2024
Selenomethionine supplementation mitigates fluoride-induced liver apoptosis and inflammatory reactions by blocking Parkin-mediated mitophagy in mice
Wang T, Li H, Li Y, Li M, Zhao H, Zhang W, Zhao T, Wang Y, Wang J, Wang J. Selenomethionine supplementation mitigates fluoride-induced liver apoptosis and inflammatory reactions by blocking Parkin-mediated mitophagy in mice. The Science Of The Total Environment 2024, 951: 175458. PMID: 39142410, DOI: 10.1016/j.scitotenv.2024.175458.Peer-Reviewed Original ResearchParkin-mediated mitophagyCysteinyl aspartate specific proteinase 3Protein expression levelsLight chain 3Expression levelsInterleukin-6Wild-typeLiver damageContents of proinflammatory factorsTumor necrosis factor-aNuclear factor kappa BLevels of liver functionMitochondrial fusionFactor kappa BParkin-/-Inflammatory signaling pathwaysMicrotubule-associated protein light chain 3MitophagyInterferon-gMitochondrial alterationsProtein light chain 3Gene knockoutIFN-gFluorosis miceLiver function
2022
Metabolic Regulation of Mitochondrial Dynamics and Cardiac Function
Rudokas M, Cacheux M, Akar F. Metabolic Regulation of Mitochondrial Dynamics and Cardiac Function. 2022, 197-211. DOI: 10.1007/978-3-031-08309-9_6.BooksMitochondrial dynamicsNormal embryonic developmentMitochondrial dynamics proteinsDynamic organellesMitochondrial networkMitochondrial fusionDynamic proteinsEmbryonic developmentFragmented mitochondriaKey proteinsKey regulatorFunctional importanceMetabolic regulationAltered regulationMitochondriaFission eventsFundamental processesProteinCardiac mitochondriaFission resultsRegulationMorphological changesRecent advancesOrganellesRegulatorMitochondrial dysfunction caused by targeted deletion of Mfn1 does not result in telomere shortening in oocytes.
Cozzolino M, Seli E. Mitochondrial dysfunction caused by targeted deletion of Mfn1 does not result in telomere shortening in oocytes. Zygote 2022, 30: 735-737. PMID: 35730364, DOI: 10.1017/s0967199422000089.Peer-Reviewed Original ResearchConceptsMitochondrial dysfunctionMaintenance of telomeresTargeted deletionEnd-protection functionTTAGGG repeatsMitochondrial fusionTelomeric repeatsSomatic cellsMitofusin 1Reactive oxygen speciesEnzyme complexWild-type miceOocyte growthDNA damageMouse oocytesTelomerase activityOocyte maturationDeletionFollicular depletionOxygen speciesTelomere lengthTelomeresFollicular developmentOocytesRepeatsMFN2 Deficiency Impairs Mitochondrial Functions and PPAR Pathway During Spermatogenesis and Meiosis in Mice
Wang T, Xiao Y, Hu Z, Gu J, Hua R, Hai Z, Chen X, Zhang J, Yu Z, Wu T, Yeung W, Liu K, Guo C. MFN2 Deficiency Impairs Mitochondrial Functions and PPAR Pathway During Spermatogenesis and Meiosis in Mice. Frontiers In Cell And Developmental Biology 2022, 10: 862506. PMID: 35493072, PMCID: PMC9046932, DOI: 10.3389/fcell.2022.862506.Peer-Reviewed Original ResearchConditional knock-outMitochondrial functionPPAR pathwayMale germ cellsRNA-seq analysisGenes up-regulatedGenes down-regulatedPathway enrichment analysisImpaired mitochondrial functionDynamic organellesMitochondrial dynamicsRNA-seqMitochondrial fusionDisrupted spermatogenesisMfn2 deficiencyGerm cellsPachytene stageOxidative phosphorylationSpermatogenesisTranscriptome profilingEnrichment analysisMfn2Cellular differentiationMolecular mechanismsLipid droplets
2019
Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging
Zhang M, Bener MB, Jiang Z, Wang T, Esencan E, Scott R, Horvath T, Seli E. Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging. Aging 2019, 11: 3919-3938. PMID: 31204316, PMCID: PMC6628992, DOI: 10.18632/aging.102024.Peer-Reviewed Original ResearchConceptsMitofusin 2Key regulatory proteinsImpaired oocyte maturationFollicle developmentMitochondrial fusionRegulatory proteinsEndoplasmic reticulumMitochondrial dysfunctionTargeted deletionOocyte maturationOocytesReproductive agingFemale subfertilityOocyte qualityOvarian follicular reserveTelomeresMitochondriaMetabolic milieuProteinReticulumDeletionFusionPhenotypeApoptosisMaturation
2016
Granulosa cell and oocyte mitochondrial abnormalities in a mouse model of fragile X primary ovarian insufficiency
Dioguardi C, Uslu B, Haynes M, Kurus M, Gul M, Miao DQ, De Santis L, Ferrari M, Bellone S, Santin A, Giulivi C, Hoffman G, Usdin K, Johnson J. Granulosa cell and oocyte mitochondrial abnormalities in a mouse model of fragile X primary ovarian insufficiency. Molecular Human Reproduction 2016, 22: 384-396. PMID: 26965313, PMCID: PMC4884918, DOI: 10.1093/molehr/gaw023.Peer-Reviewed Original ResearchConceptsMitochondrial DNA copy numberDNA copy numberFMR1 proteinMitochondrial contentTranslation productsRepeat associated non-ATG translationFMR1 mRNACGG repeatsCopy numberMitochondrial dysfunctionMitochondrial gene expressionNon-ATG translationCGG-repeat tractQuantitative RT-PCR analysisOptic atrophy 1Mitochondrial structural abnormalitiesPrimary ovarian insufficiencyGranulosa cellsMutant genotypesGene dosage effectMetaphase II eggsMitochondrial genesMitochondrial architectureMitochondrial fusionRT-PCR analysis
2014
Mitochondrial dynamics in the central regulation of metabolism
Nasrallah CM, Horvath TL. Mitochondrial dynamics in the central regulation of metabolism. Nature Reviews Endocrinology 2014, 10: 650-658. PMID: 25200564, DOI: 10.1038/nrendo.2014.160.Peer-Reviewed Original ResearchConceptsPOMC neuronsMetabolic disordersPeripheral tissue functionsCentral melanocortin systemMitochondrial dynamicsProopiomelanocortin neuronsAnorexigenic responseOrexigenic responseHypothalamic neuronsCentral regulationMelanocortin systemNeuronsDistinct signaling pathwaysSignaling pathwaysMitochondrial fusionMolecular regulatorsTissue functionDistinct functionsDisordersFatty acidsMetabolismActivationObesityAppetiteResponse
2011
Role of the Mitochondrial Fission Protein Drp1 in Synaptic Damage and Neurodegeneration
Nakamura T, Cho D, Lipton S. Role of the Mitochondrial Fission Protein Drp1 in Synaptic Damage and Neurodegeneration. 2011, 215-234. DOI: 10.1007/978-94-007-1291-1_8.Peer-Reviewed Original ResearchMitochondrial fission protein Drp1Fission protein Drp1Mitochondrial fissionProtein Drp1Dynamin-related protein 1Abnormal mitochondrial morphologyMitochondrial fusionDrp1 activityPosttranslational modificationsMitochondrial morphologyMitochondrial structureCell deathDrp1Protein 1Recent insightsNeurodegenerative diseasesSynaptic damageNeuronal cell injuryNeurodegenerative conditionsFissionMitofusinsDynaminGTPasesFusionOPA1
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