2022
The telomere maintenance mechanism spectrum and its dynamics in gliomas
Kim S, Chowdhury T, Yu H, Kahng J, Lee C, Choi S, Kim K, Kang H, Lee J, Lee S, Won J, Kim K, Kim M, Lee J, Kim J, Kim Y, Kim T, Choi S, Phi J, Shin Y, Ku J, Lee S, Yun H, Lee H, Kim D, Kim K, Hur J, Park S, Kim S, Park C. The telomere maintenance mechanism spectrum and its dynamics in gliomas. Genome Medicine 2022, 14: 88. PMID: 35953846, PMCID: PMC9367055, DOI: 10.1186/s13073-022-01095-x.Peer-Reviewed Original ResearchConceptsTERT promoter mutationsTelomere maintenance mechanismTelomerase activityGlioma samplesTERT expressionPromoter mutationsCancer management strategiesSlow growth potentialC-circle assayCancer cell immortalityGlioma patientsSeparate cohortNegative groupGlioma progressionNanoString analysisTumor tissueTelomerase enzyme activityGliomasTumor cellsConclusionsThis studyALTATRX mutationsTelomerase activationATRX lossConsiderable proportion
2017
Clinicopathological analysis of ATRX, DAXX and NOTCH receptor expression in angiosarcomas
Panse G, Chrisinger JS, Leung CH, Ingram DR, Khan S, Wani K, Lin H, Lazar AJ, Wang W. Clinicopathological analysis of ATRX, DAXX and NOTCH receptor expression in angiosarcomas. Histopathology 2017, 72: 239-247. PMID: 28796347, DOI: 10.1111/his.13337.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentAdultAgedAged, 80 and overBiomarkers, TumorCo-Repressor ProteinsDisease-Free SurvivalFemaleHemangiosarcomaHumansKaplan-Meier EstimateMaleMiddle AgedMolecular ChaperonesNuclear ProteinsPrognosisReceptors, NotchX-linked Nuclear ProteinYoung AdultConceptsNotch2 expressionWorse disease-specific survivalWorse event-free survivalDisease-specific survivalEvent-free survivalMalignant vascular tumorsPoor clinical outcomeATRX lossCase of angiosarcomaDeep soft tissuesPathogenesis of angiosarcomaTumor suppressive roleProtein 6 expressionNotch receptor expressionMental retardation syndrome XMultiple genetic alterationsSite of originInhibition of NotchAdvanced diseaseCutaneous sitesClinical outcomesPrognostic significanceClinicopathological analysisSyndrome XVascular tumors
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