2023
Characterizing experiential elements of early-life stress to inform resilience: Buffering effects of controllability and predictability and the importance of their timing
Cohodes E, Sisk L, Keding T, Mandell J, Notti M, Gee D. Characterizing experiential elements of early-life stress to inform resilience: Buffering effects of controllability and predictability and the importance of their timing. Development And Psychopathology 2023, 35: 2288-2301. PMID: 37496155, DOI: 10.1017/s0954579423000822.Peer-Reviewed Original ResearchTrauma-related symptomatologyTraumatic stressDevelopmental periodImpact of exposureUnique developmental periodTraumatic stress exposureLifetime stress exposureStress exposureProcess of riskKey theoretical frameworksEarly life stressSpecific developmental periodsMiddle childhoodAdulthood stressModeration effectIndividual perceptionsLifetime stressDimensional ratingsStressor controllabilityEffect of controllabilitySpecific dimensionsYoung adultsUnderstanding of riskEarly childhoodSymptomatologyUtility of Wrist-Wearable Data for Assessing Pain, Sleep, and Anxiety Outcomes After Traumatic Stress Exposure
Straus L, An X, Ji Y, McLean S, Neylan T, Cakmak A, Richards A, Clifford G, Liu M, Zeng D, House S, Beaudoin F, Stevens J, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Seamon M, Datner E, Chang A, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Sheridan J, Harte S, Elliott J, Kessler R, Ressler K, Koenen K. Utility of Wrist-Wearable Data for Assessing Pain, Sleep, and Anxiety Outcomes After Traumatic Stress Exposure. JAMA Psychiatry 2023, 80: 220-229. PMID: 36630119, PMCID: PMC9857758, DOI: 10.1001/jamapsychiatry.2022.4533.Peer-Reviewed Original ResearchConceptsTraumatic stress exposureAdverse posttraumatic neuropsychiatric sequelaeEmergency departmentStress exposureNeuropsychiatric sequelaeGreater pain severityPain severityDerivation cohortNeuropsychiatric symptomsMean ageStudy criteriaSerial assessmentSleep disruptionMAIN OUTCOMEHigh incidenceUseful biomarkerBaseline assessmentPainSymptom severityDiverse cohortInformed consentPatientsSymptom domainsSleepDisadvantaged populations
1999
Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation.
Chambers RA, Bremner JD, Moghaddam B, Southwick SM, Charney DS, Krystal JH. Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation. Seminars In Clinical Neuropsychiatry 1999, 4: 274-81. PMID: 10553033, DOI: 10.153/scnp00400274.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderGlutamate releaseNMDA antagonistsStress disorderN-methyl-D-aspartate (NMDA) subtypeDevelopment of PTSDDissociative symptomsStress exposureRecent preclinical dataTraumatic stress exposureHyperglutamatergic stateNeuroprotective potentialPreclinical dataNeural toxicityClinical studiesGlutamate receptorsTraumatized individualsPerceptual effectsPerceptual alterationsNeural plasticityAntagonistBrain functionSymptomsInfluence behaviorDrugs
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