2008
AQUA analysis of thymidylate synthase reveals localization to be a key prognostic biomarker in 2 large cohorts of colorectal carcinoma.
Gustavson MD, Molinaro AM, Tedeschi G, Camp RL, Rimm DL. AQUA analysis of thymidylate synthase reveals localization to be a key prognostic biomarker in 2 large cohorts of colorectal carcinoma. Archives Of Pathology & Laboratory Medicine 2008, 132: 1746-52. PMID: 18976010, DOI: 10.5858/132.11.1746.Peer-Reviewed Original ResearchConceptsThymidylate synthase expressionSynthase expressionColorectal carcinomaSignificant associationDisease-specific survivalColon cancer outcomesColon cancer survivalKey prognostic biomarkersRetrospective cohortNodal statusPrognostic valueColorectal cancerCancer outcomesCancer survivalPathologic classificationPrognostic biomarkerLarge cohortSecond cohortAQUA scoreCytoplasmic expressionNuclear expressionCohortHigh nuclearCytoplasmic ratioFirst cohort
2003
Thymidylate synthase expression in hepatic tumors is a predictor of survival and progression in patients with resectable metastatic colorectal cancer.
Gonen M, Hummer A, Zervoudakis A, Sullivan D, Fong Y, Banerjee D, Klimstra D, Cordon-Cardo C, Bertino J, Kemeny N. Thymidylate synthase expression in hepatic tumors is a predictor of survival and progression in patients with resectable metastatic colorectal cancer. Journal Of Clinical Oncology 2003, 21: 406-12. PMID: 12560427, DOI: 10.1200/jco.2003.06.060.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic Combined Chemotherapy ProtocolsColorectal NeoplasmsDisease ProgressionDisease-Free SurvivalErbB ReceptorsFemaleGenetic MarkersHepatic ArteryHumansImmunohistochemistryInfusions, Intra-ArterialLiver NeoplasmsMaleMiddle AgedPredictive Value of TestsPrognosisThymidylate SynthaseTumor Suppressor Protein p53ConceptsHepatic progression-free survivalProgression-free survivalMetastatic colorectal cancerResectable metastatic colorectal cancerOverall survivalSystemic chemotherapyPredictors of survivalHepatic tumorsColorectal cancerResection marginsIncreased levels of serum alkaline phosphataseMultivariate analysisMarker expressionIndependent predictor of outcomeFactor of poor prognosisHepatic arterial infusionEpidermal growth factor receptorLevels of serum alkaline phosphatasePredicting Overall SurvivalMultivariate Cox modelThymidylate synthase expressionPredictors of outcomeGrowth factor receptorSerum alkaline phosphataseLiver resection
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply