High Telomerase Activity in Primary Lung Cancers: Association With Increased Cell Proliferation Rates and Advanced Pathologic Stage
Albanell J, Engelhardt M, Han W, Moore M, Lonardo F, Rusch V, Langenfeld J, Klimstra D, Venkatraman E, Dmitrovsky E. High Telomerase Activity in Primary Lung Cancers: Association With Increased Cell Proliferation Rates and Advanced Pathologic Stage. Journal Of The National Cancer Institute 1997, 89: 1609-1615. PMID: 9362159, DOI: 10.1093/jnci/89.21.1609.Peer-Reviewed Original ResearchConceptsNon-small-cell lung cancerTumor cell proliferation ratePatients treated with surgeryAdvanced pathological stageTelomeric repeat amplification protocolPathological stageLung cancerCell proliferation rateHigh telomerase activityTelomerase activityTumor stageKi-67Clinical outcomesResected non-small-cell lung cancerAssociated with tumor pathologic stagePrimary non-small-cell lung cancerImmunohistochemical analysis of Ki-67Proliferation rateMultivariate Cox proportional hazards analysisTNM (tumor-node-metastasis) stageTumors treated with surgeryAnalysis of Ki-67Associated with clinical outcomesLong-term follow-upAssess tumor cell proliferation
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