Jason Crawford, PhD
Professor of Chemistry and of Microbial PathogenesisDownloadHi-Res Photo
Cards
Appointments
Chemistry
Primary
Microbial Pathogenesis
Secondary
Contact Info
Institute of Biomolecular Design and Discovery
Institute of Biomolecular Design & Discovery, PO Box 27392
West Haven, CT 06516-7392
United States
About
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Titles
Professor of Chemistry and of Microbial Pathogenesis
Appointments
Chemistry
ProfessorPrimaryMicrobial Pathogenesis
ProfessorSecondary
Other Departments & Organizations
- Chemistry
- CPIRT - Center for Pulmonary Injury, Repair, and Therapeutics
- Developmental Therapeutics
- Immunology
- Institute of Biomolecular Design and Discovery
- Microbial Pathogenesis
- Microbiology
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- PhD
- Johns Hopkins University (2007)
- MA
- Johns Hopkins University (2003)
Research
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Overview
Medical Research Interests
Bacteria; Chemistry; Host-Pathogen Interactions
ORCID
0000-0002-7583-1242- View Lab Website
Crawford Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jason Crawford's published research.
Publications Timeline
A big-picture view of Jason Crawford's research output by year.
Research Interests
Research topics Jason Crawford is interested in exploring.
Noah Wolcott Palm, PhD
Deguang Song
Zheng Wei
Richard Flavell, PhD, FRS
Andrew Goodman, PhD
Autumn York
Former YSM
101Publications
5,090Citations
Bacteria
Host-Pathogen Interactions
Publications
2026
Commensal-derived acetylcholine enhances mucosal immune education
Song D, Duncan-Lowey B, Khetrapal V, Hamchand R, Deng T, Brown H, Wu A, Martin A, Bauer K, Zhao Y, Nguyen M, Sonnert N, Leopold S, Wu Q, Crawford J, Palm N. Commensal-derived acetylcholine enhances mucosal immune education. Nature 2026, 655: 1027-1036. PMID: 42236946, PMCID: PMC13391359, DOI: 10.1038/s41586-026-10592-7.Peer-Reviewed Original ResearchCitationsAltmetricA drug–microbiome–drug interaction impacts co-prescribed medications for Parkinson’s disease
Verdegaal A, Oh J, Javdan B, Wang R, Wu Q, Wang T, González-Hernández J, Donia M, Crawford J, Goodman A. A drug–microbiome–drug interaction impacts co-prescribed medications for Parkinson’s disease. Nature Microbiology 2026, 11: 1387-1409. PMID: 41942777, PMCID: PMC13171619, DOI: 10.1038/s41564-026-02299-2.Peer-Reviewed Original ResearchCitationsAltmetric
2025
Three-component assembly and structure–function relationships of (–)-gukulenin A
Gupta V, Wang Z, Combs J, Wright T, Chen L, Lin B, Holmes R, Qin B, Oh J, Crawford J, Herzon S. Three-component assembly and structure–function relationships of (–)-gukulenin A. Science 2025, 390: eaea9310-eaea9310. PMID: 41231967, PMCID: PMC12863052, DOI: 10.1126/science.aea9310.Peer-Reviewed Original ResearchCitationsAltmetricDiscovery of a Widespread Polyamine–Low-Molecular-Weight Thiol Hybrid Pathway in Clostridioides difficile
Hunt R, Oh J, Jain A, Kuo T, Berardi D, Jian W, Song D, Wu Q, Goodman A, Palm N, Zimmermann M, Johnson C, Crawford J. Discovery of a Widespread Polyamine–Low-Molecular-Weight Thiol Hybrid Pathway in Clostridioides difficile. ACS Infectious Diseases 2025, 11: 2246-2264. PMID: 40671632, PMCID: PMC12403189, DOI: 10.1021/acsinfecdis.5c00286.Peer-Reviewed Original ResearchCitationsAltmetricTryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses
Park H, Song D, Nguyen M, Palm N, Crawford J. Tryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses. ACS Chemical Biology 2025, 20: 1775-1782. PMID: 40577169, PMCID: PMC12372651, DOI: 10.1021/acschembio.5c00313.Peer-Reviewed Original ResearchCitationsActivity of GPCR-targeted drugs influenced by human gut microbiota metabolism
Wu Q, Song D, Zhao Y, Verdegaal A, Turocy T, Duncan-Lowey B, Goodman A, Palm N, Crawford J. Activity of GPCR-targeted drugs influenced by human gut microbiota metabolism. Nature Chemistry 2025, 17: 808-821. PMID: 40181149, PMCID: PMC12412589, DOI: 10.1038/s41557-025-01789-w.Peer-Reviewed Original ResearchCitationsAltmetric
2024
Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca
Hamchand R, Wang K, Song D, Palm N, Crawford J. Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca. Nature Communications 2024, 15: 8902. PMID: 39406708, PMCID: PMC11480411, DOI: 10.1038/s41467-024-53185-6.Peer-Reviewed Original ResearchCitationsAltmetricBacterial small molecule metabolites implicated in gastrointestinal cancer development
Turocy T, Crawford J. Bacterial small molecule metabolites implicated in gastrointestinal cancer development. Nature Reviews Microbiology 2024, 23: 106-121. PMID: 39375475, PMCID: PMC12377021, DOI: 10.1038/s41579-024-01103-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricHuman AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway
Dudkina N, Park H, Song D, Jain A, Khan S, Flavell R, Johnson C, Palm N, Crawford J. Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway. Cell Chemical Biology 2024, 32: 126-144.e18. PMID: 39163853, PMCID: PMC11748234, DOI: 10.1016/j.chembiol.2024.07.011.Peer-Reviewed Original ResearchCitationsEnterococcus faecalis-derived adenine enhances enterohaemorrhagic Escherichia coli Type 3 Secretion System-dependent virulence
Martins F, Rosay T, Rajan A, Carter H, Turocy T, Mejia A, Crawford J, Maresso A, Sperandio V. Enterococcus faecalis-derived adenine enhances enterohaemorrhagic Escherichia coli Type 3 Secretion System-dependent virulence. Nature Microbiology 2024, 9: 2448-2461. PMID: 38965331, PMCID: PMC11585081, DOI: 10.1038/s41564-024-01747-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAdenineAnimalsCoculture TechniquesEnterococcus faecalisEnterocytesEnterohemorrhagic Escherichia coliEscherichia coli InfectionsEscherichia coli ProteinsGastrointestinal MicrobiomeGene Expression Regulation, BacterialHemolysin ProteinsHost-Pathogen InteractionsHumansHypoxanthineMiceType III Secretion SystemsVirulenceVirulence FactorsXanthine
News
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News
- November 14, 2025Source: Yale News
Soaking up the anti-cancer properties of a South Korean sea sponge
- October 27, 2025
YCC Publications 2025
- July 11, 2024
Protein Detects and Responds to Changes in Blood Flow
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Mailing Address
Institute of Biomolecular Design and Discovery
Institute of Biomolecular Design & Discovery, PO Box 27392
West Haven, CT 06516-7392
United States