Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity
Tregaskes C, Harrison M, Sowa A, van Hateren A, Hunt L, Vainio O, Kaufman J. Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 113: 692-697. PMID: 26699458, PMCID: PMC4725490, DOI: 10.1073/pnas.1511859113.Peer-Reviewed Original ResearchConceptsMajor histocompatibility complexChicken MHC haplotypesCell surfaceMHC haplotypesChicken major histocompatibility complexExpressed class I moleculeMajor histocompatibility complex haplotypeCell surface expression levelsClass I moleculesPeptide-loading complexB21 haplotypeChicken haplotypesResistance to Marek's diseaseExpression level of MHC class I moleculesHaplotypesGenetic associationAssembly assayHomozygote cellsClass I proteinsAllelic polymorphismI moleculesPeptide libraryTranslocation specificityPromiscuous bindingI proteinExpression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding
Chappell P, Meziane E, Harrison M, Magiera Ł, Hermann C, Mears L, Wrobel A, Durant C, Nielsen L, Buus S, Ternette N, Mwangi W, Butter C, Nair V, Ahyee T, Duggleby R, Madrigal A, Roversi P, Lea S, Kaufman J. Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding. ELife 2015, 4: e05345. PMID: 25860507, PMCID: PMC4420994, DOI: 10.7554/elife.05345.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdaptive ImmunityAllelesAmino Acid SequenceAnimalsAntigen PresentationBinding SitesCell LineChickensCrystallography, X-RayGene Expression RegulationHaplotypesHerpesvirus 2, GallidHistocompatibility Antigens Class IHIV-1Marek DiseaseModels, MolecularMolecular Sequence DataPeptidesProtein BindingRecombinant ProteinsConceptsClass I moleculesMHC class I moleculesI moleculesHuman immunodeficiency virus infectionPeripheral T cell responsesExpression of class I moleculesCell surface expression of class I moleculesT cell responsesImmunodeficiency virus infectionLevels of MHC class I moleculesCell surface expression levelsAdaptive immune responsesSurface expression of class I moleculesSurface expression levelsExpression level of MHC class I moleculesExpression levelsLethal tumorsImmune responseVirus infectionPeptide presentationMHC moleculesPeptide repertoireProtective responseInfectious pathogensPeptide binding repertoire
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