2024
Telomere transcripts act as tumor suppressor and are associated with favorable prognosis in colorectal cancer with low proliferating cell nuclear antigen expression
Kienzl P, Deloria A, Hunjadi M, Hadolt J, Haering M, Bothien A, Mejri D, Korkut-Demirbaş M, Sampl S, Weber G, Pirker C, Laengle S, Braunschmid T, Dragona E, Marian B, Gagos S, Lu L, Henson J, Lau L, Reddel R, Mikulits W, Stättner S, Holzmann K. Telomere transcripts act as tumor suppressor and are associated with favorable prognosis in colorectal cancer with low proliferating cell nuclear antigen expression. Cellular Oncology 2024, 48: 239-247. PMID: 39222177, PMCID: PMC11850466, DOI: 10.1007/s13402-024-00986-y.Peer-Reviewed Original ResearchSevere combined immunodeficiency diseaseTelomerase reverse transcriptaseProliferating Cell Nuclear AntigenEpithelial-mesenchymal transitionColorectal cancerTelomerase RNA componentTumor tissuesTelomerase activityTelomeric repeat-containing RNAProliferating cell nuclear antigen expressionAssociated with favorable prognosisOverall survival rateCombined immunodeficiency diseaseTelomere lengthEpithelial splicing regulatory protein 1TERRA expressionColorectal cancer tumor tissuesCell nuclear antigenNon-canonical functions of telomerase reverse transcriptaseCRC tumor growthExpression levelsFavorable prognosisNon-tumor tissuesImmunodeficiency diseaseAdjacent non-tumor tissues
2023
Telomere Length and Telomerase Activity Are Associated With COPD and Lung Function Abnormalities in Persons Living With HIV
Chang-Huang S, Fitzpatrick J, Dai G, Zhang M, Branchini J, Lin C, Huang P, Jan A, Huang C, Wu C, Hsieh J, Smith D, Abelman R, Byanova K, Wang R, Davis J, Crothers K, Hunt P, Segal M, Blackburn E, Lin J, Huang L. Telomere Length and Telomerase Activity Are Associated With COPD and Lung Function Abnormalities in Persons Living With HIV. 2023, a1137-a1137. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1137.Peer-Reviewed Original Research
2022
The telomere maintenance mechanism spectrum and its dynamics in gliomas
Kim S, Chowdhury T, Yu H, Kahng J, Lee C, Choi S, Kim K, Kang H, Lee J, Lee S, Won J, Kim K, Kim M, Lee J, Kim J, Kim Y, Kim T, Choi S, Phi J, Shin Y, Ku J, Lee S, Yun H, Lee H, Kim D, Kim K, Hur J, Park S, Kim S, Park C. The telomere maintenance mechanism spectrum and its dynamics in gliomas. Genome Medicine 2022, 14: 88. PMID: 35953846, PMCID: PMC9367055, DOI: 10.1186/s13073-022-01095-x.Peer-Reviewed Original ResearchConceptsTERT promoter mutationsTelomere maintenance mechanismTelomerase activityGlioma samplesTERT expressionPromoter mutationsCancer management strategiesSlow growth potentialC-circle assayCancer cell immortalityGlioma patientsSeparate cohortNegative groupGlioma progressionNanoString analysisTumor tissueTelomerase enzyme activityGliomasTumor cellsConclusionsThis studyALTATRX mutationsTelomerase activationATRX lossConsiderable proportionMitochondrial dysfunction caused by targeted deletion of Mfn1 does not result in telomere shortening in oocytes.
Cozzolino M, Seli E. Mitochondrial dysfunction caused by targeted deletion of Mfn1 does not result in telomere shortening in oocytes. Zygote 2022, 30: 735-737. PMID: 35730364, DOI: 10.1017/s0967199422000089.Peer-Reviewed Original ResearchConceptsMitochondrial dysfunctionMaintenance of telomeresTargeted deletionEnd-protection functionTTAGGG repeatsMitochondrial fusionTelomeric repeatsSomatic cellsMitofusin 1Reactive oxygen speciesEnzyme complexWild-type miceOocyte growthDNA damageMouse oocytesTelomerase activityOocyte maturationDeletionFollicular depletionOxygen speciesTelomere lengthTelomeresFollicular developmentOocytesRepeats
2021
Colorectal Cancer Stem Cell States Uncovered by Simultaneous Single‐Cell Analysis of Transcriptome and Telomeres
Wang H, Gong P, Chen T, Gao S, Wu Z, Wang X, Li J, Marjani SL, Costa J, Weissman SM, Qi F, Pan X, Liu L. Colorectal Cancer Stem Cell States Uncovered by Simultaneous Single‐Cell Analysis of Transcriptome and Telomeres. Advanced Science 2021, 8: 2004320. PMID: 33898197, PMCID: PMC8061397, DOI: 10.1002/advs.202004320.Peer-Reviewed Original ResearchConceptsCancer stem cellsCancer epithelial cellsTumor-initiating cellsCancer stem cell stateEpithelial cellsStem cell stateStem cellsRare cancer stem cellsSimultaneous single-cell analysisHeterogeneity of CSCsSingle-cell analysisNumber variation patternsHippo/YAPDepth transcriptomeSmart-seq2Phylogenetic relationshipsNormal stem cellsCell statesNonproliferative natureColorectal cancerDisplay plasticityDormant stateShort telomeresTelomerase activityTranscriptome
2020
Telomerase Reverse Transcriptase Promoter Mutations Identify a Genomically Defined and Highly Aggressive Human Pleural Mesothelioma Subgroup
Pirker C, Bilecz A, Grusch M, Mohr T, Heidenreich B, Laszlo V, Stockhammer P, Lötsch-Gojo D, Gojo J, Gabler L, Spiegl-Kreinecker S, Dome B, Steindl A, Klikovits T, Hoda MA, Jakopovic M, Samarzija M, Mohorcic K, Kern I, Kiesel B, Brcic L, Oberndorfer F, Müllauer L, Klepetko W, Schmidt WM, Kumar R, Hegedus B, Berger W. Telomerase Reverse Transcriptase Promoter Mutations Identify a Genomically Defined and Highly Aggressive Human Pleural Mesothelioma Subgroup. Clinical Cancer Research 2020, 26: 3819-3830. PMID: 32317288, DOI: 10.1158/1078-0432.ccr-19-3573.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkers, TumorCell Line, TumorCell SurvivalCell Transformation, NeoplasticComparative Genomic HybridizationDisease ProgressionDNA Mutational AnalysisExome SequencingFemaleGene Expression ProfilingHumansKaplan-Meier EstimateMaleMesothelioma, MalignantMiddle AgedMutationPleuraPleural NeoplasmsPrognosisPromoter Regions, GeneticRetrospective StudiesTelomeraseConceptsHuman malignant pleural mesotheliomaMalignant pleural mesotheliomaPromoter mutationsLuciferase promoter assaysGene expression profilingImmortalized cell linesArray comparative genomic hybridizationComparative genomic hybridizationWild-type samplesGene promoterExpression profilingPromoter assaysPromoter activityTelomerase reverse transcriptase gene promoterCell immortalizationMolecular mechanismsMutations/deletionsMalignant transformation processMPM casesSpecific mutation patternsGenomic hybridizationTelomerase activityGenomic alteration patternsMutationsChromosomal alterations
2016
Cyst Fluid Analysis in Pancreatic Intraductal Papillary Mucinous Neoplasms
Allen P, Iacobuzio-Donahue C, Klimstra D. Cyst Fluid Analysis in Pancreatic Intraductal Papillary Mucinous Neoplasms. Clinical Cancer Research 2016, 22: 4966-4967. PMID: 27573170, DOI: 10.1158/1078-0432.ccr-16-1462.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmPancreatic intraductal papillary mucinous neoplasmsPapillary mucinous neoplasmMucinous neoplasmsHigh-risk intraductal papillary mucinous neoplasmsDetect high-risk casesHigh-risk featuresCyst fluid analysisHigh-risk casesCancer precursorsCyst fluidFluid analysisTelomerase activityCystsNeoplasms
2013
Telomere length and telomerase activity during oocyte maturation and early embryo development in mammalian species
Ozturk S, Sozen B, Demir N. Telomere length and telomerase activity during oocyte maturation and early embryo development in mammalian species. Molecular Human Reproduction 2013, 20: 15-30. PMID: 23928157, DOI: 10.1093/molehr/gat055.Peer-Reviewed Original ResearchConceptsGranulosa cellsTelomerase activityProliferative granulosa cellsEarly embryosEarly embryo developmentTelomere lengthProliferative somatic cellsMammalian speciesEffects of oxidative stressOocyte maturationCancer cellsNon-dividing cellsStem cellsAdverse effects of oxidative stressShortened telomeresSomatic cellsOocytesEmbryo developmentAdverse effectsGranulosaGenotoxic agentsOxidative stressGermline cellsComprehensive review articleLength of telomeres
2007
Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance
Surovtseva Y, Shakirov E, Vespa L, Osbun N, Song X, Shippen D. Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance. The EMBO Journal 2007, 26: 3653-3661. PMID: 17627276, PMCID: PMC1949013, DOI: 10.1038/sj.emboj.7601792.Peer-Reviewed Original ResearchConceptsTelomere length regulationLength regulationChromosome end protectionSingle-copy geneNovel accessory factorTelomerase RNPTelomere proteinsTelomere maintenanceSequence similarityTelomeric DNAAccessory factorsEnd protectionTelomerase enzymeGenetic analysisSame pathwayUnsynchronized cellsS phaseRapid evolutionTelomerase activityTelomeraseTelomeresGenesProteinRegulationPOT1Comparative Analysis of the Developmental Competence of Three Human Embryonic Stem Cell Lines in Vitro
Kim S, Kim B, Gil J, Kim S, Kim J. Comparative Analysis of the Developmental Competence of Three Human Embryonic Stem Cell Lines in Vitro. Molecules And Cells 2007, 23: 49-56. PMID: 17464211, DOI: 10.1016/s1016-8478(23)07388-0.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsHESC linesHuman embryonic stem cell linesEmbryonic stem cell linesPrimordial germ cellsDevelopmental potentialEmbryonic stem cellsEmbryonic germ layersEmbryoid body formationSpecific cell typesDevelopmental competenceStem cell linesCell replacement therapyExtraembryonic tissuesStem cell technologyGerm layersTerminal differentiationGerm cellsBody formationPluripotency markersCell typesNeuronal cellsTelomerase activityStem cellsHSF6
2006
Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells
Yim HW, Slebos RJ, Randell SH, Umbach DM, Parsons AM, Rivera MP, Detterbeck FC, Taylor JA. Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells. Cancer Letters 2006, 246: 24-33. PMID: 16517060, DOI: 10.1016/j.canlet.2006.01.023.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBronchiCell Culture TechniquesCell ProliferationCells, CulturedCellular SenescenceChildDNA MethylationEpithelial CellsFemaleHumansLung NeoplasmsMaleMiddle AgedPolymerase Chain ReactionPromoter Regions, GeneticSmokingTelomeraseTime FactorsTumor Cells, CulturedConceptsNormal bronchial epitheliumTelomeric repeat amplification protocolHuman bronchial epithelial cellsBronchial epithelial cellsBronchial epitheliumTelomerase activityLung cancer historyLung cancer statusEpithelial cellsMaximum passage numberTobacco carcinogen exposureHBE cell culturesRepeat amplification protocolExtended culturingHTERT promoterShort-term cultureSmoking historyTobacco smokingPassage numberCancer historyLung carcinogenesisLung carcinomaCancer statusCarcinogen exposureCausative role
2005
Modeling aging and cancer in the telomerase knockout mouse
Chang S. Modeling aging and cancer in the telomerase knockout mouse. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 2005, 576: 39-53. PMID: 15927211, DOI: 10.1016/j.mrfmmm.2004.08.020.Peer-Reviewed Original ResearchConceptsTelomere dysfunctionRole of telomeresTelomerase-null miceTelomerase knockout miceTelomerase-deficient miceOrganismal agingSomatic cellsMammalian organismsTight regulationCellular responsesTelomerase activityNull miceKnockout miceTelomeresMouse modelTelomeraseOrganismsMiceDeficient miceRegulationAgingCellsCancer
2002
MEN1 tumor‐suppressor protein localizes to telomeres during meiosis
Suphapeetiporn K, Greally JM, Walpita D, Ashley T, Bale AE. MEN1 tumor‐suppressor protein localizes to telomeres during meiosis. Genes Chromosomes And Cancer 2002, 35: 81-85. PMID: 12203793, DOI: 10.1002/gcc.10113.Peer-Reviewed Original ResearchConceptsSomatic cellsTelomerase activityAbsence of meninTumor suppressor gene MEN1Normal cell physiologyTelomeric protein TRF2Normal telomerase activityTumor suppressor proteinRole of meninMeiotic telomeresTelomere functionProtein TRF2Meiotic cellsTranscriptional activationNuclear proteinsCell physiologyFunctional motifsDifferent proteinsTumor suppressorTelomeresMeninElevated telomerase activityDifferent tissuesJunDCancer predisposition syndrome
2001
Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres.
Goodwin E, DiMaio D. Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres. Molecular Cancer Research 2001, 12: 525-34. PMID: 11714633.Peer-Reviewed Original ResearchConceptsTumor suppressor pathwayHeLa cervical carcinoma cellsExtended telomeresReplicative senescenceHTERT geneSuppressor pathwayTelomerase activityGrowth arrestCervical carcinoma cellsRepression of telomeraseElevated telomerase activitySomatic human cellsNormal somatic human cellsShort telomeresGrowth-arrested stateSenescence-associated beta-galactosidase expressionHPV E6/E7 expressionGrowth-arrested cellsHeLa cell clonesProfound growth arrestRole of telomeraseE6/E7 genesBeta-galactosidase expressionErosion of telomeresCarcinoma cellsTelomere dysfunction and evolution of intestinal carcinoma in mice and humans
Rudolph K, Millard M, Bosenberg M, DePinho R. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nature Genetics 2001, 28: 155-159. PMID: 11381263, DOI: 10.1038/88871.Peer-Reviewed Original ResearchConceptsHuman intestinal neoplasiaProgression of mouseTelomerase activationHuman colorectal carcinogenesisTelomere dysfunctionInitiated lesionsIntestinal carcinomaColorectal carcinogenesisIntestinal neoplasiaHuman colorectalDysfunctionAdvanced stageMalignant transformationTumor progressionChromosomal instabilityColon carcinomaCarcinoma transitionMacroscopic adenomasTransient telomere dysfunctionEarly carcinogenesisCancer initiationHuman cancersTelomerase activityCarcinomaDifferential effects
2000
Rapid induction of senescence in human cervical carcinoma cells
Goodwin E, Yang E, Lee C, Lee H, DiMaio D, Hwang E. Rapid induction of senescence in human cervical carcinoma cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 10978-10983. PMID: 11005870, PMCID: PMC27134, DOI: 10.1073/pnas.97.20.10978.Peer-Reviewed Original ResearchConceptsHuman papillomavirus E6Cervical carcinoma cellsCarcinoma cellsPapillomavirus E6Cervical carcinoma cell linesCell cycle regulatory proteinsViral oncogene expressionHuman cervical carcinoma cell lineCarcinoma cell linesCycle regulatory proteinsHuman cervical carcinoma cellsE7 oncogenesE7 proteinTransient alterationsCancer cellsOncogene expressionHuman cancersPhenotypic markersTelomerase activityCell linesRegulatory proteinsRapid inductionSenescence pathwaysCellsE2 regulatory proteinInhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery
Rudolph K, Chang S, Millard M, Schreiber-Agus N, DePinho R. Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery. Science 2000, 287: 1253-1258. PMID: 10678830, DOI: 10.1126/science.287.5456.1253.Peer-Reviewed Original ResearchConceptsLiver cirrhosisChronic diseasesEnd-stage organ failureChronic liver injuryImproved liver functionExperimental liver cirrhosisLiver injuryOrgan failureLiver functionTelomerase-deficient miceTelomere dysfunctionHigh cellular turnoverTelomerase therapyChemical ablationCirrhosisAdenoviral deliveryLiver regenerationSuch diseasesDiseaseMiceTelomerase activityDysfunctionLiverCellular turnoverShort dysfunctional telomeres
1999
Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle
Seto A, Zaug A, Sobel S, Wolin S, Cech T. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature 1999, 401: 177-180. PMID: 10490028, DOI: 10.1038/43694.Peer-Reviewed Original ResearchConceptsSm proteinsSaccharomyces cerevisiae telomeraseNuclear messenger RNASmall nuclear ribonucleoprotein particleRNA polymerase IISmall nuclear ribonucleoproteinNuclear ribonucleoprotein particleTrimethylguanosine capPolymerase IIRNA processingTelomerase RNAEnzyme telomeraseNuclear ribonucleoproteinRibonucleoprotein particleProtein subunitsMessenger RNATelomeraseTelomerase activityRNAProteinEukaryotesSnRNPsYeast extractRibonucleoproteinChromosomes
1998
Telomerase: a potential marker of bladder transitional cell carcinoma in bladder washes.
Lee D, Yang S, Hong S, Chung B, Kim I. Telomerase: a potential marker of bladder transitional cell carcinoma in bladder washes. Clinical Cancer Research 1998, 4: 535-8. PMID: 9533519.Peer-Reviewed Original ResearchConceptsTransitional cell carcinomaBladder transitional cell carcinomaBladder washesCell carcinomaCytological diagnosisTelomerase activityGrade 1 transitional cell carcinomaCancer tissuesNormal tissuesHuman bladder cancer tissuesBladder wash samplesPositive telomerase activityFinal pathological diagnosisLow-grade tumorsBladder cancer tissuesTelomeric repeat amplificationPositive cytologyTransurethral resectionBladder tumorsBladder cancerPathological diagnosisWash samplesCytological specimensPatientsPotential marker
1997
High Telomerase Activity in Primary Lung Cancers: Association With Increased Cell Proliferation Rates and Advanced Pathologic Stage
Albanell J, Engelhardt M, Han W, Moore M, Lonardo F, Rusch V, Langenfeld J, Klimstra D, Venkatraman E, Dmitrovsky E. High Telomerase Activity in Primary Lung Cancers: Association With Increased Cell Proliferation Rates and Advanced Pathologic Stage. Journal Of The National Cancer Institute 1997, 89: 1609-1615. PMID: 9362159, DOI: 10.1093/jnci/89.21.1609.Peer-Reviewed Original ResearchConceptsNon-small-cell lung cancerTumor cell proliferation ratePatients treated with surgeryAdvanced pathological stageTelomeric repeat amplification protocolPathological stageLung cancerCell proliferation rateHigh telomerase activityTelomerase activityTumor stageKi-67Clinical outcomesResected non-small-cell lung cancerAssociated with tumor pathologic stagePrimary non-small-cell lung cancerImmunohistochemical analysis of Ki-67Proliferation rateMultivariate Cox proportional hazards analysisTNM (tumor-node-metastasis) stageTumors treated with surgeryAnalysis of Ki-67Associated with clinical outcomesLong-term follow-upAssess tumor cell proliferation
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