2025
Patterns of intra- and inter-tumor phenotypic heterogeneity in lethal prostate cancer
Roudier M, Gulati R, Sayar E, Patel R, Tratt M, Richards H, Cejas P, Gomez M, Qiu X, Xie Y, Hanratty B, Zaidi S, Zhao J, Adil M, Mittal C, Zhao Y, Dumpit R, Coleman I, Low J, Persse T, Galipeau P, Lee J, Tretiakova M, Chambers M, Vakar-Lopez F, True L, Perrone M, Lam H, Kollath L, Ding C, Harmon S, Cheng H, Yu E, Montgomery R, Hawley J, Lin D, Corey E, Schweizer M, Setty M, Ha G, Sawyers C, Morrissey C, Long H, Nelson P, Haffner M. Patterns of intra- and inter-tumor phenotypic heterogeneity in lethal prostate cancer. Journal Of Clinical Investigation 2025, 135: e186599. PMID: 40493417, PMCID: PMC12321404, DOI: 10.1172/jci186599.Peer-Reviewed Original ResearchMetastatic prostate cancerLethal prostate cancerProstate cancerPhenotypic heterogeneityMetastatic prostate cancer patientsMolecularly heterogeneous diseaseTumor cell populationIntra-tumor heterogeneityCellular proliferation rateMetastatic sitesSingle-cell sequencing studiesMolecular subtypesClinical featuresTumor heterogeneityTumor phenotypeTumor samplesHeterogeneous diseaseClinical managementAnatomical sitesTherapeutic approachesSubtype heterogeneityPatientsTissue-basedCell populationsProliferation rateSorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study
Khan M, Walsh J, Kurdi S, Mishra S, Mihailović J, Coman D, Hyder F. Sorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study. NMR In Biomedicine 2025, 38: e5319. PMID: 39764672, DOI: 10.1002/nbm.5319.Peer-Reviewed Original ResearchConceptsU87 tumorsSorafenib-treated tumorsUpregulated aerobic glycolysisSodium-potassium pumpInterstitial spaceTumor microenvironmentIntracellular NaTumor growthSpectroscopic imaging studiesTumor invasionGlioblastoma modelSodium levelsTumorGlioblastoma therapyImaging studiesPlaceboSorafenibMetabolic changesImmune functionCancer hallmarksAerobic glycolysisProliferative stateMeasure treatment effectsIonic changesProliferation rate
2021
High Counts of CD68+ and CD163+ Macrophages in Mantle Cell Lymphoma Are Associated With Inferior Prognosis
Li P, Yuan J, Ahmed FS, McHenry A, Fu K, Yu G, Cheng H, Xu ML, Rimm DL, Pan Z. High Counts of CD68+ and CD163+ Macrophages in Mantle Cell Lymphoma Are Associated With Inferior Prognosis. Frontiers In Oncology 2021, 11: 701492. PMID: 34527580, PMCID: PMC8435777, DOI: 10.3389/fonc.2021.701492.Peer-Reviewed Original ResearchDiffuse large B-cell lymphomaPD-L1 expressionMantle cell lymphomaKi67 proliferation rateOverall survivalPD-L1Cell lymphomaImmune checkpoint molecule PD-L1Low PD-L1 expressionLarge B-cell lymphomaX-tile softwareHigher Ki67 proliferation rateLog-rank testMCL casesNumber of M1Tissue microarray blocksB-cell lymphomaProliferation rateImmunophenotypic subclassificationInferior OSLow Ki67Better OSPoor OSPrognostic impactInferior prognosisAcute systemic loss of Mad2 leads to intestinal atrophy in adult mice
Schukken K, Zhu Y, Bakker P, Koster M, Harkema L, Youssef S, de Bruin A, Foijer F. Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice. Scientific Reports 2021, 11: 68. PMID: 33420244, PMCID: PMC7794249, DOI: 10.1038/s41598-020-80169-5.Peer-Reviewed Original ResearchConceptsAdult miceChromosomal instabilitySpindle assembly checkpointSevere intestinal phenotypeSubstantial weight lossEmbryonic lethalityLow proliferation rateP53 inactivationVillous atrophyMouse modelAneuploid cellsIntestinal phenotypeTumor evolutionIntestinal epitheliaIntestinal atrophyTissue-specific fashionMiceProliferation rateWeight lossSpindle assembly checkpoint functionAtrophyEpitheliaAssembly checkpointTissueLethality
2020
A Consensus-Developed Morphological Re-Evaluation of 196 High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms and Its Clinical Correlations
Elvebakken H, Perren A, Scoazec J, Tang L, Federspiel B, Klimstra D, Vestermark L, Ali A, Zlobec I, Myklebust T, Hjortland G, Langer S, Gronbaek H, Knigge U, Janson E, Sorbye H. A Consensus-Developed Morphological Re-Evaluation of 196 High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms and Its Clinical Correlations. Neuroendocrinology 2020, 111: 883-894. PMID: 33002892, DOI: 10.1159/000511905.Peer-Reviewed Original ResearchConceptsNeuroendocrine tumor G3High-grade gastroenteropancreatic neuroendocrine neoplasmsGastroenteropancreatic neuroendocrine neoplasmsNeuroendocrine tumorsKi-67GEP-NENsNeuroendocrine neoplasmsHigh-grade GEP-NENMedian progression-free survivalGEP-NEN patientsMedian overall survivalProgression-free survivalFirst-line chemotherapyResponse to chemotherapyMorphological criteriaOrganoid growth patternKi-67 <Proliferation rateMetastatic diseaseOverall survivalPrognostic significanceDesmoplastic stromaLonger survivalTumor cellsClinical correlates
2019
Stage IV lung carcinoids: spectrum and evolution of proliferation rate, focusing on variants with elevated proliferation indices
Rekhtman N, Desmeules P, Litvak A, Pietanza M, Santos-Zabala M, Ni A, Montecalvo J, Chang J, Beras A, Preeshagul I, Sabari J, Rudin C, Ladanyi M, Klimstra D, Travis W, Lai W. Stage IV lung carcinoids: spectrum and evolution of proliferation rate, focusing on variants with elevated proliferation indices. Modern Pathology 2019, 32: 1106-1122. PMID: 30923345, PMCID: PMC6746332, DOI: 10.1038/s41379-019-0248-2.Peer-Reviewed Original ResearchConceptsNeuroendocrine carcinomaLung carcinoidsKi-67Metastatic carcinoidMetastatic sitesPrimary tumorProliferation rateProliferation indexTherapeutic response of patientsElevated proliferation indexMedian overall survivalKi-67 rateCharacteristics of tumorsResponse of patientsLow proliferation rateElevated proliferation rateMetastatic settingTypical carcinoidOverall survivalNeuroendocrine neoplasmsClonal relationshipMitotic countTherapeutic responseMetastatic samplesProliferative progression
2018
Subject-specific brain tumor growth modelling via an efficient Bayesian inference framework
Chang Y, Sharp G, Li Q, Shih H, El Fakhri G, Ra J, Woo J. Subject-specific brain tumor growth modelling via an efficient Bayesian inference framework. Proceedings Of SPIE--the International Society For Optical Engineering 2018, 10574: 105742i. PMID: 30050231, PMCID: PMC6056378, DOI: 10.1117/12.2293145.Peer-Reviewed Original ResearchTumor growthOptimal treatmentExternal beam radiotherapyBrain tumor progressionBeam radiotherapyBrain tumor growthTumor growth modelTumor infiltrationTumor parametersTumor progressionEffective therapyClinical dataTherapy planningTumorIndividualized therapyTherapyTumor boundariesProliferation rateRadiotherapyNon-invasiveState-of-the-art methodsTreatmentState-of-the-artChemotherapy
2014
Gastroenteropancreatic high‐grade neuroendocrine carcinoma
Sorbye H, Strosberg J, Baudin E, Klimstra D, Yao J. Gastroenteropancreatic high‐grade neuroendocrine carcinoma. Cancer 2014, 120: 2814-2823. PMID: 24771552, DOI: 10.1002/cncr.28721.Peer-Reviewed Original ResearchConceptsPlatinum-based chemotherapyNeuroendocrine carcinomaGEP-NECKi-67High-grade neuroendocrine carcinomaKi-67 proliferation indexCell neuroendocrine carcinomaSmall cell carcinomaGastroenteropancreatic (GEPHigh-grade tumorsKi-67 indexProliferation rateLong-term survivalIntermediate-gradeLocalized diseaseNeuroendocrine neoplasmsPrognostic stratificationCell carcinomaProliferation indexTreatment optionsOptimal treatmentLow-gradeTumorChemotherapyPatients
2008
The Effect of Different Frequencies of Stretch on Human Dermal Keratinocyte Proliferation and Survival
Nishimura K, Blume P, Ohgi S, Sumpio BE. The Effect of Different Frequencies of Stretch on Human Dermal Keratinocyte Proliferation and Survival. Journal Of Surgical Research 2008, 155: 125-131. PMID: 19059608, DOI: 10.1016/j.jss.2008.07.029.Peer-Reviewed Original ResearchConceptsERK 1/2P38 MAPKProtein kinaseKeratinocyte proliferation rateCell deathAkt inhibitorCyclic stretchDNA synthesisAktTransferase-mediated dUTP nick-end labeling stainingRepetitive stretchApoptosisMAPKDUTP nick end labeling stainingProliferation rateHuman dermalCell numberNick end labeling stainingTUNEL-positive cellsDermal keratinocytesStretchTerminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) stainingBrdU stainingKeratinocyte proliferationProliferation
2001
Salmonella enterica Serovar Typhimurium Response Involved in Attenuation of Pathogen Intracellular Proliferation
Cano D, Martı́nez-Moya M, Pucciarelli M, Groisman E, Casadesús J, Portillo F. Salmonella enterica Serovar Typhimurium Response Involved in Attenuation of Pathogen Intracellular Proliferation. Infection And Immunity 2001, 69: 6463-6474. PMID: 11553591, PMCID: PMC98782, DOI: 10.1128/iai.69.10.6463-6474.2001.Peer-Reviewed Original ResearchConceptsIntracellular growth rateIntracellular bacterial viabilityIntracellular proliferation rateNormal rat kidney fibroblastsBacterial overgrowthNonphagocytic host cellsRat kidney fibroblastsNormal fibroblast cellsIntracellular bacterial proliferationMacrophage cellsIntracellular proliferationIntracellular bacteriaKidney fibroblastsVirulence genesFunction mutationsProliferation rateHost cellsBacterial proliferationSerovar TyphimuriumPhoP-PhoQ systemS. entericaProliferationCellsSalmonella enterica
1997
High Telomerase Activity in Primary Lung Cancers: Association With Increased Cell Proliferation Rates and Advanced Pathologic Stage
Albanell J, Engelhardt M, Han W, Moore M, Lonardo F, Rusch V, Langenfeld J, Klimstra D, Venkatraman E, Dmitrovsky E. High Telomerase Activity in Primary Lung Cancers: Association With Increased Cell Proliferation Rates and Advanced Pathologic Stage. Journal Of The National Cancer Institute 1997, 89: 1609-1615. PMID: 9362159, DOI: 10.1093/jnci/89.21.1609.Peer-Reviewed Original ResearchConceptsNon-small-cell lung cancerTumor cell proliferation ratePatients treated with surgeryAdvanced pathological stageTelomeric repeat amplification protocolPathological stageLung cancerCell proliferation rateHigh telomerase activityTelomerase activityTumor stageKi-67Clinical outcomesResected non-small-cell lung cancerAssociated with tumor pathologic stagePrimary non-small-cell lung cancerImmunohistochemical analysis of Ki-67Proliferation rateMultivariate Cox proportional hazards analysisTNM (tumor-node-metastasis) stageTumors treated with surgeryAnalysis of Ki-67Associated with clinical outcomesLong-term follow-upAssess tumor cell proliferation
1994
Inhibition of smooth muscle cell proliferation by visible light-activated psoralen.
Sumpio BE, Li G, Deckelbaum LI, Gasparro FP. Inhibition of smooth muscle cell proliferation by visible light-activated psoralen. Circulation Research 1994, 75: 208-213. PMID: 8033334, DOI: 10.1161/01.res.75.2.208.Peer-Reviewed Original Research
1987
The Extracellular Matrix as a Modulator of Angiogenesis
Madri J. The Extracellular Matrix as a Modulator of Angiogenesis. Gwumc Department Of Biochemistry And Molecular Biology Annual Spring Symposia 1987, 177-183. DOI: 10.1007/978-1-4684-5296-9_21.Peer-Reviewed Original ResearchLarge vessel endothelial cellsEndothelial cell populationCell populationsExtracellular matrixEndothelial cellsHeterogeneous cell populationsEndothelial cell behaviorMicrovascular endothelial cellsMulticellular organizationCytoskeletal organizationProliferation rateSheet migrationModulators of angiogenesisMatrix organizationCell behaviorTransport functionMatrix compositionVessel endothelial cellsMatrix componentsMatrix synthesisCellsDiverse vascular bedsSeries of responsesDifferentiationMatrix determines
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