2024
Stochastic modeling of a gene regulatory network driving B cell development in germinal centers
Koshkin A, Herbach U, Martínez M, Gandrillon O, Crauste F. Stochastic modeling of a gene regulatory network driving B cell development in germinal centers. PLOS ONE 2024, 19: e0301022. PMID: 38547073, PMCID: PMC10977792, DOI: 10.1371/journal.pone.0301022.Peer-Reviewed Original ResearchConceptsGene regulatory network structureGene regulatory networksGene expression dataExpression dataB cell differentiationSingle-cellAssociated with cell developmentGC B cell differentiationStages of B-cell differentiationB cell developmentSelection of B cellsGene regulationRegulatory networksTranscriptome dataSystems biologyHigh-affinity antibodiesRegulatory mechanismsCell developmentGenesAdaptive immune systemMRNA distributionPlasmablast stageGerminal centersDifferentiationImmune system
1991
Chicken major histocompatibility complex-encoded B-G antigens are found on many cell types that are important for the immune system.
Salomonsen J, Dunon D, Skjødt K, Thorpe D, Vainio O, Kaufman J. Chicken major histocompatibility complex-encoded B-G antigens are found on many cell types that are important for the immune system. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 1359-1363. PMID: 1996336, PMCID: PMC51017, DOI: 10.1073/pnas.88.4.1359.Peer-Reviewed Original ResearchConceptsChicken major histocompatibility complexB-G antigensB-G moleculesMajor histocompatibility complexB-F/B-L regionPolymorphic multigene familyCell typesBursal B cellsB cellsCDNA clonesSelection of B cellsB-GMultigene familyCell surface moleculesMHC class IClass II moleculesChicken bursaNorthern blottingPeripheral BErythroid lineageChickenStromal cellsFlow cytometryClass IHistocompatibility complex
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