2025
Fine‐Needle Aspiration Biopsy of Adrenal Gland Lesions: The Roles of Image Guidance, Rapid On‐Site Evaluation and Additional Tissue Sampling
Yu S, Dolezal D, Aslanian H, Cai G. Fine‐Needle Aspiration Biopsy of Adrenal Gland Lesions: The Roles of Image Guidance, Rapid On‐Site Evaluation and Additional Tissue Sampling. Cytopathology 2025, 36: 228-235. PMID: 39878416, DOI: 10.1111/cyt.13472.Peer-Reviewed Original ResearchFine-needle aspirationDiagnosis of adrenal lesionsCytological diagnostic categoriesAdrenal lesionsIndeterminate cytological diagnosisNon-diagnostic rateCytological diagnosisEndoscopic ultrasoundEUS-FNAOn-site evaluationNon-diagnosticImage guidanceComputed tomographyCT-guided fine-needle aspirationEvaluation of adrenal lesionsFine-needle aspiration diagnosisTissue samplesFine-needle aspiration proceduresLeft adrenal lesionRight adrenal lesionRapid on-site evaluationNon-ROSE groupIncrease diagnostic yieldImage guidance methodsCore tissue biopsies
2024
TERT promoter mutations and additional molecular alterations in thyroid fine-needle aspiration specimens: A multi-institutional study with histopathologic follow-up
Abi-Raad R, Shi Q, Chen F, Antony V, Hsiao W, Simsir A, Liu X, Brandler T, Cai G. TERT promoter mutations and additional molecular alterations in thyroid fine-needle aspiration specimens: A multi-institutional study with histopathologic follow-up. American Journal Of Clinical Pathology 2024, 163: 251-257. PMID: 39250709, DOI: 10.1093/ajcp/aqae117.Peer-Reviewed Original ResearchTERT promoter mutationsHistopathologic follow-upFine-needle aspirationTERT mutationsMolecular alterationsFollow-upPromoter mutationsThyroid carcinomaFine-needle aspiration diagnosisFine-needle aspiration specimensThyroid fine-needle aspiration specimensBenign thyroid neoplasmsSurgical Follow-UpAssociated with malignancyMulti-institutional studyThyroSeq v3Thyroid neoplasmsAspiration specimensTumor behaviorMalignant neoplasmsCarcinomaMalignancyNeoplasmsThyroidMutationsRisk of Pancreatitis After Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Pancreatic Cystic Lesions: A Systematic Review and Meta-Analysis
Magahis P, Chhoda A, Berzin T, Farrell J, Wright D, Rizvi A, Hanscom M, Carr-Locke D, Sampath K, Sharaiha R, Mahadev S. Risk of Pancreatitis After Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Pancreatic Cystic Lesions: A Systematic Review and Meta-Analysis. The American Journal Of Gastroenterology 2024, 119: 2174-2186. PMID: 38976379, DOI: 10.14309/ajg.0000000000002942.Peer-Reviewed Original ResearchPancreatic cystic lesionsPancreatitis riskSystematic reviewEUS-TTNBRisk factorsCystic lesionsDerSimonian-Laird methodEnglish-language studiesEndoscopic ultrasound-guided fine-needle aspirationRandom-effects modelUltrasound-guided fine-needle aspirationRisk of post-procedure pancreatitisPredisposing characteristicsFine-needle-aspirationRisk of pancreatitisFine-needle aspirationPost-procedure pancreatitisLaird methodMeta-RegressionSystematic searchPooled riskMeta-analyzedMeta-analysisPancreatitis eventsNeedle aspirationReevaluation of ovarian cyst fine-needle aspiration cytology: A 10-year institutional experience
Takeda K, Cai G, Adeniran A, Sun T. Reevaluation of ovarian cyst fine-needle aspiration cytology: A 10-year institutional experience. American Journal Of Clinical Pathology 2024, 162: aqae077. PMID: 38916141, DOI: 10.1093/ajcp/aqae077.Peer-Reviewed Original ResearchCystic fluid cytologyFine-needle aspirationFluid cytologyAmerican College of Obstetricians and Gynecologists guidelinesSingle-institution cohortRate of malignancySurgical pathology diagnosisFNA casesGynecologists guidelinesCytological diagnosisFNA cytologyPathological diagnosisPatient demographicsInstitutional experienceSurgical pathologyOvarian cyst fluidClinical circumstancesAmerican CollegeCytologyRadiological informationMalignancyGold standardCyst fluidModerate sensitivityPotential safety concernsImproving diagnostic yield of pancreatic serous cystadenoma with cyst fluid ancillary testing, adjunct immunohistochemistry, and additional fine‐needle biopsy sampling
Wang X, Zhang X, Hui P, Cai G. Improving diagnostic yield of pancreatic serous cystadenoma with cyst fluid ancillary testing, adjunct immunohistochemistry, and additional fine‐needle biopsy sampling. Cancer Cytopathology 2024, 132: 425-434. PMID: 38450993, DOI: 10.1002/cncy.22808.Peer-Reviewed Original ResearchDiagnosis of serous cystadenomaFine-needle biopsyFine-needle aspirationCyst fluid carcinoembryonic antigenPancreatic serous cystadenomaSerous cystadenomaAncillary testsCEA levelsCytological diagnosisFine-needle aspiration cell blocksFine-needle aspiration diagnosisFine-needle aspiration casesCyst fluid CEA levelsSerous cystadenoma casesFluid carcinoembryonic antigenLow CEA levelFine-needle biopsy samplingKRAS mutation analysisWild-type KRASConcurrent fine-needle aspirationImprove diagnostic yieldInhibin immunostainingAtypical cellsCytology casesDiagnostic yield
2023
Respiratory Tract
Sardana R, Cai G. Respiratory Tract. 2023, 189-215. DOI: 10.1007/978-3-031-44289-6_11.Peer-Reviewed Original ResearchRespiratory tractNeedle aspirationKey cytomorphologic featuresCommon inflammatory conditionSpectrum of diagnosesTransbronchial needle aspirationFine-needle aspirationFalse-negative diagnosesBronchoalveolar lavageClinical symptomsBronchial washPulmonary pathologyInflammatory conditionsRespiratory cytologyBrush smearsCytomorphologic featuresCytological evaluationCytologic specimensInfectious diseasesDiagnosisTractDiagnostic processAspirationInitial investigationLavagePancreas
Wang X, Cai G. Pancreas. 2023, 229-245. DOI: 10.1007/978-3-031-44289-6_13.Peer-Reviewed Original ResearchFine-needle aspirationUtility of parathyroid hormone immunocytochemistry in fine needle aspiration diagnosis of parathyroid tissue
Sardana R, Abi‐Raad R, Adeniran A, Cai G. Utility of parathyroid hormone immunocytochemistry in fine needle aspiration diagnosis of parathyroid tissue. Cytopathology 2023, 34: 597-602. PMID: 37534757, DOI: 10.1111/cyt.13283.Peer-Reviewed Original ResearchConceptsParathyroid tissueFine-needle aspirationPTH casesClinicopathological characteristicsCytomorphological featuresThyroid lesionsThinPrep slidesFine needle aspiration diagnosisNeck soft tissuePatients' clinicopathological characteristicsNeedle aspiration diagnosisNegative predictive valueClinical suspicionStudy cohortPathology databaseRetrospective studyDiagnostic challengeDifferential diagnosisInstitutional experienceNeedle aspirationCytological diagnosisFNA casesAspiration diagnosisPredictive valueAdjunct testMediastinal Staging in Non–Small-Cell Lung Cancer: Saying Goodbye to Mediastinoscopy
Dunne E, Fick C, Jones D. Mediastinal Staging in Non–Small-Cell Lung Cancer: Saying Goodbye to Mediastinoscopy. Journal Of Clinical Oncology 2023, 41: 3785-3790. PMID: 37267507, PMCID: PMC10419653, DOI: 10.1200/jco.23.00867.Peer-Reviewed Original ResearchConceptsMediastinal lymph nodesCell lung cancerConfirmatory mediastinoscopyFine-needle aspirationPositron emission tomographyLymph nodesNodal metastasisEBUS-FNALung cancerEndobronchial ultrasound-guided fine-needle aspirationOncology Grand Rounds seriesNegative findingsUltrasound-guided fine-needle aspirationThoracic Surgeons guidelinesRandomized noninferiority trialStandard of careTumor genomic analysisOwn clinical practiceResectable NSCLCN1 diseaseNodal diseaseMediastinal stagingAccurate stagingForceps biopsySurgeons guidelines
2022
Clinical and Radiologic Factors Associated With Detection of Mycobacterium tuberculosis in Children Under 5 Years old Using Invasive and Noninvasive Sample Collection Techniques—Kenya
Smith J, Song R, McCarthy K, Mchembere W, Click E, Cain K. Clinical and Radiologic Factors Associated With Detection of Mycobacterium tuberculosis in Children Under 5 Years old Using Invasive and Noninvasive Sample Collection Techniques—Kenya. Open Forum Infectious Diseases 2022, 9: ofac560. PMID: 36386048, PMCID: PMC9664973, DOI: 10.1093/ofid/ofac560.Peer-Reviewed Original ResearchSpecimen collection techniquesRadiologic factorsYoung childrenProspective cohort studyFine-needle aspirationHistory of exposurePublic health concernCritical public health concernBacteriologic confirmationAirway compressionCervical lymphadenopathyRadiological factorsCohort studyPediatric tuberculosisTB casesPresumptive tuberculosisClinical managementImmunologic evidenceNeedle aspirationPositive specimenDiagnostic testingTuberculosisLogistic regressionHealth concernMycobacterium tuberculosisComprehensive molecular profiling of pancreatic ductal adenocarcinoma in FNA, biopsy, and resection specimens
Razzano D, Bouza SJ, Hernandez PV, Wang M, Robert ME, Walther Z, Cai G. Comprehensive molecular profiling of pancreatic ductal adenocarcinoma in FNA, biopsy, and resection specimens. Cancer Cytopathology 2022, 130: 726-734. PMID: 35511415, DOI: 10.1002/cncy.22589.Peer-Reviewed Original ResearchConceptsFine-needle aspirationFine-needle biopsyPancreatic ductal adenocarcinomaOncomine Comprehensive AssayResection specimensMolecular alterationsMolecular testingFNB samplesDuctal adenocarcinomaTherapeutic implicationsSuccess rateComprehensive molecular analysisComprehensive molecular testingComprehensive molecular profilingPotential therapeutic implicationsSimilar success ratesResection casesKRAS mutationsFNB specimensFNA materialFNA specimensAmplification analysisMolecular profilingFusion assessmentGene mutations
2021
Anaplastic Thyroid Carcinoma: Cytomorphologic Features on Fine-Needle Aspiration and Associated Diagnostic Challenges
Podany P, Abi-Raad R, Barbieri A, Garritano J, Prasad ML, Cai G, Adeniran AJ, Gilani SM. Anaplastic Thyroid Carcinoma: Cytomorphologic Features on Fine-Needle Aspiration and Associated Diagnostic Challenges. American Journal Of Clinical Pathology 2021, 157: 608-619. PMID: 34661606, PMCID: PMC8973262, DOI: 10.1093/ajcp/aqab159.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAnaplastic thyroid carcinomaFine-needle aspirationCytologic featuresATC casesTumor cellsThyroid carcinomaControl groupDiagnosis of ATCAcute inflammatory cellsKey cytologic featuresNuclear membrane irregularitySingle tumor cellsAggressive malignancyInflammatory cellsClinical historyDiagnostic challengePatient prognosisInclusion criteriaNeedle aspirationCytomorphologic featuresEarly diagnosisEpithelioid cytomorphologyNuclear pleomorphismAvailable slidesElectronic databasesDiagnostic renal mass biopsy is associated with individual categories of PADUA and RENAL nephrometry scores: Analysis of diagnostic and concordance rates with surgical resection
Fonseca RB, Straub Hogan MM, Kapp ME, Cate F, Coogan A, Arora S, Gordetsky J, Smelser WW, Clark PE, Cates J, Giannico GA. Diagnostic renal mass biopsy is associated with individual categories of PADUA and RENAL nephrometry scores: Analysis of diagnostic and concordance rates with surgical resection. Urologic Oncology Seminars And Original Investigations 2021, 39: 371.e7-371.e15. PMID: 33773915, PMCID: PMC8205938, DOI: 10.1016/j.urolonc.2021.02.022.Peer-Reviewed Original ResearchConceptsCore needle biopsySmall renal massesFine-needle aspirationRenal mass biopsyDiagnostic core needle biopsyDiagnostic fine needle aspirationRenal massesNon-diagnostic rateCystic massMass biopsyConcordance rateEndophytic growthRenal sinus invasionRENAL nephrometry scoreSurgical resection specimensSurgical resectionNephrometry scoreSinus invasionRetrospective studyPreoperative aspectsResection specimensSingle institutionClinical managementSubset analysisNeedle biopsy
2020
Human germinal centres engage memory and naive B cells after influenza vaccination
Turner JS, Zhou JQ, Han J, Schmitz AJ, Rizk AA, Alsoussi WB, Lei T, Amor M, McIntire KM, Meade P, Strohmeier S, Brent RI, Richey ST, Haile A, Yang YR, Klebert MK, Suessen T, Teefey S, Presti RM, Krammer F, Kleinstein SH, Ward AB, Ellebedy AH. Human germinal centres engage memory and naive B cells after influenza vaccination. Nature 2020, 586: 127-132. PMID: 32866963, PMCID: PMC7566073, DOI: 10.1038/s41586-020-2711-0.Peer-Reviewed Original ResearchConceptsB cell clonesInfluenza vaccinationGerminal center B cellsB cellsGerminal center reactionCell clonesLymph nodesMonoclonal antibodiesPre-existing memory B cellsGerminal center B cell responsesStrain-specific monoclonal antibodiesCenter reactionUltrasound-guided fine-needle aspirationMajor public health threatEarly plasmablast responsesInfluenza virus vaccinationSeasonal influenza vaccinationCross-reactive monoclonal antibodiesB cell responsesMemory B cellsB-cell originFine-needle aspirationNaive B cellsPublic health threatHuman germinal centreThyroSeq v2 Testing: Impact on Cytologic Diagnosis, Management, and Cost of Care in Patients with Thyroid Nodule
Fazeli S, Zehr B, Amraei R, Toraldo G, Guan H, Kindelberger D, Lee S, Cerda S. ThyroSeq v2 Testing: Impact on Cytologic Diagnosis, Management, and Cost of Care in Patients with Thyroid Nodule. Thyroid 2020, 30: 1528-1534. PMID: 32349630, DOI: 10.1089/thy.2019.0191.Peer-Reviewed Original ResearchConceptsAUS/FLUSCost of careIndeterminate cytology resultsThyroid nodulesThyroSeq v2Cytology resultsCytologic diagnosisFN/SFN categoriesUndetermined significance/follicular lesionMolecular testsRate of overtreatmentRate of surgeryRate of malignancyOutcome of managementFollicular neoplasm/Fine-needle aspirationIndeterminate cytologic diagnosisOverall rateFN/SFNThyroid fine-needle aspirationNovel molecular testsThyroSeq testingLack of decreaseConsecutive patientsRetrospective studyPediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee
Christison-Lagay ER, Baertschiger RM, Dinauer C, Francis G, Malek M, Lautz T, Aldrink J, Grant C, Rhee D, Ehrlich P, Dasgupta R, Abdessalam S, Committee O. Pediatric differentiated thyroid carcinoma: An update from the APSA Cancer Committee. Journal Of Pediatric Surgery 2020, 55: 2273-2283. PMID: 32553450, DOI: 10.1016/j.jpedsurg.2020.05.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsThyroid cancerPediatric DTCAPSA Cancer CommitteeSurgical therapeutic approachUnresectable progressive diseaseLymph node basinCornerstone of treatmentAutoimmune thyroid diseaseLong-term recurrenceFine-needle aspirationNode basinTotal thyroidectomyProgressive diseaseSurgical resectionRadiological featuresSurvival outcomesCancer CommitteeThyroid diseaseTreatment strategiesFamily historyTreatment decisionsNeedle aspirationTherapeutic approachesThyroid carcinomaIodine deficiencyEndoscopic ultrasound‐guided fine needle aspiration of accessory spleen: Cytomorphologic features and diagnostic considerations
Gilani SM, Muniraj T, Farrell JJ, Aslanian HR, Cai G. Endoscopic ultrasound‐guided fine needle aspiration of accessory spleen: Cytomorphologic features and diagnostic considerations. Diagnostic Cytopathology 2020, 48: 623-628. PMID: 32315514, DOI: 10.1002/dc.24434.Peer-Reviewed Original ResearchConceptsEndoscopic ultrasound-guided fine-needle aspirationUltrasound-guided fine-needle aspirationFine-needle aspirationProminent vascularityLymphoid cellsLarge platelet aggregatesCytomorphologic featuresNeedle aspirationNeoplastic processNon-specific clinical symptomsKey cytomorphologic featuresMass-forming lesionsPancreatic tail regionMixed inflammatory cellsKey cytologic featuresSmall-sized lymphocytesPancreas/Most patientsMale patientsSurgical managementClinical symptomsInflammatory cellsMean agePeripancreatic tissueDiagnostic challenge
2019
Economics, Regulations, and Trends in Practice
Levi A, Cai G. Economics, Regulations, and Trends in Practice. 2019, 407-412. DOI: 10.1007/978-3-030-21799-0_15.ChaptersFine-needle aspirationImaging-guided biopsyLaboratory resource utilizationPractice patternsNeedle aspiration- Metastatic tumorsLiver lesionsCore needle biopsyFine-needle aspirationHepatocyte lesionsPrimary tumorDefinite diagnosisDiagnostic challengeNeedle biopsyAncillary studiesHepatocellular carcinomaNeedle aspirationCytomorphologic featuresDiagnostic pitfallsLesion lesionsLesionsCytological featuresTumorsBiopsyMorphologic comparisonCholangiocarcinomaCarcinomaLiverDiagnosis
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