2025
Depression and Low Social Support Mediate the Association of Marital Stress and 12-Month Cardiac-Specific Quality of Life in Young Adults With Acute Myocardial Infarction
Zhu C, Dreyer R, Li F, Spatz E, Caraballo C, Mahajan S, Raparelli V, Leifheit E, Lu Y, Krumholz H, Spertus J, D’Onofrio G, Pilote L, Lichtman J. Depression and Low Social Support Mediate the Association of Marital Stress and 12-Month Cardiac-Specific Quality of Life in Young Adults With Acute Myocardial Infarction. Biopsychosocial Science And Medicine 2025, 87: 129-137. PMID: 39909011, DOI: 10.1097/psy.0000000000001363.Peer-Reviewed Original ResearchConceptsLow social supportCardiac-specific quality of lifeNatural direct effectSocial supportMonths post-AMIQuality of lifeAcute myocardial infarctionMarital stressComprehensive secondary preventive strategySignificant depressive symptomsPost-AMISecondary prevention strategiesYoung adultsMyocardial infarctionSociodemographic factorsDepressive symptomsAMI survivorsCovariate adjustmentPrevention strategiesSelf-ReportContinuous scoresQoLBaseline QOLCategorical depressionDepression
2024
Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression
Asch R, Abdallah C, Carson R, Esterlis I. Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression. Neuropsychopharmacology 2024, 50: 153-163. PMID: 39039139, PMCID: PMC11525584, DOI: 10.1038/s41386-024-01913-3.Peer-Reviewed Original ResearchStudies of depressionAnimal models of chronic stressPositron emission tomographyModel of chronic stressSV2A imagingSynaptic densitySignificant depressive symptomsDevelopment of novel radiotracersDepressive symptomsNeuropsychiatric disordersSymptom severityChronic stressDrug challengeSynaptic vesicle glycoprotein 2 ANeural markersAnimal modelsSynaptic alterationsSynaptogenesis in vivoPreliminary findingsIn vivo quantificationCentral nervous systemDepressionEmission tomographySV2ASV2A positron emission tomography
2023
Depression, Inflammation, and Intestinal Permeability: Associations with Subjective and Objective Cognitive Functioning throughout Breast Cancer Survivorship
Madison A, Andridge R, Kantaras A, Renna M, Bennett J, Alfano C, Povoski S, Agnese D, Lustberg M, Wesolowski R, Carson W, Williams N, Reinbolt R, Sardesai S, Noonan A, Stover D, Cherian M, Malarkey W, Kiecolt-Glaser J. Depression, Inflammation, and Intestinal Permeability: Associations with Subjective and Objective Cognitive Functioning throughout Breast Cancer Survivorship. Cancers 2023, 15: 4414. PMID: 37686689, PMCID: PMC10487080, DOI: 10.3390/cancers15174414.Peer-Reviewed Original ResearchBreast cancer survivorsSignificant depressive symptomsIntestinal permeabilityCancer survivorsDepressive symptomsObjective cognitive functionCognitive functionStudy visitCognitive declineEpidemiological Studies Depression ScaleCancer treatment typeInflammation-associated depressionC-reactive proteinCancer Survivor StudyBreast cancer survivorshipTumor necrosis factorCognitive function testsLipopolysaccharide binding proteinHopkins Verbal Learning TestSubjective cognitive functionObjective cognitive impairmentLower verbal fluencyInflammatory indexInflammatory markersElevated inflammationLongitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease.
Yazgan I, Bartlett V, Romain G, Cleman J, Petersen-Crair P, Spertus J, Hardt M, Mena-Hurtado C, Smolderen K. Longitudinal Pathways Between Physical Activity, Depression, and Perceived Stress in Peripheral Artery Disease. Circulation Cardiovascular Quality And Outcomes 2023, 16: 544-553. PMID: 37470195, PMCID: PMC10561081, DOI: 10.1161/circoutcomes.122.009840.Peer-Reviewed Original ResearchConceptsPhysical activityPAD diagnosisDepressive symptomsLower physical activity scoresPerceived stressVascular specialty clinicsPeripheral artery diseasePhysical activity scoreSignificant depressive symptomsPatient Health QuestionnaireBehavioral health approachesSubsequent depressive symptomsINTERHEART studySymptomatic PADCardiovascular eventsPAD symptomsArtery diseaseInitial presentationActivity scoreSpecialty clinicHealth QuestionnairePatient's abilityTreatment goalsPAD managementPerceived Stress ScaleThe impact of postpartum social support on postpartum mental health outcomes during the COVID-19 pandemic
White L, Kornfield S, Himes M, Forkpa M, Waller R, Njoroge W, Barzilay R, Chaiyachati B, Burris H, Duncan A, Seidlitz J, Parish-Morris J, Elovitz M, Gur R. The impact of postpartum social support on postpartum mental health outcomes during the COVID-19 pandemic. Archives Of Women's Mental Health 2023, 26: 531-541. PMID: 37268777, PMCID: PMC10238239, DOI: 10.1007/s00737-023-01330-3.Peer-Reviewed Original ResearchConceptsMaternal-infant bondingMental health outcomesPostpartum womenHealth outcomesPoor postpartum mental healthSocial supportCOVID-19 pandemic-related changesMental healthSignificant depressive symptomsPostpartum mental healthElectronic patient portalParent-infant bondingCOVID-19 pandemicPandemic-related changesPregnant patientsPostpartum outcomesPrenatal careSelf-reported social supportWeeks postpartumPostpartum depressionBonding impairmentPostpartum anxietyPostpartum recoveryDepressive symptomsPostpartum social support
2022
Association Between Depressive Symptoms and Cardiac Structure and Function in a Peruvian Population
Santiago C, Peña M, Brown T, Shakil S, Januzzi J, Velazquez E, Miranda J, Rivera D, Checkley W. Association Between Depressive Symptoms and Cardiac Structure and Function in a Peruvian Population. Global Heart 2022, 17: 78. PMID: 36382157, PMCID: PMC9615600, DOI: 10.5334/gh.981.Peer-Reviewed Original ResearchConceptsSignificant depressive symptomsDepressive symptomsHeart failureCardiac structureTransthoracic echocardiographyEpidemiological Studies Depression ScaleCRONICAS Cohort StudyDiastolic relaxation velocityCause of disabilityMultivariable linear regressionNon-depressed subjectsCohort studyEchocardiographic measuresMiddle-income countriesWorse outcomesDepressive disorderDepression ScaleCardiac diseaseRelaxation velocityDepression symptomsNon-depressed participantsSymptomsPeruvian populationRelevant covariatesAdult participantsDepressive Symptoms and Incident Heart Failure in the Jackson Heart Study: Differential Risk Among Black Men and Women
Gaffey AE, Cavanagh CE, Rosman L, Wang K, Deng Y, Sims M, O’Brien E, Chamberlain AM, Mentz RJ, Glover LM, Burg MM. Depressive Symptoms and Incident Heart Failure in the Jackson Heart Study: Differential Risk Among Black Men and Women. Journal Of The American Heart Association 2022, 11: e022514. PMID: 35191315, PMCID: PMC9075063, DOI: 10.1161/jaha.121.022514.Peer-Reviewed Original ResearchConceptsIncident heart failureHigher depressive symptomsHF risk factorsHeart failureDepressive symptomsCause mortalityGreater riskLifestyle factorsRisk factorsCases of HFHistory of HFJackson Heart Study participantsSignificant depressive symptomsBaseline depressive symptomsJackson Heart StudyProportional hazards modelSex-specific associationsSex-specific managementCardiovascular outcomesUnadjusted associationsUnadjusted modelsHeart StudyHazards modelSymptomsStudy participants
2021
Mental Health and Wealth: Depression, Gender, Poverty, and Parenting
Smith MV, Mazure CM. Mental Health and Wealth: Depression, Gender, Poverty, and Parenting. Annual Review Of Clinical Psychology 2021, 17: 181-205. PMID: 33962537, DOI: 10.1146/annurev-clinpsy-071219-022710.Peer-Reviewed Original ResearchDepression and anxiety symptoms are related to pain and frailty but not cognition or delirium in older surgical patients
Wang S, Cardieri B, Lin H, Liu X, Sano M, Deiner S. Depression and anxiety symptoms are related to pain and frailty but not cognition or delirium in older surgical patients. Brain And Behavior 2021, 11: e02164. PMID: 33949810, PMCID: PMC8213643, DOI: 10.1002/brb3.2164.Peer-Reviewed Original ResearchConceptsAnxiety symptomsEarly cognitive declinePostoperative cognitive declineHospital Anxiety and Depression ScaleCognitive declineDepressive symptomsPreoperative depressionOlder surgical patientsSurgical patientsAssociated with early cognitive declineSymptoms of depressionOlder adultsSignificant depressive symptomsAnxiety and Depression ScaleAssociated with postoperative cognitive declineCohort study of patientsPreoperative depressive symptomsPsychiatric diagnosisElective noncardiac surgeryCognitive dysfunctionStudy of patientsCommunity dwelling older adultsPostoperative cognitive dysfunctionAnxietyIncidence of delirium
2020
Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway
van Os J, Pries L, Have M, de Graaf R, van Dorsselaer S, Delespaul P, Bak M, Kenis G, Lin B, Luykx J, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, Guloksuz S. Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway. Psychological Medicine 2020, 52: 1910-1922. PMID: 33070791, DOI: 10.1017/s0033291720003748.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum disordersChildhood adversityRisk factorsNEMESIS-2Affective dysregulationNon-genetic risk factorsSignificant depressive symptomsSample of patientsRepresentative general population sampleGenetic risk factorsGeneral population sampleSchizophrenia polygenic riskPsychosis outcomesSpectrum disorderDepressive symptomsPRS-SZPolygenic riskDysregulationPatientsPopulation samplePsychosisAffective pathwayDisordersHallucinatory experiencesDelusional ideation
2019
Rates and Correlates of Depression Symptoms in a Sample of Pregnant Veterans Receiving Veterans Health Administration Care
Kroll-Desrosiers AR, Crawford SL, Moore Simas TA, Clark MA, Bastian LA, Mattocks KM. Rates and Correlates of Depression Symptoms in a Sample of Pregnant Veterans Receiving Veterans Health Administration Care. Women's Health Issues 2019, 29: 333-340. PMID: 31105035, DOI: 10.1016/j.whi.2019.04.008.Peer-Reviewed Original ResearchConceptsEdinburgh Postnatal Depression ScaleEPDS scoresDepression symptomsPregnant veteransVeterans Health Administration (VHA) careVeterans Health Administration sitesMultivariable logistic regression modelGeneral pregnant populationSignificant depressive symptomsElectronic health record dataPostnatal Depression ScaleVeterans Affairs facilitiesHealth record dataLogistic regression modelsAntidepressant usePregnant populationActive duty servicePostpartum periodDecreased oddsDepression ScaleMedical conditionsDepressive symptomsPast diagnosisPrevalence estimatesHealth status
2015
Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease
Weintraub D, Simuni T, Caspell‐Garcia C, Coffey C, Lasch S, Siderowf A, Aarsland D, Barone P, Burn D, Chahine M, Eberling J, Espay AJ, Foster ED, Leverenz JB, Litvan I, Richard I, Troyer MD, Hawkins KA, Initiative T. Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease. Movement Disorders 2015, 30: 919-927. PMID: 25737166, PMCID: PMC4855523, DOI: 10.1002/mds.26170.Peer-Reviewed Original ResearchConceptsParkinson's Progression Markers InitiativeNeuropsychiatric symptomsPD patientsHealthy controlsProgression Markers InitiativeParkinson's diseaseCognitive impairmentUntreated PD patientsDopamine replacement therapySignificant depressive symptomsGroup differencesSymptoms of depressionQuality of lifeMild cognitive impairmentUntreated patientsDisease courseReplacement therapyICD symptomsControl disordersDepressive symptomsGeneral populationPatientsMeeting criteriaMulti-site studyBiological predictorsPrognostic Significance of Depressive Symptoms on Weight Loss and Psychosocial Outcomes Following Gastric Bypass Surgery: A Prospective 24-Month Follow-Up Study
White MA, Kalarchian MA, Levine MD, Masheb RM, Marcus MD, Grilo CM. Prognostic Significance of Depressive Symptoms on Weight Loss and Psychosocial Outcomes Following Gastric Bypass Surgery: A Prospective 24-Month Follow-Up Study. Obesity Surgery 2015, 25: 1909-1916. PMID: 25720515, PMCID: PMC4551611, DOI: 10.1007/s11695-015-1631-9.Peer-Reviewed Original ResearchConceptsGastric bypass surgeryPostoperative depressive symptomsElevated depressive symptomsDepressive symptomsBypass surgeryWeight outcomesPrognostic significanceDisorder psychopathologyLong-term weight outcomesWeight lossPoorer weight outcomesPreoperative depressive symptomsBariatric surgery patientsWeight loss outcomesSignificant depressive symptomsMethodsThree hundred fiftyQuality of lifeBeck Depression InventorySurgery patientsBattery of assessmentsHundred fiftyLoss outcomesBackgroundThis studySurgeryClinical attention
2013
Perinatal smoking and depression in women with concurrent substance use
Forray A, Gotman N, Kershaw T, Yonkers KA. Perinatal smoking and depression in women with concurrent substance use. Addictive Behaviors 2013, 39: 749-756. PMID: 24447885, PMCID: PMC3944019, DOI: 10.1016/j.addbeh.2013.12.008.Peer-Reviewed Original ResearchConceptsPregnant womenConcurrent substance useSubstance usePre-pregnancy smokersSignificant depressive symptomsWeeks of pregnancyMini Neuropsychiatric InterviewDiagnosis of depressionImpact of depressionCourse of smokingNon-depressed groupLinear mixed effects regressionSubstance abuse treatmentPerinatal smokingSmoking postpartumBaseline cohortNeuropsychiatric InterviewMixed effects regressionDepressive symptomsSmokingSmoking behaviorDepressive symptomatologyAbuse treatmentPregnancyPostpartum
2012
Comparative effectiveness trial of family-supported smoking cessation intervention versus standard telephone counseling for chronically ill veterans using proactive recruitment
Bastian L, Fish L, Gierisch J, Rohrer L, Stechuchak K, Grambow S. Comparative effectiveness trial of family-supported smoking cessation intervention versus standard telephone counseling for chronically ill veterans using proactive recruitment. Comparative Effectiveness Research 2012, 2: 45-56. DOI: 10.2147/cer.s33447.Peer-Reviewed Original ResearchComparative effectiveness trialTelephone counselingCardiovascular diseaseVeteran smokersSmoking cessationChronic illnessEffectiveness trialIll veteransEpidemiological Studies Depression ScalePoint prevalent abstinenceChronic medical illnessTelephone-based interventionNicotine replacement therapySignificant depressive symptomsLower nicotine dependenceTelephone counseling sessionsVeterans Affairs physiciansSocial supportType of interventionType of diseaseStandard armFamily support interventionMedical illnessCessation interventionsReplacement therapySeasonal trends in depressive symptoms in adolescents with type 1 diabetes
Jaser SS, Dumser S, Liberti L, Hunter N, Whittemore R, Grey M, Group T. Seasonal trends in depressive symptoms in adolescents with type 1 diabetes. Diabetes Research And Clinical Practice 2012, 96: e33-e35. PMID: 22325159, PMCID: PMC3348342, DOI: 10.1016/j.diabres.2012.01.023.Peer-Reviewed Original Research
2011
Smoking Cessation Interventions for Patients with Depression: A Systematic Review and Meta-analysis
Gierisch JM, Bastian LA, Calhoun PS, McDuffie JR, Williams JW. Smoking Cessation Interventions for Patients with Depression: A Systematic Review and Meta-analysis. Journal Of General Internal Medicine 2011, 27: 351-360. PMID: 22038468, PMCID: PMC3286553, DOI: 10.1007/s11606-011-1915-2.Peer-Reviewed Original ResearchConceptsNicotine replacement therapySignificant depressive symptomsCessation interventionsCessation strategiesDepressive symptomsCurrent depressionBrief smoking cessation counselingBroad intervention categoriesSmoking cessation counselingPooled risk ratioSmoking cessation interventionStudy eligibility criteriaMantel-Haenszel methodMore smoking cessation interventionsRandom-effects modelDifferential effectsMood managementSynthesis MethodsTwoCessation counselingUnique RCTsAbstinence ratesCessation ratesCessation servicesReplacement therapyAntidepressant trials
2010
Younger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms
Smolderen KG, Spertus JA, Vriens PW, Kranendonk S, Nooren M, Denollet J. Younger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms. Journal Of Vascular Surgery 2010, 52: 637-644. PMID: 20576397, DOI: 10.1016/j.jvs.2010.04.025.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAnkle Brachial IndexDepressionFemaleHealth Status DisparitiesHumansIncidenceLogistic ModelsMaleMiddle AgedNetherlandsOdds RatioPeripheral Vascular DiseasesProspective StudiesPsychiatric Status Rating ScalesRegistriesRisk AssessmentRisk FactorsSex FactorsTime FactorsConceptsPeripheral arterial diseaseSignificant depressive symptomsDepressive symptomsGender-age groupsYoung womenArterial diseaseSymptomatic peripheral arterial diseaseEpidemiological Studies Depression ScaleFourfold greater oddsVascular outpatient clinicAnkle-brachial indexPatients' depressive symptomsTime of diagnosisLogistic regression modelsImportant comorbidityPAD diagnosisPAD patientsClinical factorsDepression screeningOutpatient clinicCardiovascular diseaseDepression riskDepression ScaleAdditional adjustmentGreater odds
2003
Depressive symptoms are the strongest predictors of short-term declines in health status in patients with heart failure
Rumsfeld JS, Havranek E, Masoudi FA, Peterson ED, Jones P, Tooley JF, Krumholz HM, Spertus JA, Consortium C. Depressive symptoms are the strongest predictors of short-term declines in health status in patients with heart failure. Journal Of The American College Of Cardiology 2003, 42: 1811-1817. PMID: 14642693, DOI: 10.1016/j.jacc.2003.07.013.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireKCCQ summary scoreDepressive symptomsQuality of lifeHealth statusKCCQ scoresHeart failureDepressed patientsSummary scoresMulticenter prospective cohort studyStrongest predictorBaseline KCCQ scoresProspective cohort studySignificant depressive symptomsSpecific health statusTreatment of depressionShort-term worseningPredictors of changeHF careHF symptomsCohort studyPrimary outcomePotential confoundersPatient variablesMultivariable model
2002
Clinical importance of HIV and depressive symptoms among veterans with HIV infection
Kilbourne AM, Justice AC, Rollman BL, McGinnis KA, Rabeneck L, Weissman S, Smola S, Schultz R, Whittle J, Rodriguez‐Barradas M. Clinical importance of HIV and depressive symptoms among veterans with HIV infection. Journal Of General Internal Medicine 2002, 17: 512-520. PMID: 12133141, PMCID: PMC1495073, DOI: 10.1046/j.1525-1497.2002.10803.x.Peer-Reviewed Original ResearchConceptsSevere depressive symptomsIllness severityHIV symptomsDepressive symptomsHIV infectionClinical importanceHIV Symptom IndexEpidemiologic Studies Depression ScaleInfectious disease clinicPatient illness severitySeverity of illnessSignificant depressive symptomsCross-sectional studyVA Medical CenterHealth care providersDepression symptom severityAntiretroviral useDisease clinicViral loadCommon symptomsSymptom IndexDepression statusSymptom frequencyDepression ScaleMedical Center
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