2024
Early-treatment cerebral blood flow change as a predictive biomarker of antidepressant treatment response: evidence from the EMBARC clinical trial.
Dang Y, Lu B, Vanderwal T, Castellanos F, Yan C. Early-treatment cerebral blood flow change as a predictive biomarker of antidepressant treatment response: evidence from the EMBARC clinical trial. Psychological Medicine 2024, 54: 3053-3062. PMID: 38720516, DOI: 10.1017/s0033291724001156.Peer-Reviewed Original ResearchMajor depressive disorderBrain regionsTreatment of Major Depressive DisorderHamilton Depression Rating Scale scoresBiomarkers of antidepressant treatment responseCerebral blood flowBiosignatures of Antidepressant ResponseDepression Rating Scale scoresSerotonin reuptake inhibitor treatmentAntidepressant treatment responseResponse to antidepressantsTreatment responseRating Scale scoresBiomarkers of treatment responseAssociated with increased cerebral perfusionEstablishing ModeratorsAntidepressant responseAntidepressant effectsDepressive disorderTemporal cortexNeural biomarkersPostcentral regionsCerebral blood flow changesWhole-brainDisabling illness
2017
Frontotemporal dementia: latest evidence and clinical implications
Young J, Lavakumar M, Tampi D, Balachandran S, Tampi R. Frontotemporal dementia: latest evidence and clinical implications. Therapeutic Advances In Psychopharmacology 2017, 8: 33-48. PMID: 29344342, PMCID: PMC5761910, DOI: 10.1177/2045125317739818.Peer-Reviewed Original ResearchFTD syndromesFrontotemporal dementiaPharmacological interventionsSelective serotonin reuptake inhibitor (SSRI) treatmentSerotonin reuptake inhibitor treatmentPotential novel therapeutic targetDistinct neurobiological profilesReuptake inhibitor treatmentSide effect profileCurrent therapeutic modalitiesNovel therapeutic targetEffect profileClinical correlatesHistopathologic markersNonpharmacological interventionsNeurological syndromeClinical trialsTherapeutic modalitiesTherapeutic targetBehavioral symptomsUS FoodDrug AdministrationInhibitor treatmentCholinesterase inhibitorsLatest evidence0051 CIRCADIAN NEUROHORMONE EXCRETION AND OBJECTIVE SLEEP MEASURES IN TODDLERS PRENATALLY EXPOSED TO MATERNAL DEPRESSION AND ANTIDEPRESSANT MEDICATION
Mattera J, Miller-Loncar C, Anderson G, Johnsen D, Salisbury A. 0051 CIRCADIAN NEUROHORMONE EXCRETION AND OBJECTIVE SLEEP MEASURES IN TODDLERS PRENATALLY EXPOSED TO MATERNAL DEPRESSION AND ANTIDEPRESSANT MEDICATION. Sleep 2017, 40: a20-a20. DOI: 10.1093/sleepj/zsx050.050.Peer-Reviewed Original ResearchSerotonin reuptake inhibitorsSleep onset latencySerotonin reuptake inhibitor groupLonger sleep onset latencyMaternal depressionPrenatal exposure to maternal depressionDEP groupSerotonin reuptake inhibitor treatmentExposure to maternal depressionREM sleepPrenatal SRI exposurePrenatal maternal depressionShorter sleep onset latencyAssociated with disrupted circadian rhythmsPrenatal exposureHigher cortisol levelsEffects of prenatal exposureReuptake inhibitorsPsychiatric diagnosisBehavioral arousalDaytime cortisolDisrupted sleep architectureGroup statusTrained ratersNighttime cortisol
2012
Depression and Serotonin Reuptake Inhibitor Treatment as Risk Factors for Preterm Birth
Yonkers KA, Norwitz ER, Smith MV, Lockwood CJ, Gotman N, Luchansky E, Lin H, Belanger K. Depression and Serotonin Reuptake Inhibitor Treatment as Risk Factors for Preterm Birth. Epidemiology 2012, 23: 677-685. PMID: 22627901, PMCID: PMC3415566, DOI: 10.1097/ede.0b013e31825838e9.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitorsMajor depressive episodePreterm birthDepressive episodeLogistic regressionSRI useUse of SRIsSerotonin reuptake inhibitor treatmentReuptake inhibitor treatmentEarly preterm birthLate preterm birthProspective cohort studyPreterm birth riskMajor depressive disorderNominal logistic regressionBinary logistic regressionAntidepressant treatmentCohort studyHospital chartsReuptake inhibitorsSymptomatic womenBirth outcomesPregnant womenRisk factorsDepressive disorder
2011
Responses of mental stress–induced myocardial ischemia to escitalopram treatment: Background, design, and method for the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment trial
Jiang W, Velazquez EJ, Samad Z, Kuchibhatla M, Martsberger C, Rogers J, Williams R, Kuhn C, Ortel TL, Becker RC, Pristera N, Krishnan R, O'Connor CM. Responses of mental stress–induced myocardial ischemia to escitalopram treatment: Background, design, and method for the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment trial. American Heart Journal 2011, 163: 20-26. PMID: 22172432, PMCID: PMC3254211, DOI: 10.1016/j.ahj.2011.09.018.Peer-Reviewed Original ResearchConceptsMental stress-induced myocardial ischemiaCoronary heart diseaseStable coronary heart diseaseStress-induced myocardial ischemiaMyocardial ischemiaMental Stress–Induced Myocardial IschemiaSelective serotonin reuptake inhibitor (SSRI) treatmentStress testingSerotonin reuptake inhibitor treatmentEjection fraction reductionReuptake inhibitor treatmentMental stress testingPsychometric questionnairesEffects of SSRIsIschemic ST changesInduced Myocardial IschemiaAbnormal wall motionAdult patientsEscitalopram treatmentSSRI treatmentPoor outcomeTreatment trialsPlatelet activityHeart diseaseRisk factors
2004
Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment
Vythilingam M, Vermetten E, Anderson GM, Luckenbaugh D, Anderson ER, Snow J, Staib LH, Charney DS, Bremner JD. Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment. Biological Psychiatry 2004, 56: 101-112. PMID: 15231442, DOI: 10.1016/j.biopsych.2004.04.002.Peer-Reviewed Original ResearchConceptsMajor depressive disorderUrinary free cortisolHippocampal volumeHealthy subjectsMemory deficitsDepressed patientsDepressive disorderCortisol statusSelective serotonin reuptake inhibitor (SSRI) treatmentSerotonin reuptake inhibitor treatmentWechsler Memory Scale-RevisedNormal hippocampal volumesReuptake inhibitor treatmentWhole hippocampal volumeWhole brain volumeDeclarative memory deficitsEffect of treatmentMemory functionDeclarative memory functionUFC excretionAntidepressant treatmentFree cortisolHippocampal dysfunctionBaseline plasmaSuccessful treatment
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply