2024
The molecular basis of sugar detection by an insect taste receptor
Gomes J, Singh-Bhagania S, Cenci M, Chacon Cordon C, Singh M, Butterwick J. The molecular basis of sugar detection by an insect taste receptor. Nature 2024, 629: 228-234. PMID: 38447670, PMCID: PMC11062906, DOI: 10.1038/s41586-024-07255-w.Peer-Reviewed Original ResearchLigand-binding pocketGustatory receptorsD-fructoseMolecular basisStructure-guided mutagenesisSilkworm Bombyx moriPatterns of chemical groupsIon conductivitySugar selectivityAllosteric pathwaysBombyx moriExperimental binding assaysReceptor-ligand interactionsL-sorboseComputational dockingAromatic residuesActive ligandsAllosteric couplingConformational changesSugar detectionBinding assaysFunctional assaysChemical specificityChemical groupsTaste receptors
2023
The neuropeptidergic connectome of C. elegans
Ripoll-Sánchez L, Watteyne J, Sun H, Fernandez R, Taylor S, Weinreb A, Bentley B, Hammarlund M, Miller D, Hobert O, Beets I, Vértes P, Schafer W. The neuropeptidergic connectome of C. elegans. Neuron 2023, 111: 3570-3589.e5. PMID: 37935195, PMCID: PMC7615469, DOI: 10.1016/j.neuron.2023.09.043.Peer-Reviewed Original ResearchConceptsNervous systemSynaptic wiring diagramGene expression datasetsReceptor-ligand interactionsStudied neuronsKey network hubNeuronal connectionsSignaling cascadesBrain functionInput connectivityNeuromodulatory signalingChemical synapsesPeptidergic neuromodulationBiochemical analysisEssential roleNeural basisNeuropeptidesConnectomeNetwork hubsWiring diagramSimilar patternReceptor–ligand interaction controls microglial chemotaxis and amelioration of Alzheimer's disease pathology
Lau S, Fu A, Ip N. Receptor–ligand interaction controls microglial chemotaxis and amelioration of Alzheimer's disease pathology. Journal Of Neurochemistry 2023, 166: 891-903. PMID: 37603311, DOI: 10.1111/jnc.15933.Peer-Reviewed Original ResearchConceptsDanger-associated molecular patternsMicroglial chemotaxisAD pathogenesisAlzheimer's diseaseMicroglial functionRepertoire of surface receptorsHyperphosphorylated tauAlzheimer's disease pathologyAmyloid-betaMolecular machineryMicroglial receptorsReceptor-ligand interactionsPhagocytic clearanceReceptor-ligand axisMolecular patternsSurface receptorsFunctional transitionDisease pathologyChemotaxisBrain homeostasisAberrant synaptic pruningClearance activityCritical stepsReceptorsAmyloid
2020
From Chickens to Humans: The Importance of Peptide Repertoires for MHC Class I Alleles
Kaufman J. From Chickens to Humans: The Importance of Peptide Repertoires for MHC Class I Alleles. Frontiers In Immunology 2020, 11: 601089. PMID: 33381122, PMCID: PMC7767893, DOI: 10.3389/fimmu.2020.601089.Peer-Reviewed Original ResearchConceptsKiller immunoglobulin-like receptorsMajor histocompatibility complexPeptide motifsClass I moleculesCytotoxic T lymphocytesCell surfaceChicken major histocompatibility complexClass I allelesBinding peptidesI moleculesNatural killerClassical class I moleculesResistance to infectious diseasesMultigene familyRepertoire of bound peptidesI allelesThymus-derived (T) cellsReceptor-ligand interactionsNK cell functionImmunoglobulin-like receptorsPeptide-bindingMajor histocompatibility complex class I allelePeptide repertoireAllelesMHC-I molecules
2013
Induction of monocyte-to-dendritic cell maturation by extracorporeal photochemotherapy: Initiation via direct platelet signaling
Durazzo TS, Tigelaar RE, Filler R, Hayday A, Girardi M, Edelson RL. Induction of monocyte-to-dendritic cell maturation by extracorporeal photochemotherapy: Initiation via direct platelet signaling. Transfusion And Apheresis Science 2013, 50: 370-378. PMID: 24360371, PMCID: PMC4167725, DOI: 10.1016/j.transci.2013.11.008.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaExtracorporeal photochemotherapyDendritic cellsDendritic cell maturationT-cell lymphomaInduction of monocytesEvidence of inductionPost-capillary venulesDC maturationCell lymphomaClinical actionsCell maturationPlatelet signalingMonocytesPhotochemotherapyReceptor-ligand interactionsNovel mechanismInductionPhysiological inductionMaturationPrevious studiesLymphomaTherapyVenules
2012
Antigen processing and presentation: Evolution from a bird's eye view
Kaufman J. Antigen processing and presentation: Evolution from a bird's eye view. Molecular Immunology 2012, 55: 159-161. PMID: 23182425, PMCID: PMC3878743, DOI: 10.1016/j.molimm.2012.10.030.Peer-Reviewed Original ResearchConceptsClass I genesI geneTransporter associated with antigen presentationChicken MHCLevels of allelic polymorphismGene co-evolutionExpressed class I moleculeClass III regionModerate sequence diversityCo-evolutionary relationshipsNon-mammalian speciesClass I lociClass I regionClass I moleculesClass II regionCo-evolutionGenome organisationSequence diversityMultigene familyProteasome componentsPrimordial MHCI lociProcessing genesStudies of chickensReceptor-ligand interactions
2007
CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation
Choi S, Hildebrandt G, Olkiewicz K, Hanauer D, Chaudhary M, Silva I, Rogers C, Deurloo D, Fisher J, Liu C, Adams D, Chensue S, Cooke K. CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation. Blood 2007, 110: 3447-3455. PMID: 17641205, PMCID: PMC2200916, DOI: 10.1182/blood-2007-05-087403.Peer-Reviewed Original ResearchConceptsStem cell transplantationT cell responsesCCR1 expressionHost diseaseT cellsAllogeneic T-cell responsesAllogeneic stem cell transplantationCCR1-deficient miceDevelopment of GVHDCytolytic effector functionDonor cellsT cell functionChemokine receptor-ligand interactionsT cell proliferationHost target tissuesReceptor-ligand interactionsActivated T cellsAcute graftGVHD mortalityGVL activityIFNgamma secretionAllo-SCTGVHD severityLeukemic infiltrationLeukemic relapse
2006
Genetic control by riboswitches and ribozymes
Breaker R. Genetic control by riboswitches and ribozymes. The FASEB Journal 2006, 20: a455-a456. DOI: 10.1096/fasebj.20.4.a455-d.Peer-Reviewed Original ResearchGenetic switchGene expressionAptamer domainBacterial speciesCertain messenger RNAsControl gene expressionMessenger RNA stabilityNon-coding regionsComplex genetic elementsSelf-cleaving ribozymesRiboswitch classesReceptor-ligand interactionsTranscription elongationTranslation initiationRNA stabilityRNA transcriptionRiboswitchAllosteric changesGenetic controlGenetic elementsRNA structureMessenger RNATarget metabolitesRNARecent findingsCritical role for CCR1:CCL5 (RANTES) receptor ligand interactions in modulating allogeneic T cell responses following stem cell transplantation
Choi S, Hildebrandt G, Silva I, Olkiewicz K, Chensue S, Liu C, Chaudhary M, Fisher J, Lane T, Cooke K. Critical role for CCR1:CCL5 (RANTES) receptor ligand interactions in modulating allogeneic T cell responses following stem cell transplantation. Transplantation And Cellular Therapy 2006, 12: 59. DOI: 10.1016/j.bbmt.2005.11.184.Peer-Reviewed Original Research
2001
CD84 Functions as a Homophilic Adhesion Molecule and Enhances IFN-γ Secretion: Adhesion Is Mediated by Ig-Like Domain 1
Martin M, Romero X, de la Fuente M, Tovar V, Zapater N, Esplugues E, Pizcueta P, Bosch J, Engel P. CD84 Functions as a Homophilic Adhesion Molecule and Enhances IFN-γ Secretion: Adhesion Is Mediated by Ig-Like Domain 1. The Journal Of Immunology 2001, 167: 3668-3676. PMID: 11564780, DOI: 10.4049/jimmunol.167.7.3668.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAntigens, CDBinding, CompetitiveCell AdhesionCell Adhesion MoleculesCells, CulturedChildChild, PreschoolCOS CellsHumansImmunoglobulinsInterferon-gammaLymphocyte ActivationMembrane GlycoproteinsMiceProtein Structure, TertiarySignaling Lymphocytic Activation Molecule FamilyT-LymphocytesThymus GlandTumor Cells, CulturedConceptsFusion proteinExtracellular domainSoluble Ig fusion proteinDomain 1Homophilic adhesion moleculeFirst extracellular domainLymphoproliferative disease geneReceptor-ligand interactionsIg-like domains 1Cytoplasmic tailProtein 1ADisease genesCell surface moleculesHuman CD84Ligand-receptor recognitionCD2 familyMature T cellsCD84Own ligandConcurrent ligationMouse chimerasReceptor recognitionIg fusion proteinProteinCell maturation
1999
Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis
Russell K, Stern D, Polverini P, Bender J. Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis. American Journal Of Physiology 1999, 277: h2205-h2211. PMID: 10600838, DOI: 10.1152/ajpheart.1999.277.6.h2205.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCorneaEndothelial Growth FactorsEndothelium, VascularErbB ReceptorsHumansLymphokinesMiceNeovascularization, PhysiologicNeuregulinsRatsReceptor, ErbB-2Receptor, ErbB-3Receptor, ErbB-4ThrombinUmbilical VeinsVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsHuman umbilical vein endothelial cellsVascular endotheliumErbB receptorsReceptor tyrosine phosphorylationStimulation of HUVECsRapid calcium fluxReceptor family membersEndothelial cell growth factorTransmembrane tyrosine kinase receptorVascular endothelial cell growth factorEndothelial cell signalingReceptor-ligand interactionsTyrosine kinase receptorsEpidermal growth factor receptorVascular endothelial growthCell growth factorUmbilical vein endothelial cellsCell signalingGrowth factor receptorTyrosine phosphorylationVivo angiogenic responseExpression patternsGrowth regulationVein endothelial cellsIntracellular signaling
1987
Phenotypic and functional characterization of lymphocytes that bind human microvascular endothelial cells in vitro. Evidence for preferential binding of natural killer cells.
Bender J, Pardi R, Karasek M, Engleman E. Phenotypic and functional characterization of lymphocytes that bind human microvascular endothelial cells in vitro. Evidence for preferential binding of natural killer cells. Journal Of Clinical Investigation 1987, 79: 1679-1688. PMID: 3495552, PMCID: PMC424501, DOI: 10.1172/jci113007.Peer-Reviewed Original ResearchConceptsNatural killer cellsMicrovascular endothelial cellsEndothelial cellsKiller cellsE-RFCRosette forming lymphocytesRecombinant interleukin-1Human microvascular endothelial cellsReceptor-ligand interactionsLymphocyte subsetsNK effectorsNK targetsGraft rejectionNK cellsLeu-11Lymphocyte fractionInterleukin-1Microvascular endotheliumSpecific receptor-ligand interactionsAllograftsLymphocytesEC monolayersCritical targetCellsQuantitative adherence
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