023, 7: 310-322. PMID: 37171806, PMCID: PMC10579972, DOI: 10.4049/immunohorizons.2200078.Peer-Reviewed Original ResearchConceptsInclusion body myositisMemory B cellsCell infiltrateBody myositisB cellsIBM muscle biopsiesB-cell infiltratesPlasma cell infiltrateClass-switched IgGMuscle tissueAdaptive immune receptor repertoire sequencingHumoral responseHealthy controlsIgA isotypePlasma cellsCell repertoireMuscle biopsyInfiltratesDegenerative disordersDisease pathologyRepertoire sequencingSkeletal muscleDermatomyositisPolymyositisMyositisDeep learning of image-derived measures of body composition in pediatric, adolescent, and young adult lymphoma: association with late treatment effects
Tram N, Chou T, Janse S, Bobbey A, Audino A, Onofrey J, Stacy M. Deep learning of image-derived measures of body composition in pediatric, adolescent, and young adult lymphoma: association with late treatment effects. European Radiology 2023, 33: 6599-6607. PMID: 36988714, DOI: 10.1007/s00330-023-09587-z.Peer-Reviewed Original ResearchConceptsProportional hazards regression analysisHazards regression analysisLate effectsBody composition measuresAYA patientsHigh riskBody compositionCox proportional hazards regression analysisTreatment-related late effectsComposition measuresCancer treatmentSerious adverse eventsLate treatment effectsYoung adult patientsSubcutaneous adipose tissueRegression analysisCare CT imagesSingle-site studyMuscle tissueAdult patientsAdverse eventsInitial stagingPediatric patientsAdult lymphomasPrognostic value
2021
Tendon grafts with preserved muscle demonstrate similar biomechanical properties to tendon grafts stripped of muscular attachments: a biomechanical evaluation in a porcine model
Funchal LFZ, Astur DC, Pizzolatti ALA, Grimaldi AP, Jimenez AE, Moré ADO, de Mello Roesler CR, Cohen M. Tendon grafts with preserved muscle demonstrate similar biomechanical properties to tendon grafts stripped of muscular attachments: a biomechanical evaluation in a porcine model. Journal Of Experimental Orthopaedics 2021, 8: 57. PMID: 34341872, PMCID: PMC8329107, DOI: 10.1186/s40634-021-00375-6.Peer-Reviewed Original ResearchYield loadMaximum loadAutograft tendonsTendon graftBiomechanical propertiesMaterial testing machineSimilar biomechanical propertiesUltimate loadMechanical propertiesAxial strainTesting machinePreservation of muscleFailure patternsSignificant differencesBiomechanical evaluationLoadMuscle tissueStiffnessContralateral tendonHuman autograftsGroup 2Group 1Muscle tendonLevel IIIPorcine modelRemnant Muscle Preservation on Hamstring Tendon Autograft During ACL Reconstruction Promotes Volumetric Increase With Biological and Regenerative Potential
Funchal LFZ, Ortiz R, Jimenez A, Di Giunta Funchal G, Cohen M, Astur DC. Remnant Muscle Preservation on Hamstring Tendon Autograft During ACL Reconstruction Promotes Volumetric Increase With Biological and Regenerative Potential. Orthopaedic Journal Of Sports Medicine 2021, 9: 2325967121990016. PMID: 34250161, PMCID: PMC8239340, DOI: 10.1177/2325967121990016.Peer-Reviewed Original ResearchAnterior cruciate ligament reconstructionGraft diameterLysholm scoreTendon autograftGroup 2Tendon graftGroup 1Hamstring tendon autograftBetter functional scoresMuscle tissueTegner activity scaleCruciate ligament reconstructionBetter Lysholm scoresLevel of evidenceRegenerative potentialVolumetric increaseAutograft diameterCohort studyFunctional scoresLigament reconstructionMuscle preservationHistological examinationHistological characteristicsPatientsActivity Scale
2020
Nuclear filaments: role in chromosomal positioning and gene expression
Bera M, Sengupta K. Nuclear filaments: role in chromosomal positioning and gene expression. Nucleus 2020, 11: 99-110. PMID: 32453974, PMCID: PMC7529408, DOI: 10.1080/19491034.2020.1769445.Peer-Reviewed Original ResearchConceptsChromosomal contactsGene expressionLMNA mutationsInner nuclear membraneDNA damage repairGene expression profilesIntrachromosomal contactsChromosomal positioningChromosome positioningNuclear actinNuclear laminsEpigenetic modificationsLamin networkChromosomal loopsDamage repairExpression profilesNuclear membraneNuclear processesKey playersLaminsLaminopathiesMutationsElastic meshworkMuscle tissueMechanical rigidity
2019
Endocrinology
Bribiescas R. Endocrinology. 2019, 612-672. DOI: 10.1093/oxfordhb/9780198789666.013.15.ChaptersEvolutionary endocrinologyHuman life history evolutionLife-history evolutionLife-history traitsHuman variationReproductive stateHistory traitsHistory evolutionReproductive effortDimorphic tissuesBehavioral variationStress homeostasisHuman biologyEvolutionary perspectiveHuman evolutionSpecific functionsGene-environment interactionsNutritional demandsBiologyMuscle tissueEnvironmental challengesMetabolismGametogenesisImmune functionEcology
2017
Population diversity of the genetically determined TTR expression in human tissues and its implications in TTR amyloidosis
Iorio A, De Angelis F, Di Girolamo M, Luigetti M, Pradotto LG, Mazzeo A, Frusconi S, My F, Manfellotto D, Fuciarelli M, Polimanti R. Population diversity of the genetically determined TTR expression in human tissues and its implications in TTR amyloidosis. BMC Genomics 2017, 18: 254. PMID: 28335735, PMCID: PMC5364715, DOI: 10.1186/s12864-017-3646-1.Peer-Reviewed Original ResearchConceptsGenotype-phenotype correlationHuman populationComplex genotype-phenotype correlationsFamilial amyloidotic cardiomyopathyTTR expressionTTR amyloidosisGTEx projectGenome ProjectSkeletal muscle tissueAncestral groupsAncestry diversityRelevant tissuesScandinavian populationsAmyloidotic cardiomyopathyPopulation diversityAncestry groupsExpressionHuman tissuesDiversityMuscle tissueHereditary diseasePolygenic scoresTissueClinical variabilityLesser extent
2016
Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training
Ash GI, Kostek MA, Lee H, Angelopoulos TJ, Clarkson PM, Gordon PM, Moyna NM, Visich PS, Zoeller RF, Price TB, Devaney JM, Gordish-Dressman H, Thompson PD, Hoffman EP, Pescatello LS. Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training. PLOS ONE 2016, 11: e0148112. PMID: 26821164, PMCID: PMC4731199, DOI: 10.1371/journal.pone.0148112.Peer-Reviewed Original ResearchConceptsMaximum voluntary contractionResistance trainingMuscle strengthPost-resistance trainingGlucocorticoid receptor polymorphismsGreater relative sizeCortisol sensitivityReceptor polymorphismsNR3C1 polymorphismsVoluntary contractionAllele carriersCortisol actionMuscle responsesCortisol productionRT programIsometric strengthAA homozygotesG alleleT alleleVariant associatesBiceps sizeEuropean American adultsSex differencesMuscle tissueAssociation
2012
Cardiovascular dysregulation of miR‐17‐92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis
Danielson LS, Park DS, Rotllan N, Chamorro‐Jorganes A, Guijarro MV, Fernandez‐Hernando C, Fishman GI, Phoon CK, Hernando E. Cardiovascular dysregulation of miR‐17‐92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis. The FASEB Journal 2012, 27: 1460-1467. PMID: 23271053, PMCID: PMC3606524, DOI: 10.1096/fj.12-221994.Peer-Reviewed Original ResearchConceptsSmooth muscle tissueHypertrophic cardiomyopathyMiR-17Dose-dependent inductionMuscle tissueCardiovascular dysregulationArrhythmia inducibilityNovel direct targetMicroRNA cluster miR-17Lethal cardiomyopathyPremature mortalityTransgenic heartsMouse modelHeart sizeCluster miR-17CardiomyopathyPrecise mechanismLuciferase assayDirect targetExpression levelsPathological functionsExpression analysisConditional overexpressionTransgenic animalsHeartAutoantibodies Produced at the Site of Tissue Damage Provide Evidence of Humoral Autoimmunity in Inclusion Body Myositis
Ray A, Amato AA, Bradshaw EM, Felice KJ, DiCapua DB, Goldstein JM, Lundberg IE, Nowak RJ, Ploegh HL, Spooner E, Wu Q, Willis SN, O’Connor K. Autoantibodies Produced at the Site of Tissue Damage Provide Evidence of Humoral Autoimmunity in Inclusion Body Myositis. PLOS ONE 2012, 7: e46709. PMID: 23071619, PMCID: PMC3465259, DOI: 10.1371/journal.pone.0046709.Peer-Reviewed Original ResearchConceptsInclusion body myositisHumoral immune responseImmune responsePlasma cellsTissue damageBody myositisAntibody-secreting plasma cellsCell linesSingle plasma cellsMajor intermediate filament proteinMuscle tissueIBM patientsHumoral autoimmunityInflammatory myopathiesHuman-derived cell linesIBM muscleMuscle tissue sectionsMuscle tissue homogenatesMuscle diseaseTissue homogenatesTissue sectionsIntermediate filament proteinsMyositisAutoantibodiesDisease
2011
Circadian Rhythm Gene Period 3 Is an Inhibitor of the Adipocyte Cell Fate*
Costa M, So A, Kaasik K, Krueger K, Pillsbury M, Fu Y, Ptacek L, Yamamoto K, Feldman B. Circadian Rhythm Gene Period 3 Is an Inhibitor of the Adipocyte Cell Fate*. Journal Of Biological Chemistry 2011, 286: 9063-9070. PMID: 21228270, PMCID: PMC3058992, DOI: 10.1074/jbc.m110.164558.Peer-Reviewed Original ResearchConceptsTranscriptional activityCell fate decisionsWild-type miceKnock-out miceActivation of PPARGFate decisionsCell fatePER3 expressionIncreased AdiposityResponse elementExogenous expressionAdipocyte fateMesenchymal stem cellsBody compositionCellular eventsMultipotent cellsStem cellsGlucocorticoidPPARGPER3MiceAdipocytesFateCellsMuscle tissue
2007
Characterization of Single B Cell Immunoglobulin Variable Region Genes Derived from Infiltrated Muscle Tissue of Subjects with Inflammatory Myopathies
Bradshaw E, Orihuela A, McArdel S, Hafler D, Amato A, O'Connor K. Characterization of Single B Cell Immunoglobulin Variable Region Genes Derived from Infiltrated Muscle Tissue of Subjects with Inflammatory Myopathies. Clinical Immunology 2007, 123: s152. DOI: 10.1016/j.clim.2007.03.072.Peer-Reviewed Original ResearchA Local Antigen-Driven Humoral Response Is Present in the Inflammatory Myopathies
Bradshaw EM, Orihuela A, McArdel SL, Salajegheh M, Amato AA, Hafler DA, Greenberg SA, O’Connor K. A Local Antigen-Driven Humoral Response Is Present in the Inflammatory Myopathies. The Journal Of Immunology 2007, 178: 547-556. PMID: 17182595, DOI: 10.4049/jimmunol.178.1.547.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAmino Acid SequenceAntibody FormationAutoantigensB-Lymphocyte SubsetsFemaleGenes, Immunoglobulin Heavy ChainHumansImmunoglobulin Switch RegionImmunoglobulin Variable RegionMaleMicrodissectionMiddle AgedMolecular Sequence DataMutationMyocardiumMyositisReceptors, Antigen, B-CellSyndecan-1Transcription, GeneticConceptsInclusion body myositisLaser capture microdissectionBody myositisCapture microdissectionInflammatory myopathiesMuscle tissueInsertions/deletionsT cell-mediated diseaseGene sequencesCell-mediated diseaseGene transcriptsInflamed muscle tissueAg-specific responsesAg receptorB cell maturationPlasma cell populationPutative autoimmune disordersControl muscle tissueSignificant somatic mutationsIndividual cellsVariable region gene sequencesOligoclonal expansionInflammatory infiltrateSomatic mutationsMuscle weakness
2004
Evaluation of Hematopoietic Potential Generated by Transplantation of Muscle-Derived Stem Cells in Mice
Farace F, Prestoz L, Badaoui S, Guillier M, Haond C, Opolon P, Thomas JL, Zalc B, Vainchenker W, Turhan AG. Evaluation of Hematopoietic Potential Generated by Transplantation of Muscle-Derived Stem Cells in Mice. Stem Cells And Development 2004, 13: 83-92. PMID: 15068696, DOI: 10.1089/154732804773099281.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesBone Marrow CellsBone Marrow TransplantationCell DivisionCell LineageCell SeparationCell TransplantationChimeraFemaleFlow CytometryHematopoiesisHematopoietic Stem CellsHematopoietic SystemIn Situ Hybridization, FluorescenceKiller Cells, NaturalLeukocyte Common AntigensMaleMiceMice, Inbred C57BLMusclesPolymerase Chain ReactionSex FactorsStem CellsT-LymphocytesConceptsMarrow transplantationUse of muscleStem cellsTransplantation of musclesNatural killer cellsMarrow-derived stem cellsMuscle-derived hematopoietic stem cellsLevel of CFUMuscle-derived stem cellsMarrow stem cellsMuscle tissueMuscle transplantsKiller cellsTertiary recipientsHematopoietic chimerismMuscle graftsIrradiated miceAdult miceTransplantationHematopoietic stem cellsSecondary recipientsSimilar potencyMiceMurine muscleSerial transplantation
1997
Suppression of venous signal in time-of-flight MR angiography of the lower extremities after administration of gadopentetate dimeglumine.
Rofsky N, Purdy D, Johnson G, DeCorato D, Earls J, Krinsky G, Weinreb J. Suppression of venous signal in time-of-flight MR angiography of the lower extremities after administration of gadopentetate dimeglumine. Radiology 1997, 202: 177-82. PMID: 8988209, DOI: 10.1148/radiology.202.1.8988209.Peer-Reviewed Original ResearchConceptsGadopentetate dimeglumineLower extremitiesMR angiographyPeripheral vascular diseaseVenous signalDistal lower extremityMR angiogramsGadopentetate dimeglumine administrationStudent's t-testFlight MR angiographyAdult patientsAngiography timeVascular diseaseFlight MR angiogramsGradient echo sequenceAdministrationDimegluminePatientsAngiographyT-testAngiogramsExtremitiesMuscle tissueVenous suppressionImaging sections
1994
Host Range Tests with Edhazardia aedis (Microsporida: Culicosporidae) against Northern Nearctic Mosquitoes
Andreadis T. Host Range Tests with Edhazardia aedis (Microsporida: Culicosporidae) against Northern Nearctic Mosquitoes. Journal Of Invertebrate Pathology 1994, 64: 46-51. PMID: 7914904, DOI: 10.1006/jipa.1994.1067.Peer-Reviewed Original ResearchConceptsEdhazardia aedisE. aedisOvarian infectionOral ingestionNormal vegetative growthHost range testsFat body tissueBiological control agentsSuccessive host generationsNormal life cycleInfectionPredominant siteYellow fever mosquitoHost mosquitoesTransovarial transmissionMosquito hostDegree of infectionHost generationsSusceptible hostsMicrosporidian parasiteGastric caecaUninucleate sporesVegetative growthMuscle tissueControl agentsA liver factor increasing glucose uptake in rat hindquarters
Petersen K, Tygstrup N. A liver factor increasing glucose uptake in rat hindquarters. Journal Of Hepatology 1994, 20: 461-465. PMID: 8051382, DOI: 10.1016/s0168-8278(05)80490-8.Peer-Reviewed Original ResearchConceptsMin-1 xGlucose uptakeRat hindquartersIsolated rat hindquartersIsolated rat liverGlucose intoleranceIsolated perfusionLiver diseaseLiverLiver factorsKidney extractsHindquartersLiver extractsRat liverPerfusionPerfusateTissue extractsBW-1Muscle tissueSecond periodExtract fluidMumolUptakeExtractPeriod
1987
An isotopic method for measurement of muscle protein synthesis and degradation in vivo
Barrett EJ, Revkin JH, Young LH, Zaret BL, Jacob R, Gelfand RA. An isotopic method for measurement of muscle protein synthesis and degradation in vivo. Biochemical Journal 1987, 245: 223-228. PMID: 3663148, PMCID: PMC1148103, DOI: 10.1042/bj2450223.Peer-Reviewed Original ResearchConceptsNet amino acid releaseFemoral venous plasmaTissue blood flowAmino acid releaseMuscle protein synthesisHindlimb flowTissue protein degradationSpecific radioactivityContinuous infusionUptake of leucineMuscle bedArterial circulationClinical studiesPlasma concentrationsDog hindlimbBlood flowProtein synthesisAcid releaseHindlimbProtein turnoverTissue proteinsPhenylalanine incorporationRemoval of tracerMuscle tissueDogsChoroid Plexitis in White-tailed Deer (Odocoileus virginianus) in Southern New York State
Levine S, Fish D, Magnarelli L, Anderson J. Choroid Plexitis in White-tailed Deer (Odocoileus virginianus) in Southern New York State. Veterinary Pathology 1987, 24: 207-210. PMID: 3603961, DOI: 10.1177/030098588702400302.Peer-Reviewed Original ResearchConceptsChoroid plexitisHistologic evidenceSerologic evidenceNerve rootsSouthern New York StatePast infectionSpinal cordDural lesionsPneumostrongylus tenuisPlexitisLyme diseaseNew York StateSkeletal muscleInfectionBorrelia burgdorferiB. burgdorferiCausative agentIxodes damminiMuscle tissueBurgdorferiTick vectorEvidenceNerveCausal relationshipCord
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply