2024
von Meyenburg complexes are more frequently associated with cholangiocarcinoma
Jain D, Khandakar B, Ni P, Kenney B, Qin L, Deshpande V, Fiel M. von Meyenburg complexes are more frequently associated with cholangiocarcinoma. Journal Of Clinical Pathology 2024, 78: 300-306. PMID: 38729770, DOI: 10.1136/jcp-2024-209572.Peer-Reviewed Original ResearchVon Meyenburg complexesHilar CCHepatic resectionCC casesChronic viral hepatitis BAssociated liver disordersMeyenburg complexesProgress to cholangiocarcinomaDysplasia/carcinoma in situMetastatic colon carcinomaViral hepatitis BCases of CCBile duct adenomaPolycystic kidney diseaseAssociated with cholangiocarcinomaBenign lesionsCryptogenic cirrhosisHepatitis BBiliary diseaseColon carcinomaMiscellaneous disordersKidney diseaseLiver diseaseCholangiocarcinomaLiver disorders
2020
Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for limited peritoneal metastasis. The PSOGI international collaborative registry
Arjona-Sanchez A, Aziz O, Passot G, Salti G, Esquivel J, Van der Speeten K, Piso P, Nedelcut D, Sommariva A, Yonemura Y, Turaga K, Selvasekar C, Rodriguez-Ortiz L, Sanchez-Hidalgo J, Casado-Adam A, Rufian-Peña S, Briceño J, Glehen O. Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for limited peritoneal metastasis. The PSOGI international collaborative registry. European Journal Of Surgical Oncology 2020, 47: 1420-1426. PMID: 33298341, DOI: 10.1016/j.ejso.2020.11.140.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCisplatinColonic NeoplasmsCytoreduction Surgical ProceduresDisease-Free SurvivalDoxorubicinFemaleFollow-Up StudiesHumansHyperthermic Intraperitoneal ChemotherapyLaparoscopyLength of StayMaleMesotheliomaMiddle AgedMitomycinNeoadjuvant TherapyNeoplasm, ResidualOvarian NeoplasmsOxaliplatinPaclitaxelPeritoneal NeoplasmsPseudomyxoma PeritoneiRegistriesSeverity of Illness IndexSurvival RateTumor BurdenConceptsPeritoneal Surface Oncology Group InternationalHyperthermic intraperitoneal chemotherapyLength of stayCytoreductive surgeryIntraperitoneal chemotherapyPeritoneal metastasisBenign multicystic mesotheliomaLaparoscopic cytoreductive surgeryLimited peritoneal metastasesPost-operative morbidityFree of diseaseMedian length of stayIndividual patient dataMedian PCIPeritoneal diseasePeritoneal disseminationMulticystic mesotheliomaOvarian carcinomaMidterm outcomesPseudomyxoma peritoneiLaparoscopic approachPostoperative outcomesFrequent indicationInvasive histologyColon carcinoma
2008
Serrated Polyps With “Intermediate Features” of Sessile Serrated Polyp and Microvesicular Hyperplastic Polyp
Chung S, Chen Y, Panczykowski A, Schamberg N, Klimstra D, Yantiss R. Serrated Polyps With “Intermediate Features” of Sessile Serrated Polyp and Microvesicular Hyperplastic Polyp. The American Journal Of Surgical Pathology 2008, 32: 407-412. PMID: 18300810, DOI: 10.1097/pas.0b013e318158dde2.Peer-Reviewed Original ResearchConceptsSessile serrated polypsNondysplastic serrated polypsMicrovesicular hyperplastic polypsSerrated polypsHyperplastic polypsKRAS mutation statusColorectal cancer riskO6-methylguanine methyltransferaseMolecular featuresMutation statusKi-67BRAF mutationsProximal colon carcinomasStudy polypsMUC5AC expressionColon carcinomaExpressed MUC5ACCancer riskDistal lesionsProspective dataMethyltransferase expressionDiagnostic criteriaNatural historyPolypsBRAF
2007
Mutational analysis of PTPRT phosphatase domains in common human cancers
LEE J, JEONG E, LEE S, NAM S, KIM S, LEE J, YOO N, LEE S. Mutational analysis of PTPRT phosphatase domains in common human cancers. Apmis 2007, 115: 47-51. PMID: 17223850, DOI: 10.1111/j.1600-0463.2007.apm_554.x.Peer-Reviewed Original ResearchConceptsPolymerase chain reaction-based single-strand conformation polymorphismPhosphatase domainNon-small cell lung cancerMutation analysisCell lung cancerHuman cancersColon carcinomaGastric carcinomaDomain mutationsSingle-strand conformation polymorphismBreast carcinomaAcute leukemiaHepatocellular carcinomaLung cancerColon cancerProtein tyrosine phosphataseSplice-site mutationTumor suppressor genePTPRT geneConformation polymorphismMissense mutationsMutation searchPTPRTSuppressor geneSignaling pathway
2006
Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma
Bellovin DI, Simpson KJ, Danilov T, Maynard E, Rimm DL, Oettgen P, Mercurio AM. Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma. Oncogene 2006, 25: 6959-6967. PMID: 16715134, DOI: 10.1038/sj.onc.1209682.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorCadherinsCell Line, TumorColonic NeoplasmsEnzyme ActivationEpithelial CellsHumansImmunohistochemistryImmunoprecipitationNeoplasm InvasivenessPrognosisPromoter Regions, GeneticProto-Oncogene Protein c-ets-1Reverse Transcriptase Polymerase Chain Reactionrho GTP-Binding ProteinsrhoA GTP-Binding ProteinrhoC GTP-Binding ProteinRNA, Small InterferingTranscription, GeneticConceptsColon carcinomaRhoC expressionPrognostic markerRhoC protein expressionE-cadherinET-1 binding sitesClinical outcomesPoor outcomeColon cancer cellsColorectal tumorsET-1Colon cancerUse of shRNAMesenchymal transitionExpression correlatesCarcinomaAberrant expressionHigh expressionProtein expressionCancer cellsMesenchymal characteristicsEMTSubsequent activationReciprocal regulationCell migration
2005
Altered Localization of p120 Catenin During Epithelial to Mesenchymal Transition of Colon Carcinoma Is Prognostic for Aggressive Disease
Bellovin DI, Bates RC, Muzikansky A, Rimm DL, Mercurio AM. Altered Localization of p120 Catenin During Epithelial to Mesenchymal Transition of Colon Carcinoma Is Prognostic for Aggressive Disease. Cancer Research 2005, 65: 10938-10945. PMID: 16322241, DOI: 10.1158/0008-5472.can-05-1947.Peer-Reviewed Original ResearchConceptsSurvival timeMesenchymal transitionLymph node metastasisColorectal cancer progressionPoor patient outcomesE-cadherinLate-stage tumorsPatient survival timePost-EMT cellsP120ctn expressionAltered localizationLymph nodesNode metastasisAggressive diseaseTumor stagePrimary tumorTumor necrosisColorectal carcinomaPatient outcomesColon carcinoma cellsE-cadherin lossCytoplasmic stainingColon carcinomaCancer progressionCarcinoma cells
2004
Mutation of FADD gene is rare in human colon and stomach cancers
SOUNG Y, LEE J, KIM S, NAM S, PARK W, KIM S, LEE J, YOO N, LEE S. Mutation of FADD gene is rare in human colon and stomach cancers. Apmis 2004, 112: 595-7. PMID: 15601308, DOI: 10.1111/j.1600-0463.2004.apm1120906.x.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenocarcinomaAdultAgedAged, 80 and overColonic NeoplasmsDNA, NeoplasmFas-Associated Death Domain ProteinFemaleHumansMaleMiddle AgedMutation, MissensePolymerase Chain ReactionPolymorphism, Single-Stranded ConformationalSequence Analysis, DNAStomach NeoplasmsConceptsFADD geneDeath domainDeath receptor-mediated apoptosisReceptor-mediated apoptosisSomatic missense mutationsFailure of apoptosisHuman colonHallmarks of cancerFADD proteinSplice siteStomach cancerCoding regionFADDNon-small cell lung cancerMissense mutationsCell lung cancerGenesGenetic alterationsSomatic mutationsAmino acidsMutationsHuman cancersGene mutationsColon carcinomaLung cancerSomatic mutations of CASP3 gene in human cancers
Soung Y, Lee J, Kim S, Park W, Nam S, Lee J, Yoo N, Lee S. Somatic mutations of CASP3 gene in human cancers. Human Genetics 2004, 115: 112-115. PMID: 15127291, DOI: 10.1007/s00439-004-1129-3.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerNon-Hodgkin's lymphomaCell lung cancerHuman tumorsCASP3 geneSomatic mutationsMultiple myelomaSplice siteColon carcinomaGenetic alterationsHepatocellular carcinomaLung cancerStomach carcinomaCaspase-3Execution-phase caspaseUrinary bladder carcinomaRenal cell carcinomaDetection of somatic mutationsFailure of apoptosisHallmarks of cancerDevelopment of human tumorsBladder carcinomaWilms tumorBreast carcinomaCell carcinoma
2003
Inactivating mutations of CASPASE-7 gene in human cancers
Soung Y, Lee J, Kim H, Park W, Kim S, Lee J, Park J, Cho Y, Kim C, Park Y, Nam S, Jeong S, Kim S, Lee J, Yoo N, Lee S. Inactivating mutations of CASPASE-7 gene in human cancers. Oncogene 2003, 22: 8048-8052. PMID: 12970753, DOI: 10.1038/sj.onc.1206727.Peer-Reviewed Original ResearchConceptsCaspase-7 geneCaspase-7Inactivating mutationsSplice siteWild-type caspase-7Human solid cancersGenetic alterationsDetection of somatic mutationsHuman cancersT cellsSolid cancersDevelopment of human cancersApoptotic functionCoding regionSomatic mutationsGenesMutationsEsophageal carcinomaHead/neck carcinomasGene mutationsColon carcinomaHuman malignanciesUrinary bladderCarcinomaApoptosis
2001
Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
Rudolph K, Millard M, Bosenberg M, DePinho R. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nature Genetics 2001, 28: 155-159. PMID: 11381263, DOI: 10.1038/88871.Peer-Reviewed Original ResearchConceptsHuman intestinal neoplasiaProgression of mouseTelomerase activationHuman colorectal carcinogenesisTelomere dysfunctionInitiated lesionsIntestinal carcinomaColorectal carcinogenesisIntestinal neoplasiaHuman colorectalDysfunctionAdvanced stageMalignant transformationTumor progressionChromosomal instabilityColon carcinomaCarcinoma transitionMacroscopic adenomasTransient telomere dysfunctionEarly carcinogenesisCancer initiationHuman cancersTelomerase activityCarcinomaDifferential effects
1999
5‐Fluorouracil‐induced small bowel toxicity in patients with colorectal carcinoma
Fata F, Ron I, Kemeny N, O'Reilly E, Klimstra D, Kelsen D. 5‐Fluorouracil‐induced small bowel toxicity in patients with colorectal carcinoma. Cancer 1999, 86: 1129-1134. PMID: 10506695, DOI: 10.1002/(sici)1097-0142(19991001)86:7<1129::aid-cncr5>3.0.co;2-4.Peer-Reviewed Original ResearchConceptsSmall bowel toxicityBowel toxicityColorectal carcinomaColon carcinomaLow dose of 5-FUAcute small bowel toxicityDose of 5-FUAbdominal computed tomography scanAcute abdominal painRecurrence of symptomsGastrointestinal side effectsSmall bowel damageDecreased mucosal blood flowMucosal blood flowAcute toxicity episodesLower gastrointestinal tractGastrointestinal toxicityAbdominal painOral mucositisSchedule-dependentSevere toxicityTomography scanBowel damageClinical pictureLow doses
1994
Colon Carcinoma Metastatic to the Trachea
Conti J, Kemeny N, Klimstra D, Minsky B, Rusch V. Colon Carcinoma Metastatic to the Trachea. American Journal Of Clinical Oncology 1994, 17: 227-229. PMID: 8192107, DOI: 10.1097/00000421-199406000-00009.Peer-Reviewed Original Research
1987
Prognostic implications of expression of the cellular genes myc, fos, Ha‐ras and Ki‐ras in colon carcinoma
Monnat M, Tardy S, Saraga P, Diggelmann H, Costa J. Prognostic implications of expression of the cellular genes myc, fos, Ha‐ras and Ki‐ras in colon carcinoma. International Journal Of Cancer 1987, 40: 293-299. PMID: 3040597, DOI: 10.1002/ijc.2910400302.Peer-Reviewed Original ResearchCT Features of Hemorrhagic Malignant Liver Tumors
Siskind B, Malat J, Hammers L, Rigsby C, Taylor C, Radin D, Rosenfield A. CT Features of Hemorrhagic Malignant Liver Tumors. Journal Of Computer Assisted Tomography 1987, 11: 766-770. PMID: 2821089, DOI: 10.1097/00004728-198709000-00004.Peer-Reviewed Original ResearchConceptsMetastatic colon carcinomaPrimary hepatic malignancySetting of anticoagulationMalignant liver tumorsPerihepatic fluidHemorrhagic complicationsHepatic metastasesCT featuresHepatic malignanciesHepatic massNoncontrast scansPeritoneal fluidSubcapsular fluidRadiographic signsHepatocellular carcinomaLiver tumorsPatientsColon carcinomaHemorrhageLiver borderComplicationsCarcinomaTumorsHematocrit effectLiver
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