2022
New vistas unfold: Chicken MHC molecules reveal unexpected ways to present peptides to the immune system
Halabi S, Kaufman J. New vistas unfold: Chicken MHC molecules reveal unexpected ways to present peptides to the immune system. Frontiers In Immunology 2022, 13: 886672. PMID: 35967451, PMCID: PMC9372762, DOI: 10.3389/fimmu.2022.886672.Peer-Reviewed Original ResearchConceptsMajor histocompatibility complexC-terminusPeptide C-terminusNon-mammalian vertebratesStructural studiesCell surface expression levelsMajor histocompatibility complex moleculesPolymorphic TAPClassical class IClass I genesJawed vertebratesAnchor residuesI geneAcid residuesTapasin geneResponse to infectious pathogensSurface expression levelsMolecular explanationDomestic chickensPeptide bindingClass II moleculesHydrophobic pocketAllelesBinding sitesBinding peptidesHigh cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD)
Beppu S, Kinoshita M, Wilamowski J, Suenaga T, Yasumizu Y, Ogawa K, Ishikura T, Tada S, Koda T, Murata H, Shiraishi N, Sugiyama Y, Kihara K, Sugimoto T, Arase H, Standley D, Okuno T, Mochizuki H. High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD). Scientific Reports 2022, 12: 106. PMID: 34997058, PMCID: PMC8742014, DOI: 10.1038/s41598-021-04074-1.Peer-Reviewed Original ResearchConceptsNeuromyelitis optica spectrum disorderPeptide major histocompatibility complexDevelopment of neuromyelitis optica spectrum disorderAnti-aquaporin-4HLA-DQA1Associated with neuromyelitis optica spectrum disordersHigh cell surface expressionJapanese patient cohortPresence of pathogenic autoantibodiesCell surface expression levelsRelapsing autoimmune diseaseHLA-DQA1 allelesCell surface expressionSurface expression levelsAQP4 peptidesMajor histocompatibility complexAnti-aquaporinPathogenic autoantibodiesHLA-DQPatient cohortAutoimmune diseasesPathogenic roleSurface expressionIn silico 3D structure modelingHistocompatibility complex
2015
Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity
Tregaskes C, Harrison M, Sowa A, van Hateren A, Hunt L, Vainio O, Kaufman J. Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 113: 692-697. PMID: 26699458, PMCID: PMC4725490, DOI: 10.1073/pnas.1511859113.Peer-Reviewed Original ResearchConceptsMajor histocompatibility complexChicken MHC haplotypesCell surfaceMHC haplotypesChicken major histocompatibility complexExpressed class I moleculeMajor histocompatibility complex haplotypeCell surface expression levelsClass I moleculesPeptide-loading complexB21 haplotypeChicken haplotypesResistance to Marek's diseaseExpression level of MHC class I moleculesHaplotypesGenetic associationAssembly assayHomozygote cellsClass I proteinsAllelic polymorphismI moleculesPeptide libraryTranslocation specificityPromiscuous bindingI proteinExpression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding
Chappell P, Meziane E, Harrison M, Magiera Ł, Hermann C, Mears L, Wrobel A, Durant C, Nielsen L, Buus S, Ternette N, Mwangi W, Butter C, Nair V, Ahyee T, Duggleby R, Madrigal A, Roversi P, Lea S, Kaufman J. Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding. ELife 2015, 4: e05345. PMID: 25860507, PMCID: PMC4420994, DOI: 10.7554/elife.05345.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdaptive ImmunityAllelesAmino Acid SequenceAnimalsAntigen PresentationBinding SitesCell LineChickensCrystallography, X-RayGene Expression RegulationHaplotypesHerpesvirus 2, GallidHistocompatibility Antigens Class IHIV-1Marek DiseaseModels, MolecularMolecular Sequence DataPeptidesProtein BindingRecombinant ProteinsConceptsClass I moleculesMHC class I moleculesI moleculesHuman immunodeficiency virus infectionPeripheral T cell responsesExpression of class I moleculesCell surface expression of class I moleculesT cell responsesImmunodeficiency virus infectionLevels of MHC class I moleculesCell surface expression levelsAdaptive immune responsesSurface expression of class I moleculesSurface expression levelsExpression level of MHC class I moleculesExpression levelsLethal tumorsImmune responseVirus infectionPeptide presentationMHC moleculesPeptide repertoireProtective responseInfectious pathogensPeptide binding repertoire
2000
The simple chicken major histocompatibility complex: life and death in the face of pathogens and vaccines
Kaufman J. The simple chicken major histocompatibility complex: life and death in the face of pathogens and vaccines. Philosophical Transactions Of The Royal Society B Biological Sciences 2000, 355: 1077-1084. PMID: 11186309, PMCID: PMC1692814, DOI: 10.1098/rstb.2000.0645.Peer-Reviewed Original ResearchConceptsB-F/B-L regionChicken major histocompatibility complexMajor histocompatibility complexMammalian major histocompatibility complexClass II beta genesFace of pathogensExpressed class I moleculeSingle class I geneLevels of RNACell surface expression levelsRous sarcoma virusClass I genesPeptide-binding specificityHistocompatibility complexExpressed class II geneResistance to tumorsSusceptibility to tumorsKilled viral vaccinesBeta geneClass II moleculesB locusClass I moleculesSarcoma virusDisease virus
1999
Gene organisation determines evolution of function in the chicken MHC
Kaufman J, Jacob J, Shaw J, Walker B, Milne S, Beck S, Salomonsen J. Gene organisation determines evolution of function in the chicken MHC. Immunological Reviews 1999, 167: 101-117. PMID: 10319254, DOI: 10.1111/j.1600-065x.1999.tb01385.x.Peer-Reviewed Original ResearchConceptsClass II beta genesClass I genesExpressed class I moleculePeptide-binding specificityI geneBeta geneMultigene familyC4 genesI alphaClass III region genesExpressed class I genesMinimal essential MHCB-F/B-L regionRfp-Y regionCell surface expression levelsChicken genomeGene organisationEvolution of functionRRNA geneClass II alphaDO geneRfp-YChicken MHCTapasin geneGenes
1997
The “Minimal Essential MHC” Revisited: Both Peptide‐Binding and Cell Surface Expression Level of MHC Molecules are Polymorphisms Selected by Pathogens in Chickens
Kaufman J, Salomonsen J. The “Minimal Essential MHC” Revisited: Both Peptide‐Binding and Cell Surface Expression Level of MHC Molecules are Polymorphisms Selected by Pathogens in Chickens. Hereditas 1997, 127: 67-73. PMID: 9420472, DOI: 10.1111/j.1601-5223.1997.t01-1-00067.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAntigens, ViralBinding SitesChickensEvolution, MolecularGenes, MHC Class IGenes, MHC Class IIHaplotypesHistocompatibility Antigens Class IImmunity, InnateMajor Histocompatibility ComplexMarek DiseaseModels, GeneticModels, ImmunologicalPolymorphism, GeneticPoultry DiseasesSelection, GeneticSpecies SpecificityVertebratesVirus DiseasesConceptsChicken MHC haplotypesCell surface expression levelsSusceptibility to Marek's diseaseMarek's disease virusMHC of chickensMinimal essential MHCMHC haplotypesExpression level differencesMarek's diseaseChicken linesPeptide-binding specificityDisease virusClass I moleculesPeptide motifsLevels of class I expressionChickenMHC genesHaplotypesViral diseasesOutcome of infectionPeptide-bindingMHC associationsI moleculesMouse haplotypesPathogens
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