2022
Routine Cardiac Stress Testing in Potential Kidney Transplant Candidates Is Only Appropriate in Symptomatic Individuals: CON
Hu J, Sugeng L. Routine Cardiac Stress Testing in Potential Kidney Transplant Candidates Is Only Appropriate in Symptomatic Individuals: CON. Kidney360 2022, 3: 2013-2016. PMID: 36591343, PMCID: PMC9802547, DOI: 10.34067/kid.0007162021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPrevalence and predictors of automatically quantified myocardial ischemia within a multicenter international registry
Han D, Rozanski A, Miller RJH, Sharir T, Einstein AJ, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli M, Liang JX, Dey D, Berman DS, Slomka PJ. Prevalence and predictors of automatically quantified myocardial ischemia within a multicenter international registry. Journal Of Nuclear Cardiology 2022, 29: 3221-3232. PMID: 35174442, PMCID: PMC9378748, DOI: 10.1007/s12350-021-02829-x.Peer-Reviewed Original ResearchConceptsTotal perfusion deficitMyocardial ischemiaStress testingCAD risk factorsMulticenter international registryPredictor of ischemiaCardiac stress testingNuclear stress testingChi-square testConclusionThe prevalenceMulticenter registryOverall cohortTypical anginaCAD statusPerfusion deficitsInternational registryMale genderRisk factorsLVEFIschemiaPatientsImaging characteristicsPotent predictorPrevalenceRegistry
2021
Comparison of diabetes to other prognostic predictors among patients referred for cardiac stress testing: A contemporary analysis from the REFINE SPECT Registry
Han D, Rozanski A, Gransar H, Tzolos E, Miller RJH, Sharir T, Einstein AJ, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli M, Liang JX, Hu LH, Dey D, Berman DS, Slomka PJ. Comparison of diabetes to other prognostic predictors among patients referred for cardiac stress testing: A contemporary analysis from the REFINE SPECT Registry. Journal Of Nuclear Cardiology 2021, 29: 3003-3014. PMID: 34757571, PMCID: PMC9085969, DOI: 10.1007/s12350-021-02810-8.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsCoronary artery diseaseTotal perfusion deficitCardiac stress testingStress testingComparison of diabetesAdverse cardiovascular eventsStress test patientsCardiac stress test patientsREFINE SPECT registryDM statusMACE riskBackgroundDiabetes mellitusCardiovascular eventsArtery diseaseVentricular functionPrognostic predictorClinical variablesPerfusion deficitsChi-square analysisSPECT-MPIPatientsTest patientsPropensity scorePotent predictor
2019
Incremental Prognostic Value of Exercise Stress Testing in Primary Prevention
Alashi A, Riaz H, Lang R, Seballos R, Feinleib S, Sukol R, Cho L, Cremer P, Jaber W, Griffin BP, Desai MY. Incremental Prognostic Value of Exercise Stress Testing in Primary Prevention. The American Journal Of Cardiology 2019, 124: 216-223. PMID: 31104779, DOI: 10.1016/j.amjcard.2019.04.021.Peer-Reviewed Original ResearchConceptsHeart rate recoveryIncremental prognostic valueC-reactive proteinPrimary preventionPrognostic valueLong-term eventsCV diseaseDerivation groupFamily historyValidation groupStandard risk factor assessmentProspective observational cohort studyContinuous net reclassification improvementConsecutive asymptomatic adultsPremature CV diseaseSuperior risk stratificationTreadmill stress testingFuture cardiovascular eventsObservational cohort studyExercise stress testingMultivariable survival analysisRisk factor assessmentNet reclassification improvementBeats/minStress testingFractional flow reserve use during elective coronary angiography among elderly patients in the US
Kay B, Joseph T, Lehrich J, Curzen N, Nallamothu B. Fractional flow reserve use during elective coronary angiography among elderly patients in the US. IJC Heart & Vasculature 2019, 22: 160-162. PMID: 30828601, PMCID: PMC6383174, DOI: 10.1016/j.ijcha.2019.01.005.Peer-Reviewed Original Research
2018
3136Incremental and synergistic prognostic value of exercise stress testing and standard risk factor assessment in asymptomatic executives: a primary prevention study
Alashi A, Young L, Lang R, Seballos R, Feinleib S, Sukol R, Cho L, Cremer P, Jaber W, Griffin B, Desai M. 3136Incremental and synergistic prognostic value of exercise stress testing and standard risk factor assessment in asymptomatic executives: a primary prevention study. European Heart Journal 2018, 39: ehy563.3136. DOI: 10.1093/eurheartj/ehy563.3136.Peer-Reviewed Original ResearchReceipt of cardiac screening does not influence 1-year post–cerebrovascular event mortality
Sico JJ, Baye F, Myers LJ, Concato J, Ferguson J, Cheng EM, Jadbabaie F, Yu Z, Arling G, Zillich AJ, Reeves MJ, Williams LS, Bravata DM. Receipt of cardiac screening does not influence 1-year post–cerebrovascular event mortality. Neurology Clinical Practice 2018, 8: 192-200. PMID: 30105158, PMCID: PMC6075977, DOI: 10.1212/cpj.0000000000000465.Peer-Reviewed Original ResearchCardiac stress testingCoronary heart diseaseStroke/TIACardiac screeningCerebrovascular diseaseStress testingOccult coronary heart diseaseIschemic stroke/TIAChest pain historyCommon Procedural Terminology codesVA emergency departmentIntermediate-risk patientsCardiac risk scoreDays of dischargeHigh-risk patientsObservational cohort studyAcute care facilitiesExpert consensus guidelinesRoutine clinical practiceProcedural Terminology codesEligible patientsCerebrovascular eventsCohort studyPain historyConsensus guidelines
2017
Depression is associated with recurrent chest pain with or without coronary artery disease: A prospective cohort study in the emergency department
Kim Y, Soffler M, Paradise S, Jelani QU, Dziura J, Sinha R, Safdar B. Depression is associated with recurrent chest pain with or without coronary artery disease: A prospective cohort study in the emergency department. American Heart Journal 2017, 191: 47-54. PMID: 28888269, DOI: 10.1016/j.ahj.2017.06.003.Peer-Reviewed Original ResearchConceptsRecurrent chest painCoronary artery diseaseAcute chest painChest painProspective cohort studyChest pain centerClinical Anxiety ScaleEmergency departmentPerceived Stress ScalePain centerCohort studyArtery diseaseNonobstructive coronary artery diseaseObstructive coronary artery diseaseChest pain recurrenceED chest painCardiac risk factorsCardiac stress testingPatient Health QuestionnaireSignificant independent predictorsStress testingMultivariable regression modelsPain recurrenceIndependent predictorsPrimary outcome
2015
The early identification of psychosis: can lessons be learnt from cardiac stress testing?
Gupta S, Ranganathan M, D’Souza D. The early identification of psychosis: can lessons be learnt from cardiac stress testing? Psychopharmacology 2015, 233: 19-37. PMID: 26566609, PMCID: PMC4703558, DOI: 10.1007/s00213-015-4143-3.Peer-Reviewed Original ResearchConceptsCardiac stress testingCoronary artery diseaseMyocardial infarctionOutcome measuresPsychotic disordersDetection of CADManagement of schizophreniaStress testingManagement of anginaDiagnosis of schizophreniaStress testArtery diseasePsychotic episodePsychiatric disordersPredictive valueEarly identificationEarly detectionSchizophreniaPsychosisDisordersTarget populationRiskSafe stimuliRange of risksUrgent needObesity Modifies the Effect of Fitness on Heart Rate Indices during Exercise Stress Testing in Asymptomatic Individuals
Aneni EC, Oni ET, Osondu CU, Martin SS, Blaha MJ, Veledar E, Agatston AS, Feldman T, Carvalho JA, Conceição RD, Santos RD, Nasir K. Obesity Modifies the Effect of Fitness on Heart Rate Indices during Exercise Stress Testing in Asymptomatic Individuals. Cardiology 2015, 132: 242-248. PMID: 26329389, DOI: 10.1159/000435907.Peer-Reviewed Original ResearchConceptsHeart rateHR recoveryDifferent body mass index (BMI) categoriesBody mass index categoriesExercise stress testExercise stress testingExercise heart ratePeak heart rateHeart rate indexCross-sectional analysisEffects of fitnessObesity modifiesAsymptomatic cohortPeak exerciseBMI categoriesObese subjectsAsymptomatic individualsMetabolic equivalentsIndex categoriesMultivariate analysisAerobic fitnessBrazilian subjectsWeight lossStatistical significanceStress testing
2013
Inducible Myocardial Ischemia and Outcomes in Patients With Coronary Artery Disease and Left Ventricular Dysfunction
Panza JA, Holly TA, Asch FM, She L, Pellikka PA, Velazquez EJ, Lee KL, Borges-Neto S, Farsky PS, Jones RH, Berman DS, Bonow RO. Inducible Myocardial Ischemia and Outcomes in Patients With Coronary Artery Disease and Left Ventricular Dysfunction. Journal Of The American College Of Cardiology 2013, 61: 1860-1870. PMID: 23500234, PMCID: PMC3755503, DOI: 10.1016/j.jacc.2013.02.014.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseDobutamine stress echocardiogramLV ejection fractionInducible myocardial ischemiaEjection fractionMedical therapyMyocardial ischemiaCause mortalityVentricular dysfunctionArtery diseaseClinical endpointsMultivessel coronary artery diseaseOptimal medical therapyRadionuclide stress testsCoronary artery bypassSevere LV dysfunctionLeft ventricular dysfunctionStress-induced ischemiaPrevious myocardial infarctionSummed difference scoreStress testingRNS testingSTICH patientsSTICH trialArtery bypass
2011
Responses of mental stress–induced myocardial ischemia to escitalopram treatment: Background, design, and method for the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment trial
Jiang W, Velazquez EJ, Samad Z, Kuchibhatla M, Martsberger C, Rogers J, Williams R, Kuhn C, Ortel TL, Becker RC, Pristera N, Krishnan R, O'Connor CM. Responses of mental stress–induced myocardial ischemia to escitalopram treatment: Background, design, and method for the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment trial. American Heart Journal 2011, 163: 20-26. PMID: 22172432, PMCID: PMC3254211, DOI: 10.1016/j.ahj.2011.09.018.Peer-Reviewed Original ResearchConceptsMental stress-induced myocardial ischemiaCoronary heart diseaseStable coronary heart diseaseStress-induced myocardial ischemiaMyocardial ischemiaMental Stress–Induced Myocardial IschemiaSelective serotonin reuptake inhibitor (SSRI) treatmentStress testingSerotonin reuptake inhibitor treatmentEjection fraction reductionReuptake inhibitor treatmentMental stress testingPsychometric questionnairesEffects of SSRIsIschemic ST changesInduced Myocardial IschemiaAbnormal wall motionAdult patientsEscitalopram treatmentSSRI treatmentPoor outcomeTreatment trialsPlatelet activityHeart diseaseRisk factorsDo Imaging Studies Performed in Physician Offices Increase Downstream Utilization? An Empiric Analysis of Cardiac Stress Testing With Imaging
Chen J, Fazel R, Ross JS, McNamara RL, Einstein AJ, Al-Mallah M, Krumholz HM, Nallamothu BK. Do Imaging Studies Performed in Physician Offices Increase Downstream Utilization? An Empiric Analysis of Cardiac Stress Testing With Imaging. JACC Cardiovascular Imaging 2011, 4: 630-637. PMID: 21679898, PMCID: PMC3319749, DOI: 10.1016/j.jcmg.2011.04.003.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCardiac CatheterizationChi-Square DistributionEchocardiography, StressEmpirical ResearchFemaleHealthcare DisparitiesHumansInsurance, HealthLogistic ModelsMaleMiddle AgedMyocardial Perfusion ImagingMyocardial RevascularizationOffice VisitsOutpatient Clinics, HospitalPractice Patterns, Physicians'Predictive Value of TestsResidence CharacteristicsTime FactorsUnited StatesYoung AdultConceptsMyocardial perfusion imagingSubsequent myocardial perfusion imagingProportion of patientsStress echocardiographyCardiac catheterizationHospital outpatient settingPhysician's officeOutpatient settingStress testingSubsequent cardiac testingCardiac stress testingDownstream resource utilizationHospital outpatient facilitiesCardiac testingPrivate health insuranceDownstream testingOffice imagingPerfusion imagingCatheterizationImaging studiesOutpatient imagingPatientsHealth insuranceLower ratesHigh rate
2009
Results of Exercise Stress Testing in Patients with Diffuse Pulmonary Arteriovenous Malformations
Murphy J, Pierucci P, Chyun D, Henderson KJ, Pollak J, White RI, Fahey J. Results of Exercise Stress Testing in Patients with Diffuse Pulmonary Arteriovenous Malformations. Pediatric Cardiology 2009, 30: 978-984. PMID: 19636485, DOI: 10.1007/s00246-009-9491-5.Peer-Reviewed Original ResearchConceptsDiffuse pulmonary arteriovenous malformationsExercise stress testingPulmonary arteriovenous malformationsOxygen saturationMaximum exerciseArteriovenous malformationsRoom air oxygen saturationMean oxygen saturationStress testingCycle ergometer testNoncontrast chestBilateral involvementFrequent complicationComplete embolizationSerial studiesPatientsErgometer testOwn controlYoung adultsNoninvasive methodLimited experienceSignificant differencesMalformationsBaselineAge
2007
Does cardiac SPECT using attenuation and scatter correction accurately predict coronary artery disease in a minority women population?
Vashist A, Collins D, Prasad Y, Blum S, Heller E. Does cardiac SPECT using attenuation and scatter correction accurately predict coronary artery disease in a minority women population? Medical Science Monitor 2007, 13: cr386-390. PMID: 17767117.Peer-Reviewed Original ResearchConceptsMyocardial perfusion imagingCoronary artery diseasePositive predictive valueWomen patientsArtery diseaseSensitivity of MPIPredictive valueExercise stress testingGroup of patientsStress testingRecent revascularizationCardiac catheterizationCoronary angiographyFavorable prognosisRisk stratificationCatheterization laboratoryGeneral populationPatientsWomen populationPerfusion imagingAttenuation/scatter correctionNuclear imagingAngiographyPrognosisDiagnostic methods
2006
P5-40 T-wave amplitude is a more sensitive marker of myocardial ischemia than ST-segment changes in patients undergoing exercise stress testing
Naidu S, Shusterman V, Howes C, Cleman M, O’Connor M, Goldberg A, Lampert R. P5-40 T-wave amplitude is a more sensitive marker of myocardial ischemia than ST-segment changes in patients undergoing exercise stress testing. Heart Rhythm 2006, 3: s273. DOI: 10.1016/j.hrthm.2006.02.818.Peer-Reviewed Original Research
2003
Differential Menstrual Cycle Regulation of Hypothalamic-Pituitary-Adrenal Axis in Women with Premenstrual Syndrome and Controls
Roca C, Schmidt P, Altemus M, Deuster P, Danaceau M, Putnam K, Rubinow D. Differential Menstrual Cycle Regulation of Hypothalamic-Pituitary-Adrenal Axis in Women with Premenstrual Syndrome and Controls. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 3057-3063. PMID: 12843143, DOI: 10.1210/jc.2002-021570.Peer-Reviewed Original ResearchConceptsHPA axis responsePremenstrual syndromeAdrenal axisControl womenMajor depressionLuteal phaseReproductive steroidsAxis responseTreadmill exercise stress testingHPA axis modulationMenstrual cycle regulationHPA axis abnormalitiesExercise stress testingHPA axis regulationStress testingMenstrual cycle phaseAxis abnormalitiesHPA axisMenstrual cycleGonadal steroidsAbnormal responseAxis regulationAffective disordersAffective symptomsPotent modulator
2000
Role of Exercise Stress Testing and Safety Monitoring for Older Persons Starting an Exercise Program
Gill TM, DiPietro L, Krumholz HM. Role of Exercise Stress Testing and Safety Monitoring for Older Persons Starting an Exercise Program. JAMA 2000, 284: 342-349. PMID: 10891966, DOI: 10.1001/jama.284.3.342.Peer-Reviewed Original ResearchConceptsExercise stress testingAdverse cardiac eventsExercise programOlder personsCardiac eventsStress testingPhysical activityRoutine exercise stress testingSedentary older personsSymptomatic cardiovascular diseasePharmacological stress testingCurrent physician practiceRelative exercise intensityMajority of personsUnproven benefitPhysical functionCurrent guidelinesCardiovascular diseaseExercise intensityPhysician practicesSafety monitoringRiskExercisePersonsTestingAn economic analysis of an aggressive diagnostic strategy with single photon emission computed tomography myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain but nondiagnostic electrocardiograms: Results from a randomized trial
Stowers S, Eisenstein E, Wackers F, Berman D, Blackshear J, Jones A, Szymanski T, Lam L, Simons T, Natale D, Paige K, Wagner G. An economic analysis of an aggressive diagnostic strategy with single photon emission computed tomography myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain but nondiagnostic electrocardiograms: Results from a randomized trial. Annals Of Emergency Medicine 2000, 35: 17-25. PMID: 28140201, DOI: 10.1016/s0196-0644(00)70100-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedChest PainClinical ProtocolsCoronary AngiographyCost ControlElectrocardiographyEmergency TreatmentExercise TestFemaleHospital CostsHumansLength of StayMaleMedicareMiddle AgedMyocardial InfarctionReproducibility of ResultsRisk FactorsSingle-Blind MethodTomography, Emission-Computed, Single-PhotonUnited StatesConceptsEarly exercise stress testingExercise stress testingLength of stayChest painHospital costsSingle photon emissionCoronary angiographyStress testingDiagnostic strategiesTomography myocardial perfusion imagingCost/charge ratiosAggressive diagnostic strategyNegative scan resultsPositive scan resultsAcute chest painIntermediate-risk patientsAcute coronary syndromeExercise treadmill testingAdverse clinical outcomesShorter median lengthEmergency department patientsAcute myocardial infarctionScan resultsMyocardial perfusion imagingPhoton emission
1997
Long QTc and Torsades de Pointes in Human Immunodeficiency Virus Disease
KOCHERIL A, BOKHARI S, BATSFORD W, SINUSAS A. Long QTc and Torsades de Pointes in Human Immunodeficiency Virus Disease. Pacing And Clinical Electrophysiology 1997, 20: 2810-2816. PMID: 9392812, DOI: 10.1111/j.1540-8159.1997.tb05439.x.Peer-Reviewed Original ResearchConceptsLong QT syndromeHIV diseaseQTc prolongationQT syndromeIndex patientsLeft stellate ganglion blockadeHuman immunodeficiency virus (HIV) diseaseHuman immunodeficiency virus (HIV) infectionStellate ganglion blockadeStellate ganglion blockImmunodeficiency virus infectionHospital-based populationStress testingComputerized ECGElectrocardiographic stress testingGanglion blockadeHI diseaseGanglion blockHIV infectionHospitalized patientsQTc intervalLonger QTcHigh prevalenceRetrospective analysisVirus infection
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