2011
P1-07-03: Preanalytical Variables Affect Protein Expression in Formalin Fixed Paraffin Embedded Tissue – Assessment of Intrinsic Controls To Define Tissue Quality for Immunohistochemical Analysis.
Neumeister V, Lostritto K, Siddiqui S, Anagnostou V, Vassilakopoulou M, Zarrella E, Molinaro A, Hicks D, Rimm D. P1-07-03: Preanalytical Variables Affect Protein Expression in Formalin Fixed Paraffin Embedded Tissue – Assessment of Intrinsic Controls To Define Tissue Quality for Immunohistochemical Analysis. Cancer Research 2011, 71: p1-07-03-p1-07-03. DOI: 10.1158/0008-5472.sabcs11-p1-07-03.Peer-Reviewed Original ResearchIschemic timeProtein expressionBreast cancerFormalin fixationDifferent breast cancer cohortsTumor tissuePairs of biopsiesTumor heterogeneityBreast cancer cohortBreast cancer biopsiesBreast cancer specimenPre-analytical variablesHistone 4ER alphaCancer cohortImmunohistochemical analysisCancer biopsiesSecond cohortAQUA scoreCancer specimenClinical settingQuantitative immunofluorescenceResectionCancer ResBiopsy
2007
Variation in breast cancer hormone receptor and HER2 levels by etiologic factors: A population‐based analysis
Sherman ME, Rimm DL, Yang XR, Chatterjee N, Brinton LA, Lissowska J, Peplonska B, Szeszenia‐Dąbrowska N, Zatonski W, Cartun R, Mandich D, Rymkiewicz G, Ligaj M, Lukaszek S, Kordek R, Kalaylioglu Z, Harigopal M, Charrette L, Falk RT, Richesson D, Anderson WF, Hewitt SM, García‐Closas M. Variation in breast cancer hormone receptor and HER2 levels by etiologic factors: A population‐based analysis. International Journal Of Cancer 2007, 121: 1079-1085. PMID: 17487843, DOI: 10.1002/ijc.22812.Peer-Reviewed Original ResearchConceptsBody mass indexPostmenopausal womenEtiologic factorsHER2 levelsPremenopausal womenOdds ratioER alphaBreast cancer hormone receptor statusPopulation-based case-control studyBreast Cancer Hormone ReceptorsHormone receptor statusCase-control studyPopulation-based analysisPathologic characteristicsPR statusReceptor statusMass indexER betaClinical recordsMarker levelsHER2 expressionLarge tumorsBreast cancerReceptor levelsTumor features
2004
Estrogen to Antiestrogen with a Single Methylene Group Resulting in an Unusual Steroidal Selective Estrogen Receptor Modulator
Zhang JX, Labaree DC, Mor G, Hochberg RB. Estrogen to Antiestrogen with a Single Methylene Group Resulting in an Unusual Steroidal Selective Estrogen Receptor Modulator. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 3527-3535. PMID: 15240642, DOI: 10.1210/jc.2003-032005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody WeightBone and BonesCell Line, TumorCholesterolDose-Response Relationship, DrugEstradiolEstrogen AntagonistsEstrogen Receptor alphaEstrogen Receptor betaEstrogensFemaleHumansHydrocarbonsMethaneOrgan SizeRatsRats, Sprague-DawleyReceptors, EstrogenSelective Estrogen Receptor ModulatorsTransfectionUterusConceptsSelective estrogen receptor modulatorsEstrogen receptor modulatorsReceptor modulatorsBreast cancer preventionEstradiol-induced proliferationER affinityHigh ER affinityImportant therapeutic agentsPlasma cholesterolER alphaCancer preventionEstrogen agonistEstrogenic agonistTherapeutic agentsEstradiol analogsHigh estrogenic potencyCell bioassayBone growthEstrogenic activityAntiestrogensEstrogenic potencyAgonistsCritical structuresUnique mechanismGroup
2002
ER-X: A Novel, Plasma Membrane-Associated, Putative Estrogen Receptor That Is Regulated during Development and after Ischemic Brain Injury
Toran-Allerand CD, Guan X, MacLusky NJ, Horvath TL, Diano S, Singh M, Connolly ES, Nethrapalli S, Tinnikov AA. ER-X: A Novel, Plasma Membrane-Associated, Putative Estrogen Receptor That Is Regulated during Development and after Ischemic Brain Injury. Journal Of Neuroscience 2002, 22: 8391-8401. PMID: 12351713, PMCID: PMC6757764, DOI: 10.1523/jneurosci.22-19-08391.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveBlotting, WesternBrain IschemiaCaveolaeCell MembraneCell-Free SystemCells, CulturedCholesterolEnzyme ActivationEstradiolGene Expression Regulation, DevelopmentalIonophoresMiceMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein KinasesNeocortexNeuronsReceptors, EstrogenRNA, MessengerSignal TransductionSubcellular FractionsSubstrate SpecificityConceptsMAPK cascadePlasma membraneExtracellular signal-regulated kinases ERK1Neuronal differentiationPlasma membrane-associatedPlasma membrane-associated ERsProtein kinase isoformsCell-free systemMembrane-associated ERER alphaPutative ERKinases ERK1Cell divisionER betaSustained phosphorylationKinase isoformsERK activationMembrane-associatedGene-disrupted miceNovel mechanismEstrogen receptorUterine plasma membranesInhibitory regulatorIschemic stroke injuryIschemic brain injuryRaloxifene, a mixed estrogen agonist/antagonist, induces apoptosis in androgen-independent human prostate cancer cell lines.
Kim I, Kim B, Seong D, Lee D, Seo J, Hong Y, Kim H, Morton R, Kim S. Raloxifene, a mixed estrogen agonist/antagonist, induces apoptosis in androgen-independent human prostate cancer cell lines. Cancer Research 2002, 62: 5365-9. PMID: 12235008.Peer-Reviewed Original ResearchConceptsAndrogen-independent human prostate cancer cell linesMixed estrogen agonist/antagonistProstate cancer cell linesHuman prostate cancer cell linesEstrogen agonist/antagonistAgonists/antagonistsCancer cell linesER betaER alphaCell linesDU145 cellsSelective estrogen receptor modulatorsEffects of raloxifeneEstrogen receptor modulatorsPC3M cellsDose-dependent mannerCell deathM raloxifeneWestern blot analysisTime-dependent mannerRaloxifene treatmentReceptor modulatorsBreast cancerPan-caspase inhibitor zVADRaloxifene
1999
Aromatase and Estrogen Receptor Immunoreactivity in the Coronary Arteries of Monkeys and Human Subjects
Diano S, Horvath T, Mor G, Register T, Adams M, Harada N, Naftolin F. Aromatase and Estrogen Receptor Immunoreactivity in the Coronary Arteries of Monkeys and Human Subjects. Menopause The Journal Of The North American Menopause Society 1999, 6: 21-28. PMID: 10100176, DOI: 10.1097/00042192-199906010-00006.Peer-Reviewed Original ResearchConceptsCoronary arteryEstrogen receptor immunoreactivityAmount of atherosclerosisHuman placental estrogen synthetaseHuman subjectsSmooth muscle cellsPrecursor androgensReceptor immunoreactivityCardioprotective effectsCoronary circulationEstrogen formationER alphaEstrogen receptorArteryCardiovascular systemMuscle cellsEndothelial cellsEstrogenEstrogen synthetaseAromataseMonkeysFirst evidenceSubjectsCellsAtherosclerosis
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