2023
Resting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals
Dong X, Zhornitsky S, Wang W, Le T, Chen Y, Chaudhary S, Li C, Zhang S. Resting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals. The International Journal Of Neuropsychopharmacology 2023, 26: 627-638. PMID: 37579016, PMCID: PMC10519818, DOI: 10.1093/ijnp/pyac019.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityInferior frontal cortexCocaine-dependent individualsHealthy controlsVentral striatumCocaine useDorsal striatumAbstinent cocaine-dependent individualsCocaine misuseFunctional connectivityYears of drinkingLeft orbitofrontal cortexBIS-11 scoresRecent cocaine useLeft inferior frontal cortexDopaminergic deficitCortex connectivityFrontal cortexSeparate cohortHuman studiesSeverity of useAnimal studiesSecond cohortOrbitofrontal cortexBarratt Impulsivity Scale
2022
Telehealth Reduces Missed Appointments in Pediatric Patients with Tuberculosis Infection
Zhao A, Butala N, Luc CM, Feinn R, Murray TS. Telehealth Reduces Missed Appointments in Pediatric Patients with Tuberculosis Infection. Tropical Medicine And Infectious Disease 2022, 7: 26. PMID: 35202221, PMCID: PMC8877294, DOI: 10.3390/tropicalmed7020026.Peer-Reviewed Original ResearchTuberculosis infectionPediatric patientsAppointment ratesActive TB diseaseLatent tuberculosis infectionRetrospective chart reviewRisk of progressionPoor treatment adherenceChi-square testTB diseaseChart reviewTuberculosis clinicClinical variablesTreatment adherenceMissed appointmentsPatientsSecond cohortSecondary aimPrimary providersClinicTelehealthCOVID-19 pandemicTherapyHigh rateInfection
2021
Polygenic risk for major depression is associated with lifetime suicide attempt in US soldiers independent of personal and parental history of major depression
Stein MB, Jain S, Campbell‐Sills L, Ware EB, Choi KW, He F, Ge T, Gelernter J, Smoller JW, Kessler RC, Ursano RJ. Polygenic risk for major depression is associated with lifetime suicide attempt in US soldiers independent of personal and parental history of major depression. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2021, 186: 469-475. PMID: 34288400, PMCID: PMC8692314, DOI: 10.1002/ajmg.b.32868.Peer-Reviewed Original ResearchConceptsMajor depressive disorderLifetime suicide attemptsParental historySuicide attemptsMajor depressionMDD-PRSMultivariable modelLifetime historyMajor public health problemIncident suicide attemptsPolygenic riskPublic health problemUS Army soldiersRisk stratificationDepressive disorderPolygenic risk scoresRisk scoreSecond cohortHealth problemsCommon genetic variantsFirst cohortPersonal historyCohortGenetic variantsArmy soldiers
2020
Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS
Muthuraman M, Fleischer V, Kroth J, Ciolac D, Radetz A, Koirala N, Gonzalez-Escamilla G, Wiendl H, Meuth S, Zipp F, Groppa S. Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS. Neurology Neuroimmunology & Neuroinflammation 2020, 7: e681. PMID: 32024782, PMCID: PMC7051213, DOI: 10.1212/nxi.0000000000000681.Peer-Reviewed Original ResearchConceptsCortical atrophyDisability progressionLesion distributionWM lesionsEarly relapsing-remitting MSShort-term disability progressionWhite matter lesion distributionDisability Status Scale scoreRapid clinical deteriorationRelapsing-remitting MSStatus Scale scoreWhite matter lesionsIndividual patient outcomesLeft-lateralized patternClinical worseningClinical deteriorationClinical disabilityFunctional disabilityStudy cohortMatter lesionsEarly MSPatient outcomesHigh riskIndependent cohortSecond cohort
2018
Adverse Childhood Experiences, Epigenetic Measures, and Obesity in Youth
Kaufman J, Montalvo-Ortiz JL, Holbrook H, O'Loughlin K, Orr C, Kearney C, Yang BZ, Wang T, Zhao H, Althoff R, Garavan H, Gelernter J, Hudziak J. Adverse Childhood Experiences, Epigenetic Measures, and Obesity in Youth. The Journal Of Pediatrics 2018, 202: 150-156.e3. PMID: 30177354, PMCID: PMC6513669, DOI: 10.1016/j.jpeds.2018.06.051.Peer-Reviewed Original ResearchConceptsBody mass indexAdverse childhood experiencesMass indexIndices of obesityAssessment of obesityChildhood experiencesFuture longitudinal studiesObesity riskHealth burdenPsychiatric outcomesSecond cohortObesityNovel interventionsCohortEarly adversityCross-sectional measuresEpigenetic predictorsLongitudinal studySaliva DNAEpigenetic measuresWhole genome testingDiscovery sampleReplication sampleChildrenRisk
2017
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism
Chen TW, Lee CC, Liu H, Wu CS, Pickering CR, Huang PJ, Wang J, Chang IY, Yeh YM, Chen CD, Li HP, Luo JD, Tan BC, Chan TEH, Hsueh C, Chu LJ, Chen YT, Zhang B, Yang CY, Wu CC, Hsu CW, See LC, Tang P, Yu JS, Liao WC, Chiang WF, Rodriguez H, Myers JN, Chang KP, Chang YS. APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism. Nature Communications 2017, 8: 465. PMID: 28878238, PMCID: PMC5587710, DOI: 10.1038/s41467-017-00493-9.Peer-Reviewed Original ResearchConceptsOral squamous cell carcinomaSquamous cell carcinomaCell carcinomaTaiwanese oral squamous cell carcinomasClinical prognostic relevanceBetter overall survivalCancer prognostic biomarkersExpression of APOBEC3AOverall survivalPrognostic relevanceTaiwanese patientsPrognostic biomarkerSecond cohortGermline polymorphismsCancer typesProminent cancerMutational profileDeletion polymorphismPatientsCarcinomaMutation signaturesExpressionPolymorphismCohortTumors
2016
Automated hybrid closed‐loop control with a proportional‐integral‐derivative based system in adolescents and adults with type 1 diabetes: individualizing settings for optimal performance
Ly TT, Weinzimer SA, Maahs DM, Sherr JL, Roy A, Grosman B, Cantwell M, Kurtz N, Carria L, Messer L, von Eyben R, Buckingham BA. Automated hybrid closed‐loop control with a proportional‐integral‐derivative based system in adolescents and adults with type 1 diabetes: individualizing settings for optimal performance. Pediatric Diabetes 2016, 18: 348-355. PMID: 27191182, DOI: 10.1111/pedi.12399.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdolescentAdolescent BehaviorAdultAlgorithmsBlood GlucoseBlood Glucose Self-MonitoringCalibrationCohort StudiesDiabetes Mellitus, Type 1Drug Dosage CalculationsDrug MonitoringGlucoseHumansHyperglycemiaHypoglycemiaHypoglycemic AgentsInsulinPancreas, ArtificialPrecision MedicineSubcutaneous TissueYoung AdultConceptsType 1 diabetesAdolescent cohortAdult cohortHybrid closed-loop systemPump therapyPercentage of timeGlucose valuesSensor-Augmented Pump TherapyOverall glucose controlInsulin pump therapyOverall mean percentageDose insulinGlucose controlPreliminary safetyInsulin delivery systemsInitial cohortHybrid closed-loop controlClinical practiceSecond cohortCohortMean percentageTarget rangeOverall percentageDiabetesAdults
2014
Kidney Transplant Outcomes for Prior Living Organ Donors
Potluri V, Harhay MN, Wilson FP, Bloom RD, Reese PP. Kidney Transplant Outcomes for Prior Living Organ Donors. Journal Of The American Society Of Nephrology 2014, 26: 1188-1194. PMID: 25412818, PMCID: PMC4413763, DOI: 10.1681/asn.2014030302.Peer-Reviewed Original ResearchConceptsKidney transplantationOrgan donorsKidney transplantDeceased donor kidney transplantationUS kidney allocation systemPost-transplant mortalityDonor kidney transplantationKidney transplant outcomesDeceased donor transplantsPropensity score-matching methodKidney allocation systemLiving Organ DonorsLower median timePrior donorsLive organ donationPretransplant dialysisDonor transplantsTransplant outcomesMedian timeSecond cohortTransplantationOrgan procurementTransplantation NetworkKidney allocationOrgan donationMacrophage expression of tartrate-resistant acid phosphatase as a prognostic indicator in colon cancer
How J, Brown JR, Saylor S, Rimm DL. Macrophage expression of tartrate-resistant acid phosphatase as a prognostic indicator in colon cancer. Histochemistry And Cell Biology 2014, 142: 195-204. PMID: 24429833, PMCID: PMC4101067, DOI: 10.1007/s00418-014-1181-6.Peer-Reviewed Original ResearchMeSH KeywordsAcid PhosphataseAdenocarcinomaAdultAgedAged, 80 and overAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkers, TumorColonic NeoplasmsFemaleHumansIsoenzymesMacrophagesMaleMiddle AgedReceptors, Cell SurfaceTartrate-Resistant Acid PhosphataseTissue Array AnalysisTreatment OutcomeYoung AdultConceptsColorectal cancer patientsMacrophage expressionResistant acid phosphataseColon cancerCancer patientsTRAP expressionYale-New Haven HospitalDisease-specific deathPan-macrophage markerRisk reductionPrognostic indicatorCancer survivalColorectal adenocarcinomaM2 markersImproved outcomesTissue microarrayImmunohistochemical analysisSecond cohortSurvival analysisPatientsPotential biomarkersQuantitative immunofluorescenceCancerAcid phosphataseOld cases
2011
P1-07-03: Preanalytical Variables Affect Protein Expression in Formalin Fixed Paraffin Embedded Tissue – Assessment of Intrinsic Controls To Define Tissue Quality for Immunohistochemical Analysis.
Neumeister V, Lostritto K, Siddiqui S, Anagnostou V, Vassilakopoulou M, Zarrella E, Molinaro A, Hicks D, Rimm D. P1-07-03: Preanalytical Variables Affect Protein Expression in Formalin Fixed Paraffin Embedded Tissue – Assessment of Intrinsic Controls To Define Tissue Quality for Immunohistochemical Analysis. Cancer Research 2011, 71: p1-07-03-p1-07-03. DOI: 10.1158/0008-5472.sabcs11-p1-07-03.Peer-Reviewed Original ResearchIschemic timeProtein expressionBreast cancerFormalin fixationDifferent breast cancer cohortsTumor tissuePairs of biopsiesTumor heterogeneityBreast cancer cohortBreast cancer biopsiesBreast cancer specimenPre-analytical variablesHistone 4ER alphaCancer cohortImmunohistochemical analysisCancer biopsiesSecond cohortAQUA scoreCancer specimenClinical settingQuantitative immunofluorescenceResectionCancer ResBiopsy
2009
Epstein–Barr virus infection is not a characteristic feature of multiple sclerosis brain
Willis SN, Stadelmann C, Rodig SJ, Caron T, Gattenloehner S, Mallozzi SS, Roughan JE, Almendinger SE, Blewett MM, Brück W, Hafler DA, O’Connor K. Epstein–Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain 2009, 132: 3318-3328. PMID: 19638446, PMCID: PMC2792367, DOI: 10.1093/brain/awp200.Peer-Reviewed Original ResearchConceptsMultiple sclerosis brainEpstein-Barr virus infectionEBV infectionWhite matter lesionsMultiple sclerosisCentral nervous systemMatter lesionsVirus infectionSecond cohortEBV infected cellsB cell infiltrationB cell aggregatesInflammatory demyelinating diseaseB-cell infiltratesReal-time polymerase chain reaction methodologyCNS immunopathologyCNS lymphomaDemyelinating diseaseCell infiltrateSitu hybridizationCell infiltrationLarge cohortBrain pathologyNervous systemPolymerase chain reaction methodology
2008
AQUA analysis of thymidylate synthase reveals localization to be a key prognostic biomarker in 2 large cohorts of colorectal carcinoma.
Gustavson MD, Molinaro AM, Tedeschi G, Camp RL, Rimm DL. AQUA analysis of thymidylate synthase reveals localization to be a key prognostic biomarker in 2 large cohorts of colorectal carcinoma. Archives Of Pathology & Laboratory Medicine 2008, 132: 1746-52. PMID: 18976010, DOI: 10.5858/132.11.1746.Peer-Reviewed Original ResearchConceptsThymidylate synthase expressionSynthase expressionColorectal carcinomaSignificant associationDisease-specific survivalColon cancer outcomesColon cancer survivalKey prognostic biomarkersRetrospective cohortNodal statusPrognostic valueColorectal cancerCancer outcomesCancer survivalPathologic classificationPrognostic biomarkerLarge cohortSecond cohortAQUA scoreCytoplasmic expressionNuclear expressionCohortHigh nuclearCytoplasmic ratioFirst cohortIntegrating Peer-Provided Services: A Quasi-experimental Study of Recovery Orientation, Confidence, and Empowerment
Resnick SG, Rosenheck RA. Integrating Peer-Provided Services: A Quasi-experimental Study of Recovery Orientation, Confidence, and Empowerment. Psychiatric Services 2008, 59: 1307-1314. PMID: 18971407, DOI: 10.1176/ps.2008.59.11.1307.Peer-Reviewed Original ResearchConceptsTreat analysisRecovery orientationClinical measuresMental health servicesSignificant differencesTraditional clinical measuresPeer supportSubset of participantsLack of evidenceStandard careCohort 2Consecutive cohortBaseline differencesSecond cohortQuasi-experimental studyHealth servicesCohortSecondary analysisThird cohortAlcohol usePeer educationBeneficial impactSupport programsMeasures of empowermentParticipants
2007
Neoadjuvant Therapy with Paclitaxel followed by 5-Fluorouracil, Epirubicin, and Cyclophosphamide Chemotherapy and Concurrent Trastuzumab in Human Epidermal Growth Factor Receptor 2–Positive Operable Breast Cancer: An Update of the Initial Randomized Study Population and Data of Additional Patients Treated with the Same Regimen
Buzdar AU, Valero V, Ibrahim NK, Francis D, Broglio KR, Theriault RL, Pusztai L, Green MC, Singletary SE, Hunt KK, Sahin AA, Esteva F, Symmans WF, Ewer MS, Buchholz TA, Hortobagyi GN. Neoadjuvant Therapy with Paclitaxel followed by 5-Fluorouracil, Epirubicin, and Cyclophosphamide Chemotherapy and Concurrent Trastuzumab in Human Epidermal Growth Factor Receptor 2–Positive Operable Breast Cancer: An Update of the Initial Randomized Study Population and Data of Additional Patients Treated with the Same Regimen. Clinical Cancer Research 2007, 13: 228-233. PMID: 17200359, DOI: 10.1158/1078-0432.ccr-06-1345.Peer-Reviewed Original ResearchConceptsHuman epidermal growth factor receptorPathologic CR rateEpidermal growth factor receptorConcurrent trastuzumabGrowth factor receptorCR rateEfficacy dataBreast cancerStudy populationHigher pathologic complete remission rateSecond cohortPathologic complete remission rateCardiac safety dataCycles of FECCycles of paclitaxelOperable breast cancerComplete remission rateDisease-free survivalFactor receptorBreast cancer patientsNew safety concernsSame chemotherapyWeekly trastuzumabCyclophosphamide chemotherapyNeoadjuvant therapy
1998
Increased Striatal Dopamine Transmission in Schizophrenia: Confirmation in a Second Cohort
Abi-Dargham A, Gil R, Krystal J, Baldwin RM, Seibyl JP, Bowers M, van Dyck CH, Charney DS, Innis RB, Laruelle M. Increased Striatal Dopamine Transmission in Schizophrenia: Confirmation in a Second Cohort. American Journal Of Psychiatry 1998, 155: 761-767. PMID: 9619147, DOI: 10.1176/ajp.155.6.761.Peer-Reviewed Original ResearchConceptsD2 receptor availabilityAcute amphetamine challengeStriatal dopamine transmissionAmphetamine challengeReceptor availabilityDopamine releaseHealthy subjectsDopamine transmissionDopamine D2 receptor availabilityExcess dopamine releaseStriatal dopamine releaseComparison groupD2 receptor radiotracerHistory of alcoholDSM-IV criteriaSingle photon emissionNew cohortUntreated patientsReceptor radiotracerSchizophrenic patientsPatientsSecond cohortParental socioeconomic statusPositive symptomsSubstance abuse
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