2024
BSLM-10 MOLECULAR AND HISTOLOGICAL CHARACTERIZATION OF NSCLC PROGRESSION TO LEPTOMENINGEAL METASTASIS WITH COMORBID INTRAPARENCHYMAL DISEASE
Kandigian S, Chande S, Dolezal D, Tang T, Wang D, Arnal-Estapé A, Cheok S, McGuone D, Liu Y, Goldberg S, Blondin N, Chiang V, Nguyen D. BSLM-10 MOLECULAR AND HISTOLOGICAL CHARACTERIZATION OF NSCLC PROGRESSION TO LEPTOMENINGEAL METASTASIS WITH COMORBID INTRAPARENCHYMAL DISEASE. Neuro-Oncology Advances 2024, 6: i7-i7. PMCID: PMC11296776, DOI: 10.1093/noajnl/vdae090.020.Peer-Reviewed Original ResearchNon-small cell lung cancerLeptomeningeal diseaseCentral nervous systemLeptomeningeal metastasesParenchymal metastasesCerebrospinal fluidTumor cellsTyrosine kinase inhibitor treatmentCell lung cancerKinase inhibitor treatmentCerebrospinal fluid of patientsCell linesCerebral lateral ventriclesIntra-arterial injectionTGF-b signalingIn vivo passageIntraparenchymal diseaseMechanisms of progressionTumor microenvironmentMultiplex immunofluorescenceAggressive treatmentLeptomeningeal infiltrationPerivascular invasionIntraparenchymal metastasesMurine model
2019
Somatic PRKAR1A mutation in sporadic atrial myxoma with cerebral parenchymal metastases: a case report
Roque A, Kimbrough T, Traner C, Baehring JM, Huttner A, Adams J, Canosa S, Sklar J, Madri JA. Somatic PRKAR1A mutation in sporadic atrial myxoma with cerebral parenchymal metastases: a case report. Journal Of Medical Case Reports 2019, 13: 389. PMID: 31874650, PMCID: PMC6930684, DOI: 10.1186/s13256-019-2317-z.Peer-Reviewed Original ResearchMeSH KeywordsBrain NeoplasmsCarney ComplexChemoradiotherapyCyclic AMP-Dependent Protein Kinase RIalpha SubunitDopamine AgentsExome SequencingFemaleGene Expression Regulation, NeoplasticGenes, Tumor SuppressorGerm-Line MutationHeart NeoplasmsHumansIntracranial HemorrhagesMemantineMiddle AgedMyxomaTreatment OutcomeConceptsAtrial myxomaSporadic tumorsExtra-cardiac complicationsMetastatic cardiac myxomaMajority of tumorsDissemination of tumorsIntracranial hemorrhagic lesionsWhole-exome sequencingAutosomal dominant conditionConclusionsOur patientsSporadic myxomasInvasive tumor cellsParenchymal metastasesCardiac myxomaCase reportClinical behaviorHemorrhagic lesionsAneurysm formationBenign neoplasmsMyxomaSporadic lesionsVascular wallCarney complexTumorsGermline mutations
2018
NIMG-20. DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING FINDINGS IN PATIENTS WITH CENTRAL NERVOUS SYSTEM INVOLVEMENT OF SYSTEMIC LYMPHOMA
Roque A, Galluzzo D, Barbiero F, Fulbright R, Baehring J. NIMG-20. DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING FINDINGS IN PATIENTS WITH CENTRAL NERVOUS SYSTEM INVOLVEMENT OF SYSTEMIC LYMPHOMA. Neuro-Oncology 2018, 20: vi180-vi180. PMCID: PMC6217327, DOI: 10.1093/neuonc/noy148.746.Peer-Reviewed Original ResearchSystemic non-Hodgkin lymphomaADC lesionsWhite matterSystemic lymphomaSystem involvementDiffusion-weighted magnetic resonance imaging (DWI) findingsMagnetic resonance imaging (MRI) findingsPeritumoral regionAppropriate clinical settingNervous system involvementResonance Imaging FindingsNon-Hodgkin lymphomaLocation of lesionsQuantitative ADC analysisSignificant differencesPost Hoc AnalysisNumber of lesionsDiffusion-weighted imagingNormal white matterAnatomical MRI sequencesCNS disseminationCNS involvementCNS spreadParenchymal metastasesBiopsy confirmation
2014
Prognostic factors in fibrolamellar hepatocellular carcinoma in young people
Darcy D, Malek M, Kobos R, Klimstra D, DeMatteo R, La Quaglia M. Prognostic factors in fibrolamellar hepatocellular carcinoma in young people. Journal Of Pediatric Surgery 2014, 50: 153-156. PMID: 25598114, PMCID: PMC4558902, DOI: 10.1016/j.jpedsurg.2014.10.039.Peer-Reviewed Original ResearchConceptsComplete resectionPRETEXT stageFibrolamellar hepatocellular carcinomaFL-HCCOverall survivalMetastatic diseaseHepatocellular carcinomaAssociated with complete resectionPositive lymph node statusNegative regional lymph nodesFive-year OSAssociated with poor prognosisConsecutive pediatric patientsStage 4 diseaseLymph node statusMedian Follow-UpStage 1 diseaseImpact of resectionRegional lymph nodesParenchymal metastasesN1 diseaseNodal involvementNodal statusRegional lymphadenectomyNode status
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