2024
The search to understand the development of the chicken immune system: Differences in expression of MHC class I loci and waves of thymocytes as evolutionary relics?
Halabi S, Rocos N, Kaufman J. The search to understand the development of the chicken immune system: Differences in expression of MHC class I loci and waves of thymocytes as evolutionary relics? Developmental Biology 2024, 519: 38-45. PMID: 39694171, DOI: 10.1016/j.ydbio.2024.12.006.Peer-Reviewed Original ResearchConceptsClass I genesI geneEvolutionary relicMHC class I lociClass I lociPoultry industryResistance to infectious diseasesChicken immune systemClass I expressionCytotoxic T lymphocytesGenetic lociNon-polymorphicI lociGlobal poultry industryChicken MHCClass I moleculesImmune defenceLociNatural killerT cellsDay-old chicksI expressionXenopus frogsAvian immunologyWell-expressed
2022
MHC class II-restricted-presentationMHC class II and DM molecules in chickens: different yet again
Wise D, Halabi S, Afrache H, Fakiola M, Parker A, Kaufman J. MHC class II-restricted-presentationMHC class II and DM molecules in chickens: different yet again. Molecular Immunology 2022, 150: 32-33. DOI: 10.1016/j.molimm.2022.05.108.Peer-Reviewed Original ResearchIntestinal epithelial cellsClass II moleculesKO cellsClass II A genesII moleculesClass I systemResistance to infectious diseasesRT-PCRBF2 genesWestern blottingDM locusClass II BI systemA geneChicken MHCGenetic associationTapasin geneCRISPR-Cas9DMB1Tissue section stainingGenesBLB2Closely-linkedB2-microglobulinGut tissue
2020
From Chickens to Humans: The Importance of Peptide Repertoires for MHC Class I Alleles
Kaufman J. From Chickens to Humans: The Importance of Peptide Repertoires for MHC Class I Alleles. Frontiers In Immunology 2020, 11: 601089. PMID: 33381122, PMCID: PMC7767893, DOI: 10.3389/fimmu.2020.601089.Peer-Reviewed Original ResearchConceptsKiller immunoglobulin-like receptorsMajor histocompatibility complexPeptide motifsClass I moleculesCytotoxic T lymphocytesCell surfaceChicken major histocompatibility complexClass I allelesBinding peptidesI moleculesNatural killerClassical class I moleculesResistance to infectious diseasesMultigene familyRepertoire of bound peptidesI allelesThymus-derived (T) cellsReceptor-ligand interactionsNK cell functionImmunoglobulin-like receptorsPeptide-bindingMajor histocompatibility complex class I allelePeptide repertoireAllelesMHC-I molecules
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