2025
Hepatoblastoma: Comprehensive Review With Recent Updates.
Jiao J, Saxena R, Morotti R. Hepatoblastoma: Comprehensive Review With Recent Updates. Advances In Anatomic Pathology 2025 PMID: 40178831, DOI: 10.1097/pap.0000000000000495.Peer-Reviewed Original ResearchRisk stratificationLiver tumorsChildren's Hepatic tumors International CollaborationPrimary malignant liver tumorsMalignant rhabdoid tumorMalignant liver tumorsPediatric liver tumorsRare pediatric liver tumorImprove risk stratificationRisk stratification algorithmChemotherapeutic regimenComplete resectionAdjuvant chemotherapyRhabdoid tumorPretreatment extentHistological heterogeneityHistological classificationHistological featuresHepatocellular neoplasmsDisease stageHepatoblastomaTumorImproved efficacyStratification algorithmReduced toxicity
2024
Integrated surgical intervention for intradural extramedullary hemangioblastoma of the cervical spine: a case report and literature review
Wang Y, Zhu Q, Chen A, Dai C, Xu L, Sheng M, Huang Q, Lan Q, Mu Q, Li R. Integrated surgical intervention for intradural extramedullary hemangioblastoma of the cervical spine: a case report and literature review. Frontiers In Oncology 2024, 14: 1387005. PMID: 39600635, PMCID: PMC11588709, DOI: 10.3389/fonc.2024.1387005.Peer-Reviewed Original ResearchIntradural extramedullary hemangioblastomaVon Hippel-Lindau syndromeExtramedullary hemangioblastomaHippel-Lindau syndromeComplete resectionC6-C7 vertebral levelsIncreased risk of recurrenceIntraoperative bleeding riskElevated risk of bleedingComplete tumor resectionSpinal cord tumorsRisk of recurrenceRisk of bleedingSatisfactory postoperative recoveryUpregulation of CD31Hybrid operating roomInjection of embolic agentsPyramidal tract signsMuscle strengthExtramedullary regionOcclusion of blood vesselsCombined surgeryFenestration surgerySpinal hemangioblastomasSpinal tumors
2021
Determinants of survival in sinonasal and skull base chondrosarcoma: An analysis of the National Cancer Database
Rimmer RA, Mace JC, Andersen PE, Cetas JS, Ciporen JN, Dogan A, Smith TL, Geltzeiler M. Determinants of survival in sinonasal and skull base chondrosarcoma: An analysis of the National Cancer Database. International Forum Of Allergy & Rhinology 2021, 12: 699-713. PMID: 34704402, DOI: 10.1002/alr.22909.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseSkull base chondrosarcomaOverall survivalDeterminants of survivalAdjuvant treatmentCancer DatabaseMultivariate Cox regression modelingMalignant chondroid tumorsMainstay of treatmentCox regression modelingOptimal treatment regimensCases of sinonasalRegression modelingCritical neurovascular structuresConventional external beamAdjuvant radiationBetter OSFavorable OSComplete resectionTreatment regimensTumor gradeHigher OSInclusion criteriaSkull base regionMortality riskImproved outcomes and staging in non-small-cell lung cancer guided by a molecular assay
Gupta AR, Woodard GA, Jablons DM, Mann MJ, Kratz JR. Improved outcomes and staging in non-small-cell lung cancer guided by a molecular assay. Future Oncology 2021, 17: 4785-4795. PMID: 34435876, PMCID: PMC9039775, DOI: 10.2217/fon-2021-0517.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorCarcinogenesisCarcinoma, Non-Small-Cell LungChemotherapy, AdjuvantClinical Decision-MakingDatasets as TopicDisease-Free SurvivalGene Expression ProfilingGene Expression Regulation, NeoplasticHumansLung NeoplasmsMolecular Diagnostic TechniquesNeoplasm Recurrence, LocalNeoplasm StagingPneumonectomyProspective StudiesReal-Time Polymerase Chain ReactionRisk AssessmentConceptsCell lung cancerUndetectable metastasesLung cancerCell lung cancer patientsDisease-free survivalAdjuvant chemotherapy decisionsTime of surgeryLung cancer patientsSurgical resectionComplete resectionProspective studyCancer patientsChemotherapy decisionsResectionMolecular assaysPatientsPredictive benefitMetastasisCancerMortalityQuantitative PCRExpression profilesEarly stagesAssaysSurgery
2020
Surgically Managed Signet Ring Cell Esophageal Carcinomas in the National Cancer Database
Sathe TS, Resio BJ, Hoag JR, Monsalve AF, Pathak R, Blasberg JD, Mase V, Dhanasopon A, Boffa DJ. Surgically Managed Signet Ring Cell Esophageal Carcinomas in the National Cancer Database. The Annals Of Thoracic Surgery 2020, 109: 1656-1662. PMID: 32109449, DOI: 10.1016/j.athoracsur.2020.01.021.Peer-Reviewed Original ResearchConceptsSignet ring cell adenocarcinomaNational Cancer DatabaseSRC tumorsACA patientsCancer DatabaseProportional hazards regression modelsCommon histologic variantRole of esophagectomyClinical stage IRole of surgeryHazards regression modelsHigh-grade tumorsSRC histologySRC patientsAdult patientsComplete resectionWorse prognosisCell adenocarcinomaEsophageal cancerEsophageal carcinomaHistologic variantsSuperior survivalEsophageal adenocarcinomaTreatment characteristicsClinical recommendations
2019
A Recurrence Predictive Model for Thymic Tumors and Its Implication for Postoperative Management: a Chinese Alliance for Research in Thymomas Database Study
Liu H, Gu Z, Qiu B, Detterbeck FC, Roden AC, Ruffini E, Okumura M, Girard N, Xiang Y, Liu Y, Du Z, Hao Y, Fu J, Zhang P, Pang L, Chen K, Wang Y, Yu Z, Mao T, Fang W, Group A. A Recurrence Predictive Model for Thymic Tumors and Its Implication for Postoperative Management: a Chinese Alliance for Research in Thymomas Database Study. Journal Of Thoracic Oncology 2019, 15: 448-456. PMID: 31726106, DOI: 10.1016/j.jtho.2019.10.018.Peer-Reviewed Original ResearchConceptsHigh-risk patientsAdjuvant therapyPostoperative yearThymic carcinomaComplete resectionPostoperative managementNeuroendocrine tumorsBootstrap-corrected C-indexChinese AlliancePostoperative adjuvant therapyIndependent predictive factorsLow-risk patientsMultivariate Cox regressionOverall survival rateAppropriate postoperative managementThymic epithelial tumorsHigh-risk groupLow-risk groupIIIA tumorsLocoregional recurrenceDisease recurrenceB3 thymomaHistologic typeNomogram modelT stage1450P Frequency of epidermal growth factor receptor (EGFR) mutations in stage IB–IIIA EGFR mutation positive non-small cell lung cancer (NSCLC) after complete tumour resection
Tsuboi M, Herbst R, John T, Grohe C, Majem M, Goldman J, Kim S, Yu C, Miziara J, Novello S, Urban D, Akewanlop C, Öztürk A, Quang B, Kowalski D, Marmol D, Marotti M, Laus G, Wu Y. 1450P Frequency of epidermal growth factor receptor (EGFR) mutations in stage IB–IIIA EGFR mutation positive non-small cell lung cancer (NSCLC) after complete tumour resection. Annals Of Oncology 2019, 30: v589. DOI: 10.1093/annonc/mdz258.010.Peer-Reviewed Original ResearchNon-small cell lung cancerBristol-Myers SquibbComplete tumor resectionEGFR mutationsBoehringer IngelheimMerck SharpAdjuvant therapyComplete resectionTumor resectionStage IB-IIIA non-small cell lung cancerEGFRm non-small cell lung cancerMutation-positive non-small cell lung cancerEarly-stage non-small cell lung cancerEGFR mutation-positive non-small cell lung cancerEli LillyOral EGFR tyrosine kinase inhibitorPositive non-small cell lung cancerT790MEpidermal growth factor receptor (EGFR) mutationsEGFR T790M mutationEGFR tyrosine kinase inhibitorsGenentech/RocheNon-squamous histologySafety of osimertinibPlacebo-controlled studyPerioperative (P) UGT1A1 genotype guided irinotecan (iri) dosing ‘gFOLFIRINOX’ for gastroesophageal adenocarcinoma (GEA).
Catenacci D, Chase L, Lomnicki S, Karrison T, Marsh R, Rampurwala M, Narula S, Alpert L, Setia N, Xiao S, Hart J, Siddiqui U, Liao C, Polite B, Kindler H, Turaga K, Prachand V, Roggin K, Ferguson M, Posner M. Perioperative (P) UGT1A1 genotype guided irinotecan (iri) dosing ‘gFOLFIRINOX’ for gastroesophageal adenocarcinoma (GEA). Journal Of Clinical Oncology 2019, 37: 4050-4050. DOI: 10.1200/jco.2019.37.15_suppl.4050.Peer-Reviewed Original ResearchPathological response gradeG3+ toxicityGastroesophageal adenocarcinomaUGT1A1 genotypeGastric bodyGastroesophageal adenocarcinoma patientsIntestinal type histologyR0 resectionR1 resectionComplete resectionHER2 statusDose reductionHistological subtypesPET responsePostoperative dataMedian ageTumor siteSurvival outcomesBiweekly cyclesResponse gradeResectionEfficacyUGT1A1DoseEndpoint
2017
Uncommon presentation of a rare tumour - incidental finding in an asymptomatic patient: case report and comprehensive review of the literature on intrapericardial solitary fibrous tumours
Czimbalmos C, Csecs I, Polos M, Bartha E, Szucs N, Toth A, Maurovich-Horvat P, Becker D, Sapi Z, Szabolcs Z, Merkely B, Vago H. Uncommon presentation of a rare tumour - incidental finding in an asymptomatic patient: case report and comprehensive review of the literature on intrapericardial solitary fibrous tumours. BMC Cancer 2017, 17: 612. PMID: 28865431, PMCID: PMC5581469, DOI: 10.1186/s12885-017-3574-0.Peer-Reviewed Original ResearchConceptsSolitary fibrous tumorFibrous tumorAsymptomatic patientsPulmonary trunkIncidental findingBackgroundA solitary fibrous tumourRegular MRI follow-upSpindle cell mesenchymal tumorsScreening chest X-rayCoronary Computed Tomography AngiographyAsymptomatic female patientLate gadolinium enhancement imagingMRI follow-upCardiac magnetic resonanceEnlarged cardiac silhouetteLong-term followComputed tomography angiographyFirst-pass perfusionGadolinium-enhanced imagesChest X-rayInversion recovery imagesIntermediate signal intensityProton density-weighted imagesPatternless patternComplete resectionModified Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy for Hepatoblastoma in a Small Infant
Hong J, Kim J, Browning M, Wagner A, Lerret S, Segura A, Zimmerman M. Modified Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy for Hepatoblastoma in a Small Infant. Annals Of Surgery 2017, 266: e16-e17. PMID: 28288067, DOI: 10.1097/sla.0000000000002217.Peer-Reviewed Original ResearchConceptsFuture liver remnantInsufficient future liver remnantPortal vein ligationSmall infantsStaged HepatectomyLiver partitionVein ligationTumor recurrence-free survivalModified ALPPS procedureRecurrence-free survivalAssociating liver partitionSurgical treatment alternativesALPPS procedureComplete resectionHepatobiliary malignanciesLiver remnantSurgical managementHepatic tumorsHepatectomy proceduresHepatoblastomaALPPSTreatment alternativesHepatectomyInfantsClinical applicationAdjuvant Chemotherapy Guided by Molecular Profiling and Improved Outcomes in Early Stage, Non–Small-Cell Lung Cancer
Woodard GA, Wang SX, Kratz JR, Zoon-Besselink CT, Chiang CY, Gubens MA, Jahan TM, Blakely CM, Jones KD, Mann MJ, Jablons DM. Adjuvant Chemotherapy Guided by Molecular Profiling and Improved Outcomes in Early Stage, Non–Small-Cell Lung Cancer. Clinical Lung Cancer 2017, 19: 58-64. PMID: 28645632, DOI: 10.1016/j.cllc.2017.05.015.Peer-Reviewed Original ResearchConceptsHigh-risk patientsDisease-free survivalLow-risk patientsAdjuvant chemotherapyNational Comprehensive Cancer Network guidelinesCell lung cancer patientsMolecular profilingEarly-stage NSCLCHigh-risk criteriaLog-rank analysisCell lung cancerHigh-risk designationLung cancer patientsKaplan-Meyer estimatesAdjuvant treatmentNonsquamous NSCLCOccult metastasesStage IAStage NSCLCAdjuvant interventionClinicopathologic characteristicsComplete resectionConsecutive patientsDisease recurrenceNCCN criteriaComparison of surgical approach and extent of resection for Masaoka-Koga Stage I and II thymic tumours in Europe, North America and Asia: an International Thymic Malignancy Interest Group retrospective database analysis†
Fang W, Yao X, Antonicelli A, Gu Z, Detterbeck F, Vallières E, Aye RW, Farivar AS, Huang J, Shang Y, Louie BE. Comparison of surgical approach and extent of resection for Masaoka-Koga Stage I and II thymic tumours in Europe, North America and Asia: an International Thymic Malignancy Interest Group retrospective database analysis†. European Journal Of Cardio-Thoracic Surgery 2017, 52: 26-32. PMID: 28329118, PMCID: PMC6279116, DOI: 10.1093/ejcts/ezx042.Peer-Reviewed Original ResearchConceptsExtent of resectionThymic tumorsStage IAsian patientsSurgical approachOnly independent predictive factorMasaoka-Koga stage IMore stage IOutcomes of patientsPathological stage IIndependent predictive factorsIndependent risk factorOverall survival rateCumulative recurrence rateSmaller tumor sizeRetrospective database analysisNorth American patientsPartial thymectomyAdjuvant therapyParaneoplastic syndromeThymic carcinomaOverall survivalPerformance statusComplete resectionMyasthenia gravis
2016
Hepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential
Gill RM, Buelow B, Mather C, Joseph NM, Alves V, Brunt EM, Liu TC, Makhlouf H, Marginean C, Nalbantoglu I, Sempoux C, Snover DC, Thung SN, Yeh MM, Ferrell LD. Hepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential. Human Pathology 2016, 54: 143-151. PMID: 27090685, PMCID: PMC5242228, DOI: 10.1016/j.humpath.2016.03.018.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCell ProliferationClass I Phosphatidylinositol 3-KinasesDiagnosis, DifferentialDNA Mutational AnalysisFemaleGTP-Binding Protein alpha Subunits, Gq-G11Hemangioma, CavernousHemangiosarcomaHumansImmunohistochemistryKi-67 AntigenLiver NeoplasmsMaleMiddle AgedMutationNeoplasm GradingPhosphatidylinositol 3-KinasesPredictive Value of TestsProto-Oncogene Proteins c-mycTerminology as TopicTumor Suppressor Protein p53Vascular NeoplasmsYoung AdultConceptsHepatic small vessel neoplasmMalignant potentialCavernous hemangiomaVascular neoplasmImmunohistochemical stainsProliferative indexKi-67 proliferative indexTumour cell proliferative indexDisseminated intravascular coagulationKasabach-Merritt syndromePossible malignant potentialLow-grade tumorsUncertain malignant potentialRare vascular neoplasmCapture-based next-generation sequencingHistologic differential diagnosisCell proliferative indexC-myc stainingStrong p53Intravascular coagulationComplete resectionHepatic angiosarcomaDifferential diagnosisInfiltrative bordersAngiosarcoma
2015
Unresectable intrahepatic cholangiocarcinoma: Systemic plus hepatic arterial infusion chemotherapy is associated with longer survival in comparison with systemic chemotherapy alone
Konstantinidis I, Groot Koerkamp B, Do R, Gönen M, Fong Y, Allen P, D'Angelica M, Kingham T, DeMatteo R, Klimstra D, Kemeny N, Jarnagin W. Unresectable intrahepatic cholangiocarcinoma: Systemic plus hepatic arterial infusion chemotherapy is associated with longer survival in comparison with systemic chemotherapy alone. Cancer 2015, 122: 758-765. PMID: 26695839, PMCID: PMC4764409, DOI: 10.1002/cncr.29824.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBile Duct NeoplasmsBile Ducts, IntrahepaticCamptothecinCholangiocarcinomaDeoxycytidineDisease-Free SurvivalFemaleFloxuridineFluorouracilGemcitabineHepatic ArteryHumansInfusions, Intra-ArterialIrinotecanMaleMiddle AgedMitomycinRetrospective StudiesSurvival RateConceptsHepatic arterial infusionHepatic arterial infusion chemotherapySystemic chemotherapyIntrahepatic cholangiocarcinomaOverall survivalUnresectable tumorsPatients treated with systemic chemotherapyCombination groupCombination of systemic chemotherapyMemorial Sloan Kettering Cancer CenterAssociated with longer survivalAssociated with poor survivalMedian overall survivalUnresectable intrahepatic cholangiocarcinomaArterial infusion chemotherapyLymph node diseaseOutcomes of patientsLog-rank testKaplan-Meier analysisAssociated with greater survivalComplete resectionInfusion chemotherapyConsecutive patientsNode diseaseArterial infusionOssifying Parotid Carcinoma ex Pleomorphic Adenoma
Mohan S, Puram S, Yarlagadda B, Nosé V, Deschler D. Ossifying Parotid Carcinoma ex Pleomorphic Adenoma. Case Reports In Otolaryngology 2015, 2015: 395358. PMID: 26075129, PMCID: PMC4449911, DOI: 10.1155/2015/395358.Peer-Reviewed Original ResearchCarcinoma ex pleomorphic adenomaEx pleomorphic adenomaParotid massBenign parotid massesPleomorphic adenomaInitial pathological analysisAreas of carcinomaComputed tomography scanFine-needle aspirationFive-year historyComplete resectionPeripheral calcificationTomography scanPathological analysisUnique caseExtensive ossificationAdenomas
2014
Impact of Adjuvant Treatment for Microscopic Residual Disease After Non-Small Cell Lung Cancer Surgery
Hancock JG, Rosen JE, Antonicelli A, Moreno A, Kim AW, Detterbeck FC, Boffa DJ. Impact of Adjuvant Treatment for Microscopic Residual Disease After Non-Small Cell Lung Cancer Surgery. The Annals Of Thoracic Surgery 2014, 99: 406-413. PMID: 25528723, DOI: 10.1016/j.athoracsur.2014.09.033.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerPositive surgical marginsCell lung cancerSurgical marginsR1 resectionNSCLC patientsResidual diseaseLung cancerNational Cancer Data BasePathologic stage IMicroscopic residual diseaseAdministration of chemotherapyOptimal treatment approachStage pIR1 patientsAdjuvant treatmentPostoperative administrationAdjuvant approachIncomplete resectionPostoperative radiationComplete resectionImproved survivalPI patientsPositive marginsSuperior survivalPrognostic factors in fibrolamellar hepatocellular carcinoma in young people
Darcy D, Malek M, Kobos R, Klimstra D, DeMatteo R, La Quaglia M. Prognostic factors in fibrolamellar hepatocellular carcinoma in young people. Journal Of Pediatric Surgery 2014, 50: 153-156. PMID: 25598114, PMCID: PMC4558902, DOI: 10.1016/j.jpedsurg.2014.10.039.Peer-Reviewed Original ResearchConceptsComplete resectionPRETEXT stageFibrolamellar hepatocellular carcinomaFL-HCCOverall survivalMetastatic diseaseHepatocellular carcinomaAssociated with complete resectionPositive lymph node statusNegative regional lymph nodesFive-year OSAssociated with poor prognosisConsecutive pediatric patientsStage 4 diseaseLymph node statusMedian Follow-UpStage 1 diseaseImpact of resectionRegional lymph nodesParenchymal metastasesN1 diseaseNodal involvementNodal statusRegional lymphadenectomyNode statusOutcome of primary neuroendocrine tumors of the thymus: A joint analysis of the International Thymic Malignancy Interest Group and the European Society of Thoracic Surgeons databases
Filosso PL, Yao X, Ahmad U, Zhan Y, Huang J, Ruffini E, Travis W, Lucchi M, Rimner A, Antonicelli A, Guerrera F, Detterbeck F, Committee E. Outcome of primary neuroendocrine tumors of the thymus: A joint analysis of the International Thymic Malignancy Interest Group and the European Society of Thoracic Surgeons databases. Journal Of Thoracic And Cardiovascular Surgery 2014, 149: 103-109.e2. PMID: 25308116, DOI: 10.1016/j.jtcvs.2014.08.061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overChemotherapy, AdjuvantDatabases, FactualFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingNeuroendocrine TumorsProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesRisk FactorsThymectomyThymus NeoplasmsTime FactorsTreatment OutcomeYoung AdultConceptsInternational Thymic Malignancy Interest GroupMasaoka-Koga stageOverall survivalCompleteness of resectionPrimary neuroendocrine tumorThoracic Surgeons databasePrognostic factorsHistologic subtypeSurgeons databaseNeuroendocrine tumorsHigher biologic aggressivenessMasaoka-Koga stage ICommon histologic subtypeMedian overall survivalEuropean SocietyRetrospective multicenter studyKaplan-Meier methodStrong prognostic factorLog-rank testInduction therapyAdjuvant treatmentCumulative incidenceResection statusComplete resectionMulticenter studyLearning Curve to Lymph Node Resection in Minimally Invasive Esophagectomy for Cancer
Dhamija A, Rosen J, Dhamija A, Rothberg BE, Kim A, Detterbeck F, Boffa D. Learning Curve to Lymph Node Resection in Minimally Invasive Esophagectomy for Cancer. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2014, 9: 286-291. DOI: 10.1177/155698451400900405.Peer-Reviewed Original ResearchLymph node yieldComplete resectionInvasive esophagectomyNode yieldSurgeon experienceMinimally Invasive EsophagectomyLymph node resectionSingle-surgeon seriesHigh-grade dysplasiaNode resectionComplete lymphadenectomyLymph nodesSurgical marginsOncologic efficacyRetrospective reviewNegative marginsOncologic aspectsEsophageal cancerInstitutional databaseInvasive approachLate subgroupsOpen approachMultivariate analysisResectionSafe alternativeLearning Curve to Lymph Node Resection in Minimally Invasive Esophagectomy for Cancer
Dhamija A, Rosen JE, Dhamija A, Rothberg BE, Kim AW, Detterbeck FC, Boffa DJ. Learning Curve to Lymph Node Resection in Minimally Invasive Esophagectomy for Cancer. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2014, 9: 286-291. PMID: 25084251, DOI: 10.1097/imi.0000000000000082.Peer-Reviewed Original ResearchConceptsLymph node yieldComplete resectionInvasive esophagectomyNode yieldSurgeon experienceMinimally Invasive EsophagectomyLymph node resectionSingle-surgeon seriesHigh-grade dysplasiaNode resectionComplete lymphadenectomyLymph nodesRetrospective reviewSurgical marginsOncologic efficacyNegative marginsOncologic aspectsInstitutional databaseEsophageal cancerInvasive approachLate subgroupsOpen approachMultivariate analysisResectionSafe alternative
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