Sebastian Matias Cruz Gomez, PhD
Postdoctoral AssociateDownloadHi-Res Photo
About
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Titles
Postdoctoral Associate
Appointments
Medical Oncology and Hematology
Postdoctoral AssociatePrimary
Other Departments & Organizations
- Internal Medicine
- Medical Oncology and Hematology
Education & Training
- PhD
- The University of Melbourne, Doctor of Philosophy - Medicine, Dentistry and Health Sciences
- MSc
- Universidad de Chile, Facultad de Ciencias Químicas y Farmacéuticas
- BSc (Hon)
- Pontificia Universidad Católica de Valparaíso
Research
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Research at a Glance
Publications Timeline
A big-picture view of Sebastian Matias Cruz Gomez's research output by year.
8Publications
Publications
2022
A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells.
Lim HJ, Wubben JM, Garcia CP, Cruz-Gomez S, Deng J, Mak JYW, Hachani A, Anderson RJ, Painter GF, Goyette J, Amarasinghe SL, Ritchie ME, Roquilly A, Fairlie DP, Gaus K, Rossjohn J, Villadangos JA, McWilliam HEG. A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells. The Journal Of Cell Biology 2022, 221 PMID: 36129434, DOI: 10.1083/jcb.202110125.Peer-Reviewed Original Research
2020
Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens.
McWilliam HEG, Mak JYW, Awad W, Zorkau M, Cruz-Gomez S, Lim HJ, Yan Y, Wormald S, Dagley LF, Eckle SBG, Corbett AJ, Liu H, Li S, Reddiex SJJ, Mintern JD, Liu L, McCluskey J, Rossjohn J, Fairlie DP, Villadangos JA. Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 24974-24985. PMID: 32958637, PMCID: PMC7547156, DOI: 10.1073/pnas.2011260117.Peer-Reviewed Original ResearchOrgan-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes.
Frizzell H, Fonseca R, Christo SN, Evrard M, Cruz-Gomez S, Zanluqui NG, von Scheidt B, Freestone D, Park SL, McWilliam HEG, Villadangos JA, Carbone FR, Mackay LK. Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes. Science Immunology 2020, 5 PMID: 32245887, DOI: 10.1126/sciimmunol.aay9283.Peer-Reviewed Original Research
2019
Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation.
Arce M, Pinto MP, Galleguillos M, Muñoz C, Lange S, Ramirez C, Erices R, Gonzalez P, Velasquez E, Tempio F, Lopez MN, Salazar-Onfray F, Cautivo K, Kalergis AM, Cruz S, Lladser Á, Lobos-González L, Valenzuela G, Olivares N, Sáez C, Koning T, Sánchez FA, Fuenzalida P, Godoy A, Contreras Orellana P, Leyton L, Lugano R, Dimberg A, Quest AFG, Owen GI. Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation. Cancers 2019, 11 PMID: 31382462, PMCID: PMC6721564, DOI: 10.3390/cancers11081103.Peer-Reviewed Original Research
2018
A filamentous bacteriophage targeted to carcinoembryonic antigen induces tumor regression in mouse models of colorectal cancer.
Murgas P, Bustamante N, Araya N, Cruz-Gómez S, Durán E, Gaete D, Oyarce C, López E, Herrada AA, Ferreira N, Pieringer H, Lladser A. A filamentous bacteriophage targeted to carcinoembryonic antigen induces tumor regression in mouse models of colorectal cancer. Cancer Immunology, Immunotherapy : CII 2018, 67: 183-193. PMID: 29026949, DOI: 10.1007/s00262-017-2076-x.Peer-Reviewed Original Research
2017
A short hairpin RNA-based adjuvant targeting NF-κB repressor IκBα promotes migration of dermal dendritic cells to draining lymph nodes and antitumor CTL responses induced by DNA vaccination.
Gálvez-Cancino F, Roco J, Rojas-Colonelli N, Flores C, Murgas P, Cruz-Gómez S, Oyarce C, Varas-Godoy M, Sauma D, Lladser A. A short hairpin RNA-based adjuvant targeting NF-κB repressor IκBα promotes migration of dermal dendritic cells to draining lymph nodes and antitumor CTL responses induced by DNA vaccination. Vaccine 2017, 35: 4148-4154. PMID: 28666759, DOI: 10.1016/j.vaccine.2017.06.041.Peer-Reviewed Original ResearchInhibition of dopamine receptor D3 signaling in dendritic cells increases antigen cross-presentation to CD8+ T-cells favoring anti-tumor immunity.
Figueroa C, Gálvez-Cancino F, Oyarce C, Contreras F, Prado C, Valeria C, Cruz S, Lladser A, Pacheco R. Inhibition of dopamine receptor D3 signaling in dendritic cells increases antigen cross-presentation to CD8+ T-cells favoring anti-tumor immunity. Journal Of Neuroimmunology 2017, 303: 99-107. PMID: 28077213, DOI: 10.1016/j.jneuroim.2016.12.014.Peer-Reviewed Original ResearchCaveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8+ T Cell Responses.
Oyarce C, Cruz-Gomez S, Galvez-Cancino F, Vargas P, Moreau HD, Diaz-Valdivia N, Diaz J, Salazar-Onfray FA, Pacheco R, Lennon-Dumenil AM, Quest AFG, Lladser A. Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8+ T Cell Responses. Frontiers In Immunology 2017, 8: 1794. PMID: 29326695, PMCID: PMC5733362, DOI: 10.3389/fimmu.2017.01794.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Honors
honor Graduate Research Scholarship
04/12/2017International AwardThe University of MelbourneDetailsAustraliahonor National Master Degree Research Scholarship
03/01/2016International AwardCONICYT. Chilean GovernmentDetailsChile
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